Finerenone as a therapeutic option for managing chronic kidney disease (CKD) linked to type 2 diabetes (T2D) and his other potential use. A summary of current research findings by Cezary Kubuj, Grzegorz Adaśko, Michał Świda, Jakub Bazarewicz, Urszula Mazur, Marcin Siwik, Daniel Dmowski, Anna Michalska, Paulina Ogonowska, Julia Waszak

“…Finerenone is a non-steroidal selective antagonist that reduces inflammation and fibrosis by blocking MR overactivity in the kidneys, heart, and blood vessels. …”
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Chronic NaAsO2 exposure promotes migration and invasion of prostate cancer cells by Akt/GSK-3β/β-catenin/TCF4 axis-mediated epithelial-mesenchymal transition by Zhi-Hui Zhang, Hai-Xin Yan, Ming-Dong Liu, Feng-Wen Niu, Kai Yao, Shi-Yao Feng, Xi Li, Yuan-Hua Chen, Dong-Dong Xie

“…Mechanically, NaAsO2 promoted GSK-3β inactivation in the ''disruption complex'' through Akt- mediated phosphorylation at serine 9, and then inhibited the phosphorylation and ubiquitination degradation of β-catenin, which led to its nuclear translocation. Ly294002, a selective phosphatidylinositol 3-kinase (PI3K)/Akt inhibitor, suppressed the β-catenin/TCF4 complex activation and EMT through blocking Akt-mediated GSK-3β inactivation in the ''disruption complex'' in chronic NaAsO2 exposed DU145 and PC-3 cells. …”
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Antiplasmodial activity of pentyloxyamide-based histone deacetylase inhibitors against Plasmodium falciparum parasites by Wisam A. Dawood, Gillian M. Fisher, Josefa Kremeyer, Fabian Fischer, Jessica L. Home, Christopher D. Goodman, Kwong Sum Lam, Alexander G. Maier, Thomas Kurz, Katherine T. Andrews

“…The most potent compound (4o) had a P. falciparum IC50 of 20 nM and >250-fold greater selectivity for P. falciparum versus human cells. Compound 4o was also active against exoerythrocytic stage parasites (IC50 24 nM), which are a target for malaria prevention. …”
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Sugammadex versus neostigmine on postoperative adverse respiratory events in elderly patients undergoing lung resection: study protocol for a randomized controlled trial by Yuxin Wang, Xiang Li, Huimin Deng, Di Feng, Liuyuan Zhao, Feihong Lin, Tian Jin, Sheng Wang, Xin Lv, Juan Wei

“…Background Elderly patients undergoing lung resection are particularly susceptible to postoperative adverse respiratory events (AREs), due to age-related physiological decline and a higher incidence of residual neuromuscular blockade (RNMB). Sugammadex is a selective relaxant binding agent that enables rapid and complete reversal of aminosteroid neuromuscular blocking agents such as rocuronium, offering potential advantages over traditional acetylcholinesterase inhibitors like neostigmine. …”
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Electroacupuncture regulates glucose metabolism by inhibiting SGLT1 levels, inhibiting microglial polarization, and alleviating Parkinson's disease by Yanghong Zou, Tao Huang, Ailan Pang, Houjun Zhou, Xin Geng

“…Results: MPTP induced the selective loss of DA neurons in the SN of mice, altered Ca2+ homeostasis, and induced an inflammatory response. …”
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The Evidence Based Participatory Design Process Framework, in Post- Earthquake Permanent Housing Reconstruction Gillan-Zanjan (1990), Varzaghan (2012) and Kermanshah (2017) Earthqu... by Tara Jalali, Alireza Fallahi, Seyyed Gholamreza Islami, Zhaleh Sabernejad

“…This inconsistency and gap together with the lack of proper construction supervision could result in increasing physical vulnerability while blocking the way toward build back better’ goals in the affected areas and communities. …”
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An Atmospheric Bore in North China Plain and Its Impact on Nocturnal Convection by Yao Anqi, Chen Qiying, Hua Wei

“…The depth ration between near-surface light fluid and density current and Froude number of the selected profiles indicate that convection-generated density current intrudes into the nocturnal stable boundary layer, causing a complete blocking flow regime that triggers a type C bore ahead of the convective system. …”
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Design, Synthesis, and Antiproliferative Activity of Novel Indole/1,2,4-Triazole Hybrids as Tubulin Polymerization Inhibitors by Esraa Mahmoud, Dalia Abdelhamid, Anber F. Mohammed, Zainab M. Almarhoon, Stefan Bräse, Bahaa G. M. Youssif, Alaa M. Hayallah, Mohamad Abdel-Aziz

