Novel AP39-Loaded Liposomes Sustain the Release of Hydrogen Sulphide, Enhance Blood-Brain Barrier Permeation, and Abrogate Oxidative Stress-Induced Mitochondrial Dysfunction in Bra... by Al Tahan MA, Marwah MK, Dhaliwal M, Diaz Sanchez L, Shokr H, Kaur M, Ahmad S, Badhan RK, Dias IH, Sanchez-Aranguren L

“…Liposomal permeability, AP39 release kinetics, and cellular uptake were evaluated using a microvasculature BBB model. …”
Get full text

Levels of E, A, M, G immunoglobulins in children with newly diagnosed tuberculosis at the beginning of antimycobacterial therapy by O. M. Raznatovska, Yu. V. Mironchuk, O. S. Lytvynenko

“…Data resulting from the study suggest that the humoral component of immune system is also activated on the background of the cellular component of immune system activation with patient's state aggravation, which is an unfavorable prognosis for patients’ recovery.…”
Get full text

DEVELOPMENT AND CHARACTERISATION OF 3D SOLID TUMOUR CELL MODELS FOR INDIVIDUALIZED CANCER TREATMENT by A. B. Danilova, T. L. Nekhaeva, N. A. Efremova, M. A. Maydin, E. I. Fedoros, I. A. Baldueva

“…To solve the problems of personalized medicine in oncology, preclinical studies based on the use of three-dimensional cellular models of tumors in vitro, including spheroids / tumoroids, are of great importance. …”
Get full text

Study of head and neck squamous cell carcinoma transcriptome after proton therapy by E. D. Jumaniyazova, P. A. Vishnyakova, M. V. Chirkova, E. A. Karpulevich, I. Z. Eremina, K. B. Gordon, A. D. Kaprin, T. H. Fatkhudinov

“…The dose-dependence of PT effects necessitates further study of changes in cellular and molecular-genetic signatures of HNSCC after proton irradiation with different doses.…”
Get full text

Ductular reaction or hepatic reparative complex: immunohistochemical features in liver cirrhosis in patients with chronic hepatitis by V. A. Tumanskiy, S. V. Fen’

“…/HCAM+, CD34+, CD56+, expressing the markers of biliary (CK7+, CK19+) and hepatocyte (Hepar+, α-fetoprotein+) differentiation are revealed. Cellular chains and ductules in the intermediate zones of the hepatic lobules are represented by cells of biphasic differentiation: biliary (CK7+, CK19+), hepatocyte (Hepar+) differentiation and intermediate hepatobiliary CK7+ cells. …”
Get full text

Automation of flow cytometry data analysis with elastic image registration by Allison Irvine, Mohamed Mahmoud Moustafa, Sahul Patel, Aniket Patel, Lilja Hardardottir, Francesca Delvecchio, Taylor Foreman, Jean Oak, Scott J. Bornheimer, Raffaello Cimbro

“…Abstract Cell populations in flow cytometry are typically identified via visual manual gating, a time-consuming and error-prone approach to select subpopulations based on expression of cellular markers. Batch processing can be used to automate the analysis of bimodally distributed data but underperforms with highly-variable or continuously-expressed markers. …”
Get full text

Spatiotemporal dynamics and predictive modelling of land use and land cover changes for sustainable watershed management in the Karamana River Basin, India by Ganga Krishnan, Radhakrishnan Shanthi Priya, Geetha Ramesh Kumar, Ramalingam Senthil

“…This study examines the spatiotemporal dynamics of LULC changes from 1985 to 2024 and projects a future scenario for the year 2050 using the Cellular Automata–Markov (CA–Markov) chain modeling approach. …”
Get full text

Effect of a pyrimidine derivative on the level of cytokines in conditions of streptococcal wound infection by A. A. Tsibizova, A. L. Yasenyavskaya, I. N. Tyurenkov, A. A. Ozerov, M. A. Samotrueva

“…The streptococcal infection is accompanied, along with infectious and inflammatory symptoms, by a pronounced immune response to Streptococcus pyogenes, which is mediated by the functional activity of monocytes and dendritic cells responsible for the production of pro- and anti-inflammatory cytokines that regulate the interaction, proliferation and functional activity of all participants in the cellular and humoral links of immunity. The purpose is to study the effect of a pyrimidine derivative on the level of pro- (IL-1β, IL-6, IL-8) and anti-inflammatory interleukins (IL-4, IL-10) in conditions of experimental streptococcal wound infection. …”
Get full text

Development of an integrated microfluidic device for cell lysis and DNA purification by Elahe Jalilvand, Amir Shamloo

“…In the experimental study, two-colored fluids and FITC/water were used separately. The average mixing efficiency at the end of the channel was 98.95 %, differing by only 1.01 % from the computational results. …”
Get full text

