EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

“…It was verified that high EDF1 expression in NB cells led to Lactosylceramide (LacCer) accumulation, as well as downstream ganglioside-GD3, which subsequently increased the expression of CD52 and immune checkpoint genes, chemotaxis, and apoptosis-related events in activated CD8+T cells. …”
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CD4+ but not CD8+ T cells are required for protection against severe guinea pig cytomegalovirus infections. by Tyler B Rollman, Zachary W Berkebile, Dustin M Hicks, Jason S Hatfield, Priyanka Chauhan, Marco Pravetoni, Mark R Schleiss, Gregg N Milligan, Terry K Morgan, Craig J Bierle

“…CD4+ T cell depletion increased the severity of illness, caused significantly elevated viral loads, and increased the rate of congenital guinea pig cytomegalovirus (GPCMV) infection relative to animals treated with control antibody. CD8+ T cell depletion was comparably well tolerated and did not significantly affect the weight of infected guinea pigs or viral loads in their blood or tissue. …”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…In the present study, we aimed to explore the pathologic role of IFN-α in regard to dysfunction of CD8+T cells in SLE. Methods: Serum level of IFN-α was detected in SLE and healthy controls (HC). …”
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QUANTITATIVE EXPRESSION FEATURES OF PD-1 AND TIM-3 CHECKPOINT MOLECULE RECEPTORS ON CD4⁺ AND CD8⁺ T-CELLS IN BREAST CANCER OF VARYING PROGRESSION DEGREES by Yu. A. Shevchenko, M. S. Kuznetsova, Yu. N. Khantakova, I. A. Obleukhova, A. A. Khristin, S. V. Sidorov, S. V. Sennikov

“…Sustained expression of the PD-1 receptor on T-lymphocytes is also associated with the exhaustion phenotype, while it remains unclear how the expression of these inhibitory receptors normally differs from that in pathological conditions of the body, which are characterized by an increase in the number of exhausted T-cells.The aim of the study was to determine the relative and absolute number of T-cells expressing PD-1 and TIM-3, as well as the number of PD-1 and TIM-3 molecules on the surface of CD4+ and CD8+T-cells in healthy donors and breast cancer (BC) patients. …”
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Single-Cell RNA Sequencing Reveals Peripheral Immune Cell Senescence and Inflammatory Phenotypes in Patients with Premature Ovarian Failure by Liu J, Wang L, Zhong W, Cai J, Sun Y, Li S, Li J, Liu Y, Xiong F

“…The trajectory of CD8+ Effector T cells in POF patients involved the synchronous upregulation of cytotoxic-related genes and immune checkpoint molecules. …”
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Echocardiographic phenotypes of diabetic myocardial disorder: evolution over 15 months follow-up in the ARISE-HF trial by Thomas H. Marwick, Carolyn Lam, Yuxi Liu, Stefano Del Prato, Julio Rosenstock, Javed Butler, Justin Ezekowitz, Nasrien E. Ibrahim, W. H. Wilson Tang, Faiez Zannad, Riccardo Perfetti, James L. Januzzi

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Immunologic aspects of West syndrome and evidence of plasma inhibitory effects on T cell function by Terezinha C.B. Montelli, Angela M.V.C. Soares, Maria Terezinha S. Peraçoli

“…STUDY OBJECTIVE: The purpose of this study was to assess the extent of immune dysfunction in a well-defined group of epileptic patients: children with diagnosis of West syndrome (WS) or with transitions to another age-related EEG patterns, the multifocal independent spikes (MIS), and the slow spike-wave complexes (Lennox-Gastaut syndrome - LGS). …”
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Biphasic behavior of T cell subsets reflects failure of early anti-myeloma response and leads to progressive T cell dysfunction by Suchita Suryakant Jadhav, Vipin Sharma, Aharon Lion, Lasser-Katz Efrat, Iftach Shaked, Galia Luboshits, Michael A. Firer

“…Analysis of BM samples revealed a biphasic behavior of T regulatory cells, Th17 cells, CD8+ cytotoxic T cells and NK cells, as well as skewing of CD4+ and CD8+ T memory cell subset distributionss, suggesting failure of an early anti-myeloma response, which is replaced by progressive immunosuppression, and dysfunction and exhaustion of CD8+ T cell tumor cytotoxicity. …”
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Clinical and pathogenetic significance of angiogenesis factors (VEGF-A, HGF, IGF-1) in the development of cardiometabolic disorders in gout patients having different obesity phenot... by T. A. Medvedeva, N. N. Kushnarenko, M. Yu. Mishko, T. M. Karavaeva, E. V. Volgina

