Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome by Beáta-Mária Benkő, Bálint-Imre Szabó, Szabina Kádár, Edina Szabó, Gergő Tóth, Lajos Szente, Péter Tonka-Nagy, Romána Zelkó, István Sebe

“…Disulfiram (DIS), a drug for alcoholism, is under investigation as a potential adjunctive treatment, but its low bioavailability, rapid metabolism, and safety concerns urge the development of improved formulations for clinical translation. <b>Methods</b>: Screening dissolution and permeation studies were investigated for vehicle and excipient selection, following the pharmacopeia perspectives to develop and optimize the low-dose DIS rectal suppository intended for application in post-treatment Lyme disease syndrome (PTLDS). …”
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The Role of Immunohistochemistry as a Surrogate Marker in Molecular Subtyping and Classification of Bladder Cancer by Tatiana Cano Barbadilla, Martina Álvarez Pérez, Juan Daniel Prieto Cuadra, Mª Teresa Dawid de Vera, Fernando Alberca-del Arco, Isabel García Muñoz, Rocío Santos-Pérez de la Blanca, Bernardo Herrera-Imbroda, Elisa Matas-Rico, Mª Isabel Hierro Martín

“…The review also analyses the application of IHC in both muscle-invasive (MIBC) and non-muscle-invasive bladder cancer (NMIBC), with particular attention to the less extensively studied NMIBC cases. We discuss the practical advantages of IHC for subtyping, including its cost effectiveness and feasibility in standard pathology laboratories, alongside ongoing challenges such as the requirement for standardised protocols and external validation across diverse clinical settings; Conclusions: While IHC has limitations, it offers a viable alternative for laboratories lacking access to advanced molecular techniques. …”
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Combination of Alcohol and EVOH as a New Embolic Agent: Midterm Tissue and Inflammatory Effects in a Swine Model by Jean-François Hak, Farouk Tradi, Mickael Bobot, Pauline Brige, Paul Habert, Sophie Chopinet, Aurélie Haffner, Gilles Soulez, Benjamin Guillet, Vincent Vidal

“…To evaluate the vascular occlusion and midterm tissue toxicity properties of a combination of ethylene-vinyl alcohol (EVOH) (Squid 18®) (75%) and alcohol (25%)—Alco-Squid 18—in a swine model. Materials and Methods. Alco-Squid 18 (75% Squid 18® mixed with 25% alcohol) (AS18) was compared to embolization with 96% alcohol alone and to embolization with Squid 18® (S18®) alone. …”
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Shoulder arthroplasty for the management of glenoid dysplasia: a systematic review by Samuel S. Rudisill, MD, William H. Sperling, Kristin E. Yu, MD, Bradley S. Schoch, MD, Jonathan D. Barlow, MD, Joaquin Sanchez-Sotelo, MD, PhD, Erick M. Marigi, MD

“…Methodological quality was assessed using a modified Newcastle–Ottawa scale. Results: Seven studies with a mean modified Newcastle–Ottawa scale score of 10.9 ± 1.3 were included, consisting of 84 aTSA, 13 rTSA, and 22 HA cases in total. …”
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Critical Assessment of Single-Use Ureteroscopes in an In Vivo Porcine Model by Brian Ceballos, Charles U. Nottingham, Seth K. Bechis, Roger L. Sur, Brian R. Matlaga, Amy E. Krambeck

“…We compared two commonly utilized single-use ureteroscopes in a porcine model. Methods. A female pig was placed under general anesthesia and positioned supine, and retrograde access to the renal collecting system was obtained. …”
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Comparison of autologous hematopoietic cell transplantation, matched sibling donor hematopoietic cell transplantation, and chemotherapy in patients with favorable- and intermediate... by Mingyang Wang, Shulian Chen, Qiuqiu Zhang, Linyu Yuan, Xue Wang, Junshi Zhang, Xiaoyu Zhang, Yigeng Cao, Dongmei Li, Xinxiao Lu, Meijiao Wang, Xiaosi Jiang, Rongli Zhang, Xin Chen, Qiaoling Ma, Jialin Wei, Donglin Yang, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Weihua Zhai, Xingli Zhao, Erlie Jiang

