From Morphology to Gene Expression Profiling in Mycosis Fungoides: Is It Still a Diagnostic Challenge? by Alessandra Filosa, Gerardo Cazzato, Elisa Bartoli, Elena Antaldi, Federica Giantomassi, Matteo Santoni, Gaia Goteri

“…The goal of summing up all the clinico-pathological information before reaching a final diagnosis is the approach needed to reach diagnostic accuracy, especially in early MF cases. It is advisable to think of the most common clinical presentations, to be aware of the most common histopathological features, and to interpret the results of ancillary studies only in the right clinico-pathological context.…”
Get full text

Fabry Disease - literature review by Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Adrian Muzyka, Julia Rydzek, Ewa Gardocka

“…The aim of this publication is to discuss various aspects of Fabry disease based on the latest literature. Review Methods: The PubMed database was searched for scientific articles where the terms "Fabry disease" or "FD" appear in the title, abstract, or keywords. …”
Get full text

Clinical-epidemiological features of meningococcal infection in children during sporadic morbidity by G. P. Martynova, I. A. Kutishcheva, Ya. A. Bogvilene, N. F. Kuznetsova, A. V. Karasev, E. B. Bojtsova

“…Purpose: to evaluate epidemiologic situation as to meningococcal infection and reveal clinical-epidemiological features of the disease on the territory of Krasnoyarsk сity and Krasnoyarsk Krai at the present stage. Data and methods: The research gives the analysis of MI morbidity and mortality rates in children of the region according to official information from the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in Krasnoyarsk Krai for the period 2000–2014. …”
Get full text

Development of a data-driven urban immunity assessment model: providing a new benchmark for urban governance under public health emergencies by Peng Cui, Peng Cui, Saiya Cao, Ruize Qin, Fan Zhang

“…It refines the theoretical framework of urban immunity, analyzes urban immune response mechanisms, develops an immunity indicator system, assesses the spatiotemporal patterns of urban immunity, and builds a decision-making model using intelligent optimization methods to generate optimized solutions for different scenarios. …”
Get full text

Approach to Neonates and Young Infants with Fever without a Source Who Are at Risk for Severe Bacterial Infection by Susanna Esposito, Victoria Elisa Rinaldi, Alberto Argentiero, Edoardo Farinelli, Marta Cofini, Renato D’Alonzo, Antonella Mencacci, Nicola Principi

“…The aim of this review is to describe the management of young infants with FWS and to discuss the impact of recent knowledge regarding FWS management on clinical practice. Materials and Methods. PubMed was used to search for all of the studies published over the last 35 years using the keywords: “fever without source” or “fever of unknown origin” or “meningitis” or “sepsis” or “urinary tract infection” and “neonate” or “newborn” or “infant <90 days of life” or “infant <3 months”. …”
Get full text

State-of-the-Art Methodologies for Self-Fault Detection, Diagnosis and Evaluation (FDDE) in Residential Heat Pumps by Francesco Pelella, Adelso Flaviano Passarelli, Belén Llopis-Mengual, Luca Viscito, Emilio Navarro-Peris, Alfonso William Mauro

Get full text

Impact of adjuvant chemotherapy on relapse-free survival of patients with locally advanced cervical cancer by M.  P. Smirnova, A. S. Khadzhimba, S. Ya. Maksimov, A. A. Ilyin, A. V. Pletneva

“…The desire to change the current situation resulted in the studying of the effectiveness of adjuvant chemotherapy in cervical cancer patients with regional lymph nodes metastases.Objective: to evaluate the effectiveness of the combination of neoadjuvant chemoradiation plus adjuvant chemotherapy in patients with FIGO stage III cervical cancer (T1–2N1M0).Materials and methods. …”
Get full text

Proposal of a radiation-free screening protocol for early detection of interstitial lung involvement in seropositive and ACPA-positive rheumatoid arthritis by Frank Reichenberger, Florian Popp, Martin Hoffmann, Carina Fischinger, Werner von Wulffen, Nikolaus Kneidinger, Martin Welcker

“…Trial registration German Register of Clinical Studies (DRKS00028871).…”
Get full text

INFLUENCE OF UNILATERAL SCIATIC NERVE LIGATION ON THE TUMOR-BEARING RATS WITH THE FEATURES OF SYSTEMIC REGULATION by O. I. Kit, G. V. Zhukova, A. I. Shikhlyarova, A. S. Goncharova, S. Yu. Tkachev, T. P. Protasova, E. A. Lukbanova, M. V. Mindar

