Treatment of sinusitis in children: an Italian intersociety consensus (SIPPS-SIP-SITIP-FIMP-SIAIP-SIMRI-SIM-FIMMG) by Elisabetta Venturini, Margherita Del Bene, Lara Fusani, Eleonora Fusco, Alessia Morlando, Elena Chiappini, Maria Carmen Verga, Giuseppe Di Mauro, Silvia Garazzino, Guido Castelli Gattinara, Susanna Esposito, Eugenia Bruzzese, Nicola Principi, Gian Luigi Marseglia, Fabio Midulla, Mattia Doria, Daniele Donà, Stefania Stefani, Annalisa Capuano, Paolo Biasci, Antonio D’Avino, Annamaria Staiano, Alfredo Guarino, Andrea Lo Vecchio, Luisa Galli

“…The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methods. The final recommendations were obtained through a Delphi consensus of an expert panel. …”
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Curcumin-like Compound Inhibits Proliferation of Adenocarcinoma Cells by Inducing Cell Cycle Arrest and Senescence by Rafael Fonseca, Yasmin dos Santos Louzano, Cindy Juliet Cristancho Ortiz, Matheus de Freitas Silva, Maria Luiza Vieira Felix, Guilherme Álvaro Ferreira-Silva, Ester Siqueira Caixeta, Bruno Zavan, Claudio Viegas, Marisa Ionta

“…Non-small cell lung cancer (NSCLC) is the most prevalent type, accounting for 80–85% of cases, and lung adenocarcinoma is the most common and lethal NSCLC subtype, being responsible for ca. 50% of deaths. …”
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Age-Onset-Related Particularities of Pediatric MS—Understanding the Spectrum: A Tertiary Center Experience by Alice Denisa Dică, Dana Craiu, Florentina Ionela Linca, Magdalena Budișteanu, Catrinel Iliescu, Carmen Sandu, Cristina Pomeran, Diana Bârcă, Niculina Butoianu, Carmen Burloiu, Ioana Minciu, Ina Ofelia Focșa, Dana Surlică, Oana Tarța-Arsene, Cristina Cazacu, Andreea Badea, Alexandru Stefan Niculae, Daniela Adriana Ion

“…Methods: We conducted a retrospective analysis of medical records from 120 pediatric patients diagnosed with MS at a tertiary neurology center between 2018 and 2024. …”
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Efficacy of therapeutic interventions for idiopathic recurrent pregnancy loss: a systematic review and network meta-analysis by Jorge Lima, Jorge Lima, João Guerreiro, Miguel Ângelo-Dias, Sofia Silvério Serra, Teresa Costa, Natália Marto, João Feldman de Pinho, João Costa, Rodrigo Ruano, Gonçalo Silva Duarte, Gonçalo Silva Duarte

“…BackgroundApproximately 50% of cases of recurrent pregnancy loss (RPL) remain unexplained, and there is a lack of consensus concerning the effective treatments for idiopathic RPL. …”
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The global distribution and risk prediction of Anaplasmataceae species: a systematic review and geospatial modelling analysisResearch in context by Xiao-Bin Huang, Tian Tang, Jin-Jin Chen, Yuan-Yuan Zhang, Chen-Long Lv, Qiang Xu, Guo-Lin Wang, Ying Zhu, Yue-Hong Wei, Simon I. Hay, Li-Qun Fang, Wei Liu

“…We aimed to map the diversity, distribution, and potential infection risk of Anaplasmataceae members. Methods: We searched PubMed, Web of Science, bioRvix, and MedRvix for published articles to extract data on the detection of Anaplasmatacea species in vectors, animals, and humans from 1910 to 2022. …”
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PITX1 as a grading, prognostic and tumor-infiltrating immune cells marker for chondrosarcoma: a public database-based immunoassay and tissue sample analysis by Zikun Huang, Zikun Huang, Dongchen Liu, Dongchen Liu, Dongchen Liu, Ying Zhang, Ying Zhang, Weiqing Lu, Weiqing Lu, Lan Hu, Lan Hu, Jinghao Zhang, Jinghao Zhang, Lei Xie, Lei Xie, Shubiao Chen, Shubiao Chen, Shubiao Chen

