A Retrospective, Longitudinal Registry Study on the Long-Term Durability of Ivacaftor Treatment in People with Cystic Fibrosis by Christian Merlo, Teja Thorat, Lisa J. McGarry, Christina V. Scirica, Maral DerSarkissian, Catherine Nguyen, Yuqian M. Gu, Aruna Muthukumar, Joe Healy, Jaime L. Rubin, M. Alan Brookhart

Get full text

Chitosan and its derivatives-based nanostructures in conjunction with their versatile applications in bio-medicine for alleviating contiguous diseases by Ayesha Anwar, Ayesha Anwar, Muhammad Imran, Muhammad Farooq Warsi, Ibrahim A. Alsafari, Roberto Parra-Saldívar, Roberto Parra-Saldívar, Guadalupe Gutiérrez-Soto, Hafiz M. N. Iqbal

Get full text

Outcome of Mathieu Meatal-based Flip Flap Technique for Distal Hypospadias: A Retrospective Cohort Study from a Single Tertiary Care Centre, Bhubaneswar, India by Harish Chandra Tudu, Nikhil Pothugunta, Varsha Madhavnarayan Totadri, Subrat Kumar Mohanty, Pradeep Kumar Jena, Amaresh Mishra

Get full text

Interplay of health-related quality of life and comorbidities in people with type 2 diabetes mellitus treated in primary care settings in Austria: a countrywide cross-sectional stu... by Faisal Aziz, Martin Clodi, Michael Resl, Julia K Mader, Harald Kojzar, Susanne Kaser, Harald Sourij, Peter Fasching, Norbert Joachim Tripolt, Kehkishan Azhar, Caren Sourij, Bernhard Ludvik, Gersina Rega-Kaun, Claudia Ress, Lars Stechemesser, Harald Stingl, Thomas Wascher

“…Depression (p<0.001) and multimorbidity (p<0.05) severely deteriorated all HRQoL domains: physical functioning (Depression:−25.34 [95% CI −33.84 to −16.84], p<0.001); (Multimorbidity: −19.37 [95% CI −26.30 to −12.44], p<0.001), physical role limitations (−22.96 [95% CI −36.65 to −9.27], p<0.001); (−18.53 [95% CI −29.59 to −7.48], p<0.001), social functioning (−24.38 [95% CI −32.41 to −16.35], p<0.001); (−8.86 [95% CI −15.66 to −2.07], p<0.05), emotional well-being (−19.80 [95% CI −26.22 to −13.38], p<0.001); (−9.54 [95% CI −14.95 to −4.13], p<0.001), emotional role limitations (−28.26 [95% CI −41.01 to −15.52], p<0.001); (−8.15 [95% CI −18.78 to 2.49], p=0.133), bodily pains (−23.09 [95% CI −32.21 to −13.97], p<0.001); (−14.52 [95% CI −22.08 to −6.95], p<0.001), fatigue (−16.47 [95% CI −23.40 to −9.55], p<0.001); (−13.71 [95% CI −19.39 to −8.03], p<0.001), general health (−7.09 [95% CI −10.40 to −3.78], p<0.001); (−7.14 [95% CI −9.83 to −4.46], p<0.001).Conclusions Our analysis showed that advanced age, obesity, depression, cardiovascular disease, chronic lung diseases and multimorbidity were associated with poor HRQoL of individuals with T2DM at the primary care level. …”
Get full text

Can education heal? Staff and students exploring reparative pedagogies in the context of institutional harms in higher education by Havva Görkem Altunbas, Xiaoyan Guo, Yuncong Liu, Helen Knowler, Tor Wright

Get full text

Examination of Psychotropic Medication Use Following Outpatient Behavioral Assessment and Treatment by Maria G. Valdovinos, Melissa Trites, Janelle Ausenhus

Get full text

Characteristics of Inherited Metabolic Disorders Following Kidney Transplantation: A 13-Year Observational Study by Kirsty Dickson, Henry H. L. Wu, Reena Sharma, Karolina M. Stepien, Ana Jovanovic, Rajkumar Chinnadurai

“…<i>Results:</i> This generally resulted in good graft outcomes for patients with IMD. …”
Get full text

The UPBEAT nurse-delivered personalized care intervention for people with coronary heart disease who report current chest pain and depression: a randomised controlled pilot study. by Elizabeth A Barley, Paul Walters, Mark Haddad, Rachel Phillips, Evanthia Achilla, Paul McCrone, Harm Van Marwijk, Anthony Mann, Andre Tylee

“…This study explored the acceptability and feasibility of procedures for a trial and for an intervention, including its potential costs, to inform a definitive randomized controlled trial (RCT) of a nurse-led personalised care intervention for primary care CHD patients with current chest pain and probable depression.…”
Get full text

A Mayer-Rokitansky-Kuster-Hauser Syndrome in a Neonate: A Case Report by Nasrin Khalesi, Mandana Kashaki, Nastaran Khosravi, Zahra Vahedi, Mona Alinejad-Naeini

Get full text

Borderline personality disorder Athens study: a quasi-experimental pragmatic trial for the assessment of a public, psychodynamic, stepped care service for borderline personality di... by Ioannis Malogiannis, Lida Anagnostaki, Maria Aspradaki, Panagiotis Aristotelidis, Katerina Karambela, Maria Amperiadou, Vasiliki Efthymiou, Phaithra Kriezi, Ioanna Theodoridou, Pentagiotissa Stefanatou, Pentagiotissa Stefanatou, George Konstantakopoulos, George Konstantakopoulos, Kyriakos Souliotis, Lily E. Peppou, Eleni Giannoulis, Eleni Giannoulis

