Inositol polyphosphate multikinase regulates Th1 and Th17 cell differentiation by controlling Akt-mTOR signaling by Chae Min Yuk, Sehoon Hong, Dongeon Kim, Mingyo Kim, Hyun-Woo Jeong, Seung Ju Park, Hyungyu Min, Wooseob Kim, Jongbu Lim, Hyo Dam Kim, Sang-Gyu Kim, Rho Hyun Seong, Seyun Kim, Seung-Hyo Lee

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Construction of mitochondrial signature (MS) for the prognosis of ovarian cancer by Miao Ao, You Wu, Kunyu Wang, Haixia Luo, Wei Mao, Anqi Zhao, Xiaomeng Su, Yan Song, Bin Li

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Developing and validating utility parameters to establish patient-reported outcome-based perioperative symptom management in patients with lung cancer: a multicentre, prospective,... by Rui Zhang, Wei Dai, Qiang Li, Shaohua Xie, Qiuling Shi, Yuanqiang Zhang, Wenhong Feng, Xiaoqing Liao, Yunfei Mu, Xing Wei, Chuanmei Wu, Heling Zhou, Xuemei Cheng, Yanhua Jiang, Jintao He, Xiaojun Yang

“…Introduction Patient-reported outcome-based symptom monitoring and alerting have been attractive for patient care after a tumour-removal surgery. However, the implementation parameters of this patient-centred symptom management system in perioperative patients with lung cancer are still lacking. …”
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CFET Beyond 3 nm: SRAM Reliability Under Design-Time and Run-Time Variability by Sufia Shahin, Swati Deshwal, Anirban Kar, Mahdi Benkhelifa, Yogesh S. Chauhan, Hussam Amrouch

“…At the circuit level, a full array of 6T-static random access memory (SRAM) cells with the requisite peripheral circuits is simulated using SPICE after careful calibration of the industry-standard compact model of gate-all-around (BSIM-CMG) against the TCAD data. …”
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First trimester circulating miR-208b-3p and miR-26a-1-3p are relevant to the prediction of gestational hypertension by Andrée-Anne Clément, Cécilia LÉGARÉ, Véronique Desgagné, Kathrine Thibeault, Frédérique White, Michelle S. Scott, Pierre-Étienne Jacques, William D Fraser, Patrice Perron, Renée Guérin, Marie-France Hivert, Anne-Marie Côté, Luigi Bouchard

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Prediction and Mapping of Soil Total Nitrogen Using GF-5 Image Based on Machine Learning Optimization Modeling by LIU Liqi, WEI Guangyuan, ZHOU Ping

“…Fieldwork involved the careful collection of 171 soil samples, obtaining soil spectral data, chemical analysis data of soil TN content, and the GF-5 hyperspectral data. …”
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Novel pathogenic mtDNA variants in Chinese children with neurological mitochondrial disorders by Zhimei Liu, Kexin Pan, Mingzhao Wang, Yijun Jin, Wenxin Yang, Keer Chen, Chaolong Xu, Xin Duan, Ying Zou, Changhong Ren, Lifang Dai, Suzhou Zhao, Ya Wang, Lijun Shen, Fang Fang, Hezhi Fang

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Assessment of test-retest reproducibility by [18F]Bavarostat for PET imaging of HDAC6 by Mika Naganawa, Ming-Qiang Zheng, Jean-Dominique Gallezot, Robin Bonomi, Jiwei Gu, Hong Gao, Swanee Jacutin-Porte, Nabeel B. Nabulsi, Michel Koole, Koen Van Laere, David Matuskey, Yiyun Huang, Richard E. Carson

“…Arterial blood sampling and metabolite analysis were performed to derive the input function. The two scans were 28 ± 12 days apart (14–43 days, n = 6). …”
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Enfermedad periodontal en embarazadas atendidas en la Clínica Estomatológica Manuel Angulo Farrán by Yunaydis Tamayo Avila

“…Conclusions: periodontal health is often affected in pregnancy, which is accentuated with the progress of pregnancy. Dental care is essential in early pregnancy to prevent functional damage that may be permanent psychological from the periodontal disease leading to tooth loss.     …”
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Strong Hsp90α/β Protein Expression in Advanced Primary CRC Indicates Short Survival and Predicts Response to the Hsp90α/β-Specific Inhibitor Pimitespib by Sebastian B. M. Schmitz, Jakob Gülden, Marlene Niederreiter, Cassandra Eichner, Jens Werner, Barbara Mayer

“…The anti-cancer effect and chemosensitization of Pim-based therapy were prospectively confirmed in PDCS directly generated from Hsp90α/β > 40% pCRCs. Protein profiling combined with functional drug testing stratifies Hsp90α/β > 40% pCRC patients diagnosed with UICC IIb-IV for effective Pim-based therapy.…”
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The influence of evidence-based nutritional support plans on the nutritional status and adverse effects of radiotherapy in individuals with nasopharyngeal carcinoma by Xiaomei Fan, Xiaomei Fan, Huixia Cui, Haibo Peng, Haibo Peng, Shasha Liu, Li Jiang

