Deletion of Tfap2a in hepatocytes and macrophages promotes the progression of hepatocellular carcinoma by regulating SREBP1/FASN/ACC pathway and anti-inflammatory effect of IL10 by Zhiwei Li, Chun Zhang, Guixiang Huang, Zixin Zhang, Qinghao Wang, Xiran Liu, Yanling Qin, Hao Zhou, Anyi Hou, Jun He, Limin Li, Xiang Hu, Xiaofeng Ding

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Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation by Manzhen Liao, Manzhen Liao, Taoyue Yao, Yonghui Xie, Shelby Kutty, Jinqiao Liu, Wei Peng, Wei Peng, Ting Huang, Huaiyang Chen, Huaiyang Chen, Haoqin Fan, Zhenghui Xiao, Qiming Liu, Yunbin Xiao

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Multi-omics integration reveals Vha68-3 as a testicular aging-specific factor that coordinates spermatid elongation through mitochondrial metabolic homeostasis by Jun Yu, Qiuru Huang, Yangbo Fu, Lei He, Cong Shen, Xia Chen, Zhiran Li, Jiaxin Li, Chenyu Wang, Xinda Wang, Binbin Yang, Ziwen Lin, Chen Qiao, Xiaofang Tan, Xiaoqing Yang, Hao Chen, Ying Zheng, Bo Zheng, Fei Sun

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Study protocol using informatics to identify and recruit a cohort of older adults in Florida to develop teleneuropsychological norms by Glenn Smith, Ambar Perez-Lao, Gelan Ying, Ellie Mitova, Amanda Morales, David Marra, Franchesca Arias, Shellie-Anne Levy

“…They will also complete questionnaires related to sociodemographic information, depression, functionality and social determinants of health. Participants will undergo a teleneuropsychological battery examination via remote assessment. …”
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Humanized scFv Molecule Specific to an Extracellular Epitope of P2X4R as Therapy for Chronic Pain Management by Adinarayana Kunamneni, Karin N. Westlund

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Evaluation Of The Role Of Visual Evoked Potentials In Detecting Visual Impairment In Type II Diabetes Mellitus by Ruchi Kothari, Pradeep Bokariya, Smita Singh, TS Hemavaishnave

“…Both eyes of the two groups of the subjects were included in the study. Design:- Tertiary care rural hospital based, single time assessment, short term observational study. …”
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Combined metabolomic and transcriptomic analysis reveals the key genes for triterpenoid biosynthesis in Cyclocarya paliurus by Duo Chen, Xupeng Chen, Xuehai Zheng, Jinmao Zhu, Ting Xue

“…Abstract Background Cyclocarya paliurus is a high-value tree, and it contains a variety of bioactive secondary metabolites which have broad application prospects in medicine, food and health care. Triterpenoids can improve the bioactive function of C. paliurus health tea and also improve the efficacy of health care tea. …”
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A Digital Mental Health Solution to Improve Social, Emotional, and Learning Skills for Youth: Protocol for an Efficacy and Usability Study by Kayla V Taylor, Laurent Garchitorena, Carolina Scaramutti-Gladfelter, Mykayla Wyrick, Katherine B Grill, Azizi A Seixas

“…ConclusionsThe STEMSEL study plays a crucial role in assessing the feasibility and adoption of digital mental health interventions within the school-aged youth population in the United States. The findings generated from this study have the potential to dismantle obstacles to accessing mental health assistance and broaden the availability of care through evidence-based strategies. …”
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“It’s like going through life at a mediocre level”: a qualitative study of the meaning and impact of fatigue in children and young people with sickle cell disease by Brenda Agyeiwaa Poku, Karl Michael Atkin, John David Grainger, Iyamide Thomas, Rachael Oshinbolu, Abubakar Mohammed, Edith Kyewalyanga, Susan Kirk

“…Conclusions Fatigue dominates CYP’s experience of living with SCD, significantly impacting their physical, social and educational functioning and leading to isolation and stigma. Often overlooked in clinical settings, addressing fatigue should be integral to SCD care and research. …”
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Fermented Dairy Products as Precision Modulators of Gut Microbiota and Host Health: Mechanistic Insights, Clinical Evidence, and Future Directions by Yuan Gao, Yanyan Liu, Tingting Ma, Qimeng Liang, Junqi Sun, Xiaomeng Wu, Yinglong Song, Hui Nie, Jun Huang, Guangqing Mu

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Idiopathic Pulmonary Fibrosis Registry China study (PORTRAY): protocol for a prospective, multicentre registry study by Ling Zhao, Min Liu, Huaping Dai, Chen Wang, Bingbing Xie, Yanhong Ren, Jing Geng, Xuan He, Chengjun Ban, Shiyao Wang, Dingyuan Jiang, Sa Luo, Qihang Chen, Ruie Feng

