518 Modeling of cancer mutations found in pediatric DICER1 syndrome informs novel therapeutic targeting strategies by David Jee, Seungjae Lee, Dapeng Yang, Robert Rickert, Renfu Shang, Danwei Huangfu, Eric C. Lai

“…Objectives/Goals: Large-scale tumor sequencing efforts have led to annotations of novel cancer hotspot mutations that may underlie driver or cooperative function. We have sought to define the molecular consequences of such hotspots associated with pediatric DICER1 syndrome cancers, with the ultimate goal of revealing novel targets that may inform new standards of care. …”
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Cellpose as a reliable method for single-cell segmentation of autofluorescence microscopy images by Jeremiah M. Riendeau, Amani A. Gillette, Emmanuel Contreras Guzman, Mario Costa Cruz, Aleksander Kralovec, Shirsa Udgata, Alexa Schmitz, Dustin A. Deming, Beth A. Cimini, Melissa C. Skala

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A Validation Tool (VaPCE) for Postcoordinated SNOMED CT Expressions: Development and Usability Study by Tessa Ohlsen, Viola Hofer, Josef Ingenerf

“… Abstract BackgroundThe digitalization of health care has increased the demand for efficient data exchange, emphasizing semantic interoperability. …”
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A Qualitative Study Examining the Unintended Consequences from Implementing a Case Management Team to Reduce Avoidable Hospital Readmission in Singapore by Shilpa Surendran, Stephen So, Toon Wei Lim, David Bruce Matchar

“…Results: Data analysis generated seven subthemes: ineffective targeting of patient population, fund constraints, lack of patient ownership, limited post discharge follow up, comprehensive care approaches, role overlap and patient confusion. …”
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Zebrafish do not have a calprotectin ortholog. by Kona N Orlandi, Michael J Harms

“…The field would benefit from expanding the breadth of calprotectin studies into a zebrafish innate immunity model. Here, we carefully evaluated the possibility that zebrafish possess a calprotectin ortholog or a paralog that convergently evolved similar function. …”
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Costs and acceptability of simplified monitoring in HIV-suppressed patients switching to dual therapy: the SIMPL’HIV open-label, factorial randomised controlled trial by Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Karin J. Metzner, Laurent Decosterd, Huldrych F. Günthard, Patrick Schmid, Andreas Limacher, Mattia Branca, Alexandra Calmy

“… BACKGROUND: Clinical and laboratory monitoring of patients on antiretroviral therapy is an integral part of HIV care and determines whether treatment needs enhanced adherence or modification of the drug regimen. …”
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Clinical and cost-effectiveness of non-medical prescribing: A systematic review of randomised controlled trials. by Timothy Noblet, John Marriott, Emma Graham-Clarke, Debra Shirley, Alison Rushton

“…Measurements reported on one or more outcome(s) of: pain, function, disability, health, social impact, patient-safety, costs-analysis, quality adjusted life years (QALYs), patient satisfaction, clinician perception of clinical and functional outcomes.…”
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Macrophage-derived exosomes in cancer: a double-edged sword with therapeutic potential by Long Liu, Siying Zhang, Yuqing Ren, Ruizhi Wang, Yuyuan Zhang, Siyuan Weng, Zhaokai Zhou, Peng Luo, Quan Cheng, Hui Xu, Yuhao Ba, Anning Zuo, Shutong Liu, Zaoqu Liu, Xinwei Han

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Chaperone-Mediated Responses and Mitochondrial–Endoplasmic Reticulum Coupling: Emerging Insight into Alzheimer’s Disease by Manish Kumar Singh, Minghao Fu, Sunhee Han, Jyotsna S. Ranbhise, Wonchae Choe, Sung Soo Kim, Insug Kang

“…This review focuses on the relationship between stress chaperone responses and organelle function, particularly the interaction between mitochondria and the ER, in the development of new therapies for AD and related neurodegenerative disorders.…”
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Virtual stressors with real impact: what virtual reality-based biobehavioral research can teach us about typical and atypical stress responsivity by Elizabeth A. Shirtcliff, Tor T. Finseth, Eliot H. Winer, David C. Glahn, Roselynn A. Conrady, Stacy S. Drury

“…Binary thinking about whether something is (not) real has stifled advances in understanding how to measure the dosage of a stressful environment. As a function of being programmed, individualizable, and titrated, virtual reality (VR) based stressors offer the field a platform for quantifying the dose of a stressor and generating reliable dose-response curves. …”
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Pathogenesis of Cardiac Depression in Acute Destructive Pancreatitis by A. V. Ershov, V. T. Dolgikh, O. V. Korpacheva, V. V. Rusakov, N. I. Taran, N. S. Gritsenko

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Media Matters: How Information Release Shapes Monkeypox Vaccination Willingness by Huan Wang, Nan Wu

“…Despite the growing body of evidence addressing the reasons behind vaccine hesitancy, the positive role of media as a key environmental factor influencing vaccination, as well as its function in publicizing and encouraging vaccination, has been less thoroughly explored. …”
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Construction of Integrated Platform for Eco-Sustainable Tourism and Marketing in Southeast Asia Based on Machine Learning by Yi-Tui Chen, Yi-Min Li, Tzu-Wen Tseng

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Health systems governance, shocks and resilience: a scoping review of key concepts and theories by Mauricio Avendano, Didier Wernli, Stéfanie Monod, Camille Poroes, Giulia Belloni, Nolwenn Bühler

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Structure and distribution of gynaecological diseases for girls and teenage girls in the Zaporizhzhia area by N. V. Avramenko, O. V. Kabachenko, T. O. Tsaruk

“…Girls of pubertal age should become mothers of new generation, but the health of adolescents continues to deteriorate. …”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).MethodsThis study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. …”
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Actionable Wearables Data for the Neurology Clinic: A Proof‐of‐Concept Tool by Nicolette Miller, Ebenezer Chinedu‐Eneh, Jaeleene Wijangco, Kyra Henderson, Nikki Sisodia, Narender Sara, Jennifer Reihm, Shane Poole, Jim Rowson, Chu‐Yueh Guo, Jeffrey M. Gelfand, Valerie J. Block, Riley Bove

“…In multiple sclerosis (MS), monitoring step count and sleep is feasible, valid, and offers a holistic glimpse of patient functioning and worsening. However, data generated from wearables are typically unavailable at the point of care. …”
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Co-Design of a Health Screening Program Fact Sheet by People Experiencing Homelessness and ChatGPT: Focus Group Study by Nóra Radó, Orsolya Németh, Sándor Békási

“…Moreover, the involvement of generative AI technology revealed that the participants have heard about the concept of AI and text generation as a potential function, and they have not rejected its use in health care settings.…”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

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Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts by Liqi Wei, Xin Liu, Yuanqiang Li, Yu Han, Yiping Ren, Tianshu Zou, Pengcheng Yu, Yining Chen, Biao Zhang, Zixuan Wang, Jingyi Jiang, Yumi Kim, Rui Chen, Yan Cheng, Hongxia Ma

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