“…Patients with NPC admitted between May 2023 and August 2023 were allocated to the control group and received routine care, whereas those admitted between September 2023 and December 2023 were assigned to the intervention group and provided with a multidisciplinary, professional, individualized, and comprehensive evidence-based nutritional support program. …”
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Integrating genome and transcriptome analysis to decipher balanced structural variants in unsolved cases of neurodevelopmental disorders by Simona Mellone, Alice Spano, Denise Vurchio, Giulia Borgonovi, Giulia Borgonovi, Alessandro Ugonotti, Giulia Paglino, Alba Bianco, Sara Ronzani, Maurizio Sciancalepore, Flavia Prodam, Flavia Prodam, Amanda Papa, Maurizio Viri, Umberto Dianzani, Umberto Dianzani, Mara Giordano, Mara Giordano

“…Transcriptomic analysis demonstrated the monoallelic and significantly reduced expression of EP300.ConclusionThese findings highlight the crucial role of WGS in identifying disease-associated BCAs and underscore the complementary value of RNA-Seq in assessing their functional consequences. This integrated approach enhanced diagnostic accuracy and clinical management, paving the way for more comprehensive and personalized care in these two patients.…”
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Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice by Victor J. Johnson, Cynthia V. Rider, Michael I. Luster, Cynthia J. Willson, Shawn Harris, Billie Stiffler, James Blake, Esra Mutlu, Veronica Godfrey, Brian Burback, Reshan Fernando, Suramya Waidyanatha, Gary R. Burleson, Dori R. Germolec

“…Additionally, there are several weaknesses in existing immunotoxicity databases for PACs in experimental animals, limiting their applicability in quantitative risk assessment. Careful characterization of strong positive and clear negative PACs is needed in order to lay the foundation for generating robust immunotoxicity data for structurally diverse PACs that have not yet been evaluated.MethodsIn the current study, adult B6C3F1/N female mice were treated daily for 28 consecutive days by oral administration of B(a)P to provide dose levels ranging between 2 and 150 mg/kg bodyweight/day. …”
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The PKC-β selective inhibitor, Enzastaurin, impairs memory in middle-aged rats. by Mari N Willeman, Sarah E Mennenga, Ashley L Siniard, Jason J Corneveaux, Matt De Both, Lauren T Hewitt, Candy W S Tsang, Jason Caselli, B Blair Braden, Heather A Bimonte-Nelson, Matthew J Huentelman

“…Protein Kinase C-β is an important enzyme for a variety of neuronal functions; in particular, previous rodent studies have reported deficits in spatial and fear-conditioned learning and memory with lower levels of Protein Kinase C-β. …”
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Resilience-by-Design in 6G Networks: Literature Review and Novel Enabling Concepts by Ladan Khaloopour, Yanpeng Su, Florian Raskob, Tobias Meuser, Roland Bless, Leon Janzen, Kamyar Abedi, Marko Andjelkovic, Hekma Chaari, Pousali Chakraborty, Michael Kreutzer, Matthias Hollick, Thorsten Strufe, Norman Franchi, Vahid Jamali

“…The sixth generation (6G) mobile communication networks are expected to intelligently integrate into various aspects of modern digital society, including smart cities, homes, health-care, transportation, and factories. …”
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Identification and validation of DNA methylation-driven gene OSR1 as a novel tumor suppressor for the diagnosis and prognosis of breast cancer by Jian Xu, Biao Yang, Ling Cheng, Chen Gan, Runze Huang, Anlong Li, Han Ge, Longyu Hu, Meiwen Ling, Xinyi Zheng, Bao Zhao, Mingjun Zhang, Huaidong Cheng, Huaidong Cheng

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Methylglyoxal-induced RNA modifications decrease RNA stability and translation and are associated with type 2 diabetes by Edwin De Jesus Lopez Gonzalez, SWT Lai, Kelani Sun, Caree R. Carson, Carlos Hernandez-Castillo, Tala Zoukari, Kassandra Lopez, Jianying Zhang, Thomas Blevins, John Termini, Sarah C. Shuck

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Molecular mechanism of PANoptosis and programmed cell death in neurological diseases by Ketian Hou, Wenhan Pan, Lianhui Liu, Qianqian Yu, Jiahao Ou, Yueqi Li, Xi Yang, Zhenlang Lin, Jun Hui Yuan, Mingchu Fang

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THE INFLUENCE OF CRYOCORSERVED PLACENTA ON THE DYNAMICS OF CHANGES IN CLINICAL INDICATORS IN THE TREATMENT OF PATIENTS WITH PHLEGMONS OF JAW-FACIAL LOCALITIS by V.O. Lychman, K.P. Lokes, D.S. Avetikov, N.V. Gorlach, O.O. Goncharenko, Yu.R. Sharay

“…Circadian rhythms are generated by clocks that are endogenous in nature and fluctuate even in the absence of environmental signals. …”
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Association between transcranial direct current stimulation and disability and quality of life in individuals with Parkinsonism: cross-sectional study by Ravi Shankar Reddy, Ravi Shankar Reddy, Jaya Shanker Tedla, Jaya Shanker Tedla, Irshad Ahmad, Venkata Nagaraj Kakaraparthi, Snehil Dixit, Kumar Gular, Paul Silvian Samuel, Suhail Mansour Aljehani, Feras Ahmed Alarabi

“…Transcranial direct current stimulation (tDCS) has shown promise in improving motor and cognitive functions when combined with physical therapy. This study aimed to explore the association between tDCS exposure and disability levels, as well as its impact on self-reported QoL in individuals with Parkinsonism undergoing physical therapy.MethodsThis cross-sectional study enrolled 51 participants diagnosed with Parkinsonism from a tertiary care hospital’s neurology outpatient clinic. …”
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