Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by SPP1+ macrophages by Jie-Yuan Jin, Jie-Yuan Jin, Shuai Guo, Yao Deng, Ya-Qin Chen, Chen Liang, Yu-Jie Jiang, Wang Zhao, Rong Xiang

“…Molecular mechanisms underlying arrhythmias pathogenesis and its progression warrant further investigation.MethodsWe performed whole-exome sequencing on 50 arrhythmia patients (21 females, 29 males), predominantly with early-onset disease (94% ≤ 35 years). …”
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In vitro and ex vivo screening of microRNA combinations with enhanced cell penetrating peptides to stimulate intervertebral disc regeneration by Tara Ní Néill, Marcos N. Barcellona, Niamh Wilson, Fergal J. O'Brien, James E. Dixon, Caroline M. Curtin, Conor T. Buckley

“…Conclusion Our findings suggest the potential of FLR‐miRNA‐149‐5p + miRNA‐221‐3p inhibitor to create an anti‐catabolic niche within the disc to foster regeneration in moderate cases of disc degeneration, which could be utilized in further studies with the overarching aim of developing treatments for LBP.…”
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Prognostic Role of SETDB2 in Clear Cell Renal Cell Carcinoma: Linking Immune Infiltration, Cuproptosis, and Tumor Suppression by Lu SH, Lui K, Qian Y, Zhou WY, Mu YY, Zhang W

“…At present, there are few effective options for treating advanced cases of ccRCC, emphasizing the need to establish novel biomarkers and targets suitable for therapeutic intervention. …”
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Comparative efficacy and safety of rhTPO, romiplostim, and eltrombopag in the treatment of pediatric primary immune thrombocytopenia: a systematic review and network meta-analysis by Xiaofang Zhang, Xiaofang Zhang, Yuan Zhao, Minghang Yang, Xiaochun Feng, Xiaochun Feng

“…Conventional therapies, while effective in some cases, are often limited by suboptimal response rates and significant adverse effects with prolonged use. …”
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Epileptic manifestations, cognitive impairment and autism spectrum disorders in patients with agenesis of the corpus callosum: the results of neuropsychological testing by O. A. Milovanova, O. A. Коmissarovа, T. Yu. Tarakanova, S. V. Bugry, G. G. Avakyan

“…To assess the epileptic, cognitive and autistic manifestations of agenesis of the corpus callosum (ACC) in children.Material and methods. Clinical characteristics of 31 patients (median age 6.6±0.9 years) with ACC were studied. …”
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The role of artificial intelligence in promoting health and developing preventive strategies for diabetes by Ameneh Marzban

“…Dear Editor Diabetes remains a significant public health challenge, and the integration of artificial intelligence (AI) presents remarkable opportunities to enhance early diagnosis, personalized treatment, and effective prevention strategies.1 AI algorithms, including supervised learning and convolutional neural networks, can efficiently analyze large datasets to identify patterns and risk factors associated with diabetes, surpassing the capabilities of traditional methods.2 This advanced analysis enables healthcare providers to predict the likelihood of diabetes in individuals and populations, facilitating timely interventions and customized prevention strategies. …”
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AI-HOPE-TGFbeta: A Conversational AI Agent for Integrative Clinical and Genomic Analysis of TGF-β Pathway Alterations in Colorectal Cancer to Advance Precision Medicine by Ei-Wen Yang, Brigette Waldrup, Enrique Velazquez-Villarreal

“…Exploratory analysis showed better outcomes in SMAD2-mutant primary tumors vs. metastatic cases (<i>p</i> = 0.0010) and confirmed the feasibility of disaggregated ethnicity-based queries for TGFBR1 mutations, despite small sample sizes. …”
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Clinical portrait and features of antihypertensive therapy in comorbid patients with arterial hypertension and chronic obstructive pulmonary disease according to the national hyper... by Anna V. Aksenova, Ivan S. Serov, Olga А. Belova, Svetlana А. Rachkova, Irina E. Chazova