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MENUMBUHKAN KEMANDIRIAN ANAK : BELAJAR KEIKHLASAN HIDUP SANTRI PONDOK PESANTREN MIFTAHUL FALAH SRIWIJAYA BANDAR MATARAM LAMPUNG TENGAH by Syaifur Rohman

“…This is considering that pesantren is a crater of ‘candradimuka’ which function is to prepare future generations of a strong nation. …”
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PO53 | Effectiveness and safety of DOACS in patients with renal transplantation

“…However, their use requires careful monitoring, particularly regarding renal function and drug interactions. …”
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Investigating and learning lessons from early experiences of implementing ePrescribing systems into NHS hospitals: a questionnaire study. by Kathrin Cresswell, Jamie Coleman, Ann Slee, Robin Williams, Aziz Sheikh, ePrescribing Programme Team

“…At least 6% (n = 10) of the 168 English NHS Trusts have already implemented ePrescribing systems, 2% (n = 4) have no plans of implementing, and 34% (n = 55) are planning to implement with intended rapid implementation timelines driven by high expectations surrounding improved safety and efficiency of care. The majority are unclear as to which system to choose, but integration with existing systems and sophisticated decision support functionality are important decisive factors. …”
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Advances in Wearable Biosensors for Wound Healing and Infection Monitoring by Dang-Khoa Vo, Kieu The Loan Trinh

“…These innovations are leading the way toward next-generation wound care by bridging advanced materials science, biotechnology, and digital health.…”
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Using a Co-Designed Implementation Enhancement Plan to Increase the Adoption of a Digital Fall Prevention Platform: A Non-Randomized Pre-Post Interventional Study by Delaforce A, Li J, Niven P, Maddock E, Grujovski M, Fahy MJ, Good NM, Jayasena R

“…The findings have broader implications for the implementation of other fall prevention interventions.Evidence is generated in support of digital falls prevention systems in the context of providing more efficient and responsive care, as well as improved patient-staff communication and satisfaction.Keywords: implementation science, health information technology, nursing, co-design…”
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The integration and associated challenges of Mental Health Competencies in Undergraduate Nursing Education: a scoping review by Precious Chibuike Chukwuere, Nombulelo Esme Zenani, Katlego Mthimunye, Rosemary Godbold, Ghada Shahrour

“…Full-text screening was conducted for all the identified articles, and the research team carefully scrutinized this process. Results The initial literature search generated 717 articles. …”
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Tocilizumab in combination with corticosteroids: potential for managing cancer cachexia with systemic hyperinflammation by Ping Chen, Dingyi Wang, Zhouwei Zhan, Ling Chen, Yu Chen

“…Weight, body mass index, liver metastasis, Eastern Cooperative Oncology Group score, patient-generated subjective global assessments, the Anorexia/Cachexia Subscale of the Functional Assessment of Anorexia/Cachexia Therapy, handgrip strength, neutrophil-to-lymphocyte ratio, and the C-reactive protein, hemoglobin, prealbumin, and albumin levels were recorded in both groups.ResultsTocilizumab treatment favorably influenced the levels of patient biomarkers (p<0.05), ameliorated systemic inflammation, and demonstrated enhanced clinical short-term efficacy compared to the control group, including rates of symptomatic relief (60% vs. 20%, p = 0.024), improvement of serum PAB and ALB (70% vs. 25%, p = 0.004), weight gain >2% (45% vs. 15%, p = 0.038), and improvement of grip strength and 6-m walk speed (p<0.05). …”
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Disease Phenotypes in Refractory Musculoskeletal Pain Syndromes Identified by Unsupervised Machine Learning by Thomas Hügle, Tiffany Prétat, Marc Suter, Chris Lovejoy, Pedro Ming Azevedo

“…Three of five clusters responded to the multimodal treatment in terms of pain (BPI intensity), one cluster responded in terms of functional improvement (BPI interference), and one cluster notably responded to the virtual reality intervention. …”
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Defective Atg16l1 in intestinal epithelial cells links to altered fecal microbiota and metabolic shifts during pregnancy in mice by Víctor A. López-Agudelo, Maren Falk-Paulsen, Richa Bharti, Ateequr Rehman, Felix Sommer, Eike Matthias Wacker, David Ellinghaus, Anne Luzius, Laura Katharina Sievers, Manuel Liebeke, Arthur Kaser, Philip Rosenstiel

“…Observed differences included microbial genera implicated in IBD such as Lachnospiraceae, Roseburia, Ruminococcus, and Turicibacter. …”
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