Plastic surgery for the treatment of contagious diseases: lobomycosis by Rodolfo Luis Korte, Cipriano Ferreira-Junior, Ana Elisa Kadri Castilho, Laryssa Fernanda Feitosa, Anita Sperandio Porto

“…Methods: Here, we describe our 8 years of experience with lacaziosis at the Hospital de Base de Porto Velho - Rondônia; a total of 22 patients underwent surgical treatment and were followed-up. …”
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Unconventional Biomarkers in Dementia Trough Neurological Examination: A Literature Review by Salazar-Londoño, Salomón, Pérez-Foucrier, Valeria, Tengonó-Guarín, María José, Franky-Escobar, Isabella, Iragorri, Angela

“…Objectives: To describe unconventional biomarkers identifiable during neurological examination. Methods: A narrative review was conducted, searching for cognitive impairment in relation to unconventional biomarkers in PubMed, EMBASE, and SciELO databases. …”
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PaleoProPhyler: a reproducible pipeline for phylogenetic inference using ancient proteins by Patramanis, Ioannis, Ramos-Madrigal, Jazmín, Cappellini, Enrico, Racimo, Fernando

“…In contrast to the field of ancient DNA - where several computational methods exist to process and analyze sequencing data - few tools exist for handling ancient protein sequence data. …”
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Current evidence and strategies for preventing tumor recurrence following thermal ablation of papillary thyroid carcinoma by Ru Li, Luyang Yang, Ming Xu, Baofeng Wu, Qinhao Liu, Qin An, Yuchen Sun, Yi Zhang, Yunfeng Liu

“…Methods This review synthesizes existing literature on tumor progression after thermal ablation for PTC, analyzing potential causes and evaluating preventive strategies at different diagnostic and treatment stages. …”
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The Structure and Organization of Medical Care for Victims With Thermal Trauma in Emergency Situations by V. S. Borisov, S. A. Gumenyuk, A. V. Sachkov, V. I. Potapov, V. G. Teryaev, N. A. Karasev

“…The increase of an urban population in Russia up to 73% results in considerable human victims in big cities due to thermal injuries among others.THE AIM of the present research is to analyze the structure of ES victims and the efficiency of the organization of a medical care for victims with thermal injuries in Moscow in 2016–2018.MATERIAl AND METHODS We have held a retrospective analysis of 113 cases of patients of a Burn Center of Sklifosovsky Research Institute for Emergency Medicine of the Moscow Health Department, and have studies the data of an automated informational analytical system named “Emergency Medicine” for 2016 2018.RESUlTS For an absolute number of victims, fires are on the third place among different emergencies in Moscow, but on the pre­hospitalization stage, the biggest number of deaths are registered (38,2%). …”
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The role of regulatory CD4+CD25+high T-lymphocytes and their functional activity in the development of type 1 diabetes mellitus by Tatiana Vasil'evna Nikonova, Pavel Vasil'evich Apanovich, Elena Vladimirovna Pekareva, Vera Anatol'evna Gorelysheva, Sergey Alexandrovich Prokof'ev, Alexander Vasil'evich Karpukhin, Ivan Ivanovich Dedov

“…The risk group was comprised of 33 subjects (10 men and 23 women), control group included 16 subjects. In all cases, HLA genotyping was performed, autoantibodies to GDC, insulin and tyrosine phosphatase, islet cell antigens were determined, subpopulation composition of CD3+, CD4+, CD8+, CD38+, HLA DR+, CD25+, CD4+25+ lymphocytes and their functional activities (FoxP3 gene expression) studied, C-peptie and HbA1c levels measured. …”
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Integrating wastewater surveillance for future pandemic preparedness by tracking SARS-CoV-2 RNA in municipal wastewater in Southwest Iran by Rozhan Feizi, Neematollah Jaafarzadeh, Masoud Panahi Fard, Niloofar Neisi, Ali Zafarzadeh, Mohammad Sabaghan, Ali Veisi

“…Based on the results, SARS-CoV-2 RNA was detected with concentrations ranging from 0 to 2100 gene copies/L in studied samples. A strong positive correlation (r = 0.76, p < 0.01) was observed between viral RNA concentrations in wastewater and the number of confirmed COVID-19 cases in the region. …”
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Rituximab in pediatric B-cell Non-Hodgkin Lymphoma: Clinical outcomes and prognostic implications by Şefika Akyol, Turan Güzel, Alper Özcan, Serap Karaman, Mehmet Fatih Orhan, Veysiye Hülya Üzel, Mustafa Özay, Deniz Koçak Göl, Ebru Yılmaz, Baver Demir, Kamuran Karaman, Mustafa Büyükavcı, Musa Karakükcü, Ekrem Ünal

