Integrative spatial and single-cell transcriptomics elucidate programmed cell death-driven tumor microenvironment dynamics in hepatocellular carcinoma by Kai Lei, Kai Lei, Yutong Zhao, Shumin Li, Jiawei Liu, Wenhao Chen, Caihong Zhou, Yi Zhang, Jinmei Tan, Jian Wu, Qi Zhou, Qi Zhou, Jiehui Tan

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Bacterial extracellular vesicles for gut microbiome–host communication and drug development by Dingfei Qian, Peijun Xu, Xinwei Wang, Chong Du, Xiao Zhao, Jiaqi Xu

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Strategies and tactics to perform safe pancreaticoduodenectomy for 94-year-old patient: report of a case by Yu Suyama, Koichiro Haruki, Ryoga Hamura, Masashi Tsunematsu, Yoshihiro Shirai, Tomohiko Taniai, Mitsuru Yanagaki, Kenei Furukawa, Shinji Onda, Hiroaki Shiba, Toru Ikegami

“…Abstract Background Despite improvement of postoperative management, pancreatoduodenectomy still has a high rate of major complications. Therefore, careful assessment is critically important when we consider high risk surgery for extremely elderly patients. …”
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Protocol for Japan-acute retinal necrosis (J-ARN) registry: A combined prospective and retrospective cohort study. by Yoshihiko Usui, Reiko Kinouchi, Satoko Nakano, Chiharu Iwahashi, Keitaro Hase, Kenji Nagata, Masahiro Sugimoto, Eiichi Hasegawa, Kinya Tsubota, Sentaro Kusuhara, Masato Akiyama, Kenji Kashiwagi, Atsunobu Takeda, Toshikatsu Kaburaki, Hiroshi Goto, Koh-Hei Sonoda

“…A nationwide registry is needed to systematically collect data on ARN cases across Japan to improve understanding of this condition and optimize patient care. We have designed a national registry that collects data of patient characteristics, diagnosis, treatment, and visual outcome to generate evidence for the management of ARN.…”
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Revealing the physical restrictions of caecal influx in broilers through the use of solid and soluble markers by Paulien Vanderghinste, An Bautil, Michael R. Bedford, Gemma González-Ortiz, Chris Lamberigts, Imran Aslam, Maarten Roeffaers, Christophe M. Courtin

“…Both solid and soluble markers showed a larger concentration in the caeca at a young age compared to older ages (P < 0.01), possibly related to the limited caecal functioning early in life. These findings highlight the importance of carefully selecting the physical properties of fibres to be added as a function of age to further improve caecal fibre fermentation in broilers.…”
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Current status and prognostic factors of paediatric arterial ischaemic stroke in China: a study protocol for Chinese Paediatric Ischaemic Stroke Registry (CPISR) by Wei Li, Bin Zhu, Wen Sun, Fan Wu, Pan Zhang, Lulu Xiao, Huiping Wang, Gang Cai, Yingjie Xu, Wanqiu Zhang, Cuirong Duan, Mingyang Niu, Qiankun Li, Zhiwen Su

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Decidual/placental and first trimester plasma levels of hsa-miR-199a-3p|hsa-miR-199b-3p and hsa-miR-3150b-3p are associated with insulin secretion in pregnancy by Amélie Taschereau, Frédérique White, Catherine Allard, Andrea G. Edlow, François Aguet, Kristin G. Ardlie, Jose C. Florez, Jose C. Florez, Jose C. Florez, Jose C. Florez, Pierre-Étienne Jacques, Pierre-Étienne Jacques, Pierre-Étienne Jacques, S. Ananth Karumanchi, Camille E. Powe, Camille E. Powe, Camille E. Powe, Camille E. Powe, Luigi Bouchard, Luigi Bouchard, Luigi Bouchard, Marie-France Hivert, Marie-France Hivert, Marie-France Hivert

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Feasibility, acceptability, usability and quality of life levels in post-stroke patients undergoing telerehabilitation: Results from a multicentric pilot study by Luisa Cacciante, Sara Federico, Lorenza Maistrello, Pawel Kiper, Roberto De Icco, Tommaso Milanesi, Cristina Tassorelli, Roberto Gatti, Johanna Jonsdottir, Marco Franceschini, Michela Goffredo, Rocco Salvatore Calabrò, Andrea Turolla

“…Quality of life levels improved significantly from pre- to post-treatment (EQ-5D: p  = 0.0014; SF-36 general health: p  = 0.047). Caregivers perceived little or no significant care burden. …”
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Does delivering chest compressions to patients who are not in cardiac arrest cause unintentional injury? A systematic review by Frances Williamson, Pek Jen Heng, Masashi Okubo, Abel Martinez Mejias, Wei-Tien Chang, Matthew Douma, Jestin Carlson, James Raitt, Therese Djärv

