Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes by Magdalena Sevilla-González, Kirk Smith, Ningyuan Wang, Aubrey E. Jensen, Elizabeth M. Litkowski, Hyunkyung Kim, Daniel A. DiCorpo, Sarah Hsu, Jinrui Cui, Ching-Ti Liu, Chenglong Yu, John J. McNeil, Paul Lacaze, Kenneth E. Westerman, Kyong-Mi Chang, Philip S. Tsao, Lawrence S. Phillips, Mark O. Goodarzi, Rob Sladek, Jerome I. Rotter, Josée Dupuis, Jose C. Florez, Jordi Merino, James B. Meigs, Jin J. Zhou, Sridharan Raghavan, Miriam S. Udler, Alisa K. Manning

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Effect of obstructive sleep apnoea syndrome combined with renal insufficiency on all-cause mortality in elderly patients in China: a prospective cohort study by Lin Liu, Zhe Zhao, Yinghui Gao, Fengfeng Fang, Zuo Zhang, Libo Zhao, Zijun He, Kailiang Li, Hongyan Bian

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To study the prevalence of metabolic-associated fatty liver disease in a tertiary hospital in Bundelkhand region by Neha Rathore, Kuldeep Chandel, Ajeet Singh, Aniket Ashok Satale, Gaurav Singh

“…Aims and Objectives: This study aims to determine the prevalence of MAFLD in a tertiary care hospital and assess the demographic profile and associated risk factors in the Bundelkhand region. …”
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Middle hepatic vein incorporation in live donor liver graft transplantation; implication and safety by Mahmoud Ali Abdi, Tayeb Sabir Kareem, Assad Abidon Hassoun

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Evaluating the efficacy of Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis (iBEAT-OA) in the community: a study protocol for a randomised controlled trial by Abhishek Abhishek, Sameer Akram Gohir, Paul Greenhaff, Ana M. Valdes

“…This study aims to explore the benefits of iBEAT-OA (Internet-Based Exercise programme Aimed at Treating knee Osteoarthritis) in modulating pain, function and other health-related outcomes in individuals with knee OA.Methods and analysis A randomised controlled trial was designed to evaluate the efficacy of a web-based exercise programme in a population with knee OA compared with standard community care provided by general practitioners (GPs) in the UK. …”
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Women’s hospital birth experiences in Harar, eastern Ethiopia: a qualitative study using Roy’s Adaptation Model by Roseanne C Schuster, Nega Assefa, Maleda Tefera, Kedir Teji Roba, Letta Gedefa, Alex Brewis

“…Due to the prolonged hospital stay and surgical site pain, the women who were unable to care for themselves, their newborn babies and their families adapted poorly to role and function mode. …”
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Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model by Zhang K, Zhou F, Zhu C, Yuan L, Li D, Wang J, Lu W

“…Kedong Zhang,1,* Feng Zhou,1,2,* Caixia Zhu,3 Liang Yuan,4 Defu Li,4 Jian Wang,4 Wenju Lu4 1Department of Pulmonary and Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xian, Shaanxi, People’s Republic of China; 3Department of Rheumatology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China; 4State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenju Lu,; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, People’s Republic of China, Tel +86-20-83205040, Email wlu92@qq.com Jian Wang, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Department of Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, People’s Republic of China, Email jianwang@gzhmu.edu.cnPurpose: Hypoxia-inducible factor-1α (HIF-1α) plays an important regulatory role in inflammatory and hypoxic diseases. …”
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THRIVE Prevent Postoperative Hypoxemia in Elderly Patients Undergoing Laparoscopic Surgery in PACU: A Randomized Controlled Clinical Trial by Chen X, Gu K, Yang Y, Zhou B, Mo Y, Tu Y

“…Transnasal Humidified Rapid Insufflation Ventilatory Exchange (THRIVE) delivers high-flow oxygen at rates up to 60 L/min, potentially enhancing respiratory function and tolerance to hypoxia.Objective: To assess the effectiveness, safety, and patient tolerance of THRIVE in the early prevention of postoperative hypoxemia in elderly patients following laparoscopic surgery with general anesthesia.Methods: This prospective, multicenter, randomized controlled trial enrolled 200 elderly patients undergoing laparoscopic surgery who were safely extubated after general anesthesia. …”
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Analysis of the Effect of Quality Nursing on Recovery after Thoracic Surgery by Yujing Zhou, Ming Xu

“…By reviewing patient cases and departmental statistics, general information, length of stay, hospitalization cost, complication rate, pain score, bowel movement recovery time, and pulmonary function index of the two groups A and B were compared. …”
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Replacement Therapy with the Surfactant Alveofact for Neonatal Respiratory Distress Syndrome: A Pilot Study by S. A. Perepelitsa

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Efferent Treatment for Critical Conditions by S. E. Khoroshilov, A. V. Nikulin

