Underlying Mechanism of Jiuwei Shengmai Powder in Improving Myocardial Hypoxia at High Altitude Based on Network Pharmacology and Molecular Docking by Cong Wu, Yanjuan Zhu, Changpeng Xie, Haobo Liu, Yuanming Pan, Chang'e Liu

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A rare case of primary signet‐ring adenocarcinoma of anorectal region in a young patient: Diagnostic challenges and therapeutic outcomes by Bisma Shaikh, Areeba Gul, Ajeet Singh, Hamza Irfan, Tooba Ali, Riyan Karamat, Aymar Akilimali

“…The tumor exhibited extensive lymphovascular invasion and involved perirectal lymph nodes, and was staged as pT3, N2a. Immunohistochemical staining was positive for CK 7, CK 20, and SATB2, supporting the primary anorectal origin. …”
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Potentially inappropriate medication prescribing among elderly patients with cardiovascular diseases by Stojanović Goran, Đurić Dušan, Jakovljević Biljana, Turnić-Nikolić Tamara, Maričić Milena, Stojanović Svetlana, Milovanović Olivera

“…The study sample included 1,500 patients over 65 years with cardiovascular disease who had medical records at the Institute for Gerontology and Palliative Care, Belgrade. Assessment of PIM was done by standard international criteria such as the American Geriatrics Society 2015 updated Beers Criteria for PIM use in older adults. …”
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Real-World Observational Study of Incidence and Outcomes in an HR+/HER2– Early Breast Cancer Population with High-Risk of Recurrence in Finland by Ravinder Singh, Samuli Tuominen, Mariann I. Lassenius, Merja Auvinen, Astrid Torstensson, Tom Wiklund

“…High-risk status was defined as ≥ 4 positive axillary lymph nodes (ALNs) or 1–3 ALNs with either grade 3 tumor or tumor size ≥ 5 cm. …”
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Research on kd-tree Cache Optimization Based on Particle Index Sorting Algorithm by 张挺, 林震寰, 杨丁颖, 王宗锴, 陈轶凡

“…As a consequence, this divergence diminishes the efficiency of accessing node data, thereby ultimately impeding the effectiveness of <italic>kd-tree</italic> nearest neighbor searches. …”
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Identification and validation of key genes associated with cell senescence in acute myocardial infarction by Weidong Zhao, Guofu Zhu, Tianshu Chu, Liyong Wu, Hui Li, Qingwen Zhen, Rigui Wang

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The challenges of managing a patient with concurrent pulmonary tuberculosis and sarcoidosis (a case report) by R. V. Tarasov, S. S. Sadovnikova, E. V. Krasnikova, L. N. Lepekha, A. N. Tikhonskaya, E. V. Ertseva, M. A. Bagirov

“…The morphological picture corresponded to sarcoidosis in the active phase of the process. The primary care pulmonologist prescribed Metipred at a dose of 12 mg. …”
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Clinical profile, surgical management, and outcome of inferior vena cava tumors- A single-team experience by Farooq Ahmad Ganie, Masarat-ul Gani, Shahbaz Bashir, Hakeem Zubair Ashraf, Rohey Jan, Mohd Iqbal Dar, Mudasir Hamid Bhat, Shadab Maqsood

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Pancreatic surgery is safe in elderly patients with PDAC by Yueming Zhang, Siyang Han, Yaolin Xu, Liang Liu, Wenchuan Wu, Lei Zhang, chenye Shi, Chao Song, Dansong Wang, Wenhui Lou

“…Furthermore, poorer inflammatory-nutritional status was frequently associated with more complex surgical procedures, including longer surgical durations, greater intraoperative reported blood loss, and a higher number of resected lymph nodes, particularly in non-elderly patients. Conclusion With comprehensive preoperative evaluation and careful postoperative care, pancreatic surgery is safe for elderly patients in experienced pancreatic cancer centers.…”
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Rapid Development of Breast Mass With Recurrent Episodes of Hypoglycemia Should Raise Suspicion of Breast Cancer With Insulinoma: A Case Report by Tingting Liu, Lin Deng, Ruohan Su, Lin Ni, Zhiwei Wang, Wanqiu Xiong, Bing Wang, Sheng Huang

