Cancer-associated fibroblasts shape early myeloid cell response to chemotherapy-induced immunogenic signals in next generation tumor organoid cultures by Johannes Laengle, Julijan Kabiljo, Jakob Homola, Gerda Egger, Michael Bergmann, Wolfgang Weninger, Matthias Farlik, Askin Kulu, Anna Theophil, Annalena F Renner, Nathalie Stürzenbecher, Daphni Ammon, Rebecca Zirnbauer, Simone Stang, Loan Tran, Anna Chen, Markus Fabits, Velina S Atanasova, Oliver Pusch, Henning Walczak, Dietmar Herndler Brandstetter, Helmut Dolznig, Anna Kusienicka

“…Oxaliplatin and 5-fluorouracil, the standard-of-care chemotherapy for CRC, induced polarization of macrophages to a pro-inflammatory phenotype comparable to the immunogenic effects of treatment with an oncolytic virus. …”
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Diversification of sources of income in agricultural holdings in the context of multi-functional development of rural areas in Poland by Roman Rudnicki, Anna Dubownik, Mirosław Biczkowski

“…What can prove the progressing multi-functional development of agricultural holdings is a low rank of farms where incomes are generated mostly by agriculture-related activities, which is particularly conspicuous upon comparison with the percentage of agricultural holdings with incomes from work in non-agricultural sectors. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Work package 4: Development and refinement of a care transitions intervention Intervention development Functional resonance analysis method was used to model the transition process. …”
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On-demand imidazolidinyl urea-based tissue-like, self-healable, and antibacterial hydrogels for infectious wound care by Qi Wu, Krishanu Ghosal, Nadine Kana'an, Shounak Roy, Nagham Rashed, Ranabir Majumder, Mahitosh Mandal, Liang Gao, Shady Farah

“…Molecular dynamics (MD) simulation and density functional theory (DFT) calculation were employed to well-understand the extent of H-bonding and metal-ligand coordination to finetune hydrogels’ properties. …”
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Family Physicians’ Feedback on the Feature Design of a Digital Health Platform to Streamline the Care of Older Adults by Marjan Abbasi, Sheny Khera, Julia Dabravolskaj, Amira Aissiou, Reza Abbasi-Dezfouly

“…<b>Background/Objectives</b>: Family physicians are essential to a well-functioning healthcare system; however, they face significant administrative and cognitive burdens that contribute to their burnout and reduce the quality of patient care they provide. …”
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Emotional burden and self-care strategies among individuals in the sex trade during COVID-19 in Israel by Nour Shimei, Yeela Lahav-Raz, Ayelet Prior, Guy Shilo, Einat Peled

“…Building on these insights, this article examines how self-care practices functioned as relational and strategic responses to crisis. …”
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Morphological and Functional Alterations of Respiratory Muscle Performance and Spirometry Parameters in Patients with Congestive Heart Failure by V. S. Shabaev, I. V. Orazmagomedova, V. A. Mazurok, A. V. Berezina, A. E. Bautin, L. G. Vasilyeva, D. A. Aleksandrova

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Stem cell-derived pancreatic beta cells: a step closer to functional diabetes treatment? by Ikponmwosa Jude Ogieuhi, Chinonyelum Emmanuel Agbo, Victor Oluwatomiwa Ajekiigbe, Chidera Stanley Anthony, Jennifer Chinaecherem Onyehalu, Chinemelum Kingsley Nwankwo, Mercy Chisom Agu, Kaleb Lema, Olajumoke Adesola Adewole, Oluwatobi Asade, Simbiat Quadri Eniola, Ogochuku Elizabeth Obiaghanwa, Sheeba Abraham Jeyaraj, Ifeoluwa Sandra Bakare

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An Approach to, and Tool for, Predicting the Time Course of an Infectious Disease Outbreak as a Function of Behavioral Interventions by Abebe HT, Siraj A, Berhane K, Siraj D, Van Breukelen GJ

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Decoding glioblastoma survival: unraveling the prognostic potential of olfactory function in a prospective observational study by Christoph Oster, Aylin Matyar, Teresa Schmidt, Thomas Hummel, Elke Hattingen, Martha Jokisch, Daniel Jokisch, Jana Grieger, Giorgio Cappello, Kathrin Kizina, Lazaros Lazaridis, Yahya Ahmadipour, Laurèl Rauschenbach, Martin Stuschke, Christoph Pöttgen, Nika Guberina, Tobias Tertel, Bernd Giebel, Gian Luca Dreizner, Francesco Barbato, Eva-Maria Skoda, Björn Scheffler, Michael Müther, Ken Herrmann, Christoph Kleinschnitz, Ulrich Sure, Cornelius Deuschl, Martin Glas, Sied Kebir

“…Perspective This is the first longitudinal study evaluating olfactory function as a prognostic biomarker in glioblastoma. …”
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Finding Multiple Optimal Solutions to an Integer Linear Program by Random Perturbations of Its Objective Function by Noah Schulhof, Pattara Sukprasert, Eytan Ruppin, Samir Khuller, Alejandro A. Schäffer