“…BackgroundChondrosarcoma (CHS) is a rare bone cancer originating from chondrocytes, with high-grade cases associated with high mortality rates. However, the prognostic factors and therapeutic targets for CHS have not been studied.MethodsGraded gene differential analysis was conducted on 97 CHS tissues to identify genes associated with CHS grading. …”
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The Academic Esenin. To the 125th Anniversary of the Poet’s Birth by Natalia I. Shubnikova-Guseva

“…The article examines methodological and methodical principles of the Chronicle of Esenin’s Life and Work. …”
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Integrated acupuncture-pharmacotherapy for perimenopausal insomnia: a systematic review and meta-analysis by Boxiang Yang, Shengwen Jiang, Yubo Teng, Yiming Wang, Jingyi Zhang, Chang Gao, Chunhua Song, Chunhua Song

“…The evidence quality level was evaluated using the GRADEprofiler following the GRADE approach.ResultsA total of 12 eligible studies comprising 969 PMI cases were ultimately included in this meta-analysis. …”
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Safety of creatine supplementation: Analysis of Adverse Events reported in clinical trials and adverse event reports by Sarah E. Johnson, Drew E. Gonzalez, Kelly Hines, Adriana Gil, Diego A. Bonilla, Richard B. Kreider

“…Similar findings were seen when looking at other databases’ products associated with AERs.Conclusions The mention of Cr in worldwide AERs is rare (0.00072%), mostly associated with co-ingestion of other nutrients and/or drugs, and in some cases report symptoms Cr studies never observed in any clinical trial or unrelated to the known effects of Cr supplementation. …”
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Advancing dementia care: a review of Italy’s public health response within the WHO Global Action Plan and European strategies by Giancarlo Logroscino, Daniele Imperiale, Nicola Vanacore, Nicola Veronese, Giorgio Fumagalli, Cristina Basso, Federica Asta, Marco Canevelli, Eleonora Lacorte, Anna Maria Bargagli, Angela Giusti, Ilaria Bacigalupo, Guido Bellomo, Ilaria Palazzesi, Paola Piscopo, Emanuela Salvi, Valerio Zaccaria, Francesca Zambri, Martina Valletta, Massimo Corbo, Teresa Di Fiandra, Alessio Crestini, Francesco Saverio Mennini, Rosella Saulle, Alessandra Lombardi, Antonio Guaita, Luciano Sagliocca, Rosa Liperoti, MARCO TRABUCCHI, Maria Cotelli, Carlo Gabelli, Gianfranco Spalletta, Carlo Petrini, Vincenza Frisardi, Alice Fauci, Marcello Giordano, Luca Vignatelli, Luciana Riva, Camillo Marra, Francesco Nonino, Antonio Ancidoni, Simone Salemme, Domitilla Marconi, Sara Maria Pani, Nicoletta Locuratolo, Flavia Lucia Lombardo, Elisa Fabrizi, Francesco Sciancalepore, Patrizia Lorenzini, Alice Paggetti, Francesco Della Gatta, Annachiara Di Nolfi, Vittorio Palermo, Paolo Sciattella, Chiara Bini, Caterina Bianca Neve Aurora Bianchi, Fiammetta Landoni, Maria Assunta Giannini, Stefano Sensi, Cristina Lupinetti, Valeria Panetta, Antonio Matera, Francesca Lubian, Carla Melani, Gennarina Arabia, Maria Pompea Bernardi, Annarita Greco, Annalisa Di Palma, Andrea Fabbo, Federica Boschi, Antonino Riolo, Antonio Zaccardi, Antonio Mastromattei, Silvia Scalmana, Ernesto Palummeri, Elisa Lidonnici, Alessandro Amorosi, Lorenzo Blandi, Filippo Masera, Fabio Izzicupo, Alfonso Di Costanzo, Carla Severino, Patrizia Spallino, Piero Secreto, Elena Memeo, Stefano Piras, Serena Meloni, Tommaso Piccoli, Sara Madrigali, Antonella Notarelli, Micaela Gilli, Anna Laura Spinelli, Nando Scarpelli, Monica Seganfreddo, Alessandra Caci, Amalia Cecilia Bruni, Francesco Mazzoleni, Alessandro Pirani, Massimiliano Massaia, Luisa Bartorelli, Susanna Cipollari, Gabriella Porro, Mario Possenti, Manlio Matera, Patrizia Spadin, Paolo Caffarra, Andrea Capasso, Maria Pia Cozzari, Sabina Gainotti, Giuseppe Gambina, Marina Michela Gasparini, Andrea Stracciari, Gilda Losito, Elena Rendina, Federica Francescone, Francesca Galeotti, Teresa Di Fiandra, Flaminia Camilli, Elena Carbone, Giulia Carnevale, Daniela Coclite, Benedetta Contoli, Francesco Della Gatta, Annachiara Di Nolfi, Eugenio Distaso, Ylenia Druda, Sabrina Esposito, Francesco Giaquinto, Flavia L. Lombardo, Gabriella Martelli, Maria Masocco, Fabio Matascioli, Alberto Milanese, Valentina Minardi, Sandra Morelli, Antonello Napoletano, Maria Cristina Porrello, Giulia Remoli, Roberto Rivabene, Paola Scardetta, Roberta Vaccaro, Petronilla Battista, Consuelo Borgarelli, Chiara Cerami, Annalisa Chiari, Alfredo Costa, Alessandra Dodich, Elisa Faè, Elisa Favaretto, Lidia Fubini, Monica Gandelli, Donata Gollin, Claudio Ivaldi, Alessandro Lanzoni, Valentina Lavermicocca, Margherita Lazzarino, Giacomo Menabue, Maria Angela Molinari, Alessia Morelli, Fabrizio Piazza, Anna Peruzzi, Clara Ricci, Stefano Russo, Davide Zenaro, Alessandra Ceccarini, Scilla Pizzarelli, Zuzana Mitrova, Salvatore De Masi

