Hemostatic conditions following autologous transfusion of fresh vs stored platelets in experimental endotoxemia: an open-label randomized controlled trial with healthy volunteers by Stefan F. van Wonderen, Floor L.F. van Baarle, Anita M. Tuip-de Boer, Chantal A. Polet, Robin van Bruggen, Christie Vermeulen, Thomas R.L. Klei, Chi M. Hau, Rienk Nieuwland, Cornelis van ’t Veer, Anna L. Peters, Sanne de Bruin, Alexander P.J. Vlaar, Bart J. Biemond, Marcella C.A. Müller

Get full text

Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults by Chenlu Gao, Andrew S. P. Lim, Shahab Haghayegh, Ruixue Cai, Jingyun Yang, Lei Yu, Agustin Ibanez, Aron S. Buchman, David A. Bennett, Lei Gao, Kun Hu, Peng Li

Get full text

Intensive Intervention Improves Outcomes for Chronic Obstructive Pulmonary Disease Patients: A Medical Consortium-Based Management by Shunjin Zhao, Lini Zheng, Maoxian Zhu, Yuexiang Shui, Xuxin Bao, Jun Zhao

“…Patients in the control group were managed by standard care, while patients in the management group were managed with intensive medical intervention jointly by specialists in the hospital and general practitioners and healthcare workers in community health centers. …”
Get full text

Efficiency of Use of the «Lung Opening» Maneuver Under Artificial Ventilation in Patients With Acute Respiratory Distress Syndrome by A. V. Vlasenko, D. A. Ostapchenko, D. A. Shestakov, M. M. Vodneva, Ye. S. Voyevodina, N. G. Neznamova, Ye. A. Prokhorova

Get full text

Storage damage of cold-stored whole blood in CPDA maintenance fluid during the whole effective storage period by Yingyu He, Yiquan Zhang, Wanbing Liu, Lidong Zhang, Yingkai Xu, Zihan Yuan, Junying Li, Lei Liu, Fangxiong Cheng

Get full text

Upregulation of ARHGAP18 by miR-613 Inhibits Cigarette Smoke Extract-Induced Apoptosis and Epithelial-Mesenchymal Transition in Bronchial Epithelial Cells by Fu H, Liu K, Zheng Y, Zhao J, Xie T, Ding Y

“…Haifan Fu,1,2,* Kai Liu,3,* Yamei Zheng,3 Jie Zhao,3 Tian Xie,3 Yipeng Ding2,3 1Yangjiang Health Center of Qionghai County, Qionghai, Hainan Province, People’s Republic of China; 2Department of General Practice, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, Haikou, People’s Republic of China; 3Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yipeng Ding, Hainan General Hospital, No. 19, Xinhua Road, Xiuying District, Haikou, 570311, Hainan, People’s Republic of China, Tel +86 18976335858, Email ypding1961@163.comObjective: Chronic Obstructive Pulmonary Disease (COPD) is a major chronic respiratory disease affecting human health worldwide. …”
Get full text

Targeting SPATS2 in lung adenocarcinoma: implications for prognosis and immune-based therapy by Maorong Teng, Fangtao Yan, Jingping Shang, Xiaohua Sun, Yahui Wang, Jian Shen

Get full text

Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running by Marie-Therese Lingitz, Hannes Kühtreiber, Lisa Auer, Michael Mildner, Claus G. Krenn, Clemens Aigner, Bernhard Moser, Christine Bekos, Hendrik Jan Ankersmit

Get full text

Mesalamine-Induced Myocarditis and Coronary Vasculitis in a Pediatric Ulcerative Colitis Patient: A Case Report by Elimarys Perez-Colon, Gul H. Dadlani, Ivan Wilmot, Michelle Miller

Get full text

Home Respiratory Polygraphy to Detect Obstructive Sleep Apnea Syndrome after Supracricoid Partial Laryngectomy by Rosa Hernández-Sandemetrio, Natsuki Oishi, Tomás Chavero, Rafael Navarro, Isabel López, Enrique Zapater

Get full text

The Effectivity MultiModality Treatment on Rehabilitation Management of Diabetic Foot Disease Patients for Improvement of Clinical Efficacy & Hemorheological Status by Li S, Liu Y, Chen Y

“…Nursing satisfaction was also higher (96.83% vs 71.43%, P < 0.05).Conclusion: Compared with routine nursing care alone, the multimodal intervention strategy may improve clinical efficacy, hemorheology, endothelial function, self-management capabilities, and patient satisfaction in diabetic foot care. …”
Get full text

