Hybridization of metaheuristic algorithms for resource scheduling in distributed robotic control system by P. Anand Raj, M. Rajakumaran, S. Palani Murugan, S. Senthilkumar

“…Abstract This paper presents a novel Distributed Blockchain-Assisted Secure Data Aggregation (Block-DSD) scheme designed to enhance data security, energy efficiency, and scalability in Mobile Ad-hoc Networks (MANETs) for disaster-resilient communication systems (DRCS). …”
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Structural insights into cholesterol sensing by the LYCHOS-mTORC1 pathway by Shang Yu, Jin-hui Ding, Jia-le Wang, Weize Wang, Peng Zuo, Ao Yang, Zonglin Dai, Yuxin Yin, Jin-peng Sun, Ling Liang

“…Our results elucidate the structural mechanism of cholesterol sensing by the mTORC1 pathway, providing a structural basis for developing inhibitors that selectively target mTORC1 pathway by blocking LYCHOS in its expanded state.…”
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Exploring COX-Independent Pathways: A Novel Approach for Meloxicam and Other NSAIDs in Cancer and Cardiovascular Disease Treatment by Lixia Cheng, Zhenghui Hu, Jiawei Gu, Qian Li, Jiahao Liu, Meiling Liu, Jie Li, Xiaowen Bi

“…Recent studies have increasingly shown that some selective COX-2 inhibitors and NSAIDs, such as Meloxicam, may exert effects beyond COX inhibition. …”
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Mechanistic Insights into the Anti-Hepatocellular Carcinoma Effects of ACY-1215: p53 Acetylation and Ubiquitination Regulation by Yi Yin, Yutong Du, Yiting Xu, Zhuan Zhu, Yu Hu, Lingling Xu, Kunming Yang, Tian Chen, Yuyang Shi, Chengcheng Wang, Yali Zhang

“…This study investigates the anti-HCC potential of ACY-1215, a selective Histone deacetylase 6 (HDAC6) inhibitor, and its mechanism targeting p53 regulation. …”
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Eco-Friendly Fabrication of Zinc Oxide Nanoparticles Using <i>Gaultheria fragrantissima</i>: Phytochemical Analysis, Characterization, and Antimicrobial Potential by Bhoj Raj Poudel, Sujan Dhungana, Anita Dulal, Aayush Raj Poudel, Laxmi Tiwari, Devendra Khadka, Megh Raj Pokhrel, Milan Babu Poudel, Allison A. Kim, Janaki Baral

“…ZnO NPs exhibited moderate antimicrobial activity against selected microbial strains. These findings underscore the potential of <i>G. fragrantissima</i>-mediated synthesis as an environmentally sustainable and efficient method for producing ZnO NPs with multifunctional applications. …”
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Estimation of yield and yield-related genetic parameters in citron watermelon (Citrullus lanatus var. citroides) by Lenon Tembo, Mcebisi Maphosa

“…Ten high-yielding accessions were crossed in a bi-parental mating design to develop five hybrids that were evaluated together with their parents in a randomized complete block design, replicated thrice. Traits such as fruit yield, length and weight displayed the greatest potential to respond to selection owing to high heritability (61.64, 73.80% and 59.00%, respectively) and genetic advance (4585.09, 77.32 and 73.27%, respectively). …”
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Phenotypic and genotypic association of yield and yield-related traits in eggplant (Solanum melongena L.) evaluated for two seasons by Ibrahim Musa, Usman Magaji, Samuel Chukwu, Senesie Swaray, Audu Kiri

“…A randomized complete block design (RCBD) was used to arrange the plants and replicated three times. …”
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Contribution of Connexin Hemichannels to the Pathogenesis of Acute Lung Injury by Shuaiwei Wang, Yafang Sun, Yu Bai, Nannan Zhou, Na Chen, Edmund J. Miller, Yijie Zhang, Wei Li

“…Biological functions of Cx HCs have not been adequately characterized due to the inability to selectively target HCs or GJs. Recently, we developed a 6-mer peptide mimetic (P5) of the first extracellular loop of Cx43 and showed that it can block the permeability of HCs but not GJs formed by Cx43. …”
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Complicated supravesical obstruction in patients with urolithiasis: multifactorial analysis of risk factors by M. M. Khasanov, U. A. Abdufattaev, A. A. Nomanov, Sh. T. Mukhtarov

“…Supravesical obstruction (SVO) is a less frequent but potentially dangerous phenomenon that occurs when the urinary tract is blocked above the bladder, often resulting in impaired urinary passage and requiring surgery in most cases.Objective. …”
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Combined EGFR and VEGFR versus single EGFR signaling pathways inhibition therapy for NSCLC: a systematic review and meta-analysis. by Xinji Zhang, Yesheng Li, Hui Li, Yingyi Qin, Chong Bai, Feng Xu, Tianyi Zhu, Jinfang Xu, Mengjie Wu, Chaoxiang Wang, Lixin Wei, Jia He

