Zebrafish do not have a calprotectin ortholog. by Kona N Orlandi, Michael J Harms

“…The field would benefit from expanding the breadth of calprotectin studies into a zebrafish innate immunity model. Here, we carefully evaluated the possibility that zebrafish possess a calprotectin ortholog or a paralog that convergently evolved similar function. …”
Get full text

Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy by Doudou Lei, Lin Liao, Tao Qin, Xiaoxuan Guan, Kunpeng Duan, Zhiwei Gao, Weiqian Jin, Mingjing Yin, Ke Zhang, Yan Liu, Yin Chen, Huyang Gao, Jiaxiao Li, Feifei Huang, Wenjing Liu, Chengde Xia, Bailei Wang, Hualin Huang, Shengqiu Lv, Qiang Zhi, Jiahao Huang, Ming Gao, Junyu Lu

Get full text

Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers by Christoph H Mayr, Lukas M Simon, Gabriela Leuschner, Meshal Ansari, Janine Schniering, Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner, Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr, Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller

Get full text

Artificial intelligence and health empowerment in rural communities and landslide- or avalanche-isolated contexts: real case at a fictitious location by Rune Johan Krumsvik, Vegard Slettvoll

“…Therefore, all LLM recommendations and technology support were reviewed during an in-person physician examination in a family network, and the final antibiotic prescription came from the clinician, underscoring that AI functioned solely as decision support rather than autonomous care.…”
Get full text

Comprehensive Molecular Analysis of Disease-Related Genes as First-Tier Test for Early Diagnosis, Classification, and Management of Patients Affected by Nonsyndromic Ichthyosis by Tiziana Fioretti, Fabrizio Martora, Ilaria De Maggio, Adelaide Ambrosio, Carmelo Piscopo, Sabrina Vallone, Felice Amato, Diego Passaro, Fabio Acquaviva, Francesca Gaudiello, Daniela Di Girolamo, Valeria Maiolo, Federica Zarrilli, Speranza Esposito, Giuseppina Vitiello, Luigi Auricchio, Elena Sammarco, Daniele De Brasi, Roberta Petillo, Antonella Gambale, Fabio Cattaneo, Rosario Ammendola, Paola Nappa, Gabriella Esposito

Get full text

Prognostic predictions in psychosis: exploring the complementary role of machine learning models by Metten Somers, Hugo G Schnack, Rene S Kahn, Diane F van Rappard, Frank L Gerritse, Edwin van Dellen, Violet van Dee, Seyed M Kia, Caterina Fregosi, Wilma E Swildens, Anne Alkema, Albert Batalla, Coen van den Berg, Danko Coric, Lotte G Dijkstra, Arthur van den Doel, Livia S Dominicus, John Enterman, Marte Z van der Horst, Fedor van Houwelingen, Charlotte S Koch, Lisanne E M Koomen, Marjan Kromkamp, Michelle Lancee, Brian E Mouthaan, Eline J Regeer, Raymond W J Salet, Jorgen Straalman, Marjolein H T de Vette, Judith Voogt, Inge Winter-van Rossum, Wiepke Cahn

Get full text

Activity outcomes after hip arthroplasty: an information tool based on patients’ experience captured in a hospital registry by S. Cole, G. Fabiano, C. Barea, S. Cullati, T. Agoritsas, N. Gutacker, A.J. Silman, D. Hannouche, A. Lübbeke, Rafael Pinedo-Villanueva

Get full text

Immune suppressive activities of low-density neutrophils in sepsis and potential use as a novel biomarker of sepsis-induced immune suppression by Awirut Charoensappakit, Kritsanawan Sae‑khow, Nuntanuj Vutthikraivit, Patinya Maneesow, Thitiwat Sriprasart, Monvasi Pachinburavan, Asada Leelahavanichkul

“…As such, LDN (CD66b-positive cells in PBMC) was highest in intensive care unit (ICU) patients with sepsis (n=24) compared with non-sepsis (n=10) and healthy control (n=20), with a negative correlation with lymphocyte count and could predict secondary infection and mortality with the area under the curve (AUC) at 0.79 and 0.84, respectively. …”
Get full text

Ultrasound-activated bimetallic PtRu alloy nanozymes for synergistic sonodynamic and chemodynamic therapy of multidrug-resistant bacterial infection by Xiang Zheng, Lingxia Pang, Youpei Wang, Qianlei Zhao, Guoquan Pan, Xiaojun He, Yafeng Liang

“…By carefully optimizing the atomic ratio of platinum (Pt, catalytic sites) to ruthenium (Ru, adsorption sites), we synthesized ultrafine bimetallic alloy nanoplatforms with enhanced functional performance. …”
Get full text

SegMatch: semi-supervised surgical instrument segmentation by Meng Wei, Charlie Budd, Luis C. Garcia-Peraza-Herrera, Reuben Dorent, Miaojing Shi, Tom Vercauteren

“…Our FixMatch adaptation for segmentation tasks further includes carefully considering the equivariance and invariance properties of the augmentation functions we rely on. …”
Get full text

