Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition by Dirk Schadendorf, Carola Berking, Lisa Zimmer, Serigne Lo, Caroline Robert, John Haanen, Ines Pires da Silva, Paolo Antonio Ascierto, Reinhard Dummer, Michael Manos, Joanna Mangana, Marcus O Butler, Richard D Carvajal, Georgina V Long, Alon Vaisman, Christian Posch, F Stephen Hodi, Paola Queirolo, Axel Hauschild, Christian U Blank, Maria Grazia Vitale, Carlo Alberto Tondini, Leyre Zubiri, Arielle Elkrief, Karijn P M Suijkerbuijk, Mario Mandala, Alexander M Menzies, Aljosja Rogiers, Chiara Tentori, Joseph M Grimes, Megan H Trager, Sharon Nahm, Peter Bowling, Neha Papneja, April A N Rose, Jessica S W Borgers, Severine Roy, Thiago Pimentel Muniz, Tim Cooksley, Jeremy Lupu, Samuel D Saibil, Matteo S Carlino, Michael Erdmann, Laura Pala, Ryan J Sullivan, Wilson H Miller Jr, Kerry L Reynolds, Osama E Rahma, Paul C Lorigan

“…The impact of immune checkpoint inhibition (ICI) on the severity of COVID-19 illness is unknown. The aim of this study was to investigate whether ICI confers an additional risk for severe COVID-19 in patients with cancer.Methods We analyzed data from 110 patients with laboratory-confirmed SARS-CoV-2 while on treatment with ICI without chemotherapy in 19 hospitals in North America, Europe and Australia. …”
Get full text

A comparative analysis of clinical outcomes in hematological patients afflicted with bacteremia attributable to carbapenem-resistant Klebsiella pneumoniae versus Escherichia coli by Jiali Wang, Jiali Wang, Jia Liu, Qingsong Lin, Qingsong Lin, Fengkui Zhang, Fengkui Zhang, Yizhou Zheng, Yizhou Zheng, Zhijian Xiao, Zhijian Xiao, Jianxiang Wang, Jianxiang Wang, Aiming Pang, Aiming Pang, Yi He, Yi He, Erlie Jiang, Erlie Jiang, Sizhou Feng, Sizhou Feng, Mingzhe Han, Mingzhe Han, Weihua Zhai, Weihua Zhai

“…Nevertheless, there is a paucity of studies that have undertaken a comparative analysis of clinical outcomes in patients afflicted with CRKP and EC.MethodsThis study was conducted with the aim of identifying the microbiological and clinical characteristics of hematological patients suffering from bacteremia caused by CRKP and CREC.ResultsThe cohort included 90 patients with equal proportions of CRKP BSI and CREC BSI from 2017 to 2022. …”
Get full text

Low-versus high-dose aspirin for venous thromboembolic prophylaxis after total joint arthroplasty: a systematic review and meta-analysis by Peyman Mirghaderi, Mohammad-Taha Pahlevan-Fallahy, Payman Rahimzadeh, Mohammad Amin Habibi, Fatemeh Pourjoula, Alireza Azarboo, Alireza Moharrami

“…This meta-analysis sought to compare the efficacy and complication rate of low-dose (162 mg per day) versus high-dose (HD, 650 mg per day) aspirin after TJA surgery. Methods In four main databases, we searched from inception until September 2024 for articles comparing the rate of VTE following TJA(TKA/THA) using only aspirin chemoprophylaxis with different dosages. …”
Get full text

Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib by Menghui Wang, Yueheng Li, Junhui Su, Xinjue Dong, Ao Liu, Yuqi Yang, Xinyi Tang, Ruijie Chen, QingQuan Li, Hongshan Wang, Hong Xiao

“…Abstract Background Many cases of advanced hepatocellular carcinoma (HCC) are resistant to the widely used drug sorafenib, which worsens prognosis. …”
Get full text

Older Adults with Diabetes in Korea: Latest Clinical and Epidemiologic Trends by Kyuho Kim, Bongseong Kim, Kyuna Lee, Yu-Bae Ahn, Seung-Hyun Ko, Sung Hee Choi, Kyungdo Han, Jae-Seung Yun

“…Results The absolute number of newly diagnosed cases of diabetes among older adults doubled over the past decade. …”
Get full text

Ocrelizumab – a monoclonal antibody – in the treatment of adult patients with multiple sclerosis: a systematic review by D. L. Klabukova, M. E. Holownia-Voloskova, M. V. Davydovskaya, T. N. Ermolaeva, K. I. Polyakova, A. G. Fisun, K. A. Kokushkin

“…Aim: To analyze the efficacy, safety and pharmacoeconomic aspects of using ocrelizumab in adult patients with relapsing/remitting multiple sclerosis (R/R MS).Materials and Methods. We used the commonly accepted PICo(S) questionnaire with the following specifics: the population – patients with R/R MS; the intervention – ocrelizumab; the comparators – all disease-modifying treatments for MS; the outcomes – the annualized relapse rate, confirmed disability progression, MRI results, quality-adjusted years of survival (QALYs), adverse events, and other clinical outcomes. …”
Get full text

