The M3 muscarinic receptor is required for optimal adaptive immunity to helminth and bacterial infection. by Matthew Darby, Corinna Schnoeller, Alykhan Vira, Fiona Jane Culley, Saeeda Bobat, Erin Logan, Frank Kirstein, Jürgen Wess, Adam F Cunningham, Frank Brombacher, Murray E Selkirk, William G C Horsnell

“…Ex vivo lymphocyte stimulation of cells from intact BALB/c mice infected with N. brasiliensis and S. typhimurium with muscarinic agonists resulted in enhanced production of IL-13 and IFN-γ respectively, which was blocked by an M3R-selective antagonist. Our data therefore indicate that cholinergic signalling via the M3R is essential for optimal Th1 and Th2 adaptive immunity to infection.…”
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Design and Simulation of an Ultrahigh-resolution Spectral-domain Optical Coherence Tomography by Mohammad Hossein Vafaie, Maryam Ansarian, Hossein Rabbani

“…At fourth, the most important requirements of a UHR SD-OCT are explained, where suitable optical equipment is selected for each arm based on these requirements. …”
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Two-year-olds’ visual exploration of response options during memory decisions predicts metamemory monitoring one year later by Sarah Leckey, Diana Selmeczy, Simona Ghetti

“…Overall, this research reveals potential building blocks of emerging metamemory monitoring.…”
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Covariance Structures in Conventional and Organic Cropping Systems by Abdullah A. Jaradat

“…Guidelines are needed to develop proper statistical analyses procedures and select appropriate models of covariance structures in response to expected temporal variation in long-term experiments. …”
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Modern opportunities of therapeutic treatment of allergic conjunctivitis. A review by D. Yu. Maychuk

“…In contrast to previous antihistamines, levocabastine blocks vasodilatation and reduces vascular permeability increase. …”
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Research on key technologies of safety monitoring data sharing for railway engineering construction based on blockchain by Yuhong LIU, Liang YANG, Chunhui PIAO, Zhiguo ZHANG

“…In order to solve the problems that the monitoring data was easy to be tampered with in the process of railway engineering construction safety monitoring, and the authenticity of the data might be questioned during the accountability of accidents, a blockchain-based railway engineering construction safety monitoring data sharing model was proposed.The characteristics of automatic execution of smart contracts ensured the transparency of the process of monitoring data on the chain.In the PBFT algorithm, there was a problem that the Byzantine nodes and the normal nodes were selected as the master node with the same probability, a reputation-based practical Byzantine fault tolerance algorithm was proposed.Streaming data on the chain might cause network congestion, which simplified the consensus protocol and reduced the time complexity from O(n²) to O(n).A comparative experiment was conducted using Hyperledger Caliper to prove that the delay of the improved algorithm is lower than PBFT algorithm, and the throughput is higher than PBFT algorithm.A quantitative analysis of the possibility of attack and the probability of successful attack was carried out, and it was determined that the smart contract provides tamper-proof modification for the monitoring data on the chain.Comparative analysis proves that the proposed blockchain-based railway engineering construction safety monitoring data sharing model is good than other models in terms of consensus efficiency, TPS and block generation speed.…”
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Improving Productivity and fruit Quality of Barhee date Palm by Foliar Application of GA3 and NAA by Samy El-Kosary, Ayman Shabaan, AbdelRahamn Haseeb

“… The field experiment was designed to evaluate tested treatments to select which suitable treatment should be recommended to be used for Barhee date palm trees grown at Alexandria desert road near El-Sadat city, Egypt. …”
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Using of Dual Laterolog to detect fracture parameters for Nubia Sandstone Formation in Rudeis-Sidri area, Gulf of Suez, Egypt by Tarek F. Shazly, Elhamy Tarabees

“…The unfractured parts of the block matrix in hard rocks are slightly affected by invasion. …”
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The genesis of Mordenite occurrences: Diagenetic and hydrothermal alteration processes of Paleocene volcanics in Ilıca (Yıldızeli), Türkiye by Hülya Ateş

“…The Yıldızeli region, located south of the İzmir-Ankara-Erzincan suture zone and northeast of the Kırşehir block, is significant for its mineral deposits. This area consists of Paleocene-Miocene volcano-sedimentary units. …”
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Veratridine Induces Vasorelaxation in Mouse Cecocolic Mesenteric Arteries by Joohee Park, Christina Sahyoun, Jacinthe Frangieh, Léa Réthoré, Coralyne Proux, Linda Grimaud, Emilie Vessières, Jennifer Bourreau, César Mattei, Daniel Henrion, Céline Marionneau, Ziad Fajloun, Claire Legendre, Christian Legros

