The phosphatase inhibitor BVT-948 can be used to efficiently screen functional sexual development proteins in the malaria parasite Plasmodium berghei by Xitong Jia, Yong Wang, Meilian Wang, Hui Min, Zehou Fang, Haifeng Lu, Jiao Li, Yaming Cao, Lunhao Bai, Jinghan Lu

“…Seven of the 8 genes selected for phenotype screening play roles in P. berghei sexual development, and 4 of these were associated with gametocytogenesis. …”
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Enhanced Acetone-Sensing Performance of a Bilayer Structure Gas Sensor Composed of a ZnO Nanorod Top Layer and a ZnFe₂O₄ Nanoparticle Decorated ZnO Nanorod Bo... by Hao Wu, Huichao Zhu, Jianwei Zhang, Jun Yu, Zhenan Tang, Guanyu Yao, Wenqing Zhao, Guohui Wu, Xia Jin

“…Covering this layer with ZnO nanorods further increased the response by an additional 1.6 times, and simultaneously enhanced the selectivity to acetone. The top layer improves gas sensing performance by introducing heterojunctions with the bottom layer, partially blocking acetone gas at the bottom layer to facilitate a more complete reaction, and filtering ethanol interference.…”
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Saline-alkali soil reclamation and utilization in China: progress and prospects by Guangzhou WANG, Gang NI, Gu FENG, Haley M. BURRILL, Jianfang LI, Junling ZHANG, Fusuo ZHANG

“…This review first summarizes the general principles and technologies of saline soil reclamation to support plant growth, including leaching salts or blocking the rise of salts, and soil fertility enhancement to improve the buffering capacity. …”
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Improved PEG-Based Construction of Analog Fountain Codes by Xue Li, Qin Huang

“…Simulation results indicate that it has good block error rate (BLER) in short block length regime.…”
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A Synoptic- and Remote Sensing-based Analysis of a Severe Dust Storm Event over Central Asia by Parya Broomandi, Kaveh Mohammadpour, Dimitris G. Kaskaoutis, Aram Fathian, Sabur F. Abdullaev, Vladimir A. Maslov, Amirhossein Nikfal, Ali Jahanbakhshi, Bakhyt Aubakirova, Jong Ryeol Kim, Alfrendo Satyanaga, Alireza Rashki, Nick Middleton

“…The prevailing meteorological conditions showed an intensification of air subsidence over eastern Kazakhstan, featured in a typical omega-blocking system over the region and two troughs to its west and east axis, one day before the dust storm. …”
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Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors by Dominika Kołodziej-Sobczak, Łukasz Sobczak, Wojciech Płaziński, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Klaudia Hołub, Barbara Zdzisińska, Karol Jaroch, Barbara Bojko, Krzysztof Z. Łączkowski

“…Moreover, compound 3j was found to be highly selective towards T47D cancer cells. The cellular mechanism of compound 3j action was associated with the inhibition of DNA replication via blocking the S phase of interphase and induction of apoptosis. …”
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Anti-Influenza A Virus Activity of <i>Rhododendron brachycarpum</i> Extract and Identification of Hyperoside as the Active Constituent by Yung Hun Park, Soo Yong Shin, Hayeong Choi, Jae Hyeok Lee, You Jin Kim, Seong Ji Woo, Wonkyun Ronny Im, Sung Ho Jeon

“…Hyperoside, purified via bioactivity-guided fractionation and HPLC analysis, demonstrated potent antiviral activity, with an IC50 of 66.59 μM (30.92 μg/mL) and a CC50 of 318.9 μM (148.1 μg/mL), indicating a favorable selectivity index. It significantly suppressed viral mRNA and protein expression in infected cells. …”
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The Stabilization Mechanism of a Stable Landslide Dam on the Eastern Margin of the Tibetan Plateau, China: Insights from Field Investigation and Numerical Simulation by Liang Song, Yanjun Shang, Yunsheng Wang, Tong Li, Zhuolin Xiao, Yuchao Zhao, Tao Tang, Shicheng Liu

“…Field investigation shows that the Conaxue Co landslide dam was formed by a high-speed long-runout landslide blocking the river, with its structure exhibiting a typical inverse grading pattern characterized by coarse-grained rock overlying fine-grained layers. …”
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How URAT1 inhibitors can shape the future of chronic gout treatment: a narrative review of uricosurics past and present by Robert T. Keenan, Zancong Shen, Shunqi Yan, Li-Tain Yeh, Michael H. Pillinger

“…Newer uricosurics have different chemical structures from their predecessors, resulting in greater URAT1 selectivity in order to reduce off-target effects. Several of these have shown promising results in clinical trials and could prove to be viable alternatives to suboptimal existing therapies. …”
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Prevalence of Depression Symptoms and its related Factors in School Students by Khadijeh Jahangasht, Shahla Asiri, Sedigheh Pakseresht, Ehsan Kazemnejad Leili