Mechanisms of Cell Damage and Protection in Ischemia/Reperfusion and Experimental Rationale for the Use of Lithium-Based Preparations in Anesthesiology by V. V. Moroz, D. N. Silachev, E. Yu. Plotnikov, L. D. Zorova, I. B. Pevzner, O. A. Grebenchikov, V. V. Likhvantsev

Get full text

Severe Aplastic Anemia Complicated with Fatal Invasive Fungal Infections in a Young Patient Harboring Perforin Gene Polymorphisms by Maria I. Krithinaki, Ioannis Kokkinakis, Styliani Markatzinou, Christos Masaoutis, Elena Solomou, Ioanna Papakitsou, Nektaria Xirouchaki, Ioannis Liapis, Helen A. Papadaki, Charalampos G. Pontikoglou

Get full text

Persistent thrombocytopaenia as an independent risk factor for 28-day mortality and multiorgan failure in exertional heatstroke: a retrospective study of 217 patients by Li Zhong, Yan Liu, Conglin Wang, Zheying Liu, Lei Su, Zhifeng Liu, Ming Wu

Get full text

Therapeutic potential of Medical Nutrition Therapy (MNT) in Non-Alcoholic Fatty Liver Disease (NAFLD) by Abdul-Malik Bawah, Kasim Abdulai, Priscilla Cecilia Akpene Amenya

“…Conclusion: MNT effectively manages and provides superior benefits in NAFLD by improving liver function, metabolic health, and inflammation compared to general dietary advice and standard medical care. …”
Get full text

Changes in medication safety indicators in England throughout the covid-19 pandemic using OpenSAFELY: population based, retrospective cohort study of 57 million patients using fede... by Paul Griffiths, Ben Goldacre, David Evans, Sam Harper, Orla Macdonald, Alex J Walker, Richard Croker, Anthony J Avery, Caroline E Morton, Jessica Morley, Brian MacKenna, William Hulme, Sarah Rodgers, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, John Parry, Frank Hester, James Barrett, Amelia Green, Helen Curtis, Sebastian Bacon, Simon Davy, George Hickman, Tom Ward, Louis Fisher, Jon Massey, Iain Dillingham, Christopher Bates, Lisa EM Hopcroft, Kerry Oliver, Dai Evans, Becky Smith, Shaun O’Hanlon, Alex Eavis, Richard Jarvis, Dima Avramov, Aaron Fowles, Nasreen Parkes

“…Objective To implement complex, PINCER (pharmacist led information technology intervention) prescribing indicators, on a national scale with general practice data to describe the impact of the covid-19 pandemic on safe prescribing.Design Population based, retrospective cohort study using federated analytics.Setting Electronic general practice health record data from 56.8 million NHS patients by use of the OpenSAFELY platform, with the approval of the National Health Service (NHS) England.Participants NHS patients (aged 18-120 years) who were alive and registered at a general practice that used TPP or EMIS computer systems and were recorded as at risk of at least one potentially hazardous PINCER indicator.Main outcome measure Between 1 September 2019 and 1 September 2021, monthly trends and between practice variation for compliance with 13 PINCER indicators, as calculated on the first of every month, were reported. …”
Get full text

Domain‐Specific Prediction of Clinical Progression in Parkinson's Disease Using the Mosaic Approach by Marlene Tahedl, Ulrich Bogdahn, Bernadette Wimmer, Dennis M. Hedderich, Jan S. Kirschke, Claus Zimmer, Benedikt Wiestler

“…On the contrary, for general motor function, the unrestricted, whole‐brain MAP yielded higher power. …”
Get full text

NEUROPROTECTIVE ROLE OF BASIC FIBROBLAST GROWTH FACTOR IN ISCHEMIC BRAIN LESION: A REVIEW by I. V. Ostrova, M. Sh. Avrushchenko

Get full text

Profile of registrars and reasons for specialisation by M.S. Green, M. Nel, E.A.M. Prinsloo

“…Many respondents (76.9%) had worked in general practice or primary care for a median of two years (range 0.25 to 18 years). …”
Get full text

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging by Ping Bai, Ashley Gomm, Chi‐Hyeon Yoo, Prasenjit Mondal, Fleur Marie Lobo, Hui Meng, Yanting Zhou, Weiyao Xie, Hsiao‐Ying Wey, Rudolph E. Tanzi, Can Zhang, Changning Wang, Yu Lan

Get full text