血清miR-491-5p和miR-21-5p对急性缺血性卒中患者静脉溶栓后出血转化的预测价值 Predictive Value of Serum miR-491-5p and miR-21-5p on Hemorrhagic Transformation after Intravenous Thrombolysis in Acute Ischemic St... by 王笑寒1，潘燕1，张小林1，刘坦2 (WANG Xiaohan1, PAN Yan1, ZHANG Xiaolin1, LIU Tan2 )

“…Abstract: Objective To investigate the predictive value of serum microRNA-491-5p (miR-491-5p) and microRNA-21-5p (miR-21-5p) for hemorrhagic transformation after intravenous thrombolysis in patients with acute ischemic stroke (AIS). Methods A total of 312 patients with AIS who underwent intravenous thrombolysis at Nanyang Central Hospital from January 2021 to February 2023 were retrospectively selected as the study objects. …”
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Manifestaciones neurológicas asociadas a la vacuna contra COVID-19 by R. Alonso Castillo, J.C. Martínez Castrillo

“…Methods: We carried out a review through bibliographic searches in PubMed. …”
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Copper and Zinc Levels, Prevalence of Common Variants of Genes Involved in Their Metabolism and Psoriasis Disease by Tadeusz Dębniak, Piotr Baszuk, Ewa Duchnik, Karolina Rowińska, Magdalena Boer, Magdalena Kiedrowicz, Mariola Marchlewicz, Cezary Cybulski, Martyna Feherpataky, Róża Derkacz, Anna Dębniak, Emilia Rogoża-Janiszewska, Wojciech Marciniak, Marcin Lener, Jan Lubiński, Rodney J. Scott, Jacek Gronwald

“…Thus, microelements, such as zinc and copper, may play a significant role in this disease’s development. <b>Methods:</b> Due to the paucity and inconsistency of literature data, we studied the levels of copper and zinc in blood and serum from 301 unselected psoriatic patients and 301 matched healthy controls and examined any associations among the microelements and clinical course or SOD2 (rs4880), CAT (rs1001179), GPX1 (rs1050450), and DMGDH (rs921943) DNA variants. …”
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Chronic lymphocytic leukemia in combination with COVID-19: clinical features and unfavorable prognosis factors by O. L. Kochneva, E. A. Baryakh, E. N. Misyurina, E. I. Zhelnova, K. V. Yatskov, T. S. Chudnova, Yu. Yu. Polyakov, A. B. Makeshova, M. A. Mingalimov, D. D. Ivanova, L. T. Shimanovskaya, E. N. Zotina, T. N. Tolstykh, E. Yu. Grishina, D. E. Gagloeva, V. N. Yakimets, A. I. Koneva, E. A. Karimova

“…Binet stage C also showed a significant unfavorable prognosis. When studying all cases of death (n = 51), complications such as myelotoxic agranulocytosis, secondary bacterial complications and severe interstitial pulmonary damage &gt;75 % were identified.Conclusion. …”
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exoALMA. III. Line-intensity Modeling and System Property Extraction from Protoplanetary Disks by Andrés F. Izquierdo, Jochen Stadler, Maria Galloway-Sprietsma, Myriam Benisty, Christophe Pinte, Jaehan Bae, Richard Teague, Stefano Facchini, Lisa Wölfer, Cristiano Longarini, Pietro Curone, Sean M. Andrews, Marcelo Barraza-Alfaro, Gianni Cataldi, Nicolás Cuello, Ian Czekala, Daniele Fasano, Mario Flock, Misato Fukagawa, Himanshi Garg, Cassandra Hall, Iain Hammond, Thomas Hilder, Jane Huang, John D. Ilee, Andrea Isella, Kazuhiro Kanagawa, Geoffroy Lesur, Giuseppe Lodato, Ryan A. Loomis, Ryuta Orihara, Daniel J. Price, Giovanni Rosotti, Leonardo Testi, Hsi-Wei Yen, Gaylor Wafflard-Fernandez, David J. Wilner, Andrew J. Winter, Tomohiro C. Yoshida, Brianna Zawadzki