“…<b>Conclusions:</b> The results showed that compound <b>7i</b>, an oxime-based derivative, was the most effective at blocking tubulin, with an IC₅₀ value of 3.03 ± 0.11 µM. …”
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Exploring the Potential of HIV Integrase Inhibitors as Therapeutic Agents Against HSV and HCMV: A Molecular Docking Study by Rao AM, SM F, Somashekara D, Gayam PKR, Rahangdale RR, Patil SS, Hariharapura RC

“…Schrodinger software was used for docking studies, protein–ligand interaction and simulation studies. The selected drugs were screened to analyse their anti- HSV-1 and HSV-2 activities by Cytopathic effect (CPE) inhibition assay and RT-PCR using Vero cells as host. …”
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Dravet syndrome: novel insights into SCN1A-mediated epileptic neurodevelopmental disorders within the molecular diagnostic-therapeutic framework by Guirui Zhang, Guirui Zhang, Shupeng Huang, Mingzhen Wei, Yongmo Wu, Zhengyi Xie, Jin Wang, Jin Wang, Jin Wang

“…Additionally, novel molecules such as the Nav1.1-selective agonist Hm1a and 5HT2BR receptor modulators offer new avenues by remodeling neuronal electrophysiology and neurotransmitter homeostasis. …”
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Results of Water Inflow Elimination in Wells Draining Gas Сondestate Deposits by E. Vaganov, S. Sokhoshko, A. Sarancha, E. Levitina, I. Krasnov, T. Kharitonova

“…At the initial stage of LPW implementation, a water-repellent agent is used, which has selective filterability in the most permeable and watered reservoir intervals. …”
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Sagittal alignment to predict efficiency in pulsed radiofrequency for cervical facet joint pain by Cheng-Yo Yen, Sheng-Min Lin, Hong Yu Chen, Shih-Wei Wang, Yu-Duan Tsai, Cien-Leong Chye, Te-Yuan Chen, Hao-Kuang Wang, Kuo-Wei Wang

“…In the patient selection, clinical and sagittal alignment parameters are rarely discussed for the outcome. …”
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A comprehensive evaluation of deep learning approaches for ground-level ozone prediction across different regions by Guanjun Lin, Hang Zhao, Yufeng Chi

“…Our analysis also identifies the most influential meteorological factors among the top-performing DL models, offering insights for feature selection and optimization in model development. This research contributes to a deeper understanding of the design and selection of appropriate DL architectures for predicting the concentrations of ozone and other air pollutants.…”
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Evaluation of the resistance of the breeding material beetroot to Cercospora amid epiphytoty in greenhouses the Moscow region by E. G. Kozar, S. A. Vetrova, I. A. Engalycheva, M. I. Fedorova

“…When creating resistant to Cercospora interline hybrids based on CMS, the selection of parent components plays an important role. …”
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Development of 89Zr-anti-CD103 PET imaging for non-invasive assessment of cancer reactive T cell infiltration by Danique Giesen, Hans van Eenennaam, Hans W. Nijman, Marco de Bruyn, Arjan Kol, Xiaoyu Fan, Marta A. Wazynska, Sander M.J. van Duijnhoven, Annechien Plat, Philip H. Elsinga

“…For human anti-human CD103 PET development two clones were selected based on strong binding to the CD103+ CD8+ T cell subpopulation in ovarian cancer tumor digests, non-overlapping binding epitopes and differential CD103 blocking properties. …”
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Assessing variability and detecting the effective traits on yield of chickpea (Cicer arietinum L.) promising lines under drought stress condition by Sayyed Saeed Moosavi, Mohammad Reza Abdollahi, Fatemeh Abdi, Homayoun Kanouni

“…In fact, three factors of heredity, high diversity and severity of selection are effective factors in increasing the response to selection. …”
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Genetic diversity and relationships between some agronomic traits of chickpea genotypes (Cicer arietinum L.) under non-stress and terminal drought stress conditions by Maryam Rezaeinia, Mohammad Reza Bihamta, Seyed Ali Peyghambari, Alireza Abbasi, Fatemeh Gharajedaghi

“…Genetic diversity in chick pea collection can be used in breeding program for selection of genotype with desirable agronomic traits. …”
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Segment search for local extremums of images based on the analysis of brightness of adjacent homogeneous areas by V. Yu. Tsviatkou, Anh Tuan Nguyen

“…Morphological search algorithms provide the selection of non-strict extremes, but have a high computational complexity. …”
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Nutritional support as an obligatory component of accompanying therapy for head and neck tumors during radiotherapy and chemoradiotherapy by A. V. Boyko, A. R. Gevorkov, E. E. Volkova, S. V. Shashkov

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Complex for Research and Measurement of Parameters and Characteristics of Radio Technical Facilities by M. S. Svirid

“…The selection of replaceable modules with a given local oscillator frequency makes it possible to provide signal radiation in the microwave and EHF frequency ranges.…”
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