Clinical effectiveness of a child-specific dynamic stretching programme, compared to usual care, for ambulant children with spastic cerebral palsy (SPELL trial): a parallel group r... by Tim Theologis, Daniel C. Perry, Ines Rombach, David J. Keene, Ioana R. Marian, Morag Andrew, Catherine Barry, Loretta Davis, Gregory Firth, Heidi Fletcher, Beth Fordham, Vivi Gregory Osborne, Helen Gregory Osborne, Lesley Katchburian, Joanna O'Mahoney, Jeremy R. Parr, Rachel Rapson, Jennifer Ryan, Fema Er, Megan Stone, Helen Wood, Sally Hopewell

“…Participants (n = 334) will be randomized (centralized computer-generated one:one allocation ratio) to either: 1) a dynamic stretching exercise programme, with six one-to-one physiotherapy sessions over 16 weeks; or 2) usual NHS care, with a single physiotherapy session and an assessment, and advice regarding self-management and exercise. …”
Get full text

GLIMPSE: An Ultrafaint ≃105 M⊙ Pop III Galaxy Candidate and First Constraints on the Pop III UV Luminosity Function at z ≃ 6–7 by Seiji Fujimoto, Rohan P. Naidu, John Chisholm, Hakim Atek, Ryan Endsley, Vasily Kokorev, Lukas J. Furtak, Richard Pan, Boyuan Liu, Volker Bromm, Alessandra Venditti, Eli Visbal, Richard Sarmento, Andrea Weibel, Pascal A. Oesch, Gabriel Brammer, Daniel Schaerer, Angela Adamo, Danielle A. Berg, Rachel Bezanson, Rychard Bouwens, Iryna Chemerynska, Adélaïde Claeyssens, Miroslava Dessauges-Zavadsky, Anna Frebel, Damien Korber, Ivo Labbe, Rui Marques-Chaves, Jorryt Matthee, Kristen B. W. McQuinn, Julian B. Muñoz, Priyamvada Natarajan, Alberto Saldana-Lopez, Katherine A. Suess, Marta Volonteri, Adi Zitrin

“…Detecting the first generation of stars, Population III (Pop III), has been a long-standing goal in astrophysics, yet they remain elusive even in the JWST era. …”
Get full text

Arteriovenous cerebral high-flow shunts: genetic analysis of patients from a pediatric tertiary care center by Ferruccio Romano, Patrizia De Marco, Giulia Amico, Marisa Mallamaci, Marco Pavanello, Gianluca Piatelli, Marcello Scala, Federico Zara, Federico Zara, Federico Zara, Federico Zara, Federico Zara, Francesca Faravelli, Mariasavina Severino, Mariasavina Severino, Domenico Tortora, Domenico Tortora, Francesco Pasetti, Lucio Castellan, Silvia Buratti, Silvia Buratti, Silvia Buratti, Valeria Capra

Get full text

Prognostic value of the Naples Prognostic Score in adult chronic obstructive pulmonary disease: NHANES 2005–2018 by Yue Kang, Yue Kang, Yingjian Tan, Yongxin Tie, Yujing Zhang, Chenyu Cui, Yuanyuan Zhao

Get full text

Clinical effectiveness of an individually tailored strengthening programme, including progressive resistance exercises and advice, compared to usual care for ambulant adolescents w... by Sally Hopewell, David J. Keene, Ioana Marian, Daniel C. Perry, Ines Rombach, Morag Andrew, Catherine Barry, Loretta Davis, Gregory Firth, Heidi Fletcher, Beth Fordham, Vivi Gregory Osborne, Helen Gregory Osborne, Lesley Katchburian, Joanna O'Mahoney, Jeremy Parr, Rachel Rapson, Jennifer Ryan, Elnaz Saeedi, Megan Stone, Helen Wood, Tim Theologis

“…Participants (n = 334) will be randomized (centralized computer-generated 1:1 allocation ratio) to either: 1) a progressive resistance exercise programme, with six one-to-one physiotherapy sessions over 16 weeks; or 2) usual NHS care, with a single physiotherapy session and an assessment session, and advice regarding self-management and exercise. …”
Get full text

HLA antibodies and their value during renal transplantation by M. Sh. Khubutia, N. V. Borovkova, R. V. Storozhev, N. V. Doronina, M. V. Storozheva, A. S. Pertsev, A. V. Pinchuk

Get full text

Advancing the understanding, measurement and monitoring of healthy ageing: A systematically derived framework and dataset mapping associated constructs, measures and measurement ap... by Andreea Alexandra Piriu, Maria Vittoria Bufali, Giulia Cappellaro, Amelia Compagni, Aleksandra Torbica

Get full text

Impact of genetic test interpretation on a VPS13B missense variant in Cohen syndrome by Gudrun Schottmann, Carmen Martínez Almudéver, Julia C. M. Knop, Eun Kyung Suk, Zianka Meyer, Jürgen Kohlhase, Nastassja Himmelreich, Nastassja Himmelreich, Jirko Kühnisch, Jirko Kühnisch, Claus-Eric Ott, Wenke Seifert

“…CS is predominantly caused by rare homozygous or compound heterozygous pathogenic variants in the vacuolar protein sorting-associated 13B (VPS13B) gene, which disrupt protein translation and lead to a loss of function (LoF) of the encoded VPS13B protein.MethodsThe widespread incorporation of next-generation sequencing approaches in genetic diagnostics increases the number of individuals carrying VPS13B mutant alleles. …”
Get full text

Using computer-generated protein models to analyze mutations linked to Amelogenesis Imperfecta. by Nazlee Sharmin, Jerald Yuan, Ava K Chow

