Dementia with lewy bodies patients with high tau levels display unique proteome profiles by Sinead Greally, Mukesh Kumar, Christoph Schlaffner, Hanne van der Heijden, Elisabeth S. Lawton, Deeptarup Biswas, Sabina Berretta, Hanno Steen, Judith A. Steen

“…Abstract Background Clinical studies have long observed that neurodegenerative disorders display a range of symptoms and pathological features and, in some cases, overlap, suggesting that these diseases exist on a spectrum. …”
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Register-based cumulative prevalence of Autism Spectrum Disorders during childhood and adolescence in Central Italy by Marco Valenti, Roberto Vagnetti, Francesco Masedu, Maria Chiara Pino, Alessandro Rossi, Maria Luisa Scattoni, Monica Mazza, EAGLE GROUP

“…Background: Studies have evaluated the prevalence of Autism Spectrum Disorders (ASD), focusing on different ages during childhood and adolescence. …”
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Catheter Ablation of Frequent PVCs in Structural Heart Disease: Impact on Left Ventricular Function and Clinical Outcomes by Nikias Milaras, Nikolaos Ktenopoulos, Paschalis Karakasis, Aikaterini-Eleftheria Karanikola, Vasileios Michopoulos, Konstantinos Pamporis, Panagiotis Dourvas, Anastasios Apostolos, Zoi Sotiriou, Stefanos Archontakis, Athanasios Kordalis, Konstantinos Gatzoulis, Skevos Sideris

“…<b>Objective:</b> To review the evidence on the efficacy of RFA for PVC suppression in patients with SHD, specifically evaluating its impact on LVEF and clinical outcomes. <b>Methods:</b> A review of the literature was conducted using PubMed and the Cochrane Library, focusing on studies published after 2010 that included adult patients with SHD and a PVC burden >4% on 24 h Holter monitoring. …”
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The Evolution of Methotrexate Applications: A Multidimensional Approach to Treating Various Disorders – A Literature Review by Tomasz Tamborski, Michalina Zagalska, Adam Jan Ząbek, Jakub Paweł Kuźniar, Marta Turek, Adam Grzebinoga, Julia Szlążek, Barbara Roguska, Magdalena Szostak, Emilia Gabriela Chrzanowska

“…While effective, it has significant toxicity risks, particularly at high doses, necessitating therapeutic drug monitoring (TDM) to minimize adverse effects like nephrotoxicity and mucositis. MethodsThis review synthesizes data from review articles, original studies, meta-analyses, and clinical guidelines, covering MTX’s mechanisms, pharmacokinetics, clinical applications, toxicity management, and TDM role. …”
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Cost-utility analysis of current COVID-19 vaccination program recommendations in Canada by Alison E. Simmons, Rafael N. Miranda, Michael W.Z. Li, Gebremedhin B. Gebretekle, Min Xi, Marina I. Salvadori, Bryna Warshawsky, Eva Wong, Raphael Ximenes, Melissa K. Andrew, Sarah Wilson, Matthew Tunis, Ashleigh R. Tuite

“…Results: Between July 2024 and September 2025, a program similar to current Canadian recommendations was estimated to avert 3.1 % (95 % credible interval (CrI): 3.0 to 3.2 %) of outpatient cases, 8.8 % (95 % CrI: 7.3 to 10.4 %) of inpatient cases, 3.6 % (95 % CrI: 2.8 to 4.3 %) of PCC cases, and 9.4 % (95 % CrI: 5.6 to 13.8 %) of deaths compared to no vaccination. …”
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Germline genomic profiling of patients with early-onset colorectal cancer by G. Mauri, M. Puzzono, A. Mannucci, F. Gaudioso, H. Mittal, L. Mosca, V. Burgio, S. Ghezzi, M. Ronzoni, S. Mariano, R. Rosati, L. Monti, U. Cavallari, A. Sartore-Bianchi, S. Siena, G.M. Cavestro

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Safety of topical corticosteroids in atopic eczema: an umbrella review by Ingrid Muller, Miriam Santer, Matthew J Ridd, Joanne R Chalmers, Amanda Roberts, Hywel C Williams, Sinéad M Langan, Kim S Thomas, Sandra Lawton, Amina Ahmed, Douglas J C Grindlay, Emma Axon

