Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients with Chronic Obstructive Pulmonary Disease by Ying Tang, Xiaodan Li, Man Wang, Qi Zou, Shasha Zhao, Bowen Sun, Lijun Xu, Yanfang Jiang

“…The frequencies of CD3+ T, CD4+ T, CD8+ T, B, NK, and NKT-like cells were determined using flow cytometry. …”
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Influence of polyfunctional Tbet+ T cells on specific clinical events in chronic lymphocytic leukaemia by Yeong Jer Lim, Yeong Jer Lim, Andrew D. Duckworth, Kim Clarke, Paul Kennedy, Indrani Karpha, Indrani Karpha, Melanie Oates, Matthew Gornall, Nagesh Kalakonda, Nagesh Kalakonda, Joseph R. Slupsky, Andrew R. Pettitt, Andrew R. Pettitt

“…IntroductionT-cell dysfunction is a hallmark of chronic lymphocytic leukemia (CLL), but the extent to which individual CD4+ or CD8+ T-cell subpopulations influence specific clinical events remains unclear. …”
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TIM3 and TIGIT-expressing CD4 T cells are impacted by kidney transplantation and associated with risk of infection by Harry Pickering, Subha Sen, Monica Cappelletti, Erik L. Lum, Suphamai Bunnapradist, Elaine F. Reed, Joanna M. Schaenman

“…IntroductionOlder kidney transplant patients experience higher rates of infection compared with younger transplant patients suggesting the impact of age-associated immune dysfunction. However, little is known about the impact of immunosuppression including antithymocyte globulin (ATG) induction, as well as whether T cell subtypes can predict risk for infection.MethodsWe collected blood from 91 patients before and then 3 months after kidney transplantation and analyzed CD4 and CD8 T cell phenotypes to determine the impact of immunosuppression on immune maturation, senescence, and infection.ResultsAfter transplantation the number of naïve T cells decreased overall, while TIM3-expressing naïve and central memory (CM) CD4 T cell frequency increased, with more striking change in patients receiving ATG compared with basiliximab induction. …”
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Advanced pentosan polysulfate sodium maculopathy with low cumulative exposure and hydroxychloroquine use by Elena Flester, Shaden H. Yassin, Shyamanga Borooah

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p38 mitogen-activated protein kinase drives senescence in CD4+ T lymphocytes and increases their pathological potential by Luis González-Osuna, Sandra Yasuyo Fukada, María Paz Hernández-Cáceres, Patricia Luz-Crawford, Cristian Cortez, Carolina Rojas, Paola Carvajal, Alfredo Sierra-Cristancho, Rolando Vernal

“…Abstract Background In several diseases, senescent T lymphocytes increase in number and release a senescence-associated secretory phenotype (SASP) with inflammatory and osteoclastogenic potential, favoring inflammation and bone loss. It is well known that the activation of p38 mitogen-activated protein kinase (p38 MAPK) orchestrates senescence in CD8+ T lymphocytes. …”
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Prenatal Exposure to Respiratory Syncytial Virus Alters Postnatal Immunity and Airway Smooth Muscle Contractility during Early-Life Reinfections. by Paul M Brown, Terri J Harford, Vandana Agrawal, Belinda Yen-Lieberman, Fariba Rezaee, Giovanni Piedimonte

“…Cytokine/chemokine analyses revealed reduced IFN-γ, IL-2, IL-12, IL-17A, IL-18, and TNF-α, as well as elevated nerve growth factor (NGF) expression. …”
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Prognostic value and immunotherapy analysis of immune cell-related genes in laryngeal cancer by Sen Zhang, Jianrui Pan, Huina Guo, Xiaoya Guan, Chenxu Yan, Lingling Ji, Xiansha Wu, Hui Huangfu

“…Tumor Immune Dysfunction and Exclusion (TIDE) analysis showed higher TIDE and exclusion scores in the high-risk group, whereas the CD8 score was higher in the low-risk group. …”
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Predicting prognosis and immunotherapy response of ferroptosis-related genes in colorectal cancer by Hongyun Wei, Keyu Ren, Yanchun Jin, Yao Wen, Bin Cao, Yu Gan, Ying Shi, Zhihong Wu, Linlin Chen

“…Immune infiltration analysis revealed higher infiltration levels of CD8 + T cells, regulatory T cells, and resting NK cells in the high-risk group, as well as higher dysfunction scores, suggesting possible immunotherapy tolerance. …”
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Enhancing understanding of endometrial function in patients with PCOS: clinical and immunological insights by Yaxin Guo, Jingfei Yang, Hong Chen, Yueping Zhou, Yan Yang, Biao Wang, Luyang Zha, Dijia Bai, Wenxuan Li, Xiaojuan Tang, Zishui Fang, Fei Li, Lei Jin

“…T cell subsets including CD4+CD8−T cells, CD4−CD8+T cells, Th1, Th2, Th17 and Treg cells in the endometrium were determined by flow cytometry. …”
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Reduced T and NK Cell Activity in Glioblastoma Patients Correlates with TIM-3 and BAT3 Dysregulation by Farah Ahmady, Peter Curpen, Louis Perriman, Adilson Fonseca Teixeira, Siqi Wu, Hong-Jian Zhu, Arpita Poddar, Aparna Jayachandran, George Kannourakis, Rodney B. Luwor