“…Knowledge of 3D protein structure is essential to studying protein function. However, crystallized complete protein structures related to teeth and oral development are rare in the Protein Data Bank. …”
Get full text

Functional Imaging of Liver Cancer (FLIC): Study protocol of a phase 2 trial of 18F-DCFPyL PET/CT imaging for patients with hepatocellular carcinoma. by Esther Mena, Joanna Shih, Joon-Yong Chung, Jennifer Jones, Atoosa Rabiee, Cecilia Monge, Baris Turkbey, Liza Lindenberg, Kilian E Salerno, Michael Kassin, Brad Wood, Jonathan Hernandez, Roberto Maass-Moreno, Babak Saboury, Neha Jakhete, Jason K Molitoris, Keith R Unger, Peter L Choyke, Freddy E Escorcia

“…The purpose of this Functional Imaging Liver Cancer (FLIC) trial is to assess the ability of 18F-DCFPyL-PET/CT to detect sites of HCC.…”
Get full text

A multidisciplinary and structured approach for comprehensive evaluation of functional outcomes, adverse events, psychosocial outcomes and health-related quality of life after loca... by Leonie G. Tigelaar, Lianne M. Haveman, Willem P. Bekkering, Irene L. B. Oude Lansink, Christel D. Rohrich, Hinke Van der Hoek, Laura R. Beek, Jennifer Van Dijk, Marjolein E. M. Langemeijer, Relinde W. Slooff-Lentink, Alied M. Van der Aa-Van Delden, Heleen Maurice-Stam, Annemarie M. L. Peek, Helena J. H. Van der Pal, Maria M. W. Koopman, Leontien C. M. Kremer, Stijn J. Westerbos, Harm Van Tinteren, Jos A. M. Bramer, Jos A. M. Bramer, Michiel A. J. Van de Sande, Michiel A. J. Van de Sande, Martha A. Grootenhuis, Hendrik W. B. Schreuder, Hendrik W. B. Schreuder, Johannes H. M. Merks, Johannes H. M. Merks

“…Assessments are structured by standardized assessment sets that we developed based on literature review and joint national expertise in bone sarcoma care. The sets comply with international guidelines such as the World Health Organization's International Classification of Functioning, disability and health, and include a combination of patient-reported, clinician-reported and performance-based outcome measures for comprehensive representation of outcomes.DiscussionThis study will generate valuable knowledge on the functional outcomes, adverse events, psychosocial outcomes and quality of life of a national cohort of pediatric bone sarcoma patients in follow-up care. …”
Get full text

Smartphone tests quantify lower extremities dysfunction in multiple sclerosis by Kimberly Jin, Peter Kosa, Bibiana Bielekova

“…IntroductionIncreasing shortage of neurologists compounded by the global aging of the population have translated into suboptimal care of patients with chronic neurological diseases. …”
Get full text

La fecundidad en la ciudad de Rosario, Argentina: proyecciones y retroproyecciones de la tasa global de fecundidad y las tasas específicas de fecundidad by Lucía Andreozzi, Nora Ventroni

Get full text

Health Care for the Elderly People by María Aveiga Hidalgo, Clara Elisa Pozo Hernández, Olga Mireya Alonzo Pico, Erika León León

“…<strong>Background:</strong> during the aging process, biological, psychological changes and in the social role of the individual are generated, conditions that require special care. <br /><strong>Objective:</strong> to identify the current situation of health care offered by the staff of the San Juan Pablo II Daytime Gerontological Center in Azaya-Ibarra. …”
Get full text

Development of a 1.0 KVA Fuelless Generator by Blessing Ngozi Goodluck Aliemeke, Munirat Abdullawal Momoh, Mercy Onoshioze Asekhome, Christian Azuka Anani, Afoke Chief Vincent

“…Comprehensive performance testing validated the functionality and reliability of the developed generator under various load conditions. …”
Get full text

E-cigarettes: An Emerging Threat to the Respiratory Health of Our Next Generation by Caitlin Hon Ning Yeung

Get full text

Comparison of predicted and actual dermatitis generated from computed tomography images and dose distribution maps by Yasuhide Miyabe, Saori Oshiro, Hiroto Seki, Yusuke Muroi, Eriko Kawashima, Megumi Hosoda, Kento Ohashi, Hiromu Yamanaka, Mingliang Shao, Hiromi Sugawara, Jyunetsu Mizoe, Ritsuko Komaki

Get full text

Exosome may be the next generation of promising cell-free vaccines by Zelan Dai, Ruiru Cai, Hong Zeng, Hailian Zhu, Youwei Dou, Shibo Sun

Get full text

Characterization of human living myocardial slices culture-induced adaptations: a translational perspective by Jort S.A. van der Geest, Ernest Diez Benavente, Willem B. van Ham, Pieter A. Doevendans, Linda W. van Laake, Teun P. de Boer, Vasco Sampaio-Pinto, Joost P.G. Sluijter

“…This study aims to characterize adaptations occurring in human living myocardial slices (LMS) during ex vivo culture.During culture, LMS demonstrated progressive enhancements in contractile function including stronger force generation, reduced diastolic tension, and faster contraction-relaxation kinetics. …”
Get full text

Editorial: Empowering suicide prevention efforts with generative AI technology by Inbar Levkovich, Zohar Elyoseph, Sean Lauderdale, Gunther Meinlschmidt, Gunther Meinlschmidt, Bénédicte Nobile, Bénédicte Nobile, Dorit Hadar Shoval, Yossi Levi-Belz, Shiri Shinan-Altman, J. P. Grodniewicz

Get full text