“…Objective An umbrella review summarising all safety data from systematic reviews of topical corticosteroids (TCS) in adults and children with atopic eczema.Methods Embase, MEDLINE, PubMed, Cochrane Database of Systematic Reviews and the Centre of Evidence Based Dermatology map of eczema systematic reviews were searched until 7 November 2018 and Epistemonikos until 2 March 2021. …”
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Histocompatibility HLA class I in anterior uveitis patients with and without spondyloarthritis by I. A. Guseva, A. A. Godzenko, I. Yu. Razumova

“…Anterior uveitis (AU) and ankylosing spondylitis (AS) are associated with histocompatibility human leukocyte antigen (HLA)-B27. Previous genetic studies conducted in different populations have also demonstrated other genetic associations, including HLA, both  general and individual ones for AU and AS.Objective: to investigate the association of HLA class I with AU depending on the presence or absence of spondyloarthritis (SpA).Patients and methods. …”
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Efficacy and Safety of Combined Androgen Deprivation Therapy (ADT) and Docetaxel Compared with ADT Alone for Metastatic Hormone-Naive Prostate Cancer: A Systematic Review and Meta-... by Tobias Engel Ayer Botrel, Otávio Clark, Antônio Carlos Lima Pompeo, Francisco Flávio Horta Bretas, Marcus Vinicius Sadi, Ubirajara Ferreira, Rodolfo Borges Dos Reis

“…<h4>Methods</h4>Several databases were searched, including MEDLINE, EMBASE, LILACS, and CENTRAL. …”
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Immuno-oncologic profiling by stage-dependent transcriptome and proteome analyses of spontaneously regressing canine cutaneous histiocytoma by Alina K. Loriani Fard, Alexander Haake, Vladimir Jovanovic, Sandro Andreotti, Michael Hummel, Benjamin-Florian Hempel, Achim D. Gruber

“…Our data suggest that major immuno-oncological pathways are not regulated during regression of CCH on the mRNA or protein levels as detectable by the methods used. Instead, our data provide further evidence supporting previous hypotheses towards a role of immune stimulatory B7 family ligands and CD28 family receptors in the regression of CCH.…”
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Title not available by Paulo Breno Noronha Liberalesso, Eliana Garzon, Elza M.T. Yacubian, Américo C. Sakamoto

“…<sec><title>Objective</title>To evaluate clinical data, electroencephalogram, etiology, classification, treatment, morbidity, and mortality in acute refractory status epilepticus.</sec><sec><title>Methods</title>Fifteen patients, mean age of 41.3 years-old, six males, with refractory status epilepticus, were retrospectively studied. …”
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Consumption of dairy products and colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). by Neil Murphy, Teresa Norat, Pietro Ferrari, Mazda Jenab, Bas Bueno-de-Mesquita, Guri Skeie, Anja Olsen, Anne Tjønneland, Christina C Dahm, Kim Overvad, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Laura Nailler, Rudolf Kaaks, Birgit Teucher, Heiner Boeing, Manuela M Bergmann, Antonia Trichopoulou, Pagona Lagiou, Dimitrios Trichopoulos, Domenico Palli, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, Petra H M Peeters, Vincent K Dik, Elisabete Weiderpass, Eiliv Lund, Jose Ramon Quiros Garcia, Raul Zamora-Ros, Maria José Sánchez Pérez, Miren Dorronsoro, Carmen Navarro, Eva Ardanaz, Jonas Manjer, Martin Almquist, Ingegerd Johansson, Richard Palmqvist, Kay-Tee Khaw, Nick Wareham, Timothy J Key, Francesca L Crowe, Veronika Fedirko, Marc J Gunter, Elio Riboli

“…<h4>Background</h4>Prospective studies have consistently reported lower colorectal cancer risks associated with higher intakes of total dairy products, total milk and dietary calcium. …”
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Assessment of Troponin Levels as a Biomarker of Myocardial Injury in Patients with Fatal Covid-19 for the Period 2020 to 2022: A Literature Review by Zainab Tawfeeq Al-Joubouri, Shaymaa Galeel Shamran, Rehab Mazi Jabbar, Entesar Gh. Ajeena