“…However, the comparative effectiveness of these approaches in favorable- and intermediate-risk AML remains unclear and requires further investigation.MethodsIn this retrospective study, 111 patients diagnosed with de novo favorable- and intermediate-risk AML, categorized according to the ELN 2022 guidelines, were investigated to compare outcomes following autologous HSCT (auto-HSCT), matched sibling donor HSCT (MSD-HSCT), and chemotherapy. …”
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Differential Protein-Coding Gene Expression Profile in Patients with Prostate Cancer by Lorena Albarracín-Navas, Maylin Almonte-Becerril, Enmanuel Guerrero, Josue Rivadeneira, Marcelino Telechea-Fernández, Elizabeth Guzmán, Fanny Calderón, María José Hernández-Leal, Tamara Otzen, Carlos Manterola, Galo Duque, Ángela L. Riffo-Campos

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Pediatric cardiac surgical site infections: A single-center quality improvement initiativeCentral MessagePerspective by Nhat Chau, HBSc, Crystal Tran, HBSc, CCRP, Megan Clarke, MN, RN, CIC, Jennifer Kilburn, MN, RN, Cecilia St. George-Hyslop, MEd, RN, CNCCPC, Diana Young, RN, Sandra L. Merklinger, MN-NP, PhD, Erica Mosolanczki, MN-NP, Vivian Trinder, MN-NP, Jill O'Hare, MN-NP, Karen Clarke, RN, Kate McCormick, MScN, RN, Rachel D. Vanderlaan, MD, PhD, FRCSC

“…Our institution reported elevated SSI rates of 3.48 per 100 cases over a 5-year period above target rates of 2.5 per 100 cases. …”
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Incidence of mortality and surgical reintervention following thoracic endovascular aortic repair for uncomplicated type B aortic dissection by Aryan Shah, BSc, Joshua Lefort, Prangad Gupta, Panagiotis Leonidas Papalazarou, Ujash Sooriyakumaran, BHSc, Mohammad El-Diasty, MD, PhD, Michael Yacob, MD, MEd, RPVI, FRCSC

“…This systematic review aims to evaluate mortality, surgical reintervention, and adverse outcomes after TEVAR in patients with uTBAD, stratified by timing of intervention. Methods: In accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched MEDLINE and Embase for studies on TEVAR outcome data for uTBAD published between 2014 and 2024. …”
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Geographical clustering and socioeconomic factors associated with hypoglycemic events requiring emergency assistance in Andalusia (Spain) by Fernando Gomez-Peralta, Cristina Abreu, Manuel Benito, Rafael J Barranco

“…Introduction The geographical distribution of hypoglycemic events requiring emergency assistance was explored in Andalusia (Spain), and potentially associated societal factors were determined.Research design and methods This was a database analysis of hypoglycemia requiring prehospital emergency assistance from the Public Company for Health Emergencies (Empresa Pública de Emergencias Sanitarias (EPES)) in Andalusia during 2012, which served 8 393 159 people. …”
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The Potentials and Role of Diffusion-Weighted Magnetic Resonance Imaging in Evaluating the Efficiency of Antitumor Treatment of Patients with Breast Liver Metastasis by А. B. Lukiyanchenko, B. М. Medvedeva, E. S. Kolobanova, К. A. Romanova, S. S. Magamedova

“…To compare the informative value of using dynamic magnetic resonance imaging (MRI) and diffusion-weighted MRI (DW-MRI) in patients with breast liver metastasis during chemotherapy.Material and methods. The investigation enrolled 30 patients with breast liver metastasis during their treatment. …”
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Abstract 239: Effects of the COVID‐19 Pandemic on Stroke Treatment in Australia by Grace Datta

“…Methods Initially, we conducted secondary research on stroke treatment in Australia. …”
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Testicular appendix (hydatid of Morgagni) torsion in adult urological management: evaluation of treatment outcomes by I. S. Shormanov, D. N. Shedrov, D. Y. Garova, A. I. Ryzhkov

“…To evaluate and compare long-term results of various treatment options for patients with testicular appendix torsion over the age of 18 years.Materials &amp; methods. The age of patients is from 18 to 46 years. …”
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Risk of acute pericarditis after pulsed-field ablation pulmonary vein isolation by Juliana Pérez-Pinzón, MD, Shu Yang, MD, Timothy Maher, MD, Andrew H. Locke, MD, Peter Zimetbaum, MD, Kapil Kumar, MD, Alexei Shvilkin, MD, Charles I. Haffajee, MD, Alfred E. Buxton, MD, Andre d’Avila, MD, Gregory F. Michaud, MD, FHRS, Jonathan W. Waks, MD, Patricia Tung, MD, MPH, FHRS

“…Methods: We prospectively identified cases of PAP in 322 patients who underwent PFA PVI ablation between April 2024 and December 2024 and 1750 patients who underwent RFA PVI between January 2022 and December 2024. …”
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Terlipressin at esophageal varicose bleeding at liver cirrhosis with portal hypertension syndrome by B. N. Kotiv, I. I. Dzidzava, D. P. Kashkin, A. V. Smorodsky, A. V. Slobodyanik, S. A. Soldatov, M. V. Koldin

