235 Root cause analysis of barriers and facilitators to accrual to a pragmatic, EHR-embedded clinical trial by Lindsay Lennox, Bethany M Kwan, Adit A Ginde, Thomas W. Flaig, Sarah V Kautz, Matthew Mimnall, Andrew Nicklwsky, Goldie Komaie, Christine Velez, Aaron Babour, Laurie Blmberg-Romero, Cecilia C. Low Wang

“…We summarized data from the EHR by eligibility, provider encounters, and alerts, and generated CONSORT diagrams and tables to trace the enrollment pathway. …”
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The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design by Jared C. Roach, Junko Hara, Deborah Fridman, Jennifer C. Lovejoy, Kathleen Jade, Laura Heim, Rachel Romansik, Adrienne Swietlikowski, Sheree Phillips, Molly K. Rapozo, Maria A. Shay, Dan Fischer, Cory Funk, Lauren Dill, Michael Brant‐Zawadzki, Leroy Hood, William R. Shankle

“…Secondary outcome measures include the Functional Assessment Staging Test (FAST), a measure of function. …”
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Trial Conduct, Baseline Characteristics, and Symptom Burden of Patients in the ARISE Study by Charles L. Daley, James D. Chalmers, Patrick A. Flume, David E. Griffith, Naoki Hasegawa, Kozo Morimoto, Kevin L. Winthrop, Chau-Chyun Sheu, Korkut Avsar, Dario Andrisani, Luigi Ruffo Codecasa, Dayton W. Yuen, Mariam Hassan, Marie-Laure Nevoret, Kevin Mange

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To what extent is equity entrenched in HIV/AIDS-related policy documents in Ethiopia? A policy content analysis by Aklilu Endalamaw, Charles F. Gilks, Yibeltal Assefa

“…Health information systems should be designed in such a way that they generate and manage information to assess the extent of (in)equity and the progress towards equity in HIV/AIDS services.…”
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Metal oxides on the frontlines: Antimicrobial activity in plant-derived biometallic nanoparticles by Krishnan Anbarasu, Sathishkumar Kuppusamy, Devi Okram Ricky, Agrawal Smita, Debnath Abhijit, Arasu Mariadhas Valan, Sundaram Thanigaivel, Subramanian Kumaran, Karunakaran Rohini

“…One of the main themes involves antioxidant activity, as the biometallic nanoparticles made from plants have the natural capacity to scavenge free radicals, which enhances their antimicrobial effectiveness. The work carefully evaluates the processes behind this dual function, providing insight into the complex interactions between metal oxides and chemicals originating from plants. …”
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Advancing the Integration of Digital Health Technologies in the Drug Development Ecosystem by Sakshi Sardar, Cheryl D Coon, Scottie Kern, Huong Huynh, Diane Stephenson, Joshua Rubin Abrams, Grace V Lee, Cecile Ollivier, Joseph A Hedrick, Martijn LTM Müller, Luc J W Evers, Lada Leyens, Collin Hovinga, Shu Chin Ma, Klaus Romero

“…We propose the development of various standardized consensus frameworks to clearly lay out processes for various stakeholders and facilitate the seamless integration of the next generation of health care–sensing technologies into drug development.…”
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A novel variant in the ALDH3A2 gene causative of Sjögren–Larsson syndrome evaluated in silico aids in proper genetic counseling and planning management by Ishwarya Chandrashekar Thirugnanam, Vigneshwaran Gurunadan, Srikanth Jilla, Sreelatha Komandur, Qurratulain Hasan

“…This study presents the findings of a case involving an 18-month-old female child with congenital ichthyosis and feeding difficulties who was referred for genetic testing. Next-generation sequencing identified a novel homozygous variant, c.1150A>C (p. …”
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Regenerative activity of stomach epithelial cells at small-intestinal obstruction by V. Ye. Milyukov, K. K. Nguyen

“…Suppression of metabolic processes of epithelial cells of coating layer and cells of cervical and fundic parts of the glands at preservation of main cells metabolism causes reduction of mucosal preoperative activity and may cause suppression of regenerative capacity and decrease of protective function.…”
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Large-scale genomic analysis reveals significant role of insertion sequences in antimicrobial resistance of Acinetobacter baumannii by Fei Xie, Lifeng Wang, Song Li, Long Hu, Yanhua Wen, Xuming Li, Kun Ye, Zhimei Duan, Qi Wang, Yuanlin Guan, Ye Zhang, Qiqi Shi, Jiyong Yang, Han Xia, Lixin Xie