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An Uncommon Cause of Cardiac Arrest: Tamponade Secondary to Malignant Pericardial Effusion From Myxoid Sarcoma by Marianna Weaver, James Bradley, Shahab Ghafghazi, Christopher Fine

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Vibrotactile Stimulation in Lower Extremity Amputation Patients Using a Noninvasive Vibration Device: A Pilot Study by Floris V. Raasveld, MD, Jenna Daddario, PA, Wen-Chih Liu, MD, Dun-Wei Huang, MD, Rachel E. Cross, BA, Karan Amin, BA, Arthur Graham, CP, David Crandell, MD, David Hao, MD, Ian L. Valerio, MD, MS, MBA, FACS, Kyle R. Eberlin, MD

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Health-Related Quality of Life and Perceived Stigma in Eosinophilic Esophagitis: A Real-World, US, Web-Based Survey by Benjamin D. Gold, Bridgett Goodwin, Kimberly Davis, Carolyn Sweeney, Maria Reynolds, Jeanne Jiang, Tao Fan, Mena Boules, Szu-Ta Chen, David A. Katzka

“…Anxiety scores (adolescent and adult scores, respectively: 54.8 and 59.7) and depression scores (54.5 and 56.3) were higher in those with EoE than in the general population. Most participants reported experiencing perceived stigma, which was most commonly from family, friends, classmates, or health-care professionals. …”
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Adrenomedullin Therapy for Moderate-to-Severe COVID-19 Pneumonia: Double-Blind Placebo-Controlled Phase 2a Trial by Toshihiro Kita, Norio Ohmagari, Sho Saito, Hiroshi Mukae, Takahiro Takazono, Taka-Aki Nakada, Tadanaga Shimada, Yuji Hirai, Yuichiro Shindo, Kosaku Komiya, Atsushi Saito, Masaya Yamato, Koichiro Homma, Masaki Okamoto, Yoshihiro Yamamoto, Yoshikazu Mutoh, Chihiro Hasegawa, Nobuaki Mori, Fukumi Nakamura-Uchiyama, Mitsuru Honda, Keisuke Tomii, Hiroshi Ishii, Ichiro Takajo, Koji Watanabe, Kazuo Kitamura

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Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study by Nour Al Jalbout, Hamid Shokoohi, Christopher Kabrhel, David M Dudzinski, Mads Dam Lyhne, Andrew S Liteplo, Oana Alina Zeleznik, Asger Andersen, Onyinyechi Franca Eke, Christina C Morone, Calvin K Huang, Thomas F Heyne, Mannudeep K Kalra

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Magnesium disturbances in critically ill children by Selma Amar, Sofia Martín Acedo, Santiago Rodríguez-Tubio, Claudia Olalla, Cristina De Ángeles, José Ángel Zamorano, Rosario Pérez, Blanca Ramírez, Jesús López-Herce, Rafael González

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Heterogeneity of NeuN Protein Distribution as a Marker of Morphological Personalization of Cerebral Cortex Neurons: an Experimental Study by Arkady M. Golubev, Maxim A. Lyubomudrov, Anastasia S. Babkina, Zoya I. Tsokolaeva

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Human Neural Stem Cells Reduce Hypoxia-Ischemic Neurological Impairment Through the Regulation of Inflammatory M1/M2 Microglias in Rats by Ding YB, Zhao Y, Chen BY, Wang Q, Wang ZY, Luan Z, Yi B

“…Ya-Bing Ding,1,2,* Yuan Zhao,1– 3,* Bing-Yu Chen,1 Qian Wang,1 Zhao-Yan Wang,1 Zuo Luan,1,2 Bin Yi4 1Department of Pediatrics, The Sixth Medical Center of PLA General Hospital, Beijing, People’s Republic of China; 2Department of Pediatrics, The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Department of Neonatology, Children’s Hospital of Shanxi, Women Health Centre of Shanxi, Taiyuan, People’s Republic of China; 4Department of Pediatrics, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zuo Luan, Department of Peadiatric, The Sixth Medical Center of PLA General Hospital, Beijing, 100048, People’s Republic of China, Tel +86-18600310270, Fax +86-1066958303, Email luanzuodoctor@126.com Bin Yi, Gansu Provincial Maternity and Child-care Hospital, Lanzhou, Gansu, 730000, People’s Republic of China, Email www.0931@163.comObjective: This study aims to investigate the therapeutic efficacy and migration of human neural stem cell (hNSC) therapy in a rat model of moderate to severe Hypoxic-ischemic encephalopathy (HIE).Methods: hNSCs were transplanted into the brain ventricle of HIE-induced rats. …”
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IκB Kinase Inhibitor VII Modulates Sepsis-Induced Excessive Inflammation and Cardiac Dysfunction in 5/6 Nephrectomized Mice by Mei Ding, Dede Lian, Lirong Zhang, Tiechao Jiang, Wei Wang

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