“…The distinct negative effect of increased aging rate, measured by animal weight, on tumor development and lifespan in studied rats was shown, but not in the cases of sciatic nerve ligation. …”
Get full text

Metabolic-imaging of human glioblastoma live tumors: A new precision-medicine approach to predict tumor treatment response early by Mariangela Morelli, Francesca Lessi, Serena Barachini, Serena Barachini, Romano Liotti, Romano Liotti, Nicola Montemurro, Paolo Perrini, Orazio Santo Santonocito, Carlo Gambacciani, Matija Snuderl, Francesco Pieri, Filippo Aquila, Azzurra Farnesi, Antonio Giuseppe Naccarato, Paolo Viacava, Francesco Cardarelli, Gianmarco Ferri, Gianmarco Ferri, Paul Mulholland, Diego Ottaviani, Fabiola Paiar, Gaetano Liberti, Francesco Pasqualetti, Francesco Pasqualetti, Michele Menicagli, Paolo Aretini, Giovanni Signore, Sara Franceschi, Chiara Maria Mazzanti

“…Therefore, better treatment screening approaches are needed. In this study, we have developed a novel functional precision medicine approach to test the response to anticancer treatments in organoids derived from the resected tumors of glioblastoma patients.MethodsGB organoids were grown for a short period of time to prevent any genetic and morphological evolution and divergence from the tumor of origin. …”
Get full text

Renal prognostic value of serum monoclonal immunoglobulin in cryoglobulinemic glomerulonephritis by Lei Ma, Yuanyuan Xia, Yun Fan, Dan Zhou, Xinchen Yao, Yongzhong Zhong, Fan Yang, Feng Xu, Shaoshan Liang, Yujie Wang, Xiaodong Zhu, Dacheng Chen, Rong Tan, Zhengyun Zhu, Dandan Liang, Caihong Zeng

“…AimsTo explore the clinicopathological features and renal outcome in patients with cryoglobulinemic glomerulonephritis (Cryo-GN) without confirmed systemic autoimmune diseases.MethodsSixty-nine patients with Cryo-GN from a single center were recruited in this retrospective study. …”
Get full text

Transcriptomic profiling of cytomegalovirus infection in cardiac transplantation: proof-of-concept for a new strategy in tissue markers application by Ilaria Barison, Diego Perazzolo, Chiara Castellani, Alessia Giarraputo, Elisabetta Rossi, Elisabetta Rossi, Luca Vedovelli, Sonia Anna Minuzzo, Chiara Tessari, Nicola Pradegan, Giuseppe Toscano, Francesco Tona, Cristina Basso, Gino Gerosa, Susanna Mandruzzato, Susanna Mandruzzato, Davide Abate, Dario Gregori, Annalisa Angelini, Marny Fedrigo

“…BackgroundCytomegalovirus (CMV) infection is a relevant threat to heart-transplanted patients during the first year after surgery, leading to increased morbidity and, in some cases, mortality. This proof-of-concept study aims to assess the transcriptomic profile of CMV infection in cardiac transplanted patients as a new diagnostic approach to discriminate infection and Acute Cellular Rejection (ACR) on EMB specimens.MethodsWe performed a microarray-based messenger RNA (mRNA) and micro-RNA (miRNA) profiling. …”
Get full text

Efficacy and safety of the combined use of celecoxib, diacerein and a combination of glucosamine and chondroitin for the control of musculoskeletal pain associated with osteoarthri... by A. E. Karateev, E. Yu. Polishchuk, A. M. Lila, A. N. Ananyev, L. V. Ananyeva, A. V. Bondarev, A. A. Bondareva, A. R. Bukanbaeva, S. V. Vorster, S. A. Gadzhieva, D. G. Danilov, R. I. Eliseev, I. S. Zabelin, M. Yu. Ignatenko, I. V. Itkina, A. E. Kolesnikov, M. Yu. Konoplyanskaya, Yu. G. Krasnoyarova, S. I. Kukushkin, V. A. Lila, O. V. Makareva, V. S. Myagkikh, I. V. Nelgovskaya, N. V. Ocheredko, R. A. Panov, I. A. Polyakov, A. S. Prozorov, S. S. Rubina, M. E. Ryabochkina, M. A. Takhaev, E. R. Tokareva, T. V. Tolbina, M. I. Fominykh, V. V. Tsarev, E. I. Sharipova, M. V. Sheven, G. I. Shcherbakov, S. A. Yanchenkova