“…In response, the Italian Fund for Alzheimer’s and other Dementias (IFAD) was established in 2020 to align national efforts with the WHO GAP’s objectives. This study analyses IFAD activities from 2021 to 2023, offering insights into Italy’s public health response to dementia and its relevance to global strategies.Methods We conducted a structured, iterative review of all activities coordinated by the Italian Dementia Observatory (OssDem-Istituto Superiore di Sanità (ISS)) within IFAD 2021–2023. …”
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Impact of all-oral bedaquiline-based shorter regimens in the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis by Ming Liu, Lianping Yang, Shanquan Chen, Yan He, Nathorn Chaiyakunapruk, Wai-kit Ming, Jing Yu, Tesfaye Regassa Feyissa, Xiaohan Chen, Getahun Fetensa, Ebisa Turi, Ginenus Fekadu, Tadesse Tolossa, Firomsa Bekele, Xinyao Yi, Dinka Dugassa

“…This systematic review and meta-analysis aimed to examine the impact of these regimens, synthesising data from recent clinical trials and observational studies.Methods We searched multiple databases, including Medline and Scopus, for studies published from 2012 to February 2024. …”
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Deep Screening for X Chromosome Parent-of-Origin Effects on Neurobehavioral and Neuroanatomical Phenotypes in 47,XXY Klinefelter Syndrome by Isabella G. Larsen, Rachel Gore Moses, Bryce A. Seifert, Siyuan Liu, Samuel Li, Andrew J. Oler, Elizabeth Levitis, Lukas Schaffer, Rylee Duncan, Colleen Jodarski, Michael Kamen, Jia Yan, François M. Lalonde, Rajarshi Ghosh, Erin Torres, Liv S. Clasen, Jonathan Blumenthal, Morgan Similuk, Armin Raznahan, Magdalena A. Walkiewicz

“…Methods: A cohort of 58 individuals with XXY/KS underwent duo or trio genome sequencing with parents (n = 151), measurement of 66 neurobehavioral phenotypes by standardized research assessments, and measurement of over 1000 anatomical phenotypes by structural magnetic resonance imaging. …”
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Dietary antioxidants and flavonoids are inversely associated with prostate cancer risk and mortality: evidence from NHANES and machine learning by Yanyang Jin, Dong-shan Lv, Li-po Zhou, Li Xiao, Guang-quan Tong, Abdallah Karim, Shuai Xue, Hongyang Tian, Cheng-cai Wang, Kun Feng, Ding-ming Song, You-liang Guan