“…<h4>Background</h4>Lung cancer is a heterogeneous disease with multiple signaling pathways influencing tumor cell survival and proliferation, and it is likely that blocking only one of these pathways allows others to act as salvage or escape mechanisms for cancer cells. …”
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Blockade of TRPM7 channel activity and cell death by inhibitors of 5-lipoxygenase. by Hsiang-Chin Chen, Jia Xie, Zheng Zhang, Li-Ting Su, Lixia Yue, Loren W Runnels

“…All three inhibitors were also effective in blocking the native TRPM7 current in HEK-293 cells. …”
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Deletion of Rac1GTPase in the Myeloid Lineage Protects against Inflammation-Mediated Kidney Injury in Mice. by Miki Nagase, Hidetake Kurihara, Atsu Aiba, Morag J Young, Tatsuo Sakai

“…The LPS-driven cytokine induction was dose-dependently blocked by the Rac1 inhibitor EHT1864, NADPH oxidase inhibitor diphenyleneiodonium, and NF-κB inhibitor BAY11-7082. …”
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Computational Screening of Heterocyclic L-Type Calcium Channel Blockers for Potential Anti-Parkinson’s Activity by Thomas Kurian, Rani Sebastian

“…The receptor protein CavAb in complex with Br- Verapamil was selected as a target for studying the interaction and prediction of calcium channel blocking activity of five heterocyclic compounds based on chemical structural features. using two popular software’s, Auto Dock and PyRx. …”
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Feeding behaviour patterns in relation to body weight and gait in broilers by Malou van der Sluis, Britt de Klerk, István Fodor, Esther D. Ellen

“…Data on feeder visits of 58 randomly selected and subsequently RFID-tagged broilers were used, that were housed in a group of approximately 800 birds in a 45 m2 pen. …”
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Persistence of the Immune Response to an Intramuscular Bivalent (GI.1/GII.4) Norovirus Vaccine in Adults by Geert Leroux-Roels, Robert L. Atmar, Jakob P. Cramer, Ian Escudero, Astrid Borkowski

“…This report focuses on the single-dose 15/50 (µg GI.1/GII.4c) composition, which had been selected for further clinical development. Results: For single-dose 15/50 recipients (N = 105), GI.1-specific and GII.4c-specific histoblood-group antigen-blocking (HBGA) antibodies appeared to have persisted to 5 years, waning from a peak at 4 to 8 weeks, and plateauing above baseline after 3 years. …”
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Design of a humanized CD40 agonist antibody with specific properties using AlphaFold2 and development of an anti-PD-L1/CD40 bispecific antibody for cancer immunotherapy by Kun Du, He Huang

“…This novel anti-PD-L1/CD40 bispecific antibody holds potential for strong anti-tumor therapeutic efficacy by selectively restricting CD40 stimulation in tumors.…”
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Deucravacitinib Improved Interstitial Pneumonia Along with KL-6 Reduction in a Patient with Psoriasis: A Case Report by Mima Y, Ohtsuka T, Akiyama N, Norimatsu Y

“…Therefore, we consider that deucravacitinib may have contributed to the improvement of IP by blocking these signaling pathways, thereby suppressing chronic T cell–driven inflammation and fibrosis. …”
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Role of сathepsin G in pathogenesis of chronic obstructive lung disease: possible ways of regulation by V. A. Beloglazov, I. A. Yatskov

“…According to most researchers, powerful and selective CG inhibitors may be developed in future on the basis of SFTI-1, thus requiring further in-depth research.…”
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Optimization of Truck Platoon Size in Freeway Diverging Areas Based on Comprehensive Performance Evaluation by Zhifa Yang, Zongyao Li, Zhuo Yu, Wencai Sun, Jingjing Tian

“…However, in freeway diverging areas, excessively long truck platoons can cause a blocking effect on small vehicles exiting the freeway, thereby causing congestion and impacting the traffic flow in the section. …”
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459 Development of small molecules targeting an epigenetic modulator for pediatric neuroblastoma by Joseph McPherson, William Pomerantz, Molly Sneddon, Anang Shelat, Wenwei Lin, Taosheng Chen, Marcus Fischer, Natalia Tretyakova

“…Nanoluciferase bioluminescence resonance energy transfer (NanoBRET) will be used to confirm BPTF PHD engagement by compounds. Selective toxicity in neuroblastoma cells upon inhibitor treatment will be gauged by comparing cell growth and viability in the IMR-32 cell line against the HEK293 cell line. …”
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