Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii by Fei Xie, Lifeng Wang, Song Li, Long Hu, Yanhua Wen, Xuming Li, Kun Ye, Zhimei Duan, Qi Wang, Yuanlin Guan, Ye Zhang, Qiqi Shi, Jiyong Yang, Han Xia, Lixin Xie

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Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem by Sakshi Sardar, Cheryl D Coon, Scottie Kern, Huong Huynh, Diane Stephenson, Joshua Rubin Abrams, Grace V Lee, Cecile Ollivier, Joseph A Hedrick, Martijn LTM Müller, Luc J W Evers, Lada Leyens, Collin Hovinga, Shu Chin Ma, Klaus Romero

“…We propose the development of various standardized consensus frameworks to clearly lay out processes for various stakeholders and facilitate the seamless integration of the next generation of health care–sensing technologies into drug development.…”
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A novel variant in the ALDH3A2 gene causative of Sjögren–Larsson syndrome evaluated in silico aids in proper genetic counseling and planning management by Ishwarya Chandrashekar Thirugnanam, Vigneshwaran Gurunadan, Srikanth Jilla, Sreelatha Komandur, Qurratulain Hasan

“…Management strategies focus on symptomatic relief through topical moisturizers and dietary modifications, emphasizing a multidisciplinary approach to patient care, especially in low-resource settings where gene therapy is not yet an option. …”
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Emotional distress and well-being among people with motor neurone disease (MND) and their family caregivers: a qualitative interview study by Lucy Yardley, Adam W A Geraghty, Cathryn Pinto, Laura Dennison

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Regenerative activity of stomach epithelial cells at small-intestinal obstruction by V. Ye. Milyukov, K. K. Nguyen

“…Suppression of metabolic processes of epithelial cells of coating layer and cells of cervical and fundic parts of the glands at preservation of main cells metabolism causes reduction of mucosal preoperative activity and may cause suppression of regenerative capacity and decrease of protective function.…”
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Costs and acceptability of simplified monitoring in HIV-suppressed patients switching to dual therapy: the SIMPL’HIV open-label, factorial randomised controlled trial by Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J. Metzner, Laurent Decosterd, Huldrych F. Günthard, Patrick Schmid, Andreas Limacher, Mattia Branca, Alexandra Calmy

“… BACKGROUND: Clinical and laboratory monitoring of patients on antiretroviral therapy is an integral part of HIV care and determines whether treatment needs enhanced adherence or modification of the drug regimen. …”
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Current status and future perspectives of antibody-drug conjugates in breast cancer therapy by LIN Jialin, WANG Wenna, XU Binghe

“…Early monitoring, individualized dose modifications, and supportive care measures have been shown to effectively reduce the incidence of severe adverse events. …”
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Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma by Jie Chen, Chengyu Feng, Yufei Lan, Xiangtian Chen, Zhengqi Peng, Zihan Huang, Ruiqing Wang, Wenxin Zhang, Yingying Ye, Zhilei Mao, Dongyue Pan, Lihua Yang

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Randomised clinical trial research within Aboriginal and Torres Strait Islander primary health services: a qualitative study by Tim Usherwood, Jennifer Reath, Amanda Jane Leach, Hasantha Gunasekera, Deborah Askew, Penelope Abbott, Chelsea Watego, Wendy CY Hu, Letitia Campbell, Claudette Tyson, Robyn Walsh, Sylvia Hussey, Kerrie Doyle, Jessica Armstrong-Kearns

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Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy by Quan H. Phung, Alexander K. Tsai, Byoung U. Park, Robben Schat, Richard Spong, L. Jill Tsai, Amit A. Kulkarni, Emmanuel S. Antonarakis, Emmanuel S. Antonarakis, Arjun Gupta

“…Transplant-related immunosuppression was adjusted, and pancreas and kidney transplant function were monitored closely. Potential organ rejection was monitored using donor-derived cell-free DNA. …”
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Possible Improvement of the Sagittal Spinopelvic Alignment and Balance through “Locomotion Training” Exercises in Patients with “Locomotive Syndrome”: A Literature Review by Takashi Yurube, Masaaki Ito, Toru Takeoka, Nobuyoshi Watanabe, Hideyo Inaoka, Kenichiro Kakutani, Ryosuke Kuroda, Kotaro Nishida

“…The JOA recommends “locomotion training” exercise intervention to be effective in maintaining motor function that comprises two simple exercises—squatting and single-leg standing. …”
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Important features of retail shoes for women with rheumatoid arthritis: A Delphi consensus survey. by Peta Ellen Tehan, William J Taylor, Matthew Carroll, Nicola Dalbeth, Keith Rome

“…<h4>Objectives</h4>Footwear management aims to preserve foot function, reduce the burden of foot pain and maintain joint mobility in women with rheumatoid arthritis (RA). …”
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Impact of Coconut Oil and Its Bioactive Metabolites in Alzheimer’s Disease and Dementia: A Systematic Review and Meta-Analysis by Duaa Bafail, Abrar Bafail, Norah Alshehri, Noura Hamdi Alhalees, Ahmad Bajarwan

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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).MethodsThis study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. …”
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Development of the system of state financing of Compulsory Health Insurance by А. V. Larionov, S. V. Russkikh, S. V. Maslennikov

“…It would be practical to redistribute the functions of financing health care between the Federal Fund for CHI and its territorial branches. …”
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TINJAUAN YURIDIS KEBIJAKAN PEMERINTAH KABUPATEN JEMBER TERHADAP EKSPLOITASI GUMUK by Isnania Citra Saisabela, ICS, Isnania Citra Saisabela, ICS, Fauziyah Fauziyah, FA

“…Economic growth must be consistent with the protection of environment. The current generation must be bequeathed to the next generation of good natural. …”
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Virtual stressors with real impact: what virtual reality-based biobehavioral research can teach us about typical and atypical stress responsivity by Elizabeth A. Shirtcliff, Tor T. Finseth, Eliot H. Winer, David C. Glahn, Roselynn A. Conrady, Stacy S. Drury

“…Binary thinking about whether something is (not) real has stifled advances in understanding how to measure the dosage of a stressful environment. As a function of being programmed, individualizable, and titrated, virtual reality (VR) based stressors offer the field a platform for quantifying the dose of a stressor and generating reliable dose-response curves. …”
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Genetic analysis of a novel TSC1 splice mutation causing tuberous sclerosis without neurological phenotypes by Xiu-juan Yao, Ying Lin, Jing Zou, Zun-lin Cai, Zi-Yan Xu, Xiao-qin Li, Qian Chen, Hong-ping Yu, Jian-hui Zhang, Dan-dan Ruan, Mei-zhu Gao, Li Zhang, Jie-wei Luo, Bao-song Xie

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Optimal Sca-1-based procedure for purifying mouse adipose-derived mesenchymal stem cells with enhanced proliferative and differentiation potential by Xingyu Tao, Jialian Wang, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu, Bailin Niu

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Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential by Long Liu, Siying Zhang, Yuqing Ren, Ruizhi Wang, Yuyuan Zhang, Siyuan Weng, Zhaokai Zhou, Peng Luo, Quan Cheng, Hui Xu, Yuhao Ba, Anning Zuo, Shutong Liu, Zaoqu Liu, Xinwei Han

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