“…Using cluster random sampling method, 26 schools and from each class in every school, 24 students were selected. Finally, 624 students, including 322 girls and 302 boys in age range of 6 to 12 years old in first to sixth grade were enrolled. …”
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THE ROLE OF PROTEIN OXIDATIVE MODIFICATION IN REDOX-REGULATION OF CASPASE-3 ACTIVITY IN BLOOD LYMPHOCYTES DURING OXIDATIVE STRESS IN VITRO by O. L. Nosareva, Ye. A. Stepovaya, N. V. Ryazantseva, Ye. V. Shakhristova, O. N. Vesnina, V. V. Novitsky

“…With help of enzymoimmunoassay the level of protein carbonyl derivatives was evaluated; caspase-3 activity was registered by spectrofluorometric method.Results. Protein SH-group blocking in blood lymphocytes during oxidative stress in vitro was accompanied by protein-bound glutathione concentration rapid decrease in connection with increase of protein carbonyl derivatives content and caspase-3 activity. …”
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Enhancement of Human Immunodeficiency Virus-Specific CD8⁺ T Cell Responses with TIGIT Blockade Involves Trogocytosis by Nazanin Ghasemi, Kayla A. Holder, Danielle P. Ings, Michael D. Grant

“…Natural killer (NK) and CD8⁺ T cell function is compromised in human immunodeficiency virus type 1 (HIV-1) infection by increased expression of inhibitory receptors such as TIGIT (T cell immunoreceptor with Ig and ITIM domains). Blocking inhibitory receptors or their ligands with monoclonal antibodies (mAb) has potential to improve antiviral immunity in general and facilitate HIV eradication strategies. …”
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Comparative Assessment of the Clinical Course, Drug Therapy and Outcomes in Myocardial Infarction without or with Obstructive Coronary Artery Disease by O. A. Fomina, S. S. Yakushin

“…The second group was selected by the copy method comparatively to the first group. …”
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Horizontal DNA Transfer Mechanisms of Bacteria as Weapons of Intragenomic Conflict. by Nicholas J Croucher, Rafal Mostowy, Christopher Wymant, Paul Turner, Stephen D Bentley, Christophe Fraser

“…Both constitutive and transient competence for transformation were found to provide an effective defence against parasitic MGEs; transient competence could also be effective at permitting the selective spread of MGEs conferring a benefit on their host bacterium. …”
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Russian TV channels and social media in the transformation of the media field by Kruglova Lyudmila A., Shchepilova Galina G.

“…A sample of TV channels was selected based on average annual ratings as well as thematic segmentation. …”
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Electrophysiological effects of kappa-opioid analgesic, RU-1205, using machine learning methods by K. Yu. Kalitin, O. Yu. Mukha, A. A. Spasov

“…It is assumed that this effects may be due to its functional selectivity, or the presence of an additional mechanism of action that involves blocking p38 mitogen-activated protein kinase (MAPK).The aim of the study was an experimental identification of RU-1205 mechanisms of action associated with the inhibition of MAPK p38 and functional selectivity for kappa opioid receptors.Materials and methods. …”
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Ion-Channel-Targeting Scorpion Recombinant Toxin as Novel Therapeutic Agent for Breast Cancer by Natalia Mata de los Rios, Argel Gastelum-Arellanez, Herlinda Clement, Karely Álvarez-Cruz, Diana Romero-Terrazas, Carolina Alvarado-González, Luis Carlos Hinojos-Gallardo, Gerardo Corzo, Gerardo Pável Espino-Solis

“…Scorpion venom peptides, known for their selective ion-channel-blocking properties, have demonstrated promising antineoplastic activity. …”
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Opioid drug seeking after early-life adversity: a role for delta opioid receptors by Sophia C. Levis, Matthew T. Birnie, Yiyan Xie, Noriko Kamei, Puja V. Kulkarni, Johanna S. Montesinos, Christina R. Perrone, Catherine M. Cahill, Tallie Z. Baram, Stephen V. Mahler

“…In a rodent model, we previously found that ELA enhances risk for opioid addiction selectively in females, but the mechanisms for this effect are unclear. …”
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Correlation analysis and path coefficients for yield components in nine experimental tomato lines by Gonzalo Quispe-Choque, Nancy Huanca-Alanoca

“…The objective of the research was to analyze the main variables related to tomato yield, and to guide the selection of materials for the INIAF vegetable breeding program. …”
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THE TECHNOLOGY OF WELL BORE INCLINATION CONTROL AT DIRECTIONAL DRILLING (BHA) by Emil V. Khnychkin, Vladimir Vasil’evich Fedorenko

“…Article also shows case study calculations and inclination intensity control technology block diagram.…”
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