“…The vegetal alkaloid toxin veratridine (VTD) is a selective voltage-gated Na⁺ (Na_V) channel activator, widely used as a pharmacological tool in vascular physiology. …”
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Formation of a set of indicators to assess the effectiveness of functioning of urban public passenger transport by Yuliya А. Koleber, Sergey М. Mochalin

“…Based on the results of the study, a fairly complete set of indicators was formed and grouped into enlarged blocks for each of the system participants: for the passenger, for the carrier, for the customer of transport services. …”
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A spatiotemporal model for urban taxi Origin–Destination prediction based on Multi-hop GCN and Hierarchical LSTM by Jiang Rong, Wangtu Xu, Yanjie Wen

“…HLSTM unit incorporates a standard LSTM gate to manage cell state updates, enabling selective access to the internal memory. So that longer-term information which is only situationally relevant can be accessed selectively. …”
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Preparation of nanoparticle-stabilized foam fracturing fluid and its foam stabilization mechanism by YANG Zhaozhong, ZHENG Nanxin, ZHU Jingyi, LI Xiaogang

“…In order to prove it, the synergistic foam stabilization ability of SNP and five types of surfactants is evaluated, and the optimal foams system is selected based on the foams comprehensive value. The proppant carrying ability, rheology, and stability of the selected foam fracturing fluid system are evaluated, and the performance improvement of the fracturing fluid by SNP is analyzed. …”
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Evaluation and Optimization of Traditional Mountain Village Spatial Environment Performance Using Genetic and XGBoost Algorithms in the Early Design Stage—A Case Study in the Cold... by Zhixin Xu, Xiaoming Li, Bo Sun, Yueming Wen, Peipei Tang

“…This study began by selecting a benchmark model based on simulations of courtyard PET (Physiological Equivalent Temperature) and MRT (mean radiant temperature). …”
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EFFICACY AND TOLERABILITY OF LACOSAMIDE (VIMPAT) FOR TREATMENT OF EPILEPSY IN ADULTS (A REVIEW) by O. A. Pylaeva, K. Yu. Mukhin, M. B. Mironov

“…The assumed action mechanism differs from that of other AEDs: this drug selectively lowers the pathological hyperactivity of neurons without affecting their physiological activity, decreases abnormal epileptogenic neuronal excitability, selectively enhances slow inactivation of sodium channels without affecting rapid inactivation. …”
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FGS-YOLOv8s-seg: A Lightweight and Efficient Instance Segmentation Model for Detecting Tomato Maturity Levels in Greenhouse Environments by Dongfang Song, Ping Liu, Yanjun Zhu, Tianyuan Li, Kun Zhang

“…This study provides a reliable technical solution for the selective harvesting of greenhouse tomatoes.…”
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A Self-Supervised Monocular Depth Estimation Framework Based on Detail Recovery and Feature Fusion by Shun Li, Chongzheng Huang, Xiangzhe Li, Zhengyou Liang

“…Based on the encoder-decoder architecture, EDFNet introduces three key modules: the Adaptive Selective Attention Module (ASAM), the Multi-Dimensional Attention Fusion Module (MDAFM), and the Hybrid Parallel Convolution Block (HPCB). …”
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Comprehensive analysis of 111 Pleuronectiformes mitochondrial genomes: insights into structure, conservation, variation and evolution by Suxu Tan, Wenwen Wang, Jinjiang Li, Zhenxia Sha

“…Therefore, we aim to analyze the genomic structure, codon preference, nucleotide diversity, selective pressure and repeat sequences, as well as reconstruct the phylogenetic relationship using the mitochondrial genomes of 111 flatfish species. …”
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Exploring the health insurance dynamics during the COVID-19 pandemic in Delhi NCR, India by Ruchi Thakur, Mohd Shannawaz, Shazina Saeed, Kavitha Rajsekar

“…A simple random sampling technique was used to select blocks/sectors in the Delhi NCR region and then a systematic sampling method was applied to identify participants for data collection. …”
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Detection of Seed Potato Sprouts Based on Improved YOLOv8 Algorithm by Yufei Li, Qinghe Zhao, Zifang Zhang, Jinlong Liu, Junlong Fang

“…Seed potatoes without sprouts usually need to be manually selected in mechanized production, which has been the bottleneck of efficiency. …”
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