“…Methods: We retrospectively analyzed 62 pediatric B-NHL patients treated at tertiary centers. …”
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The genetic overlap between major depressive disorder, white blood cell counts and interleukin 6 by Erik D Wiström, Kevin S O'Connell, Elise Koch, Piotr Jaholkowski, Guy F.L. Hindley, Nils Eiel Steen, Pravesh Parekh, Charge Consortium, Oleksandr Frei, Nadine Parker, Alexey Shadrin, Srdjan Djurovic, Anders Dale, Ole A Andreassen, Olav B Smeland

“…Here we aimed to identify genetic architecture jointly associated with MDD, white blood cell (WBC) count and interleukin 6 (IL-6) levels. Methods: Using genome-wide association studies summary statistics on MDD (330,173 cases and 727,595 controls), WBC counts (nmax = 563,946) and IL-6 (n = 52,654), we performed linkage disequilibrium (LD) score regression, bivariate causal mixture model (MiXeR), conjunctional false discovery rate (conjFDR) and Mendelian randomization (MR) analyses. …”
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Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy by Yu Chen, Xuan Wang, Jie Dai, Li Zhou, Xuefeng Xia, Jun Guo, Xue Bai, Lu Si, Bixia Tang, Chuanliang Cui, Xiaoting Wei, Xinan Sheng, Siming Li, Zhihong Chi, Lili Mao, Bin Lian, Xieqiao Yan, Yan Kong, Caili Li, Xuan Gao, Lirui Tang, Linzi Sun, Zhonghui Qi, Zelong Xu

“…Primary malignant melanoma of the esophagus (PMME) is a rare, highly aggressive disease with a poorer prognosis compared with that of non-esophageal mucosal melanoma (NEMM). In this study, we retrospectively analyzed the efficacy of anti-programmed death (PD)-1 in patients with PMME and explored its molecular basis.Methods The response and survival of patients with PMME and NEMM under anti-PD-1 monotherapy were retrospectively analyzed. …”
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The spectrum and efficacy of antiepileptic drugs in patients with infantile spasms in Russia by T. G. Okhapkina, I. V. Shuljakova, E. S. Ilina, G. V. Kalmykova, M. V. Prytkina, E. D. Belousova

“…According to the international recommendations, the treatment of infantile  spasms (IS) begins with hormones or vigabatrin (in the cases of tuberous sclerosis complex –  TSC). However, in the Russian Federation, other antiepileptic drugs (AEDs) are often used as the first line medications.Aim: to analyze the current practice of prescribing AEDs for the treatment of epileptic spasms.Materials and Methods. …”
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Enhancement of Tuberculosis Detection and Prevention in HIV-Infected Patients by O. P. Frolova, T. I. Sharkova, O. V. Butylchenko, L. P. Severova, N. G. Ershova

“…Tuberculosis incidence and HIV infection incidence in the regions of the Russian Federation are declining, but the proportion of HIV positive people among the entire cohort of tuberculosis patients is clearly growing.The objective: to determine causes for increasing proportion of HIV infected people among tuberculosis patients and to provide additional recommendations for enhancement of tuberculosis detection in HIV infected patients. as well as prevention of its transmission.Subjects and Methods. The cohort of new tuberculosis patients with concurrent HIV infection (TB/HIV coinfection) in the Russian Federation region with a high prevalence of HIV infection was studied based personal medical records of patients for the first 6 months of 2022 (682 cases totally).Results. …”
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Active Herpes Virus Infection in Young Children by N. Yu. Egorova, O. V. Molochkova, L. N. Guseva, N. L. Waltz, K. P. Chusov

“…In children from birth to 1 year of life, CMV infection in the form of a mono-infection with symptoms of CNS damage, generalized forms, neutropenia is more common (79% of cases). In children aged 1 to 2 years, in 76% of cases, HHV-6 infection is detected, more often in mixed variants. …”
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A retrospective cohort analysis of alignment parameters for spinal tumor patients with instrumentation at the cervicothoracic junction by Christian B. Schroeder, ScM, Madison J. Michles, MS, Rahul A. Sastry, MD, Alexander A. Chernysh, BS, Owen P. Leary, BS, Felicia Sun, MD, Joaquin Q. Camara-Quintana, MD, Adetokunbo A. Oyelese, MD, PhD, Albert E. Telfeian, MD, PhD, Jared S. Fridley, MD, Ziya L. Gokaslan, MD, Patricia Zadnik Sullivan, MD, Tianyi Niu, MD