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Clinical and neuropathological associations of plasma Aβ42/Aβ40, p‐tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders by Binita Rajbanshi, Igor Prufer Q C Araujo, Lawren VandeVrede, Peter A. Ljubenkov, Adam M. Staffaroni, Hilary W. Heuer, Argentina Lario Lago, Eliana Marisa Ramos, Leonard Petrucelli, Tania Gendron, Jeffrey L. Dage, William W. Seeley, Lea T. Grinberg, Salvatore Spina, Randall J. Bateman, Howard J. Rosen, Bradley F. Boeve, Adam L. Boxer, Julio C. Rojas, for the ALLFTD Consortium

“…They may detect AD co‐pathology in the setting of other primary neurodegenerative diseases, but this has not been systematically studied. METHODS We compared the clinical, neuroimaging, and neuropathological associations of plasma Aβ42/Aβ40 (mass spectrometry), p‐tau217 (electrochemiluminescence), and neurofilament light ([NfL], single molecule array [Simoa]), as markers of AD co‐pathology, in a sporadic frontotemporal dementia (FTD) cohort (n = 620). …”
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Estimated cost-effectiveness of early screening strategies for newborn hearing impairment using a Markov model by Cheng Wen, Cheng Wen, Cheng Wen, Cheng Wen, Cheng Wen, Xiaomo Wang, Xiaomo Wang, Xiaomo Wang, JunTao Shu, Yu Ruan, Yu Ruan, Yu Ruan, Jinge Xie, Jinge Xie, Jinge Xie, Xiaohua Cheng, Xiaohua Cheng, Xiaohua Cheng, Beier Qi, Beier Qi, Beier Qi, Hui En, Hui En, Hui En, Gang Qin, Lihui Huang, Lihui Huang, Lihui Huang, Demin Han, Demin Han, Demin Han

“…To estimate the cost-effectiveness of different newborn hearing screening strategy is necessary.MethodsA decision tree for a simulated cohort population of 9.56 million newborns was developed: (1) Only universal newborn hearing screening (UNHS); (2) Targeted deafness genetic screening; (3) Concurrent hearing and genetic screening. …”
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Analysis of Clinical Epidemiological Characteristics of 15,967 Lung Cancer Surgery Patients in Yunnan Cancer Hospital from 2013 to 2022 by Ruke TANG, Yujie LEI, Lianhua YE, Guangqiang ZHAO, Xudong XIANG, Gaofeng LI, Guangjian LI, Xi WANG, Ying CHEN, Kaiyun YANG, Xiaobo CHEN, Jiapeng YANG, Min ZHAO, Bingquan XIANG, Qiubo HUANG, Guangcan LUO, Hongwei ZHANG, Yunchao HUANG

“…Methods Clinical data were collected from 15,967 patients who underwent lung cancer surgery at Yunnan Cancer Hospital between 2013 and 2022. …”
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Place of Death of Cancer Patients Treated at a German Comprehensive Cancer Center by Julia Berendt, Maria Heckel, Christoph Ostgathe, Stephanie Stiel, Peter Stachura, Andreas Becker, Matthias W. Beckmann, Susanne Gahr

“…Objective: We assessed the place of death of cancer patients treated at a Comprehensive Cancer Center (CCC), caring for an average of 2220 primary cases per year. Methods: Dataset includes information on cancer patients who were treated at least once in a German CCC, died between 2009 and 2013, and for whom a place of death could be assigned. …”
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Distinct pathways for genetic and epigenetic predisposition in familial and bilateral Wilms tumor by Jenny Wegert, Silke Appenzeller, Taryn D. Treger, Heike Streitenberger, Barbara Ziegler, Sabrina Bausenwein, Christian Vokuhl, Conor Parks, Eva Jüttner, Susanne Gramlich, Karen Ernestus, Steven W. Warman, Jörg Fuchs, Jochen Hubertus, Dietrich von Schweinitz, Birgit Fröhlich, Norbert Jorch, Ralf Knöfler, Carsten Friedrich, Selim Corbacioglu, Michael C. Frühwald, Arnulf Pekrun, Dominik T. Schneider, Jörg Faber, Jana Stursberg, Markus Metzler, Nils Welter, Kathy Pritchard-Jones, Norbert Graf, Rhoikos Furtwängler, Sam Behjati, Manfred Gessler