“…Cardiovascular diseases (CVD) and chronic obstructive pulmonary disease (COPD) are the two leading causes of death in the world. Studies show a close mutually aggravating relationship between arterial hypertension (AH) and COPD. …”
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Prevalence of Rocahepevirus ratti (rat hepatitis E virus) in humans and rats in China by Xiuji Cui, Jianwen Situ, Ting Tang, Zhiyu Li, Dongzhui Chen, Stanley Siu-Fung Ho, Hiu-Laam Chung, Tsz-Chung Wong, Yonghao Liang, Chaowen Deng, Yongxian Su, Huijun Cai, Simon Kam-Fai Lo, Shiyao Huang, Sheng Zeng, Liyuan Zhang, Yunchun Chen, Shusheng Wu, Estie Hon-Kiu Shun, Nicholas Foo-Siong Chew, James Yiu-Hung Tsoi, Kelvin Hon-Yin Lo, Fanfan Xing, Vincent Chi-Chung Cheng, Kwok-Yung Yuen, Feifei Yin, Jasper Fuk-Woo Chan, Siddharth Sridhar

“…Methods: In this multicenter cross-sectional study, we used fully validated rHEV IgG enzymatic immunoassays and reverse transcription PCR in 1,199 individuals with (n = 655) or without hepatitis (n = 544) recruited from three centers in China (Hainan, Hong Kong, and Shenzhen). …”
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Triglyceride glucose waist circumference and non alcoholic fatty liver disease: a systematic review and meta analysis by Ziyi Xin, Lanlan Feng, Qingwen Yu, Yongmin Shi, Ting Tang, Xuhan Tong, Siqi Hu, Yao You, Shenghui Zhang, Xingwei Zhang, Mingwei Wang, Jiake Tang

“…To investigate this association, this comprehensive meta-analysis was conducted. Methods A systematic electronic search was conducted using the PubMed, Embase, and Web of Science databases from their inception until July 2024 to identify observational studies assessing the relationship between TyG-WC and the risk of NAFLD. …”
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Palynostratigraphy of the Shemshak and Dalichai formations boundary, north of Semnan and its paleogeographic significance by Fereshteh Sajjadi, Firoozeh Hashemi Yazdi, Mohaddeseh Maleki

“…Material & MethodsTwenty-one samples were collected from shale intervals at the Deh-Soufian stratigraphic section (N 35° 47' 44" and E 53° 40' 03"); nine samples from the uppermost of the Shemshak Formation and twelve samples base of the Dalichai Formation. …”
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Disease phenotypic and outcome of very-early onset inflammatory bowel disease in Asian children: an understudied population by Way-Seah Lee, Way-Seah Lee, Kee-Seang Chew, James-Guoxian Huang, James-Guoxian Huang, Pornthep Tanpowpong, Karen S. C. Mercado, Almida Reodica, Veena Logarajah, K. L. W. Hathagoda, Shaman Rajindrajith, Yoko Kin-Yoke Wong, Suporn Treepongkaruna, Marion Margaret Aw, Marion Margaret Aw

