Lactylation-driven TNFR2 expression in regulatory T cells promotes the progression of malignant pleural effusion by Yao Liu, Qiong Zhou, Siyu Zhang, Wenbei Peng, Haolei Wang, Xuan Xiang, Linlin Ye, Xiaoshan Wei, Zihao Wang, Qianqian Xue

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518 Modeling of cancer mutations found in pediatric DICER1 syndrome informs novel therapeutic targeting strategies by David Jee, Seungjae Lee, Dapeng Yang, Robert Rickert, Renfu Shang, Danwei Huangfu, Eric C. Lai

“…Objectives/Goals: Large-scale tumor sequencing efforts have led to annotations of novel cancer hotspot mutations that may underlie driver or cooperative function. We have sought to define the molecular consequences of such hotspots associated with pediatric DICER1 syndrome cancers, with the ultimate goal of revealing novel targets that may inform new standards of care. …”
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Living with, managing and minimising treatment burden in long term conditions: a systematic review of qualitative research. by Sara Demain, Ana-Carolina Gonçalves, Carlos Areia, Rúben Oliveira, Ana Jorge Marcos, Alda Marques, Ranj Parmar, Katherine Hunt

“…<h4>Background</h4>'Treatment burden', defined as both the workload and impact of treatment regimens on function and well-being, has been associated with poor adherence and unfavourable outcomes. …”
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Clinical and cost-effectiveness of non-medical prescribing: A systematic review of randomised controlled trials. by Timothy Noblet, John Marriott, Emma Graham-Clarke, Debra Shirley, Alison Rushton

“…Measurements reported on one or more outcome(s) of: pain, function, disability, health, social impact, patient-safety, costs-analysis, quality adjusted life years (QALYs), patient satisfaction, clinician perception of clinical and functional outcomes.…”
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Cellpose as a reliable method for single-cell segmentation of autofluorescence microscopy images by Jeremiah M. Riendeau, Amani A. Gillette, Emmanuel Contreras Guzman, Mario Costa Cruz, Aleksander Kralovec, Shirsa Udgata, Alexa Schmitz, Dustin A. Deming, Beth A. Cimini, Melissa C. Skala

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Carbon monoxide as a cellular protective agent in a swine model of cardiac arrest protocol. by John C Greenwood, Ryan W Morgan, Benjamin S Abella, Frances S Shofer, Wesley B Baker, Alistair Lewis, Tiffany S Ko, Rodrigo M Forti, Arjun G Yodh, Shih-Han Kao, Samuel S Shin, Todd J Kilbaugh, David H Jang

“…Out-of-hospital cardiac arrest (OHCA) affects over 360,000 adults in the United States each year with a 50-80% mortality prior to reaching medical care. Despite aggressive supportive care and targeted temperature management (TTM), half of adults do not live to hospital discharge and nearly one-third of survivors have significant neurologic injury. …”
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DNA dioxygenase TET2 deficiency aggravates sepsis-induced acute lung injury by targeting ITGA10 via the PI3K/AKT signaling pathway by Hongxue Fu, Bin Gao, Xin Zhou, Yingting Hao, Chang Liu, Ailin Lan, Jingyi Tang, Fachun Zhou

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Lysophospholipid metabolism, clinical characteristics, and artificial intelligence-based quantitative assessments of chest CT in patients with stable COPD and healthy smokers by Qiqiang Zhou, Lvxinhe Xing, Mi Ma, Bianba Qiongda, Deyuan Li, Ping Wang, Yahong Chen, Ying Liang, Meilang ChuTso, Yongchang Sun

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Assessment of frontal EEG measurement in out-of-hospital cardiac arrest: a prospective observational feasibility study – study protocol by Paul Zajic, Alexander Pichler, Michael Eichinger, Michael Eichlseder, Philipp Zoidl, Alexander C Reisinger, Simon Orlob, Stefan Hatzl, Anna Eberl, Thomas Kuenzer, Lioba Heuschneider, Gabriel Honnef, Martin Rief, Helmar Bornemann-Cimenti

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Prognostic predictions in psychosis: exploring the complementary role of machine learning models by Metten Somers, Hugo G Schnack, Rene S Kahn, Diane F van Rappard, Frank L Gerritse, Edwin van Dellen, Violet van Dee, Seyed M Kia, Caterina Fregosi, Wilma E Swildens, Anne Alkema, Albert Batalla, Coen van den Berg, Danko Coric, Lotte G Dijkstra, Arthur van den Doel, Livia S Dominicus, John Enterman, Marte Z van der Horst, Fedor van Houwelingen, Charlotte S Koch, Lisanne E M Koomen, Marjan Kromkamp, Michelle Lancee, Brian E Mouthaan, Eline J Regeer, Raymond W J Salet, Jorgen Straalman, Marjolein H T de Vette, Judith Voogt, Inge Winter-van Rossum, Wiepke Cahn

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Epidemiology and hospitalization costs of chronic kidney disease in Romania by Ildiko Aliz Bradacs, László-István Bába, László Lorenzovici, Andreea Mihaela Precup, Szabolcs Farkas- Ráduly, Gyongyi Tar, Vasile Nastase, Lucia Georgeta Daina, Raul Bozu, Gyula Jozsef Nagy, Dimitrie Cristian Siriopol, Dorel Sandesc, Ovidiu Horea Bedreag, Florin Buicu, Gabriel Mircescu, Gener Ismail

“…KDIGO severity grades 1-5 were considered, including dialysis costs. The costs generated by the chronic care of RRTs were not considered here. …”
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Postgraduate Students Perception of Using Chatgpt in Clinical Management and Research: A Qualitative Exploratory Study by Muhammad Shah, Shimee Shahzadi, Shehzad Akbar Khan

“… OBJECTIVES This study investigated how postgraduate residents see ChatGPT's function in clinical and research settings. METHODOLOGY May 1, 2024, to September 30, 2024, was the time frame for this research. …”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).MethodsThis study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. …”
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Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population by Yamei Zheng, Jie Zhao, Meihua Liu, Yunchan Liu, Yipeng Ding, Tian Xie

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Global projections of heat stress at high temporal resolution using machine learning by P. Georgiades, P. Georgiades, T. Economou, T. Economou, Y. Proestos, J. Araya, J. Lelieveld, J. Lelieveld, M. Neira

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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

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Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis by Lin Xie, Fei Xue, Cheng Cheng, Wenhai Sui, Jie Zhang, Linlin Meng, Yue Lu, Wenjing Xiong, Peili Bu, Feng Xu, Xiao Yu, Bo Xi, Lin Zhong, Jianmin Yang, Cheng Zhang, Yun Zhang

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Identification of passive wrist-worn accelerometry outcomes for improved disease monitoring and trial design in motor neuron diseaseResearch in context by Cory J. Holdom, Rakesh Pilkar, Christine C. Guo, Ruben P.A van Eijk, Nadia Sethi, Robert D. Henderson, Shyuan T. Ngo, Frederik J. Steyn

“…Summary: Background: Motor neuron disease (MND) leads to progressive functional decline, making reliable measures of disease progression critical for patient care and clinical trials. …”
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Pathogenesis and current status of the treatment of lung cancer associated with idiopathic pulmonary fibrosis by Yuanyuan Zhang, Chang Qi, Qi Wei, Yalun Li, Panwen Tian

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Organoid: Biomedical application, biobanking, and pathways to translation by Aprajita Sinha, Maheshree Maibam, Ronit Jain, Kalash Aggarwal, Asish Kumar Sahu, Pawan Gupta, Sayan Paul, Bharti Bisht, Manash K. Paul

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