“…Case A 57‐year‐old female with a rapidly enlarging mass in the left breast for over 1 year, currently measuring approximately 11 × 10 × 8 cm, with multiple enlarged and fused lymph nodes palpable in the ipsilateral axilla and bilateral neck. …”
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Whole slide images as non-fungible tokens: A decentralized approach to secure, scalable data storage and access by Arlen Brickman, Yigit Baykara, Miguel Carabaño, Sean M. Hacking

“…DLT and off-chain network solutions present numerous opportunities for advancements in clinical care, education, and research. Such approaches uphold the principles of equitable healthcare data ownership, security, and democratization, and are poised to drive significant innovation.…”
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Analysis of the current situation and factors influencing the utilization of somatic and somatic-mental disorder comorbidity and health services among middle-aged and older adult p... by Mo Xue, Qianqian Zhang, Jialing Wu, Kan Tian

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STRUCTURAL FEATURES OF PURULENT INFLAMMATORY DISEASES OF THE MAXILLOFACIAL REGION IN RESIDENTS OF THE POLTAVA REGION by D.V. Steblovskyi, M.G. Skikevich, V.V. Bondarenko

“…Despite the improvement of the quality of medical care, improvement of known and discovery of new methods of treatment, the number of patients with this pathology has a clear temporary tendency to increase. …”
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Impact of the COVID-19 pandemic on the diagnosis, tumor characteristics, and survival outcomes of colorectal cancer: a retrospective cohort study by Enver Yarikkaya, Merve Cin, Sena Ecin-Demezoglu, Beste Noyan-Mod, Mert Mahsuni Sevinc, Yakup Bozkaya, Nevra Dursun-Kepkep

“…DESIGN: Retrospective cohort study SETTING: Tertiary-care center PATIENTS AND METHODS: We included 284 patients newly diagnosed with CRC, stratified into two cohorts: those diagnosed one year before and during the first year of the pandemic. …”
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The role of ultrasonography in the diagnosis and management of chronic pancreatitis: Opportunities, limitations and prospects for development – a literature review by Jakub Pokrzepa, Karolina Baran, Katarzyna Bartnik, Gabriela Blecharz, Marlena Jankowska, Natalia Jańczyk, Karolina Mędrysa, Michał Presak, Julia Szwech, Jakub Adamski

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Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival by Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni

“…These results show that miRNA-based targeted therapeutics provide new opportunities to treat rGBM and bypass the resistance to standard of care therapy.…”
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Clinical case of COVID-19 in a patient with Hodgkin's lymphoma by D. A. Malashenko, Zh. B. Ponezheva, A. N. Turapova, E. P. Rodionov, A. A. Ploskireva, M. A. Magomedov, N. G. Burda, I. I. Tsvetaev, T. A. Trubina

“…Hodgkin's lymphoma is a localized or disseminated proliferation of cells of the lymphoreticular system, which can affect the lymph nodes, spleen, liver or bone marrow. Due to the progressive insufficiency of cellular and humoral immunity of the underlying pathology, as well as suppressing the immune response of treatment, such patients have a high risk of infection with SARSCoV-2, severe course.Objective. …”
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Local-free recurrence survival after breast-conserving surgery and the breast cancer complex treatment by A. D. Zikiryahodjaev, M. V. Ermoshchenkova, A. R. Bosieva, J. F. Omarova, N. N. Volchenko, I. V. Reshetov

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Symptom network analysis of pregnancy stress, depressive symptoms and quality of life: a cross-sectional study of pregnant women in Xinjiang, China, 2023–2024 by Sufeila Shalayiding, Weicui Meng, Xiaoting Wang, Bahedana Sailike, Ting Jiang

“…Conclusion This study suggests that psychological intervention programs for pregnant women should focus on increasing their confidence in taking care of their children and becoming competent mothers, fostering the spirit of “teamwork” between husband and wife, and improving the quality of life and mental health of pregnant women.…”
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Diagnostic performance of a new algorithm combining simple, non-invasive and inexpensive tests for predicting the presence of advanced liver fibrosis in patients with chronic hepat... by Jean Nana, Jean Luc Bosson, Kristina Skaare, Céline Vermorel, Vincent Leroy, Tarik Asselah, Michael Adler, Jean-Pierre Zarski

“…This study evaluated the utility of combining new, simple, non-invasive, and inexpensive tests to predict advanced liver fibrosis in CHB patients, assisting primary care physicians, especially in resource-limited settings. …”
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