“…Material and methods. Statistical analysis of data obtained during a 3-month open observational study was performed. …”
Get full text

A prediction approach to COVID-19 time series with LSTM integrated attention mechanism and transfer learning by Bin Hu, Yaohui Han, Wenhui Zhang, Qingyang Zhang, Wen Gu, Jun Bi, Bi Chen, Lishun Xiao

“…This paper builds a prediction approach for small size COVID-19 time series in a city. Methods Numbers of COVID-19 daily confirmed cases were collected from November 1, 2022 to November 16, 2023 in Xuzhou city of China. …”
Get full text

Traffic-related air pollution and spectacles use in schoolchildren. by Payam Dadvand, Mark J Nieuwenhuijsen, Xavier Basagaña, Mar Alvarez-Pedrerol, Albert Dalmau-Bueno, Marta Cirach, Ioar Rivas, Bert Brunekreef, Xavier Querol, Ian G Morgan, Jordi Sunyer

“…<h4>Purpose</h4>To investigate the association between exposure to traffic-related air pollution and use of spectacles (as a surrogate measure for myopia) in schoolchildren.<h4>Methods</h4>We analyzed the impact of exposure to NO2 and PM2.5 light absorbance at home (predicted by land-use regression models) and exposure to NO2 and black carbon (BC) at school (measured by monitoring campaigns) on the use of spectacles in a cohort of 2727 schoolchildren (7-10 years old) in Barcelona (2012-2015). …”
Get full text

EXPERIENCE OF REMOTE OBSTETRIC CENTERS IN THE KEMEROVO REGION IN THE CONTEXT OF A NEW CORONAVIRUS INFECTION by Светлана Ивановна Елгина, Ирина Анатольевна Ушакова, Елена Владимировна Рудаева, Нонна Марковна Шибельгут, Вадим Гельевич Мозес

“…Aim – to determine the effectiveness of dynamic monitoring and routing of pregnant women, women in labor and maternity hospitals in the context of the spread of a new coronavirus infection in obstetric remote consultation centers. Materials and methods. The course of pregnancy and childbirth, as well as the health status of newborns, were retrospectively studied in 24 women with COVID-19 who were in repurposed infectious diseases hospitals in Kemerovo. …”
Get full text

A switch in hepatic cortisol metabolism across the spectrum of non alcoholic fatty liver disease. by Adeeba Ahmed, Elizabeth Rabbitt, Theresa Brady, Claire Brown, Peter Guest, Iwona J Bujalska, Craig Doig, Philip N Newsome, Stefan Hubscher, Elwyn Elias, David H Adams, Jeremy W Tomlinson, Paul M Stewart

“…<h4>Objective and methods</h4>In vitro studies defined 11β-HSD1 expression in normal and NASH liver samples. …”
Get full text

DIAGNOSTIC SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH PRIMARY MITRAL VALVE PROLAPSE by A. V. Yagoda, N. N. Gladkikh, Т. E. Zangelova

“…To evaluate diagnostic significance of the type A vascular endothelial growth factor (VEGF-A) and its receptors type 1 and 2 (VEGF-R1 and VEGF-R2) in primary mitral valve prolapse (MVP) patients.Material and methods. Totally, 83 MVP patients studied: 61 males, 22 females; mean age 21,93±4,22 y. o. …”
Get full text

Comparative characteristics of the transcriptional activity of CDH1, CTNNB1 genes and the expression levels of E-cadherin, β-catenin proteins, coded by these genes, in intestinal-t... by V. A. Tumanskiy, T. A. Khrystenko

“…Aim: to compare the mRNA expression levels of CDH1 and CTNNB1 genes and the immunohistochemical expression levels of E-cadherin and β-catenin proteins in intestinal-type gastric adenocarcinoma. Materials and methods. The molecular genetic (real-time PCR) and immunohistochemical studies of the intestinal-type gastric adenocarcinoma (30 patients; I, II and III clinical stages were included) and of the normal stomach mucosa (10 samples) were conducted. …”
Get full text

Geopathogenic zones and oncological morbidity of the population by M. P. Hrebniak, O. V. Kirsanova, V. V. Taranov

“…The aim of the work is to establish the effect of a geopathogenic zone on the cancer incidence in the population. Materials and methods. Over a 12-year period, the oncological incidence in the population has been studied. …”
Get full text