“…BackgroundThere is a paucity of knowledge on disease phenotype and outcome of very early-onset (VEO) inflammatory bowel disease (VEO-IBD) from recently developed and developing countries, including from Southeast Asia. We studied disease phenotype, clinical characteristics, management and outcome of VEO-IBD in South and Southeast Asian children.Materials and methodsWe extracted data from a multicentre Asian pediatric (onset &lt;18 years) IBD registry. …”
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Real-world use of complement inhibitors for haemolytic uraemic syndrome: an analysis of the European Rare Kidney Disease Registry cohortResearch in context by Aleksandra Vujović, Anne-Laure Sellier-Leclerc, Maria Cristina Mancuso, Olivia Boyer, Atif Awan, Antonio Gargiulo, Sebastian Loos, Marc Fila, Augustina Jankauskiene, Gema Ariceta, Nele Kanzelmeyer, Enrico Vidal, Maria Van Dyck, Tanja Kersnik Levart, Naděžda Šimánková, Stephane Decramer, Jonas Hofstetter, Marina Vivarelli, Savino Sciascia, Nicole C.A.J. van de Kar, Franz Schaefer, Nicole C.A.J. van de Kar, Marina Vivarelli, Savino Sciascia, David Kavanagh, René Andersen, Mia Faerch, Soren Rittig, Miquel Blasco, Pedro Arango Sancho, Alvaro Madrid, Gema Ariceta, Loreto Gesualdo, Camillo Carrara, Piero Ruggenenti, Kai-Uwe Eckardt, Jan Halbritter, Dominik Müller, Adrian Schreiber, Evelyn Seelow, Yahsou Delmas, Jerome Harambat, Brigitte Llanas, Nathalie Godefroid, Eric Goffin, Johann Morelle, Adrian Catalin Lungu, George Reusz, Péter Sallay, Attila Szabo, Kalman Tory, Jan Ulrich Becker, Kathrin Burgmaier, Volker Burst, Sandra Habbig, Max Liebau, Roman-Ulrich Mueller, Lutz Weber, Mette Damholt, Anne-Lise Kamper, Karl Emil Nelveg-Kristensen, Hanne Nørgaard, Ida Maria Schmidt, Soeren Soerensen, Wladimir Szpirt, Agnieszka Jaskólska, Monika Miklaszewska, Anna Moczulska, Elżbieta Szczęsny-Choruz, Katarzyna Zachwieja, Peter Conlon, Atif Awan, Michael Wiesener, Anja Büscher, Rainer Büscher, Lars Pape, Francesca Becherucci, Paola Romagnani, Ann Raes, Thomas Renson, Evelien Snauwaert, Johan Vande Walle, Jill Vanmassenhove, Mark Eijgelsheim, Casper Franssen, Coen Stegeman, Florian Grahammer, Thomas Henne, Tobias Huber, Christian Krebs, Sebastian Loos, Anne Mühlig, Jun Oh, Ulf Panzer, Raphael Schild, Jessica Kaufeld, Stefanie Haeberle, Franz Schaefer, Tanja Wlodkowski, Juuso Tainio, Elisa Ylinen, Obbo Bredewold, Wieneke Michels, Dorien Peters, Antonius Rabelink, Arghya Ray, Joris Rotmans, Siebe Spijker, Y.K. Onno Teng, Kathleen Claes, Noel Knops, Tanja Kersnik Levart, Anamarija Meglič, Gregor Novljan, Agnieszka Gach, Monika Pawlak-Bratkowska, Małgorzata Stańczyk, Marcin Tkaczyk, Pierre Cochat, Anne-Laure Sellier-Leclerc, Teresa Cavero, Eduardo Guiterrez, Joaquin Martinez, Enrique Morales, Hernando Trujillo, Gianluigi Ardissino, Valentina Capone, Sara Testa, Denis Morin, Martin Konrad, Ilaria Luongo, Gabriele Malgieri, Luigi Annicchiarico Petruzzelli, Wilbert van der Meijden, Jack Wetzels, Mattia Parolin, Enrico Vidal, Thérésa Kwon, Olivia Boyer, Aude Servais, Laurent Mesnard, Alena Parikova, Silvie Rajnochova-Bloudickova, Janka Slatinska, Ondrej Viklicky, Martin Bezdicka, Nadezda Simankova, Dana Thomasova, Jakub Zieg, Francesco Emma, Rocco Baccaro, Giuseppe Grandaliano, Alessandro Naticchia, Francesco Pesce, Margherita Baldassarri, Andrea Guarnieri, Anna Maria Pinto, Alessandra Renieri, Stephane Decramer, Stanislas Faguer, David Ribes, Thomas Simon, Stephanie Tellier, Daniel Gale, Christoph Licht, Michal Malina, Candice Roufosse, Neil Sheerin, Susana Carvajal Arjona, Renée de Wildt, Uwe Korst, Christiane Mockenhaupt, Francisco Monfort, Mireya Vicenta Rios Carratala