Efficacy of indigo naturalis nanofibrous patches in the treatment of chronic plaque psoriasis: a 4-week prospective, randomized, semi-compartmental paired, positive drug-controlled... by Yuechun Zhao, Jiaqi Li, Ningxin Zhang, Mingyue Liu, Pengyu Wang, Ning Li, Ruodan Xu, Ping Song

“…We developed an IN-poly (ε -caprolactone, PCL)/poly (ethylene oxide, PEO) nanofibrous patch using electrospinning technology. Preliminary studies demonstrated its potential to reduces keratinocyte proliferation, inflammation, and neovascularization, addressing limitations of conventional IN formulations such as poor absorption and skin staining.AimsTo evaluate the safety and efficacy of the IN-PCL/PEO patch for chronic plaque psoriasis.MethodsThe clinical trial included 36 patients diagnosed with chronic plaque psoriasis. …”
Get full text

Exploration of Automated Measurement for Ossicular Chains Based on 3-Dimensional Geometric Information by Mengshi Zhang, Yufan Zhang, Sihui Guo, Xiaoguang Li, Li Zhuo, Yuxue Ren, Wei Chen, Yili Feng, Ruowei Tang, Han Lv, Pengfei Zhao, Zhenchang Wang, Hongxia Yin

“…Accurate preoperative ossicular-chain measurements are essential for creating prostheses; however, current methods rely on cadaver studies or manual measurements from 2-dimensional images, which are time-intensive and laborious and depend heavily on radiologist expertise. …”
Get full text

Efficacy and safety of midazolam compared to fentanyl as adjuvants to hyperbaric bupivacaine in spinal anesthesia: a systematic review and meta-analysis of randomized controlled tr... by Molla Amsalu Tadesse, Eniyew Assimie Alemu, Mengesha Dessie Allene, Melkam Mulugeta Abebe, Agmuas Asichale Alimawu, Fetene Seyoum Kebede, Emebet Seyum Wondemu

“…Abstract Background Various drugs have been used as adjuvants to local anesthetics to prolong analgesia and reduce the dosage and side effects of local anesthetics in regional anesthesia and peripheral nerve blocks. Methods The literature search was conducted using Google Scholar, PubMed, and the Cochrane Library for randomized controlled trials comparing fentanyl or midazolam to bupivacaine in spinal anesthesia. …”
Get full text

The Impact of HbA1C on Postoperative Complications Following Orthopaedic Surgeries to the Foot and Ankle: A Systematic Review by Jacek Parylo MB ChB, BSc (hons), Erika Pond, Paula McQuail MB BCh, BAO, MCh, FRCSI, Basil Budair MBBS, MSc, FRCS (Tr & Orth)

“…Foot and ankle surgery is particularly fraught with difficulty given the predilection T2DM has for the foot in the development of Charcot neuroarthropathy on top of other complications. Methods: PubMed, Embase, Medline, Ovid, Cochrane library, and Trip medical database were searched to identify studies concerning postoperative complications and their relationship to pre-operative HbA1C measurements following foot and ankle surgeries. …”
Get full text

Insights into the expansion of Oropouche virus in Brazil: epidemiological and environmental aspects by Igor Pereira Godinho, Ítalo Faria Dória, Victor de Melo Rocha, Bárbara Alves Miranda, Lucas Fernandes Chamhum Salomão, Brunello Stancioli, Adriana Alves Oliveira Paim, Jordana G. Alves Coelho dos Reis, Samille Henriques Pereira, Flávio Guimarães da Fonseca

“…Current diagnostic strategies rely almost exclusively on molecular detection methods, and there are no vaccines for effective prevention. …”
Get full text

A systematic review and meta-analysis on the association between PM2.5 exposure and increased influenza risk by Ava Orr, Ava Orr, Rebekah L. Kendall, Zeina Jaffar, Jon Graham, Jon Graham, Christopher T. Migliaccio, Jonathon Knudson, Curtis Noonan, Erin L. Landguth

“…., increased hospital admissions, confirmed influenza cases), synthesizing previous findings related to pollutant effects and exposure durations.MethodsWe searched PubMed, Web of Science, and Scopus for relevant studies up to 1 January 2010, following Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines for selection and analysis.ResultsOur review included 16 studies and found that a 10 μg/m3 increase in daily PM2.5 levels was associated with an increase of 1.5% rise in influenza risk (95% CI: 0.08%, 2.2%), with significant variations across different temperatures and lag times post-exposure. …”
Get full text

Genetic and peripheral biomarkers of comorbid posttraumatic stress disorder and traumatic brain injury: a systematic review by Kiriana Cowansage, Reshmi Nair, Jose M. Lara-Ruiz, Daniel E. Berman, Courtney C. Boyd, Tiffany L. Milligan, Daniel Kotzab, Dawn M. Bellanti, Lisa M. Shank, Maria A. Morgan, Derek J. Smolenski, Ida Babakhanyan, Nancy A. Skopp, Daniel P. Evatt, Marija S. Kelber

