Development and content validation of a financial and functional outcomes tool for diabetes-related foot disease in patients undergoing major lower limb amputation: a prospective o... by Sadaf Khan, Nadeem Ahmed Siddiqui, Muhammad Anees Khaliq, Muhammad Ammar Pirzada, Ziaur Rehman, Fareed Shaikh, Amna Riaz

“…Objective To develop and content validate a questionnaire to assess the financial and functional impact of major lower limb amputation in patients with diabetes-related foot disease.Design Prospective observational study.Setting This study was conducted at a tertiary care centre in Pakistan.Participants We conducted a thorough literature review and a group interview with 10 participants, resulting in domain identification and item generation. …”
Get full text

Emberger Syndrome – A Family History Over 3 Generations by Laura Rüegsegger, Urs Schanz, Katja Seipel, Thomas Pabst, Jürg Schwegler, Elisabeth Schmidt, Adrian Schmidt

“…# Introduction Haploinsufficiency of _GATA2_ leads to impaired genesis and function of hematopoietic stem and progenitor cells, resulting in impairment of all subsequent blood cell lineages. …”
Get full text

Development of a Fifteen-Minute City Index Using Walkability Scores and Age-Classified Population: The Case of Pasig City, Metro Manila, Philippines by Carlo Angelo R. Mañago, Marielle G. Nasalita, Cesar V. Saveron, Ynah Andrea D. Sunga, Alexis Richard C. Claridades

“…In the case of Pasig City, social function service areas were generated in terms of walkability and walking speeds per age group. …”
Get full text

Instantaneous EEG Signal Analysis Based on Empirical Mode Decomposition Applied to Burst-Suppression in Propofol Anaesthesia by G. Sobolova, M. S. Fabus, M. Fischer, M. Drobny, B. Drobna-Saniova

Get full text

Development and usability testing of an integrated geriatric care model (SMART system) to promote integrated home-based geriatric care by Rongrong Guo, Huan Fan, Shuqin Xiao, Ziling Zheng, Fangyu Yang, Yanyan Xiao, Xue Yang, Ying Wu

“…The personalized interventions and implementation approaches generated by the SMART system, after being reviewed and adjusted by professional geriatric nurses, will be sent to the corresponding care providers to facilitate coordinated care services. …”
Get full text

Next-generation carbon nanotube electrochemical sensors for liquid biopsy applications by Samuel Rantataro, Eero Gustafsson, Ilkka Varjos

“…Contrasting that, we report the development of a highly-sensitive electrochemical sensor assay, which is based on pristine carbon nanotube (CNT) electrodes functionalized with casein blocking layer and sequence-specific probes for ctDNA. …”
Get full text

Chlamydophila psittaci pneumonia followed by lower gastrointestinal ischemic necrosis: a case report by Shifeng Shao, Jun Liu, Zhenbing Wu, Shasha Wu

Get full text

The Knowledge of Caregivers About Care for People Living With Dementia and Its Associations in Nursing Homes and Home Care—A Quantitative Study by Sabien Johanna Everdina Bosman, Marlijn Abbink, Marleen Hermien Lovink, Anke Persoon

“…ABSTRACT Aim This study is intended to generate insight into the knowledge possessed by formal caregivers in the Netherlands about care for people living with dementia. …”
Get full text

Short-Term Effects of Strengthening Exercises of the Lower Limb Rehabilitation Protocol on Pain, Stiffness, Physical Function, and Body Mass Index among Knee Osteoarthritis Partici... by Muhammad Tariq Rafiq, Mohamad Shariff A. Hamid, Eliza Hafiz

“…Fifty overweight or obese participants with knee OA were randomly divided into two groups by a computer-generated number. Participants in the rehabilitation protocol group (RPG) were provided with leaflets explaining the strengthening exercises of the LLRP and instruction of daily care (IDC), while the participants in the control group (CG) were provided with leaflets explaining the IDC only for a duration of four weeks. …”
Get full text

Evaluating Social Assistive Robots in Clinical Nursing Care: Mixed Method Pilot Study on Health Care Workers’ Perceptions and Adoption by Janika Leoste, Kadi Lubi, Kristel Marmor, Katrin Kangur

“…However, actual use would need proper emotional adequacy from the robot and aligning its functionalities with specific care needs. The future studies need to examine long-term impacts on care quality and job satisfaction, and also strategies to address generational differences and technophobia among health care staff. …”
Get full text

Use of Technology to Support Health Care Providers Delivering Care in Low- and Lower-Middle-Income Countries: Systematic Umbrella Review by Adam Craig, Harriet Lawford, Maggie Miller, Liuyi Chen-Cao, Leanna Woods, Siaw-Teng Liaw, Myron Anthony Godinho