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Current status and future perspectives of antibody-drug conjugates in breast cancer therapy by LIN Jialin, WANG Wenna, XU Binghe

“…Notably, structural optimizations in next-generation ADCs have led to significant improvements in their safety profile. …”
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Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma by Jie Chen, Chengyu Feng, Yufei Lan, Xiangtian Chen, Zhengqi Peng, Zihan Huang, Ruiqing Wang, Wenxin Zhang, Yingying Ye, Zhilei Mao, Dongyue Pan, Lihua Yang

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Case Report: Metastatic small bowel adenocarcinoma with DNA mismatch repair deficiency in an organ transplant recipient treated with anti-PD-1 immunotherapy by Quan H. Phung, Alexander K. Tsai, Byoung U. Park, Robben Schat, Richard Spong, L. Jill Tsai, Amit A. Kulkarni, Emmanuel S. Antonarakis, Emmanuel S. Antonarakis, Arjun Gupta

“…We present a case of a 65-year-old woman with a history of kidney and pancreas transplants for type 1 diabetes mellitus who presented with small bowel obstruction and was found to have a poorly differentiated small bowel adenocarcinoma with multifocal osseous and nodal metastases. Plasma-based next generation circulating tumor deoxyribonucleic acid (DNA) sequencing revealed mismatch repair deficiency and an exceptionally high tumor mutational burden (TMB) of 1069 mutations/megabase (mut/Mb). …”
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Possible Improvement of the Sagittal Spinopelvic Alignment and Balance through “Locomotion Training” Exercises in Patients with “Locomotive Syndrome”: A Literature Review by Takashi Yurube, Masaaki Ito, Toru Takeoka, Nobuyoshi Watanabe, Hideyo Inaoka, Kenichiro Kakutani, Ryosuke Kuroda, Kotaro Nishida

“…The JOA recommends “locomotion training” exercise intervention to be effective in maintaining motor function that comprises two simple exercises—squatting and single-leg standing. …”
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Randomised clinical trial research within Aboriginal and Torres Strait Islander primary health services: a qualitative study by Tim Usherwood, Jennifer Reath, Amanda Jane Leach, Hasantha Gunasekera, Deborah Askew, Penelope Abbott, Chelsea Watego, Wendy CY Hu, Letitia Campbell, Claudette Tyson, Robyn Walsh, Sylvia Hussey, Kerrie Doyle, Jessica Armstrong-Kearns

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TINJAUAN YURIDIS KEBIJAKAN PEMERINTAH KABUPATEN JEMBER TERHADAP EKSPLOITASI GUMUK by Isnania Citra Saisabela, ICS, Isnania Citra Saisabela, ICS, Fauziyah Fauziyah, FA

“…Economic growth must be consistent with the protection of environment. The current generation must be bequeathed to the next generation of good natural. …”
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Optimal Sca-1-based procedure for purifying mouse adipose-derived mesenchymal stem cells with enhanced proliferative and differentiation potential by Xingyu Tao, Jialian Wang, Yuan Yan, Peifeng Cheng, Bin Liu, Huimin Du, Bailin Niu, Bailin Niu

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Development of the system of state financing of Compulsory Health Insurance by А. V. Larionov, S. V. Russkikh, S. V. Maslennikov

“…It would be practical to redistribute the functions of financing health care between the Federal Fund for CHI and its territorial branches. …”
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The PANEN nomogram: clinical decision support for patients with metastatic pancreatic neuroendocrine neoplasm referred for peptide receptor radionuclide therapy by Aviral Singh, Aviral Singh, Aviral Singh, Sebastian Sanduleanu, Harshad R. Kulkarni, Thomas Langbein, Philippe Lambin, Richard P. Baum

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Genetic analysis of a novel TSC1 splice mutation causing tuberous sclerosis without neurological phenotypes by Xiu-juan Yao, Ying Lin, Jing Zou, Zun-lin Cai, Zi-Yan Xu, Xiao-qin Li, Qian Chen, Hong-ping Yu, Jian-hui Zhang, Dan-dan Ruan, Mei-zhu Gao, Li Zhang, Jie-wei Luo, Bao-song Xie

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FEATURES OF FREE RADICAL OXIDATION AND ANTIOXIDANT PROTECTION IN CHILDREN WITH SUGAR DIABETES OF THE FIRST TYPE by I. M. Bykov, L. G. Ivchenko, D. A. Domenyuk, N. Yu. Kostyukova, A. P. Storozhuk, D. M. Ilijev

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