“…The frequency and spectrum of underlying changes have not been systematically investigated. Methods We analyzed 129 children with suspected Wilms tumor predisposition, 20 familial cases, and 109 children with bilateral disease, enrolled over 30 years in the German SIOP93-01/GPOH and SIOP2001 studies. …”
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Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling by Giuseppe Cecere, Theresa M. Ballard, Frederic Knoflach, Michael Honer, Joerg F. Hipp, Pilar Garces, Thomas Mueggler, Basil Künnecke, Andreas Bruns, Eric P. Prinssen, Philipp Schoenenberger, Philipp Janz, Roger Redondo, Barbara Biemans, Henner Knust, Andrés Olivares-Morales, Alessandro Brigo, Jan Michael Schulz, Daniel Bertrand, Michael Saxe, Eoin C. O’Connor, Maria-Clemencia Hernandez

“…Positive modulation of GABAA-α5 receptors may provide a novel therapeutic approach without the typical side effects associated with non-selective GABAA positive allosteric modulators such as diazepam.MethodsAlogabat was assessed for binding and functional activity at GABAA-α5β3γ2 receptors in vitro and in electrophysiological studies using hippocampal slices. …”
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A Breast Cancer Polygenic Risk Score Validation in 15,490 Brazilians Using Exome Sequencing by Flávia Eichemberger Rius, Rodrigo Santa Cruz Guindalini, Danilo Viana, Júlia Salomão, Laila Gallo, Renata Freitas, Cláudia Bertolacini, Lucas Taniguti, Danilo Imparato, Flávia Antunes, Gabriel Sousa, Renan Achjian, Eric Fukuyama, Cleandra Gregório, Iuri Ventura, Juliana Gomes, Nathália Taniguti, Simone Maistro, José Eduardo Krieger, Yonglan Zheng, Dezheng Huo, Olufunmilayo I. Olopade, Maria Aparecida Azevedo Koike Folgueira, David Schlesinger

“…To assess the use of PRS for breast cancer (BC) risk in Brazil, we evaluated four PRSs in the Brazilian population. <b>Methods:</b> We analyzed a Brazilian cohort composed of 6206 women with a history of breast cancer and 8878 unphenotyped adults as controls. …”
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Determinants of Malaria Vaccine Acceptance: A Systematic Review and Meta‐Analysis of Awareness, Acceptance, Hesitancy, and Willingness to Pay by Ganesh Bushi, Mahalaqua Nazli Khatib, Renuka Jyothi. S, Irwanjot Kaur, Abhishek Sharma, Suhaib Iqbal, M. Ravi Kumar, Ashish Singh Chauhan, Teena Vishwakarma, Praveen Malik, Quazi Syed Zahiruddin, Mahendra Pratap Singh, Muhammed Shabil, Rachana Mehta, Sanjit Sah, Hawra Albayat, Tarek Sulaiman, Ali Al bshabshe, Nawal A. Al Kaabi, Hayam A Alrasheed, Mubarak Alfaresi, Amal A. Sabour, Eman Alamri, Maha F. Al‐Subaie, Ali A. Rabaan

“…It remains a major global health issue, with 263 million cases and 597,000 deaths in 2023, primarily affecting young children and pregnant women. …”
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Measurement of calcitonin and cea in the needle washout fluid from thyroid nodule for the diagnosis of medullary thyroid carcinoma by N. V. Severskaya, I. V. Chebotareva, N. V. Zhelonkina, A. S. Belyakova, P. A. Isaev, V. V. Polkin, A. A. Ilyin, S. A. Ivanov, A. D. Kaprin