“…Digital health innovations (DHIs) promise more efficient and equitable health care delivery. However, their implementation often outpaces the generation of evidence supporting their effectiveness, resulting in fragmented projects that are poorly aligned with local system needs. …”
Get full text

Next-Generation Cancer Treatment: Photoimmunotherapy’s Promise for Unresectable Head and Neck Cancers by Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher

Get full text

Efficacy of Combined High-Intensity Laser Therapy and Collagenase Chemonucleolysis in Lumbar Disc Herniation Management: a Prospective Randomized Controlled Trial by Peng Song, Chao Ma, Chenchen Xu, Yongjun Zhang, Yan Yuan

“…Conclusions Our findings demonstrate that high-intensity laser therapy augmentation of collagenase chemonucleolysis significantly improves early postoperative pain and functional outcomes in patients with lumbar disc herniation. …”
Get full text

Ampicillin treatment in persister cell studies may cause non-physiological artifacts by Michel Fasnacht, Hena Comic, Isabella Moll

“…Considering the increasing number of moonlighting functions described for ribosomal proteins, we investigated a potential regulatory role of tL2 in persister cells after ampicillin treatment. …”
Get full text

Generation of Spatial Structure of Urban Parks Based on Spatial Analysis of Agent-Based Models by Huizi KONG, Tianming LIU, Jiajie LIAO, Liu CUI

“…This research employs agent-based models (ABM) to simulate spatial information and explore the spatial function distribution of planned sites under urban spatial function penetration, thereby guiding the structural morphology of scheduled sites.MethodsThis research adopts a spatial network analysis design method using slime mold intelligence based on mapping point of interest (POI) data. …”
Get full text

STAGER checklist: Standardized testing and assessment guidelines for evaluating generative artificial intelligence reliability by Jinghong Chen, Lingxuan Zhu, Weiming Mou, Anqi Lin, Dongqiang Zeng, Chang Qi, Zaoqu Liu, Aimin Jiang, Bufu Tang, Wenjie Shi, Ulf D. Kahlert, Jianguo Zhou, Shipeng Guo, Xiaofan Lu, Xu Sun, Trunghieu Ngo, Zhongji Pu, Baolei Jia, Che Ok Jeon, Yongbin He, Haiyang Wu, Shuqin Gu, Wisit Cheungpasitporn, Haojie Huang, Weipu Mao, Shixiang Wang, Xin Chen, Loïc Cabannes, Gerald Sng Gui Ren, Iain S. Whitaker, Stephen Ali, Quan Cheng, Kai Miao, Shuofeng Yuan, Peng Luo

Get full text

consHLA: a next generation sequencing consensus-based HLA typing workflow by Rachel Bowen-James, Weilin Wu, Marie Wong-Erasmus, Julian M. W. Quinn, Chelsea Mayoh, Mark J. Cowley

“…Abstract Background Human Leukocyte Antigens (HLA) play central roles in histocompatibility and immune system functions, including antigen presentation. Accurate typing of Class I and II HLA genes is crucial for transplant tissue matching, characterising autoimmune diseases and informing cancer immunotherapy. …”
Get full text

Summarizing Online Patient Conversations Using Generative Language Models: Experimental and Comparative Study by Rakhi Asokkumar Subjagouri Nair, Matthias Hartung, Philipp Heinisch, Janik Jaskolski, Cornelius Starke-Knäusel, Susana Veríssimo, David Maria Schmidt, Philipp Cimiano

“…ConclusionsTaken together, our results suggest that state-of-the-art pretrained language models are a valuable tool to provide qualitative insights about the patient experience to better understand unmet needs, patient priorities, and how a disease impacts daily functioning and quality of life to inform processes aimed at improving health care delivery and ensure that drug development focuses more on the actual priorities and unmet needs of patients. …”
Get full text

Dynamic URP: Revisiting Urethral Retro-Resistance Pressure for Contemporary Sphincter-Targeted Therapy by Nicole Fleischmann

“…ΔURP has the potential to revive and repurpose a once-abandoned method into a clinically actionable biomarker for next-generation continence care.…”
Get full text

A Survey of 5G Core Network User Identity Protections, Concerns, and Proposed Enhancements for Future 6G Technologies by Paul Scalise, Michael Hempel, Hamid Sharif

“…In this paper, we explore the 5G specifications to understand the most important list of identifiers and their use across Virtual Network Functions (VNF), and points of exposure within the Core Network (CN). …”
Get full text