“…Since then, it has been spreading rapidly and has caused a global pandemic, infecting more than 29 million people and causing more than ‎‎900,000 deaths as of September 15, 2020. In most cases this disease mainly affects the respiratory ‎system and can cause a syndrome called acute respiratory distress, leading to acute ‎respiratory failure. …”
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Local Seismicity Analysis of the Western Part of the Taimyr Peninsula According to the Data of the Single Seismic Station “KOLBA” by Konechnaya Yana, Antonovskaya Galina

“…Cleaning seismic catalogs from man-made events has always been an urgent task, especially after the installation of each new seismic station in a little-studied area of the Arctic. The difficulty in determining the event nature lies in the absence of a regional hodograph and any reference data such as samples of waveforms, reliable information about the place, time and methods of industrial explosions, the absence of these events on the records of other seismic stations. …”
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The evolutionary history of Plasmodium falciparum from mitochondrial and apicoplast genomes of China-Myanmar border isolates by Yini Tian, Run Ye, Dongmei Zhang, Yilong Zhang

“…Abstract Background The frequent communication between African and Southeast Asian (SEA) countries has led to the risk of imported malaria cases in the China-Myanmar border (CMB) region. Therefore, tracing the origins of new malaria infections is important in the maintenance of malaria-free zones in this border region. …”
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Outbreaks of tularemia in Russia (1997–2023) by T. N. Demidova, T. V. Mikhailova, A. S. Semikhin, D. V. Tranquilevsky, E. A. Gurina, N. V. Sheenkov

“…Retrospective data on morbidity and epizootological studies from the archives of the Gamaleya National Research Center for Epidemiology and Microbiology of the Ministry of Health of the Russian Federation for 1997–2023, 375 cards of epidemiological investigations of tularemia cases were used. …”
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IMPACT OF PREGNANCY ON THE ACTIVITY OF RHEUMATOID ARTHRITIS AND ITS THERAPY ACCORDING TO PROSPECTIVE FOLLOW-UP DATA by E. V. Matyanova, N. M. Kosheleva, Z. S. Alekberova, E. N. Aleksandrova

“…Later prospective studies have demonstrated that only 48–66% of women have clinical improvement during pregnancy, postpartum exacerbation of RA develops in 70% of cases, and most patients need drug therapy.Objective: to assess changes of RA activity with DAS28-CRP during pregnancy and postpartum; to examine the impact of RA activity during early pregnancy on further course of the disease; and to determine drug therapy requirement in pregnant women with RA.Subjects and methods. …”
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IDIOPATHIC LOBULAR PANNICULITIS IN RHEUMATOLOGY PRACTICE: THE AUTHORS’ OWN DATA by O. N. Egorova, B. S. Belov, S. I. Glukhova, S. G. Radenska-Lopovok

“…The disease was found in all age groups, but it accounted for more than half (57%) of cases at the most able-bodied age (45–60 years). …”
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The Italian Perinatal Surveillance System SPItOSS: insights from Confidential Enquiries by Michele Antonio Salvatore, Silvia Salvi, Paola D’Aloja, Patrizia Vergani, Roberto Bellù, Carlo Dani, Federico Mecacci, Maria Rosa D’Anna, Sergio Ferrazzani, Giuseppe Battagliarin, Piermichele Paolillo, Simonetta Picone, Luca Ramenghi, Giovanni Vento, Serena Donati, The Italian Perinatal Surveillance System-SPItOSS Working Group

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The Role of Morcellation in En Bloc Resection of Large Bladder Tumors by Nadav Dekel, Ekaterina Laukhtina, Andrey Morozov, Eva Compérat, Eddie Fridman, Shay Golan, Jeremy Yuen-Chun Teoh, Yossef Molchanov, Maxim Yakimov, Thomas R. W. Herrmann, Dmitry Pushkar, Jesús Moreno Sierra, Juan Gómez Rivas, Shahrokh F. Shariat, Dmitry Enikeev

“…This narrative review aims to evaluate the feasibility of ERBT with subsequent morcellation for large bladder tumors, focusing on its role in tumor extraction and its impact on pathological assessment. <b>Methods</b>: A comprehensive literature search was conducted across multiple databases to identify studies evaluating the use of morcellation in ERBT for large bladder tumors. …”
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