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Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models
Published 2025-04-01“…PSB-172656 is selective for MRGPRX2 versus all other MRGPRX subtypes. …”
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Opioid-free postoperative pain management in total knee and hip arthroplasty: A scoping review
Published 2025-04-01“…Most TKA studies (n = 20) reported use of at least one systemic analgesic and 18 employed postoperative peripheral nerve blocks. Neuraxial analgesia (epidural or spinal block) was the predominant form of postoperative analgesia in THA (n = 10), followed by peripheral nerve blocks (n = 7), and systemic analgesia (n = 7). …”
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A bifunctional catalyst for direct CO2 conversion to clean fuels: Mechanistic insights and a comprehensive kinetic model
Published 2024-12-01“…The pathway involves sequential reactions starting from CO2 adsorption on catalyst sites, followed by successive transformations leading to the formation of hydrocarbon building blocks. Ultimately, a developed MFTS kinetic model based on the MD-evaluated mechanism, which accurately predicts product selectivity across various operational conditions, indicating its robustness and reliability, is presented.…”
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Saccadic Palsy following Cardiac Surgery: Possible Role of Perineuronal Nets.
Published 2015-01-01“…Sections of formalin-fixed paraffin-embedded brainstem blocks were applied to double-immunoperoxidase staining of parvalbumin and three different components of PN. …”
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Preparation and properties of pea-gravel grouting with sodium bentonite for hydraulic shield tunnel
Published 2025-07-01“…A method was developed to simulate the construction process of PGG to cast the blocks with a size of 900 mm×500 mm×250 mm. Using the samples drilled from the blocks, the cylinder specimens with a diameter of 100 mm and a height of 200 mm were manufactured for testing the axial compressive strength and the modulus of elasticity of PGG, while those with a diameter of 170 mm and a height of 150 mm were repaired to be the circular truncated conic specimens for testing the PGG impermeability. …”
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The mitogenome of Triatoma brasiliensis brasiliensis (Hemiptera: Reduviidae), the main Chagas disease vector in the semi-arid region of northeastern Brazil
Published 2025-04-01“…Phylogenetic relationships were inferred using conserved blocks of 13 protein-coding genes and 22 transfer RNA genes. …”
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Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression
Published 2025-01-01“…The inability of rimonabant to block the antidepressant effect of S-KET highlights the complexity of its interaction with the ECS, warranting further investigation into the molecular pathways.…”
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Spinal astrocyte-derived interleukin-17A promotes pain hypersensitivity in bone cancer mice
Published 2024-12-01“…IL-17A overexpression in spinal astrocytes directly induced thermal hyperalgesia and mechanical allodynia, which could be rescued by CaMKIIα inhibitor. Moreover, selective knockdown IL-17RA in spinal Vglut2+ or Vgat+neurons, but not in astrocytes, significantly blocked the bone cancer-induced hyperalgesia. …”
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Effect of N3-Methyladenine and an Isosteric Stable Analogue on DNA Polymerization
Published 2010-01-01“…The toxicity of 3-mA has been attributed to its ability to block DNA polymerization. Using Me-lex, a compound that selectively and efficiently reacts with DNA to afford 3-mA, we have observed in yeast a mutational hotspot at the 5′-terminus of an A4 tract. …”
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Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum.
Published 2025-07-01“…Rocaglamide A (Roc-A), a plant-derived rocaglate, binds the CpeIF4A-RNA-ATP complex with high affinity (Kd = 33.7 nM) and blocks protein synthesis in excysting sporozoites (IC50 ≈ 3.7 µM). …”
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Vedolizumab for inflammatory bowel diseasesI
Published 2018-08-01“…Besides, due to α4β7 integrin heterodimer selectivity of vedolizumab, it provides selective block of intestinal leukocyte migration, without affection of central nervous system therefore the risk of the progressing multifocal leukoencephalopathy is not established. …”
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Enzymatic characterization and polyurethane biodegradation assay of two novel esterases isolated from a polluted river.
Published 2025-01-01“…Interestingly, polluted environments exert selective pressure on native microbial communities that have the metabolic capacity to tolerate and transform different contaminants, including plastics. …”
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Mechanism of μ-conotoxin PIIIA binding to the voltage-gated Na+ channel NaV1.4.
Published 2014-01-01“…The dissociation constants (Kd) computed for two selected binding modes in which Lys9 or Arg14 from the toxin protrudes into the filter of the channel are within 2 fold; both values in close proximity to those determined from dose response data for the block of NaV currents. …”
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Application of chondroprotective agents to inhibit osteodestructive processes in the subchondral bone in patients with osteoarthritis
Published 2022-04-01“…The control sampling included 4,000 articles randomly selected out of 97,331 found by the request “osteoarthritis NOT bone NOT resorption NOT osteopenia NOT osteoporosis” (i.e. publications on OA that do not cover issues of bone metabolism).Results. …”
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Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-ind...
Published 2024-01-01“…We recently developed a reversible, selective, central nervous system penetrant, and orally available MAGL inhibitor, compound 4f. …”
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Multi‐environmental trial and stability study of Ethiopian sesame (Sesamum indicum L.) genotypes at Western Oromia
Published 2025-06-01“…A multi‐environmental yield trial is used to assess genotype‐by‐environment interaction for selecting superior genotypes. The current study was initiated to identify stable and high‐yielding sesame genotypes. …”
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Influence of the quality of compounds on the adhesion properties of metal cord.
Published 2020-06-01“…All methods are based on extracting (pulling) metal cord from a block of vulcanized rubber and fixing the required load. …”
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THE EFFECT OF INOCULATION WITH AZOTOBACTER BACTERIA AND DIFFERENT LEVELS OF NITROGEN FERTILIZER ON 1-VEGETATIVE GROWTH OF POTATO PLANT (Solanum tuberosum L.)
Published 2010-04-01“…Desiree , a factorial randomized complete block design (F.RCBD) was selected for the experimental with three replicates . …”
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Multicast communication protocol based on quantum key distribution against trojan horse attacking
Published 2014-07-01“…In the sending sequence, n are selected randomly as the test states. Channel test is carried out with the inequality of CHSH. …”
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