“…To compare efficacy of vasoactive therapy by terlipressin and octreotide at bleeding from varicose veins of the esophagus in patients with liver cirrhosis.Material and methods. Investigation was based on the retrospective analysis of results of treatment of 72 patients with liver cirrhosis and portal hypertension syndrome. …”
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Unveiling the Genetic Landscape of Coronary Artery Disease Through Common and Rare Structural Variants by Kruthika R. Iyer, Shoa L. Clarke, Rodrigo Guarischi‐Sousa, Ketrin Gjoni, Adam S. Heath, Erica P. Young, Nathan O. Stitziel, Cecelia Laurie, Jai G. Broome, Alyna T. Khan, Joshua P. Lewis, Huichun Xu, May E. Montasser, Kellan E. Ashley, Natalie R. Hasbani, Eric Boerwinkle, Alanna C. Morrison, Nathalie Chami, Ron Do, Ghislain Rocheleau, Donald M. Lloyd‐Jones, Rozenn N. Lemaitre, Joshua C. Bis, James S. Floyd, Gregory L. Kinney, Donald W. Bowden, Nicholette D. Palmer, Emelia J. Benjamin, Matthew Nayor, Lisa R. Yanek, Brian G. Kral, Lewis C. Becker, Sharon L. R. Kardia, Jennifer A. Smith, Lawrence F. Bielak, Arnita F. Norwood, Yuan‐I Min, April P. Carson, Wendy S. Post, Stephen S. Rich, David Herrington, Xiuqing Guo, Kent D. Taylor, JoAnn E. Manson, Nora Franceschini, Katherine S. Pollard, Braxton D. Mitchell, Ruth J. F. Loos, Myriam Fornage, Lifang Hou, Bruce M. Psaty, Kendra A. Young, Elizabeth A. Regan, Barry I. Freedman, Ramachandran S. Vasan, Daniel Levy, Rasika A. Mathias, Patricia A. Peyser, Laura M. Raffield, Charles Kooperberg, Alex P. Reiner, Jerome I. Rotter, Goo Jun, Paul S. de Vries, Themistocles L. Assimes

“…Single variant tests were performed on 58 706 SVs in a study sample of 11 556 CAD cases and 42 907 controls. …”
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Surgical site infections after caesarean section across sub-Sahara Africa: a scoping review of prevalence and associated factors by Rebekah Wood, Anna Borodova, Sophie Wolter, Micheline N’Guessan, Amadou Aziz Diallo, Mamadou Kamis Diallo, Katharina Heldt, Carlos Rocha, Ibrahima Nabé, Bamourou Diané, Mahamoud Sama Cherif, Sophie Alice Müller

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A Novel Variant in TUBB4B Causes Progressive Cone‐Rod Dystrophy and Early Onset Sensorineural Hearing Loss by Margherita Scarpato, Francesco Testa, Anna Nesti, Roberta Zeuli, Rosa Boccia, Gennaro Auletta, Sandro Banfi, Francesca Simonelli, Marianthi Karali

“…Methods We performed whole‐exome sequencing and a full ophthalmological and audiological examination of the affected members in an Italian family segregating syndromic IRD with early onset deafness. …”
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Whole exome sequencing identifies a new DPY19L2 variant c.1232_1233insA in Tunisian infertile patient with globozoospermia by Wiem Ayed, Nicolas Thierry-Mieg, Wajh Hammami, Meriem Ben Khalifa, Sonia Mnallah, Hanène Eloumi, Amel Zhioua, Anis Chaker, Fethi Zhioua, Pierre F. Ray, Ahlem Amouri

“…Patients and methods Eighteen infertile men with total and partial globozoospermia were investigated. …”
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PERIOPERATIVE NUTRITIONAL SUPPORT IN GASTRIC CANCER PATIENTS UNDERGOING RADICAL SURGERY by A. L. Potapov, A. D. Dorozhkin, S. V. Gamayunov, V. Yu. Skoropad, I. P. Kostjuk, D. D. Kudryavtsev, S. A. Ivanov, A. D. Kaprin

“…The purpose of this review was to analyze current data on nutritional support (Ns) in gastric cancer patients undergoing radical surgery. Material and methods. a literature search was conducted in the electronic databases eLIBRaRY.Ru, PubMed using the keywords «surgery», «stomach cancer», «nutrition», «ERas». …”
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