“…Methods: A retrospective review of a single institutional spine tumor database identified seventeen patients who underwent spinal fusion crossing the CTJ from 2015 to 2023. …”
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Association of Pre-Implantation Uterine Artery Doppler with Clinical Pregnancy in Assisted Reproductive Technology: A Systematic Review and Meta-Analysis by Antonios Siargkas, Areti Faka, Panagiota Kripouri, Evangelos Papanikolaou, Sofoklis Stavros, Ekaterini Domali, Dimos Sioutis, Chrysi Christodoulaki, Apostolos Mamopoulos, Ioannis Tsakiridis, Themistoklis Dagklis

“…<i>Background and Objectives:</i> This meta-analysis aimed to determine whether pre-implantation uterine artery (UtA) Doppler measurements are associated with clinical pregnancy in women undergoing assisted reproductive technologies (ART). <i>Materials and Methods:</i> A systematic search of MEDLINE, Scopus, and the Cochrane Library from inception until 25 March 2025 was conducted to identify relevant studies. …”
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Epidemiological and clinical impact of hepatitis E virus coinfection in chronic hepatitis B infected patients in Hebei, China by Yuzhu Shi, Yuzhu Shi, Yuchen Xie, Yuchen Xie, Ying Chen, Li Yang, Huixia Gao, Yun Guo, Fumin Feng, Jianhua Lu, Erhei Dai

“…However, epidemiological data on HBV/HEV coinfection in the Hebei region are scarce, necessitating further investigation.MethodsWe conducted a multicenter cross-sectional study for infectious diseases across six tertiary hospitals. …”
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Comparison of Perioperative Outcomes of Holmium Laser Enucleation of the Prostate for Standard (≤149 ml) Versus Very Large (≥150 ml) Prostate Glands: Retrospective Analysis of a Pr... by Jacob Schmidt, Jorien Krediet, Holger Beutel, Ayoub Hidayat Allah, Nella Gagel, Isabel Lichy, Bernhard Ralla, Maha Ullmann, Robert Peters, Frank Friedersdorff, Martin Kanne

“…Background and objective: Our objective was to evaluate whether a very large prostate volume significantly affects the incidence of perioperative complications and compromises outcomes among patients undergoing holmium laser enucleation of the prostate (HoLEP). Methods: We retrospectively analyzed data for 1815 adult patients who underwent HoLEP at Evangelisches Krankenhaus Königin Elisabeth Herzberge, Berlin, between January 2019 and May 2024. …”
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RASON promotes KRASG12C-driven tumor progression and immune evasion in non-small cell lung cancer by Jianzhuang Wu, Kexin Xie, Yixuan Zhang, Weiyi Zhang, Rongjie Cheng, Yaliang Zhang, Yugui Xia, Tongyan Liu, Rong Yin, Yudong Qiu, Tao Xu, Rutian Li, Qi Sun, Chao Yan

“…Herein, we aim to explore the role of RASON in KRASG12C-driven NSCLC and its therapeutic potential. Methods Immunohistochemistry analysis of NSCLC patient cohorts was performed to demonstrate the correlation between RASON expression and NSCLC progression. …”
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Rectal Spacer Reduces Gastrointestinal Side Effects of Radiation Post Radical Prostatectomy by Anne Hong, Damien Bolton, Trung Pham, David Angus, David Pan, Daryl Lim Joon, Alwin Tan, Kevin McMillan, Yee Chan, Paul Manohar, Joe Thomas, Huong Ho, Peter Orio, Emily Holt, Margaret Cokelek, Nathan Lawrentschuk, Farshad Foroudi, Michael Chao

“…<b>Objectives:</b> Our objective was to assess the rate of complications and gastrointestinal adverse effects of rectal spacer insertion for salvage post prostatectomy radiation therapy. <b>Methods:</b> A retrospective observational study was performed. …”
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Does Body Mass Index and Height Influence the Incident Risk of Ischemic Stroke in Newly Diagnosed Type 2 Diabetes Subjects? by Donghui Duan, Hui Li, Jiaying Xu, Liping Wong, Guodong Xu, Fanqian Kong, Sixuan Li, Qinghai Gong, Xiaohong Zhang, Jinshun Zhao, Lina Zhang, Guozhang Xu, Wenhua Xing, Liyuan Han

“…To estimate the incident risk of ischemic stroke (IS) in newly diagnosed type 2 diabetes (T2D) subjects according to different body mass index (BMI) and height categories. Methods. A total of 25,130 newly diagnosed T2D subjects were included in this study. …”
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