“…MORSE maps multiplicative perturbations to the coefficients in an instance’s objective function, generating a modified instance that retains an optimum of the original problem. …”
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Optimisation of Several Estimating Functions by Multicriterial Analysis of Civil Engineering Structure in Service Stage Monitoring by Daniel LEPĂDATU, Dorina ISOPESCU, Ion RUSU, Loredana JUDELE, Gabriel SANDULACHE

“… In order to ensure the safety of engineering structures and especially those with special regimen such as the viaducts requiring careful monitoring of spatial displacements, it is necessary to find an optimal combination of criteria that are evaluated by a multi-criteria analysis to avoid major structural degradation and their effects on of the entire structure that can generate catastrophes with major losses of human lives. …”
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Telemonitoring for Chronic Heart Failure: Narrative Review of the 20-Year Journey From Concept to Standard Care in Germany by Sebastian Spethmann, Gerhard Hindricks, Kerstin Koehler, Stefan Stoerk, Christiane E Angermann, Michael Böhm, Birgit Assmus, Sebastian Winkler, Martin Möckel, Mirja Mittermaier, Monika Lelgemann, Daniel Reuter, Ralph Bosch, Alexander Albrecht, Stephan von Haehling, Thomas M Helms, Stefan Sack, Tarek Bekfani, Jan Wolfgang Gröschel, Magdalena Koehler, Christoph Melzer, Jan Wintrich, Bettina Zippel-Schultz, Georg Ertl, Claus Vogelmeier, Nikolaos Dagres, Jasmin Zernikow, Friedrich Koehler

“… BackgroundChronic heart failure (CHF) is a major cause of morbidity and mortality worldwide, placing a significant burden on health care systems. The concept of telemedicine for CHF was first introduced in the late 1990s, and since 2010, studies have demonstrated its potential to improve patient outcomes and reduce health care costs. …”
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A functional analysis of two 3D-scanned antique pistols from New Zealand by John LaRocco, Dong-Guk Paeng

“…Preservation of historical weapons requires continual and careful maintenance. Digital three-dimensional (3D) scanning can assist in preservation and analysis by generating a 3D computer model. …”
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The Mobility Makeover: Exploring the Interest, Need and Feasibility of a Mobility Aid Personalisation Programme in Long-Term Care by Pauli Gardner, Jaclyn Ryder, Colleen Whyte, Norma Restivo

“…There are several important implications of this research including identifying the potential benefits of a device personalisation programme and how this might ‘work’ in a care home and providing insight into what may be lost in current systems where the function and efficiency of mobility device prescription are prioritised. …”
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Gestión de riesgos en la realización de pruebas de función pulmonar pospandemia by Luis Puente Maestu, Juana M. Martínez Llorens, José Luis Valera Felices, Yolanda Torralba García, Marian Gimeno Peribáñez, Eusebi Chiner, Roberto Cabestre, Juan Rodríguez Hermosa, Raúl Godoy Mayoral, Celeste Marcos, Ana Balaña Corberó, Carlos Almonacid

“…A ministerial order issued by the Ministry of Health is mentioned, which lifts the mandatory use of facemasks in certain settings, in alignment with the strategy to return to normalcy.The proposal provides an in-depth analysis of the infectious risk to healthcare workers and patients in pulmonary function laboratories, concluding that current practices —along with the use of surgical masks and viral filters— minimize the generation and transmission of infectious aerosols.Detailed recommendations are provided for risk management, including architectural controls, administrative measures, hygiene practices, and personal protective protocols, with the goal of safeguarding both healthcare professionals and patients.The cited bibliography reinforces the scientific evidence base underlying the proposed recommendations and demonstrates a careful and deliberate approach to the safe and efficient reintroduction of spirometry and other pulmonary function tests into routine healthcare.…”
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HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages by Parker S. Woods, Rengül Cetin-Atalay, Angelo Y. Meliton, Kaitlyn A. Sun, Obada R. Shamaa, Kun Woo D. Shin, Yufeng Tian, Benjamin Haugen, Robert B. Hamanaka, Gökhan M. Mutlu

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Opportunities, challenges, and requirements for Artificial Intelligence (AI) implementation in Primary Health Care (PHC): a systematic review by Farzaneh Yousefi, Reza Dehnavieh, Maude Laberge, Marie-Pierre Gagnon, Mohammad Mehdi Ghaemi, Mohsen Nadali, Najmeh Azizi

“…Abstract Background Artificial Intelligence (AI) has significantly reshaped Primary Health Care (PHC), offering various possibilities and complexities across all functional dimensions. …”
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Continuity of Ideas and Generations. Historical Facts About the Activities of the Sheremetev Hospital (for the 100th Anniversary of the N.V. Sklifosovsky Research Institute for Eme... by S. A. Kabanova, Yu. S. Goldfarb, E. V. Grafova, E. E. Lukyanova, S. S. Petrikov, M. L. Rogal, M. Sh. Khubutiya

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Pathway-specific engineered mouse allograft models functionally recapitulate human serous epithelial ovarian cancer. by Ludmila Szabova, Sujata Bupp, Muhaymin Kamal, Deborah B Householder, Lidia Hernandez, Jerome J Schlomer, Maureen L Baran, Ming Yi, Robert M Stephens, Christina M Annunziata, Philip L Martin, Terry A Van Dyke, Zoe Weaver Ohler, Simone Difilippantonio

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