“…Cell surface TIM-3, but not ENTPD1, was also elevated on activated CD4⁺ and CD8⁺ T cells, as well as on NK cells from glioblastoma patients compared to healthy donor T and NK cells. …”
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The single-cell immune landscape of HIV-associated aggressive B-cell lymphoma by Xiaomei Zhang, Zailin Yang, Xiaoqing Xie, Jun Li, Qing Xiao, Guofa Xu, Ben Ma, Xudong Xie, Yi Liu, Liuyue Zhai, Yifeng Tang, Huihui Fu, Sanxiu He, Tingting Liu, Dehong Huang, Censi Zeng, Yixing Zhou, Renzhi Hu, Binling Guo, Chaoyu Wang, Shunsi Liang, Qin Luo, Jing Lv, Yingyu Nan, Jieping Li, Qiying Li, Shengqiang Wang, Yongzhong Wu, Yao Liu

“…Additionally, HAL exhibited senescence-like dysfunction in T cells, characterized by the reductions in regulatory activity of Treg and cytotoxic activity of CD8+ T cells, as well as decreases expression of IL7R genes and increases expression of FOS and FOSB genes. …”
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Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis by Na Li, Yanli Li, Ting Yu, Wenjin Chen, Mengzhuang Gou, Wenkai Zheng, Zhaofan Liu, Xiaoying Wang, Jiao Fang, Jinghui Tong, Song Chen, Baopeng Tian, Chiang-Shan R. Li, Li Tian, Yunlong Tan

“…Immunosenescence markers were assessed by flow cytometry and included the percentage of naïve or memory T cell subsets labeled by CD4+/CD8+, CD45RA+(naïve)/CD45RO (memory), or CD95+(memory), as well as the intracellular levels of selected cytokines (IL-1β, IL-6, TNF-α, and IFN-γ) in T cell subsets. …”
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Vasoprotective Effects of Hyperoside against Cerebral Ischemia/Reperfusion Injury in Rats: Activation of Large-Conductance Ca2+-Activated K+ Channels by Wen-Ming Hong, Yue-Wu Xie, Meng-Yu Zhao, Tian-Hang Yu, Li-Na Wang, Wan-Yan Xu, Shen Gao, Hua-Bao Cai, Yan Guo, Fang Zhang

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Neuronal damage and memory deficits after seizures are reversed by ascorbic acid? O dano neuronal e o déficit de memória após convulsões são revertidos pelo ácido ascórbico? by Adriana da Rocha Tomé, Chistiane Mendes Feitosa, Rivelilson Mendes de Freitas

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Molecular basis identification and hypnotic drug interactions for cognitive impairment related to sleep deprivation by Shun Zeng, Nannan Liu, Andong Zhang, Na Duan, Bo Xu, Chunqi Ai

“…The STRING and CytoHuba plugins were utilized to identify the protein-protein interactions (PPIs) as well as the hub genes in the main PPI subnetworks following the drug interaction of the hub genes and GEPIA-based survival analysis of the DEGs. …”
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Cryptococcosis in Pediatric Renal Transplant Recipients: Comparative Insights from Adult Cases by Guido Gembillo, Chiara Terzo, Salvatore Silipigni, Luca Soraci, Emmanuele Venanzi Rullo, Ylenia Russotto, Chiara Casuscelli, Maria Elsa Gambuzza, Maria Princiotto, Lorenzo Lo Cicero, Luigi Peritore, Concetto Sessa, Domenico Santoro

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A phase I/II trial of WT1-specific TCR gene therapy for patients with acute myeloid leukemia and active disease post-allogeneic hematopoietic cell transplantation: skewing towards... by Francesco Mazziotta, Lauren E. Martin, Daniel N. Egan, Merav Bar, Sinéad Kinsella, Kelly G. Paulson, Valentin Voillet, Miranda C. Lahman, Daniel Hunter, Thomas M. Schmitt, Natalie Duerkopp, Cecilia C. S. Yeung, Tzu-Hao Tang, Raphael Gottardo, Yuta Asano, Elise C. Wilcox, Bo Lee, Tianzi Zhang, Paolo Lopedote, Livius Penter, Catherine J. Wu, Filippo Milano, Philip D. Greenberg, Aude G. Chapuis

“…We previously reported that post-HCT immunotherapy with Epstein-Barr virus (EBV)-specific donor CD8+ T cells engineered to express a Wilms Tumor Antigen 1-specific T-cell receptor (TTCR-C4) appeared to prevent relapse in high-risk patients. …”
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Divergent B-cell and cytotoxic TNK cell activation signatures in HLA-B27-associated ankylosing spondylitis and acute anterior uveitis by Eisa Mahyari, Sean Davin, Kimberly Ogle, Emma Fale-Olsen, Carley Shaut, Tammy M. Martin, Jasvinder S. Ahuja, Eric Suhler, Atul Deodhar, James T. Rosenbaum, James T. Rosenbaum, Tejpal Gill, Tejpal Gill

“…Future studies incorporating HLA-B27-negative AS and AAU patients, along with validation of B-cell and myeloid dysfunction in these diseases, may provide novel biomarkers and therapeutic targets.…”
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Immunohistochemical changes of maxillary sinus mucosa with underlying adenomatous polyposis by Yu. M. Andreychyn, I. S. Kovalenko

“…Immunohistochemical investigation of the cellular composition of these infiltrates proved the presence of CD8+ T-killer cells, CD4+ T-helper cells, CD68+ macrophages as well as single plasma cells. …”
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LRP11 promotes stem-like T cells via MAPK13-mediated TCF1 phosphorylation, enhancing anti-PD1 immunotherapy by Zhishui Chen, Gang Chen, Li Chen, Xiangli Zhao, Lingjuan Sun, Zhibo Ma, Xiaosheng Tan, Yuhao Tu, Jingzeng Wang, Peixiang Lan

“…Background Tumor-infiltrating T cells enter an exhausted or dysfunctional state, which limits antitumor immunity. …”
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