“…The measurement of cea in the needle washout fluid (FNa-cea) in mtc has not been studied.Objective: to assess the diagnostic value and propose cut-off values for FNA-CT and FNacea in the thyroid nodule to diagnose mtc.Material and Methods. …”
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The R-RAS2 GTPase is a signaling hub in triple-negative breast cancer cell metabolism and metastatic behavior by Claudia Cifuentes, Lydia Horndler, Pilar Grosso, Clara L Oeste, Alejandro M. Hortal, Jennifer Castillo, Isabel Fernández-Pisonero, Alberto Paradela, Xosé Bustelo, Balbino Alarcón

“…This phenomenon mirrors human TNBC, where RRAS2 is overexpressed in approximately 75% of cases, particularly in tumors associated with the postpartum period. …”
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Electroestimulación funcional para miembros superiores tras el accidente cerebrovascular: una revisión sistemática (Functional electrostimulation for upper limbs after stroke: a s... by Juan David Hernández Niño, Karina Pitombeira Pereira-Pedro, Irimia Mollinedo Cardalda, Iris Machado de Oliveira

“…Results: after applying the inclusion and exclusion criteria, 14 studies were obtained that applied the FES in the upper limb. …”
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Incidence of Bell’s palsy after coronavirus disease (COVID-19) vaccination: a systematic review and meta-analysis by Atena Soltanzadi, Omid Mirmosayyeb, Amin Momeni Moghaddam, Hamed Ghoshouni, Mahsa Ghajarzadeh

“…The most commonly administered vaccines were Pfizer followed by Moderna.In total, 4.54e+07 individuals received vaccines against COVID-19, and 1739 cases developed Bell’s palsy. In nine studies, controls (individuals without vaccination) were enrolled. …”
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M-CSF Protects Against Ulcerative Colitis via Aconitate: Mendelian Randomization and Experimental Evidence by Zhang Y, Huang L, Yue N, Mai Z, Kong C, Tian C, Wei DR, Yao J, Wang L, Li D

“…Yuan Zhang,1,2,&amp;ast; Longbin Huang,3,&amp;ast; Ningning Yue,3,&amp;ast; Zhiliang Mai,3,&amp;ast; Chen Kong,3 Chengmei Tian,4 Dao-ru Wei,5 Jun Yao,1 Lisheng Wang,1 Defeng Li1 1Department of Gastroenterology, Shenzhen People’s Hospital (the Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 2Department of Medical Administration, Huizhou Institute for Occupational Health, Huizhou, Guangdong, People’s Republic of China; 3Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, People’s Republic of China; 4Department of Emergency, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China; 5Department of Rehabilitation, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, Guangdong, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Lisheng Wang, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), No. 1017, Dongmen North Road, Luohu District, Shenzhen, 518020, People’s Republic of China, Tel +86 755 25533018, Email wanglsszrmyy@163.com Defeng Li, Department of Gastroenterology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University; the First Affiliated Hospital, Southern University of Science and Technology), No. 1017, Dongmen North Road, Luohu District, Shenzhen, 518020, People’s Republic of China, Tel +86 755 25533018, Email ldf830712@163.comBackground: Although cytokines have been implicated in the development of ulcerative colitis (UC), the potential mediating role of metabolite levels in this association remains unclear.Methods: Utilizing data from genome-wide association studies (GWAS) encompassing 91 circulating cytokines, 1400 blood metabolites, and 178,689 UC cases, we performed a two-sample Mendelian randomization (MR) analysis to investigate the effect of metabolites mediated cytokines on the development of UC. …”
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Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis by Ioannis Parodis, Julius Lindblom, Daniel Toro-Domínguez, Lorenzo Beretta, Maria O. Borghi, Jessica Castillo, Elena Carnero-Montoro, Yvonne Enman, Chandra Mohan, Marta E. Alarcón-Riquelme, Guillermo Barturen, Dionysis Nikolopoulos, Lorenzo Beretta, Barbara Vigone, Jacques-Olivier Pers, Alain Saraux, Valérie Devauchelle-Pensec, Divi Cornec, Sandrine Jousse-Joulin, Bernard Lauwerys, Julie Ducreux, Anne-Lise Maudoux, Carlos Vasconcelos, Ana Tavares, Esmeralda Neves, Raquel Faria, Mariana Brandão, Ana Campar, António Marinho, Fátima Farinha, Isabel Almeida, Miguel Angel Gonzalez-Gay Mantecón, Ricardo Blanco Alonso, Alfonso Corrales Martínez, Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa, Rik Lories, Ellen De Langhe, Nicolas Hunzelmann, Doreen Belz, Torsten Witte, Niklas Baerlecken, Georg Stummvoll, Michael Zauner, Michaela Lehner, Eduardo Collantes, Rafaela Ortega-Castro, Ma Angeles Aguirre-Zamorano, Alejandro Escudero-Contreras, Ma Carmen Castro-Villegas, Norberto Ortego, María Concepción Fernández Roldán, Enrique Raya, Inmaculada Jiménez Moleón, Enrique de Ramon, Isabel Díaz Quintero, Pier Luigi Meroni, Maria Gerosa, Tommaso Schioppo, Carolina Artusi, Carlo Chizzolini, Aleksandra Zuber, Donatienne Wynar, Laszló Kovács, Attila Balog, Magdolna Deák, Márta Bocskai, Sonja Dulic, Gabriella Kádár, Falk Hiepe, Velia Gerl, Silvia Thiel, Manuel Rodriguez Maresca, Antonio López-Berrio, Rocío Aguilar-Quesada, Héctor Navarro-Linares

