Current progress and remaining challenges of peptide–drug conjugates (PDCs): next generation of antibody-drug conjugates (ADCs)? by Dongyuan Wang, Feng Yin, Zigang Li, Yu Zhang, Chen Shi

“…In this review, we first carefully analyzed the general consideration of successful PDC design learning from ADCs. …”
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SARS-CoV-2 variants reveal features critical for replication in primary human cells. by Marie O Pohl, Idoia Busnadiego, Verena Kufner, Irina Glas, Umut Karakus, Stefan Schmutz, Maryam Zaheri, Irene Abela, Alexandra Trkola, Michael Huber, Silke Stertz, Benjamin G Hale

“…Overall, our study uncovers sequence features in SARS-CoV-2 variants that determine cell-specific replication and highlights the need to monitor SARS-CoV-2 stocks carefully when phenotyping newly emerging variants or potential variants of concern.…”
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Socially interactive agents for robotic neurorehabilitation training: conceptualization and proof-of-concept study by Rhythm Arora, Pooja Prajod, Matteo Lavit Nicora, Matteo Lavit Nicora, Daniele Panzeri, Giovanni Tauro, Giovanni Tauro, Rocco Vertechy, Matteo Malosio, Elisabeth André, Patrick Gebhard

“…IntroductionIndividuals with diverse motor abilities often benefit from intensive and specialized rehabilitation therapies aimed at enhancing their functional recovery. Nevertheless, the challenge lies in the restricted availability of neurorehabilitation professionals, hindering the effective delivery of the necessary level of care. …”
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Prospects and Challenges in Artificial Intelligence use and the Christian faith: Augustinian and other considerations by Prof. G.M. Naidoo, Prof. A. Nicolaides

“…This leads to severe negative spiritual and functional consequences for Christian churches of all denominations as well as for communities in general.  …”
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Cost evaluation of acute ischemic stroke in Latin America: a multicentric studyResearch in context by Luiza Borba Dittrich, Ana Paula Beck da Silva Etges, Joana Siqueira de Souza, Miriam Allein Zago Marcolino, Eva Rocha, Pablo Amaya, Miguel A. Barboza, Andrés Gaye Saavedra, Gonzalo Pérez Hornos, Carlos Abanto, Ana Lucía Castillo-Soto, Natalia Llanos-Leyton, Virginia Pujol Lereis, María Soledad Rodriguez Pérez, Matías Alet, Victor Navia, Solange Lopez, Antonio Arauz, Fabiola Serrano, Bruna Chwal, Leonardo Augusto Carbonera, Raul Gomes Nogueira, Gustavo Saposnik, Carisi Anne Polanczyk, Sheila Cristina Ouriques Martins, Ana Cláudia de Souza

“…This study measures the real costs associated with acute ischemic stroke care in Latin America using Time–Driven Activity-Based Costing (TDABC). …”
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Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany by Anne-Kathrin Ruß, Stefan Schreiber, Wolfgang Lieb, J. Janne Vehreschild, Peter U. Heuschmann, Thomas Illig, Katharina S. Appel, Maria J. G. T. Vehreschild, Dagmar Krefting, Lennart Reinke, Alin Viebke, Susanne Poick, Stefan Störk, Jens-Peter Reese, Thomas Zoller, Lilian Krist, David Ellinghaus, Bärbel U. Foesel, Christian Gieger, Bettina Lorenz-Depiereux, Martin Witzenrath, Gabriele Anton, Michael Krawczak, Jan Heyckendorf, Thomas Bahmer

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Non-invasive biopsy diagnosis of diabetic kidney disease via deep learning applied to retinal images: a population-based study by Ziyao Meng, MEng, Zhouyu Guan, MD, Shujie Yu, MBBS, Yilan Wu, BSc, Yaoning Zhao, BSc, Jie Shen, PhD, Cynthia Ciwei Lim, MMed, Tingli Chen, MD, Dawei Yang, PhD, An Ran Ran, PhD, Feng He, MSc, Haslina Hamzah, BSc, Sarkaaj Singh, MSc, Anis Syazwani Abd Raof, MSc, Jian Wen Samuel Lee-Boey, MBBS, ProfMBBS Soo-Kun Lim, MBBS, ProfMD Xufang Sun, MBBS, Shuwang Ge, MD, ProfMD Gang Xu, MD, Prof Hua Su, MD, Yang Cheng, MD, Feng Lu, PhD, ProfPhD Xiaofei Liao, PhD, ProfPhD Hai Jin, PhD, Chenxin Deng, MMed, Lei Ruan, MD, ProfMD Cuntai Zhang, MD, Chan Wu, MD, ProfMD Rongping Dai, MD, Yixiao Jin, MSc, Wenxiao Wang, PhD, Tingyao Li, BSc, Ruhan Liu, PhD, Jiajia Li, PhD, Jia Shu, BEng, Yuwei Lu, MBBS, Xiangning Wang, MD, Qiang Wu, MD, Yiming Qin, BEng, Jin Tang, MD, Xiaohua Sheng, MD, Qiong Jiao, MD, ProfPhD Xiaokang Yang, MD, ProfPhD Minyi Guo, MD, Gareth J McKay, PhD, ProfPhD Ruth E Hogg, PhD, Gerald Liew, MBBS, Evelyn Yi Lyn Chee, PhD, ProfPhD Wynne Hsu, PhD, ProfPhD Mong Li Lee, PhD, Simon Szeto, MBChB, ProfMD Andrea O Y Luk, MBChB, ProfMD Juliana C N Chan, MBChB, Carol Y Cheung, PhD, Gavin Siew Wei Tan, FRCSEd, Yih-Chung Tham, PhD, ProfMD PhD Ching-Yu Cheng, PhD, Charumathi Sabanayagam, MD PhD, ProfPhD Lee-Ling Lim, MD PhD, ProfMD PhD Weiping Jia, MD PhD, ProfMD PhD Huating Li, MD PhD, Bin Sheng, Prof, Tien Yin Wong, Prof