Effect of oral sodium bicarbonate supplementation on urine TGF-𝜷 in normal serum bicarbonate CKD, a randomized controlled trial by Nipon Ngupis, Bancha Satirapoj, Theerasak Tangwonglert, Ouppatham Supasyndh, Paramat Thimachai, Narongrit Siriwattanasit

“…Abstract The consequences of chronic subclinical metabolic acidosis, characterized by an increase in single nephron ammonium generation, contribute to the progression of chronic kidney disease (CKD). …”
Get full text

Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity by Eamonn MM Quigley, Thomas J Borody, Sabine Hazan, Neil Stollman, Huseyin S Bozkurt, Sonya Dave, Andreas J Papoutsis, Jordan Daniels, Brad D Barrows

“…Objective The study objective was to compare gut microbiome diversity and composition in SARS-CoV-2 PCR-positive patients whose symptoms ranged from asymptomatic to severe versus PCR-negative exposed controls.Design Using a cross-sectional design, we performed shotgun next-generation sequencing on stool samples to evaluate gut microbiome composition and diversity in both patients with SARS-CoV-2 PCR-confirmed infections, which had presented to Ventura Clinical Trials for care from March 2020 through October 2021 and SARS-CoV-2 PCR-negative exposed controls. …”
Get full text

The model of saving the mental health of the adolescent population in the city of Kirov by M V Zlokazova, N V Semakina

“…A special position in the healthcare of the Russian Federation is occupied by the protection of the health of the younger generation, therefore, in the implementation of national projects, much attention is paid to the development of infrastructure for providing multiprofessional medical care to children and the prevention of mental and somatic diseases.Purpose. …”
Get full text

Strategies and applications of antibacterial surface-modified biomaterials by Qianwei Su, Yunyun Xue, Chuyao Wang, Qirong Zhou, Yu Zhao, Jiacan Su, Baoku Zhu

“…The review also highlights current and emerging applications in medical implants, wound care, and hygienic textiles. Finally, key limitations and future opportunities are critically examined, offering insights into the rational design and clinical translation of next-generation antibacterial biomaterials.…”
Get full text

Enhanced genotype-phenotype analysis using multimodal adaptive optics and 3D protein structure in Bietti Crystalline Dystrophy by Aarushi Kumar, Young Joo Sun, Ditte K. Rasmussen, Aubrey Hargrave, Claudia Phillips, Jennifer T. Vu, Mauricio G.S. Costa, Loh-Shan B. Leung, Charles Yu, Alfredo Dubra, Vinit B. Mahajan

Get full text

Isoliensinine exerts antitumor effects in lung adenocarcinoma by inhibiting APEX1-driven ROS production by Cheng Chen, Cheng Chen, Cheng Chen, Chenying Shu, Dan Shen, Dan Shen, Dan Shen, Zhaowei Yan, Zeyi Liu, Zeyi Liu, Zeyi Liu, Jian-An Huang, Jian-An Huang, Jian-An Huang

Get full text

Testing an inverse modeling approach with gradient boosting regression for stroke volume estimation using patient thermodilution data by Vasiliki (Vicky) Bikia, Dionysios Adamopoulos, Dionysios Adamopoulos, Dionysios Adamopoulos, Marco Roffi, Marco Roffi, Georgios Rovas, Stéphane Noble, Stéphane Noble, François Mach, François Mach, Nikolaos Stergiopulos

“…Stroke volume (SV) is a major indicator of cardiovascular function, providing essential information about heart performance and blood flow adequacy. …”
Get full text

Validation of a Clinical Scale for Early Detection of Infections at the Exit Site of Central Venous Catheters for Hemodialysis by José Luis Cobo-Sánchez, Ian Blanco-Mavillard, Raquel Pelayo-Alonso, Noelia Mancebo-Salas, Ismael Fernández-Fernández, Irene Larrañeta-Inda, Ana Ulzurrun-García, Isidro Sánchez-Villar, Fernando González-García, Julia Hernando-García, Ma Jesús Rollán-de la Sota, Luís Miguel Vieira-Barbosa Lopes, Ma del Rosario Prieto-Rebollo, Carolina Sesmero-Ramos, Catalina Jaume-Riutort, Rafael Casas-Cuesta, Mateo Alcántara-Crespo, Joan Ernest de Pedro-Gómez

Get full text

Postimplementation Evaluation in Assisted Living Facilities of an eHealth Medical Device Developed to Predict and Avoid Unplanned Hospitalizations: Pragmatic Trial by Jacques-Henri Veyron, François Deparis, Marie Noel Al Zayat, Joël Belmin, Charlotte Havreng-Théry

“…ConclusionsThe Presage Care system has been implemented with success in assisted living facilities. …”
Get full text

The Ethical Significance of Brain-Computer Interfaces as Enablers of Communication by Toma Gruica

“…In this latter case, the BCI functions ethically by creating the very possibility for ethical engagement where none previously existed. …”
Get full text