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Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy by Tingyan Wang, Cori Campbell, Alexander J. Stockdale, Stacy Todd, Karl McIntyre, Andrew Frankland, Jakub Jaworski, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Erik Mayer, Christopher R. Jones, Hizni Salih, Gail Roadknight, Stephanie Little, Theresa Noble, Kinga A. Várnai, Cai Davis, Ashley I. Heinson, Michael George, Florina Borca, Louise English, Luis Romão, David Ramlakhan, Kerrie Woods, Jim Davies, Eleni Nastouli, Salim I. Khakoo, William Gelson, Graham S. Cooke, Eleanor Barnes, Philippa C. Matthews, Eleanor Barnes, Philippa C. Matthews, William Gelson, Graham S. Cooke, Salim I. Khakoo, Eleni Nastouli, Jim Davies, Kerrie Woods, Alexander J. Stockdale, Stephen Ryder, Ahmed Elsharkawy, Nicholas Easom, William Bernal, Shazaad Ahmad, Douglas Macdonald, Tingyan Wang, Cori Campbell, Simon Stanworth, Suzanne Maynard, Gail Roadknight, Stephanie Little, Kinga A. Várnai, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Christopher R. Jones, Jakub Jaworski, Cai Davis, Florina Borca, Ashley Heinson, Michael George, Heidi MacNaughton, Yun Kim, Josune Olza Meneses, Louise English, Timothy Roberts, Luis Romão, David Ramlakhan, Stacy Todd, Heather Rogers, Karl McIntyre, Andrew Frankland, Hizni Salih, Theresa Noble, Lara Roberts, Finola Higgins, Javier Vilar, Ruth Norris, George Tilston, Ilina Serafimova, Sarah Montague, Juliette Verheyden, Irene Juurlink, Kathryn Jack, Alex Waldren-Glenn, Lizzie Poole, Victoria Day, Berit Reglar

“…Methods: Utilising large scale, routinely collected electronic health records from six centres in England, collated by the National Institute for Health and Care Research Health Informatics Collaborative (NIHR HIC), we applied latent class mixed models to investigate VL trajectory patterns in adults receiving NA treatment. …”
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