“…Although flavonoids and antioxidants show promise in experimental models, evidence from population-based studies remains limited.ObjectivesThis research aimed to investigate the relationship between the consumption of antioxidants and flavonoids in the diet and the risk and survival of PCa, as well as to assess the potential of machine learning models in identifying significant dietary factors.MethodsData from 2,629 male participants aged ≥40 years from National Health and Nutrition Examination Survey (NHANES) 2007–2010 were analyzed. …”
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Outcomes of definitive radiotherapy vs. laryngectomy followed by adjuvant radiotherapy in patients with locally advanced laryngeal squamous cell carcinoma: real-world experience in... by Ali Kazemian, Ebrahim Esmati, Reza Ghalehtaki, Borna Farazmand, Nima Mousavi-Darzikolaee, Reyhaneh Bayani, Mahdieh Razmkhah, Maryam Taherioun, Niloufar Saeedi, Farrokh Heidari, Kaveh Zakeri

“…Surgical treatment can impair patients’ voice and swallowing function, making definitive radiotherapy a viable alternative for locally advanced cases. Methods To compare the outcomes of definitive versus adjuvant radiotherapy in patients with primary locally advanced laryngeal cancer, we retrospectively evaluated consecutive patients treated from 2007 to 2020. …”
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Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma by Ge Zhang, Zhenfa Zhang, Lianmin Zhang, Guangyao Zhou, Pengpeng Zhang, Dingli Wang, Shuai Jiang

“…While post-translational modifications are known to influence tumor progression, their prognostic value in LUAD remains largely unexplored.Methods We developed a post-translational modification learning signature (PTMLS) using machine learning techniques, analyzing data from 1231 LUAD patients across seven global cohorts. …”
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Invasive pulmonary aspergillosis after heart transplantation by M. A. Simonenko, M. Yu. Sitnikova, P. A. Fedotov, Yu. V. Sazonova, M. A. Bortsova, K. I. Monosova, L. A. Vasilievna, L. B. Mitrofanova, G. V. Nikolaev, M. L. Gordeev, M. A. Karpenko

“…Objective: to assess the incidence, determine the peculiarities of the course of invasive pulmonary aspergillosis (IPA) and identify risk factors for IPA in heart transplant recipients.Materials and methods. From January 2010 to December 2019, 137 heart transplantations (HT) were performed: mean age 46 ± 14 years; male 102 (74%) and female 35 (26%). …”
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Effect of salicylic acid spraying and application of biofertilizers on the physiological characteristics and yield of chickpea (Cicer arietinum L.) cultivars under rainfed conditio... by Fardin Momeni, Alireza Abdali Mashhadi, Seyeed Ataolah Siadat, Babak Pakdaman Sardrood, Mokhtar Ghobadi

“…In most years, in west of Iran, the amount of rainfall is low and the distribution of rainfall is not suitable. In many cases, rainfed lands are affected by drought stress. …”
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Abstract 002: Examining Pulling Force Using Combined Stentreiver and Aspiration Technique in a Medium Vessel Thrombectomy Model by Amir M. Molaie, Kenichi Sakuta, Keiko Fukuda, Taichiro Imahori, Kentaro Suzuki, Satoshi Tateshima, Naoki Kaneko

“…Average pulling force was noted to decrease from the first to the last run in most cases, with an average drop of 26.4% at the fourth run. …”
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A Meta-analysis of the effect of five-element music therapy for patients with insomnia (五行音乐对失眠患者干预效果的Meta分析) by WU Yang (吴洋), GAI Haiyun (盖海云), MA Minghui (马明会)

“…Meta-analysis was performed on the papers that met the nadir criteria. Results Twelve studies with a total of 1346 cases were finally included. …”
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Prevalence and Clinical Characteristics of NEUROD1‐MODY in Chinese Early‐Onset Type 2 Diabetes Mellitus and a Literature Review by Tianhao Ba, Qian Ren, Siqian Gong, Meng Li, Hong Lian, Xiaoling Cai, Wei Liu, Yingying Luo, Simin Zhang, Rui Zhang, Lingli Zhou, Yu Zhu, Xiuying Zhang, Jing Chen, Jing Wu, Xianghai Zhou, Yufeng Li, Xirui Wang, Fang Wang, Liyong Zhong, Xueyao Han, Linong Ji

“…Methods We performed next‐generation sequencing in 679 patients with EOD to screen rare variants in NEUROD1 exons and evaluated the effects of variants using in vitro experiments. …”
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