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Long‐Term Treatment With Subcutaneous Treprostinil in Patients With Severe Inoperable Chronic Thromboembolic Pulmonary Hypertension in the Multimodal Therapy Era (Data From CTREPH... by Pavel Jansa, Roela Sadushi‐Kolici, Nika Skoro‐Sajer, Grzegorz Kopec, Iveta Simkova, Regina Steringer‐Mascherbauer, Barbara Salobir, Jaroslav Lindner, Irene M. Lang

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Effectiveness and safety of adjuvant software based on virtual reality for post-thoracoscopic surgery pain: study protocol for a randomized controlled trial by Xijia Feng, Wei Guo, Benyuan Jiang, Tong Li, Yi Lu, Song Xu, Wenzhao Zhong, Hecheng Li

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Cold atmospheric plasma effectively kills chordoma cells through induction of intracellular reactive oxygen species by Sophie Peeters, Peter B. Wu, Blake Haist, Amber Armellini, Wi Jin Kim, Zhitong Chen, Richard Obenchain, George Ayad, Weihong Ge, Aparna Bhaduri, Graeme Sabiston, Robert M. Prins, Richard Wirz, Anthony C. Wang

“…Oftentimes, tumor infiltration into functionally critical, or difficult-to-access areas, precludes optimal resection. …”
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Analysis of modern employers’ requirements to responsibilities and competencies of pharmaceutical staff by A. A. Kotvitska, Yu. S. Bratishko, A. V. Volkova, D. Yu. Tarasenko, O. V. Posylkina, A. B. Olkhovska

“…It has also been established that recently, together with the increasing competition in the pharmaceutical labor market, employment requirements for applicants for vacant positions of retail pharmacist, pharmacy director, and medical (pharmaceutical) representative have been revised. In general, employers put forward more than 50 requirements for applicants for the positions under consideration; these requirements can be divided into functional, professional and personal. …”
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Clinic and diagnosis of encephalopathy of critical conditions in children with infectious diseases by E. S. Egorova, A. V. Klimkin, A. A. Vilnits, N. V. Skripchenko, V. B. Voitenkov, Yu. P. Vasilyeva, M. A. Bedova

“…Purpose: to assess the functional state of the brain in critically ill encephalopathy in children with infectious diseases.Materials and methods: 75 patients aged from 1 month to 17 years 11 months with infectious diseases, who were in the intensive care unit of the clinic, were examined, divided into two groups: the main group and the comparison group. …”
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Children’s and Their Parents’ Experiences With Home-Based Guided Hypnotherapy: Qualitative Study by Ilse N Ganzevoort, Adriëlla L van der Veen, Manna A Alma, Marjolein Y Berger, Gea A Holtman

“… Abstract BackgroundManagement of children with functional abdominal pain (FAP) or irritable bowel syndrome (IBS) is difficult in primary care. …”
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FEATURES OF CYTOKINE PROFILE IN PATIENTS WITH ATHEROSCLEROSIS by E. P. Turmova, E. V. Markelova, A. A. Silayev, P. A. Lukyanov, I. V. Chikalovets

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Advanced therapeutic strategy for managing surgical site infections with natural nanoemulsion-antimicrobial combination by Fatma Alshehri, Nada K. Alharbi, AbdelNaser Zaid, AbdelNaser Zaid, Amira H. Eltrawy, Shereen Fawzy, Attia M. Gabr, Attia M. Gabr, Sawsan A. Zaitone, Sawsan A. Zaitone, Majid Alhomrani, Majid Alhomrani, Abdulhakeem S. Alamri, Abdulhakeem S. Alamri, Rasha A. Mosbah, Rasha A. Mosbah, Rana Elshimy, Abdallah Tageldein Mansour, Mahmoud M. Bendary

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Efficacy of Tirzepatide Dual GIP/GLP‐1 Receptor Agonist in Patients With Idiopathic Intracranial Hypertension. A Real‐World Propensity Score‐Matched Study by Ahmed Y. Azzam, Muhammed Amir Essibayi, Nathan Farkas, Mohammed A. Azab, Mahmoud M. Morsy, Osman Elamin, Adam Elswedy, Ahmed Saad Al Zomia, Hammam A. Alotaibi, Ahmed Alamoud, Oday Atallah, Hana J. Abukhadijah, Adam A. Dmytriw, Amanda Baker, Deepak Khatri, Neil Haranhalli, David J. Altschul

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Right-sided hemicolectomy in 90-year-old patient with cecum cancer by A. M. Sidorenko, T. A. Semenova, V. V. Varvarov

“…Purpose of the work is to describe a case of radical treatment of cecum cancer in 90-year-old patient. It is generally known that most of the patients with malignant tumors are people of older age groups. …”
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Digital Therapeutics in China: Comprehensive Review by Nan Jiang, Xiru Yu, Yuxi Yang, Guanqiao Li, Chanchan He, Man Ping Wang, Yih Chung Tham, Tien Yin Wong, Keqin Rao

“…Meta-analysis for cognitive disorder DTx showed significant improvement in global cognitive function in DTx-treated participants (SMD 0.65, 95% CI 0.37-0.94), despite notable heterogeneity (I²=71.7%). …”
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