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Body Image Concerns and Psychological Distress in Adults with Hearing Aids: A Case-Control Study by Enrico Apa, Silvia Ferrari, Daniele Monzani, Andrea Ciorba, Luca Sacchetto, Virginia Dallari, Riccardo Nocini, Silvia Palma

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A case report of insulinoma presenting with seizures and localized on endoscopic ultrasound by Waseem Umer, Ahmed Salah Mohammed, Adeel Ahmad Khan, Muhammad Umar Saddique, Muhammad Zahid

“…Abstract Insulinomas are rare functioning neuroendocrine (NEN) tumors. Up to 10% of insulinomas are associated with multiple endocrine neoplasia 1 (MEN1). …”
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Association between placental insufficiency and manifestations of preeclampsia by A. N. Strizhakov, Yu. V. Tezikov, I. S. Lipatov, D. V. Pechkurov

“…The incidence rates of PI and PE, both in the communities and in the tertiary care hospital, pointed to their intercorrelation. …”
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The challenges of hepatic epithelioid hemangioendothelioma: the diagnosis and current treatments of a problematic tumor by Manar Mikhail Atyah, Yongliang Sun, Zhiying Yang

“…Other characteristics include asymptomatic manifestation, lack of unique hepatic functional alterations, high rates of misdiagnosis and late-stage identification when metastases already exist. …”
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Changes in the Plasma Sex Hormone Profile in Males with Severe Concomitant Injury by K. N Yezhova, A. V. Volkov, D. A. Ostapchenko, V. V. Moroz

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A Methodological and Structural Review of Parkinson’s Disease Detection Across Diverse Data Modalities by Abu Saleh Musa Miah, Taro Suzuki, Jungpil Shin

“…Parkinson’s Disease (PD) is a progressive neurological disorder that primarily affects motor functions and can lead to mild cognitive impairment (MCI) and dementia in its advanced stages. …”
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Comparison of marker-less 2D image-based methods for infant pose estimation by Lennart Jahn, Sarah Flügge, Dajie Zhang, Luise Poustka, Sven Bölte, Florentin Wörgötter, Peter B. Marschik, Tomas Kulvicius

“…This indicates limited generalization capabilities of infant-pose estimators to other infant datasets, meaning that one should be careful when choosing infant pose estimators and using them on infant datasets which they were not trained on. …”
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Toxicological and histopathological effects of sodium benzoate used in commercially available fruit juice on liver and kidney tissue in mice model by Dina Akter, Md Meskatul Islam, Md Imam Hossain, Md Esrafil, Bishnu Pada Dey, Luthfunnesa Bari, Md Abu Zubair

“…Group-1 was control that caring with normal standard diet and water, whereas mice in group-2, 3 and 4 were treated with market juice-1, 2, and 3. …”
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Improving Participant Recruitment in Clinical Trials: Comparative Analysis of Innovative Digital Platforms by Alexia Georgia Bikou, Elena Deligianni, Foteini Dermiki-Gkana, Nikolaos Liappas, José Gabriel Teriús-Padrón, Maria Eugenia Beltrán Jaunsarás, Maria Fernanda Cabrera-Umpiérrez, Christos Kontogiorgis

“…ResultsA total of 24 digital platforms were identified that supported clinical trial recruitment phases. In general, most of them (n=22, 80%) are headquartered and operating in the United States, providing a range of functionalities including electronic consent (n=14, 60% of the platforms), participant matching, and monitoring of patients’ health status. …”
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Perimesencephalic Subarachnoid Hemorrhage Bleeding Patterns Are Not Always Benign: Prognostic Impact of an Aneurysmal Pathology by Emily Hoffmann, Công Dùy Bui, David Ventura, Manfred Musigmann, Alexandra Valls Chavarria, Markus Holling, Vivek S. Yedavalli, Jeremy J. Heit, Christian Paul Stracke, Tobias D. Faizy, Hermann Krähling, Burak Han Akkurt

“…<b>Background/Objectives</b>: Perimesencephalic subarachnoid hemorrhage (pmSAH) is generally considered to be a benign variant of spontaneous SAH. …”
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A novel hypothesis on the relationship between maternal education and obesity in children; the mediating role of maternal and child self-control—ABIS a population-based cohort stud... by Pär Andersson White, Pär Andersson White, Johnny Ludvigsson, Johnny Ludvigsson, Michael P. Jones, Tomas Faresjö

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Dynamics and stability of a within-host HIV-HBV co-infection model with time delays by Ahmed M. Elaiw, Abdulaziz S. Alhmadi, Abdulaziz S. Alhmadi, Aatef D. Hobiny

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Impact of public versus non public insurance on hispanic kidney transplant outcomes using UNOS database by Charat Thongprayoon, Oscar A. Garcia Valencia, Caroline C. Jadlowiec, Shennen A. Mao, Michael A. Mao, Napat Leeaphorn, Justin H. Pham, Eva Csongradi, Iasmina M. Craici, Pooja Budhiraja, Wisit Cheungpasitporn

“…Abstract Disparities in access to care and transplantation outcomes, including prolonged waitlist times and reduced living donor transplantation rates, are well-documented in Hispanic kidney transplant patients. …”
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