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Prenatal Bisphenol B Exposure Induces Adult Male Offspring Reproductive Dysfunction via ERα Inhibition-Triggered MHC I-Mediated Testicular Immunological Responses by Nannan Chen, Xiaotian Li, Shenrui Zhou, Xin Peng, Senlin Xue, Yuetong Liu, Tingwang Jiang, Wei Yan

“…These results underscore not only the toxicological risks associated with BPB but also potential therapeutic targets for mitigating male reproductive dysfunction.…”
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Highly differentiated T cells link systemic and vascular inflammation in a mouse model of recurrent psoriasis by Fabio Casciano, Paolo Severi, Laura Marongiu, Anna Caproni, Chiara Terranova, Alex Spitilli, Davide Ferrari, Chiara Ruzza, Peggy Marconi, Paola Rizzo, Paola Rizzo, Francesca Granucci, Paola Secchiero, Eva Reali

“…Recurrent psoriasis-like condition in mice also induced increased activation of memory T cells, augmented frequencies of CXCR3+4-1BB+ and PD-1+TIM-3+ CD4+ T cells as well as CD8+ T cells with a highly differentiated phenotype. …”
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Current insights into the interplay between gut microbiota-derived metabolites and metabolic-associated fatty liver disease by Rachmad Anres Dongoran, Fang-Cen Tu, Chin-Hung Liu

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A Combined Extract from <i>Dioscorea bulbifera</i> and <i>Zingiber officinale</i> Mitigates PM_2.5-Induced Respiratory Damage by NF-κB/TGF-β1 Pathway by In Young Kim, Hyo Lim Lee, Hye Ji Choi, Yeong Hyeon Ju, Yu Mi Heo, Hwa Rang Na, Dong Yeol Lee, Won Min Jeong, Ho Jin Heo

“…In addition, it significantly alleviated respiratory dysfunction in BALB/c mice exposed to PM_2.5. …”
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An atlas of immune cell exhaustion in HIV-infected individuals revealed by single-cell transcriptomics by Shaobo Wang, Qiong Zhang, Hui Hui, Kriti Agrawal, Maile Ann Young Karris, Tariq M. Rana

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Immunological factor development of external genital endometriosis by M. A. Levkovich, N. V. Ermolova, I. I. Krukier, T. N. Pogorelova, L. V. Kravchenko

“…Thus, among fertile women with preserved childbearing function, the disease is generally diagnosed in approximately 6-7%, while among patients suffering from infertility, its frequency can reach 20-48%.However, the causes that determine reproductive dysfunction in patients with EGE are not well understood. …”
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Mitochondrial mass and mitochondrial membrane potential of peripheral lymphocytes: promising biomarkers of systemic lupus erythematosus by Guanfei Zhao, Haolong Li, Yutong Miao, Linlin Cheng, Yuying Chen, Yuan Huang, Hongyun Zhao, Yongmei Liu, Yipei Jing, Shasha Wang, Yongzhe Li, Rui Zhang

“…These markers also showed significant alternations between inactive and active SLE.ConclusionOur data showed that patients with SLE exhibit mitochondrial dysfunction. Several MMP-Low and SCMM in CD8+T cell subsets could serve as potential biomarkers for diagnosing SLE. …”
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Terminal differentiation of T cells is strongly associated with CMV infection and increased in HIV-positive individuals on ART and lifestyle matched controls. by Thijs Booiman, Ferdinand W Wit, Arginell F Girigorie, Irma Maurer, Davide De Francesco, Caroline A Sabin, Agnes M Harskamp, Maria Prins, Claudio Franceschi, Steven G Deeks, Alan Winston, Peter Reiss, Neeltje A Kootstra, Co-morBidity in Relation to Aids (COBRA) Collaboration

“…Despite long-term ART (median of 12.2 years), HIV-infected adults had lower CD4+ T-cell counts and higher CD8+ T-cell counts compared to well-matched HIV-negative COBRA participants. …”
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Single-cell transcriptome reveals the reprogramming of immune microenvironment during the transition from MASH to HCC by Yu Huang, Ying Xie, Yuqing Zhang, Zhemian Liu, Weihua Jiang, Yingying Ye, Jiale Tang, Zhenhua Li, Zhinan Yin, Xue-Jia Lin

“…Abstract Background The immunological landscape of metabolic dysfunction-associated steatohepatitis (MASH)-driven hepatocellular carcinoma (HCC) is not well understood. …”
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Extracellular vesicles in endometrial-related diseases: role, potential and challenges by Zilu Wang, Feng Li, Wenqiong Liu

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Prevention and Management of Small-for-Size Syndrome of Liver Transplantation by Nam-Joon Yi

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