“…The secondary outcome measures will include measures of general psychopathology, psychosocial functioning, quality of life and retention in treatment. …”
Get full text

Excess costs of transgender and gender-diverse people with gender incongruence and gender dysphoria compared with people from the general population in Germany: a secondary analysi... by Judith Dams, Hans-Helmut König, Thomas Grochtdreis, Peer Briken, Alexander Konnopka, Janis Renner, Arne Dekker, Timo Nieder

Get full text

The Surprise Question and Health-Related Quality of Life in Patients on Hemodialysis: A Cross-Sectional Multicenter Study by Jeanette M. Wallin, Stefan H. Jacobson, Lena Axelsson, Jenny Lindberg, Carina I. Persson, Jenny Stenberg, Agneta Wennman-Larsen

Get full text

Characterization of human living myocardial slices culture-induced adaptations: a translational perspective by Jort S.A. van der Geest, Ernest Diez Benavente, Willem B. van Ham, Pieter A. Doevendans, Linda W. van Laake, Teun P. de Boer, Vasco Sampaio-Pinto, Joost P.G. Sluijter

“…This study aims to characterize adaptations occurring in human living myocardial slices (LMS) during ex vivo culture.During culture, LMS demonstrated progressive enhancements in contractile function including stronger force generation, reduced diastolic tension, and faster contraction-relaxation kinetics. …”
Get full text

Mental health literacy among Jordanian nurses: a cross-sectional study and scale validation by Walid Al-Qerem, Anan Jarab, Judith Eberhardt, Fawaz Alasmari, Alaa Hammad, Amani Moh’d Ibrahim Alfarajat, Sarah Abu Hour, Lujain Al-sa’di, Rama AlKhateeb, Walaa Ashran

“…Despite nurses’ pivotal role in patient care, their level of mental health literacy (MHL) in Jordan remains underexplored. …”
Get full text

Implementation of group interpersonal therapy to treat depression in people living with HIV: A first evaluation of IPT dissemination in Senegal by Hawa Abou Lam, Hélène Font, Véronique Petit, Salaheddine Ziadeh, Judicaël Malick Tine, Ibrahima Ndiaye, Ndeye Fatou Ngom, Babacar Ndiaye, Daniel Sarr, Dominique Diouf, Nathalie de Rekeneire, Antoine Jaquet, Moussa Seydi, Charlotte Bernard, the IeDEA West Africa Cohort Collaboration

“…General linear mixed models were used to describe changes in outcomes over time. …”
Get full text

The Impact of Parental Support on Adherence to Therapist-Assisted Internet-Delivered Acceptance and Commitment Therapy in Primary Care for Adolescents With Anxiety: Naturalistic 12... by Anna Larsson, Sandra Weineland, Linnea Nissling, Josefine L Lilja

“…The aims were to examine treatment adherence, symptoms of anxiety and depression, psychological flexibility, and overall functioning. MethodsAdolescents with anxiety were recruited within the regular primary care patient flow during the implementation phase of therapist-assisted iACT for adolescents. …”
Get full text

Understanding parents’ experiences of disease course and influencing factors: a 3-year follow-up qualitative study among parents of children with functional abdominal pain by Mette Brekke, Anne Brodwall

“…Objective Functional abdominal pain is a common symptom in children and adolescents. …”
Get full text

Supporting self-management of low back pain with an internet intervention in primary care: a protocol for a randomised controlled trial of clinical and cost-effectiveness (SupportB... by Beth Stuart, Paul Little, Lucy Yardley, Stephanie Hughes, Adam W A Geraghty, Elaine Hay, Gemma Mansell, Nadine E Foster, Jonathan Hill, Gareth Griffiths, Frances Webley, Lorraine Durcan, Alannah Morgan, Sarah Bathers, Stephanie Butler-Walley, Simon Wathall, Linda Leigh

“…Internet interventions may provide accessible support for self-management of LBP in primary care. The aim of this randomised controlled trial is to determine the clinical and cost-effectiveness of the ‘SupportBack’ internet intervention, with or without physiotherapist telephone support in reducing LBP-related disability in primary care patients.Methods and analysis A three-parallel arm, multicentre randomised controlled trial will compare three arms: (1) usual primary care for LBP; (2) usual primary care for LBP and an internet intervention; (3) usual primary care for LBP and an internet intervention with additional physiotherapist telephone support. …”
Get full text

Ischemia during exercise stress testing, an indication of coronary vasomotor dysfunction? by Diantha J.M. Schipaanboord, Tijn P.J. Jansen, Luuk Scherpenhuijzen, Caïa Crooijmans, Aukelien C. Dimitriu-Leen, Pim van der Harst, Tim P. van de Hoef, René van Es, Hester M. den Ruijter, Peter Damman, N. Charlotte Onland-Moret, Suzette E. Elias-Smale

Get full text

Psychometric analysis of the patient-reported outcomes measurement information system parent proxy physical function–upper extremity item bank for children with Duchenne muscular d... by Linda Pax Lowes, Corinne M. Le Reun, Teofil Ciobanu, Lindsay N. Alfano, Natalie F. Reash, Megan A. Iammarino, Shivangi Patel, Ivana F. Audhya

“…A new customized 21-item measure demonstrated overall good fit to Rasch model expectations (p = 0.095; nonsignificant) and the ability to discriminate among respondents with different levels of upper extremity function (0.95 PSI; excellent reliability). Upper extremity function was generally well targeted across the severity spectrum, except for the least severe patients.ConclusionThe customized PROMIS PP UE measure conformed to Rasch assumptions, indicating that it can serve as a reliable option for caregiver-reported upper extremity assessment in DMD.…”
Get full text