“…We included published studies examining differences in peripheral biomarkers among civilian, military, and veteran participants with both TBI and PTSD compared to those with TBI alone as well as, in some cases, PTSD alone and healthy controls. …”
Get full text

Patient outcomes after attending pre-pump education class: disparities in initiation and glycemic outcomes by Marinés Castillo Echevarría, Riley E. Evans, Jessica A. Schmitt

“…BackgroundAt Children’s of Alabama, all patients with insulin dependent diabetes are considered for continuous subcutaneous insulin infusion therapy (CSII, also known as insulin pump). In some cases, eligibility depends on insurance requirements, including six months of MDI therapy, CSII education, and a six-week glucose log with four daily readings.ObjectiveEvaluate factors influencing CSII initiation after “Prepump class” and assess glycemic changes in CSII starters.MethodsA retrospective review of pre-pump class attendees from January 2022 to July 2023 was completed. …”
Get full text

Carbohydrate Determinants of Chorionic Villi Glycoconjugates of Human Embryos, Lost due to Sporadic and Recurrent Miscarriages by Zastavnyy I., Yashchenko A., Lutsyk A.

“…Materials and methods. Tissue samples of chorionic villi of 8 human embryos, lost due to sporadic and recurrent miscarriages in the first trimester of pregnancy (gestational age 4-13 weeks), were subjected to lectin histochemistry investigation. …”
Get full text

DeepGenMon: A Novel Framework for Monkeypox Classification Integrating Lightweight Attention-Based Deep Learning and a Genetic Algorithm by Abdulqader M. Almars

“…Hence, these models often need significant computational power and memory. <b>Methods</b>: This paper proposes a novel lightweight framework called DeepGenMonto accurately classify various types of skin diseases, such as chickenpox, melasma, monkeypox, and others. …”
Get full text

Prophylactic and therapeutic efficacy of human monoclonal antibodies against H5N1 influenza. by Cameron P Simmons, Nadia L Bernasconi, Amorsolo L Suguitan, Kimberly Mills, Jerrold M Ward, Nguyen Van Vinh Chau, Tran Tinh Hien, Federica Sallusto, Do Quang Ha, Jeremy Farrar, Menno D de Jong, Antonio Lanzavecchia, Kanta Subbarao

“…We generated neutralizing anti-H5N1 human monoclonal antibodies (mAbs) and tested their efficacy for prophylaxis and therapy in a murine model of infection.<h4>Methods and findings</h4>Using Epstein-Barr virus we immortalized memory B cells from Vietnamese adults who had recovered from infections with HPAI H5N1 viruses. …”
Get full text

Current update on malaria in pregnancy: a systematic review by Awoke Minwuyelet, Delenasaw Yewhalaw, Melkamu Siferih, Getnet Atenafu

“…Objectives To review the epidemiological patterns of malaria in pregnancy and its impact on maternal and neonatal health, and to analyze the availability and effectiveness of drug treatment options. Methods Relevant articles published only in English were searched using electronic databases such as PubMed, Web of Science, Scopus, and Pro-Quest. …”
Get full text

Radiogenomic approach to glial tumors imaging under conditions of initial diagnostic measures: adaptation principles development by N. E. Maslov, G. E. Trufanov, V. M. Moiseenko, D. A. Valenkova, A. Yu. Efimtsev, N. A. Plakhotina, A. S. Sidorina

“…Despite the fact that biopsy is considered to be the «gold standard» for brain tumors differential diagnosis, it is though quite difficult to perform due to the complexity of surgical access, common cases of the repeat procedure impossibility, serious complications and mortality.Aim: a search for imaging features providing prognostic data on the presence of certain mutations and gene expression in gliomas, obtained using traditional pulse sequences and characterized by the absence of restrictions on applicability depending on the tumors visible morphological features.Material and methods: retrospective analysis of 49 eligible patients' primary brain MRI data between 2021 and 2023 from Almazov National Medical Research Centre (n = 31) and Napalkov Oncological Centre (n = 18) with glial tumors and subsequently identified status of the target variable; preprocessing of MR images using the histogram matching; regions of interest determination and semi-automated slice-by-slice segmentation with subsequent extraction of radiomics features; search for predictive radiomics features regarding the status of target variable using statistical analysis tools.Results. …”
Get full text

Artificial intelligence in molecular and genomic prostate cancer diagnostics by A. O. Morozov, A. K. Bazarkin, S. V. Vovdenko, M. S. Taratkin, M. S. Balashova, D. V. Enikeev

“…To evaluate the possibilities of using artificial intelligence in early diagnosis and prognosis of prostate cancer.Materials &amp; methods. We conducted a systematic review of the literature on the Medline citation database. …”
Get full text