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Dual targeting of the mitochondrial Lon peptidase 1 and the chymotrypsin-like proteasome activity as a potential therapeutic strategy in malignant astrocytoma models
Published 2025-05-01“…Using gain- and loss-of-function genetic models, we discovered that LonP1 is both necessary and sufficient to drive BT317 drug sensitivity in established and patient-derived glioma stem-like cells by generating ROS and inducing apoptosis. …”
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423
Association of the blood urea nitrogen to serum albumin ratio and all-cause mortality in critical ill acute ischemic stroke patients: a retrospective cohort study of MIMIC-IV datab...
Published 2025-01-01“…PurposeWe aim to ascertain the extent to which the blood urea nitrogen (BUN) to serum albumin (ALB) ratio (BAR) could be implemented to anticipate the short- and long-term prognosis of acute ischemic stroke (AIS) patients in intensive care units (ICUs).MethodsThe data was derived from the Marketplace for Intensive Care Medical Information-IV (MIMIC-IV v3.0) database, primarily pertaining to AIS patients as categorized by the International Classification of Diseases (ICD)-9 and ICD-10. …”
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Approaches to assess new pneumococcal vaccines for immunogenicity, development and licensure
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Potential of water sediments in construction materials: Current approaches and critical consideration of future challenges
Published 2025-01-01“…Human activities result in sediment accumulation, so the reservoirs gradually lose their functionality, impacting their ability to manage large flood inflows, supply water, and generate hydroelectric power. …”
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426
A Latent Class Analysis of Nutrition Impact Symptoms in Cancer Survivors
Published 2024-10-01“…The findings of this work will inform and allow for more individualised nutrition care. By tailoring interventions to these specific groups, we can enhance the precision of care, improve prognostic accuracy, and significantly elevate the quality of life of survivors. …”
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Plant Dominant Low-Protein Diet, Nutritional Status (Phase Angle) and Progression of Renal Failure: Case-Report Study
Published 2024-02-01“…Liver and thyroid function and ferritin and potassium levels were within normal limits. …”
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Fabrication of Palladium-Decorated Zinc Oxide Nanostructures for Non-Enzymatic Glucose Sensing
Published 2025-06-01“…The growing global burden of diabetes necessitates the development of glucose sensors that are not only reliable and sensitive but also cost-effective and amenable to point-of-care use. In this work, we report a non-enzymatic electrochemical glucose sensor based on laser-induced graphene (LIG), functionalized with zinc oxide (ZnO) and palladium (Pd) nanostructures. …”
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Automotive DNN-Based Object Detection in the Presence of Lens Obstruction and Video Compression
Published 2025-01-01“…Recent advances in sensing, processing, machine learning, and communication technologies are accelerating assisted and automated functions development for commercial vehicles. Environmental perception sensor data streams are processed to generate a correct and complete situational awareness. …”
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An Educational App for the Selection of Blood Glucose Meters: A Cross-Sectional Study
Published 2024-12-01“…The results showed a high correlation with laboratory measurements and similarity in key functionalities between the models. The application, tested on 30 individuals aged 18 to 79 years, demonstrated stability, speed, and a user-friendly interface, facilitating efficient data processing and generating recommendations.…”
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Automated Digital Safety Planning Interventions for Young Adults: Qualitative Study Using Online Co-design Methods
Published 2025-02-01“…Young adult participants also highlighted specific features that could support core coping skill acquisition (eg, self-tracking, coping skill idea generation, reminders). ConclusionsEngaging young adults in the design process of a digital suicide prevention tool revealed critical considerations that must be addressed if the tool is to effectively expand access to evidence-based care to reach young people at risk for suicide-related thoughts and behaviors. …”
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Cellpose as a reliable method for single-cell segmentation of autofluorescence microscopy images
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The Significance of Oxidized Low-Density Lipoproteins and Receptors LOX-1 in Type 2 Diabetes Mellitus
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Cardiovascular-kidney-metabolic syndrome definition and its role in the prevention, risk staging, and treatment. An opportunity for the Nephrology
Published 2024-11-01“…Three publications offer the rational basis of a conceptual decalogue and action plan and a new cardiovascular risk stratification equation since the age of 30 that includes measures of renal function/damage, among others, to promote effective cardiovascular, renal, and metabolic prevention. …”
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