“…We aimed to examine real-world C5 inhibitor use and its impact on patient outcomes. Methods: This retrospective cohort study used longitudinal data from the European Rare Kidney Disease Registry, collected from 76 nephrology centres across 24 European countries between January 1, 2019 and January 31, 2024. …”
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FimH confers mannose-targeting ability to Bacillus Calmette-Guerin for improved immunotherapy in bladder cancer by Yang Zhang, Chao Yan, Ru Jia, Qiang Lv, Fan Huo, Qiang Cao, Qiju Huang, Zhu A Wang, Dan Theodorescu, Pengchao Li

“…Thus, to improve the efficacy of BCG immunotherapy is the long-term pursuit of the bladder cancer field.Methods To increase the adhesion of BCG to the urothelium we overexpressed FimH, a mannose binding protein naturally used by uropathogenic Escherichia coli to adhere to human urothelium, onto the surface of BCG. …”
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Developing a screening tool and intervention strategy for elder neglect in persons with dementia in primary care: protocol to use a multistep process by Sophie Park, Tony Rosen, Alyssa Elman, Karl Pillemer, Mark S Lachs, E-Shien Chang, Jerad Moxley, Daniel Baek, Elaine Gottesman, Amy Shaw, David Hancock, Kristin Lees Haggerty, Helena Costantini, Mariana Cury Hincapie, Marco Ceruso, Adrienne D Jaret, David Burnes, Sara Czaja

“…We plan to: (1) develop a novel primary care screening tool to identify elder neglect in persons with dementia, (2) develop an innovative technology-driven intervention for caregivers and (3) pilot both for feasibility and acceptability in primary care.Methods and analysis We will use a multistep process to develop a screening tool, including a modified Delphi approach with experts, and multivariable analysis comparing confirmed cases of neglect in patients with dementia from the existing data registry to non-neglected controls. …”
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Sphingolipid metabolites as potential circulating biomarkers for sarcopenia in men by Je Hyun Seo, Jung‐Min Koh, Han Jin Cho, Hanjun Kim, Young‐Sun Lee, Su Jung Kim, Pil Whan Yoon, Won Kim, Sung Jin Bae, Hong‐Kyu Kim, Hyun Ju Yoo, Seung Hun Lee

“…The associations between sphingolipid metabolites identified from mouse and cell studies and sarcopenia status were assessed in men in an age‐matched discovery (72 cases and 72 controls) and validation (36 cases and 128 controls) cohort; women with sarcopenia (36 cases and 36 controls) were also included as a discovery cohort. …”
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Educational mediamorphosis and constructivist paradigm by Arūnas Vyšniauskas

“…In the following three chapters the author, in comparison to preceding chapters, contemplates over both theoretical (methodological) and practical issues characterising the constructionist paradigm: Creative studying instead of receptive studying by explorative methods Cognitive teaching of a master and computerised education Perspectives of new pedagogical researches …”
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Reliability and validity of the total cerebral small vessel disease score: a systematic review and meta-analysis by Guilherme Diogo Silva, João Paulo Mota Telles, Carolina de Medeiros Rimkus, Germana Titoneli Vieira, Emily Figueiredo Vieira Neves Yuki, Raymundo Soares de Azevedo, Gisela Tinone, Leandro Tavares Lucato, Rosa Maria Pereira, Adriana Bastos Conforto

“…The summary Cohen’s kappa values for intra-rater reliability ranged from 0.78 to 0.84 (four studies, 250 cases were randomized from 3,654 participants). …”
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Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. by Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale

“…<h4>Methods and findings</h4>Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5). …”
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Effect of Nickel Content and Cooling Rate on the Microstructure of as Cast 316 Stainless Steels by Lei Chen, Yang Wang, Yafeng Li, Zhengrui Zhang, Zhixuan Xue, Xinyu Ban, Chaohui Hu, Haixiao Li, Jun Tian, Wangzhong Mu, Kun Yang, Chao Chen

“…The effect of the cooling rate on the ferrite content and precipitation phases of the high Ni content of the 316 stainless steel casting (H-316) is studied by remelting experiments and different methods of quenching of liquid steel. …”
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