Postoperative radiotherapy with an electron beam on keloid scar: epidemiological evaluation in a teaching hospital by Balduino Ferreira de Menezes, Lucas Vannuchi Magnani, Batista de Oliveira, Aristides Augusto Palhares

“…They have a unique pathophysiology and multiple specific genetic and cellular factors, which have not yet been fully elucidated. …”
Get full text

Development and Transportation Pathway Evaluation of Liposomes with Bile Acids for Enhancing the Blood-Brain Barrier Penetration of Methotrexate by Natthan Charernsriwilaiwat, Rattanan Thaitrong, Samarwadee Plianwong, Praneet Opanasopit, Pucharee Songprakhon, Thirapit Subongkot

“…For transport pathway evaluation across the blood-brain barrier of these liposomes, CLSM revealed that fluorescent liposomes were present inside cells treated with specific endocytosis inhibitors, indicating that the cellular internalization of the particles was not involved in endocytosis. …”
Get full text

Population dynamics of Euphyllura olivina Costa, 1857 (Psyllidae: Hemiptera) in olive trees in the semi-arid region of Djelfa (Algeria) by Nassima CHAABANE, Smail CHAFAA, Frah NAAMA, Yassine NOUIDJEM, Fateh MIMECHE

Get full text

Doxorubicin delivery of green-synthesized gold nanoparticles to MDA-MB-231 cells and collagen type II identification from yellow nose skate cartilage by Eun-Young Ahn, Youmie Park

“…Doxorubin (DOX) was loaded onto the skAu, and the average size of the DOX-loaded AuNPs (c-skAuD) was measured to be 14.6 ± 0.5 nm by high-resolution transmission electron microscopy. …”
Get full text

Biosynthesis of silver nanoparticles using Lawsonia inermis and their biomedical application by Eman Alhomaidi, Saade Abdalkareem Jasim, Hawraz Ibrahim M. Amin, Marcos Augusto Lima Nobre, Mehrdad Khatami, Abduladheem Turki Jalil, Saja Hussain Dilfy

“…The green synthesis of Ag‐NPs by Lawsonia inermis extract and its cellular toxicity and the antimicrobial effect was studied. …”
Get full text

Virulence Is More than Adhesion and Invasion Ability, an In Vitro Cell Infection Assay of Bovine <i>Mycoplasma</i> spp. by Elhem Yacoub, Daniel Kos, Murray Jelinski

“…The study objective was to compare the adhesion and cellular invasion characteristics of these bovine <i>Mycoplasma</i> spp. using Madin–Darby Bovine Kidney (MDBK) epithelial cells. …”
Get full text

Structural comparison of homologous protein-RNA interfaces reveals widespread overall conservation contrasted with versatility in polar contacts. by Ikram Mahmoudi, Chloé Quignot, Carla Martins, Jessica Andreani

“…Protein-RNA interactions play a critical role in many cellular processes and pathologies. However, experimental determination of protein-RNA structures is still challenging, therefore computational tools are needed for the prediction of protein-RNA interfaces. …”
Get full text

RMIS-Net: a fast medical image segmentation network based on multilayer perceptron by Binbin Zhang, Guoliang Xu, Yiying Xing, Nanjie Li, Deguang Li

“…Comprehensive evaluations on two benchmark datasets (2018 Data Science Bowl for cellular structure segmentation and ISIC-2018 for lesion boundary delineation) demonstrate RMIS-Net’s superior performance, achieving state-of-the-art metrics including an average F1-score of 0.91 and mean intersection-over-union of 0.82. …”
Get full text

Development of a Sun Protection Factor for contact lenses (CL-SPF) by Tom Drew, James S. Wolffsohn, Andrew Devitt, Sasha Kieran

“…Despite the UV-blocking characteristics of sunglasses, ocular surface protection can be substantially reduced at certain solar angle and head orientation combinations; on average, 76%–89% of light was prevented from reaching the ocular surface depending on the intensity of the tint (80%–20% transmission). …”
Get full text

Science literacy levels of plant metabolism learning for biology education students by Risanti Dhaniaputri, Erni Angraini

“…The question material used in the test instrument is knowledge of photosynthesis, cellular respiration, phytochemical biosynthesis pathways, and implementation of plant metabolism concepts in the fields of health and pharmacology. …”
Get full text

Insights into the Thriving of <i>Bacillus megaterium</i> and <i>Rhodotorula mucilaginosa</i> in Mining Areas: Their Adaptation and Tolerance Under Extreme Levels of Cu and Mn by Alfonso Álvarez-Villa, Maribel Plascencia-Jatomea, Kadiya Calderón, Katiushka Arévalo-Niño, Guadalupe López-Avilés, Francisco Javier Almendariz-Tapia

“…Understanding microbial adaptation and tolerance based on the cellular concentration and biosorption capacity provides critical insights for evaluating microbial performance under heavy metal stress, which is essential for selecting efficient strains or consortia for bioremediation applications. …”
Get full text