ADAM12 abrogation alters immune cell infiltration and improves response to checkpoint blockade therapy in the T11 murine model of triple-negative breast cancer by Guanpeng Wang, Yeni Romero, Indhujah Thevarajan, Anna Zolkiewska

“…ADAM12, a member of cell surface metalloproteases, is selectively upregulated in mesenchymal/claudin-low TNBCs, where its expression is largely restricted to tumor cells. …”
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The epidemiology and phenomenology of non-antipsychotic-induced dystonia: a hybrid systematic-narrative review by Kirsten Catthoor, Johan Detraux, Marc De Hert

“…Conclusions Although MID is most common with dopamine receptor-blocking antiemetics, many other medications may also produce dystonic reactions, particularly in children and adolescents. …”
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A Review of Quinazoline-Based EGFR/VEGFR-2 Dual Inhibitors as Potent Anticancer Agents: Structure-Activity Relationship and Docking Studies by Fatemeh Yousefbeyk, Saeed Ghasemi

“…Therefore, VEGFR-2 inhibitors could be attractive agents for blocking angiogenesis and tumor growth. Due to the common downstream signaling pathways of EGFR and VEGFR-2, simultaneous inhibition of both receptor tyrosine kinases can be used as a valuable method in cancer therapy. …”
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Effects of WSSV and ammonia nitrogen stress on the enzyme activity and transcriptome of Litopenaeus vannamei by Shan Gao, Linxin Dai, Yue Wang, Zuluan Liang, Yinhuan Zhou, Chengbo Sun

“…In this study, Litopenaeus vannamei was selected as the research object to determine the critical concentration of ammonia nitrogen that triggered the outbreak of WSSV. …”
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Targeting eIF4A with RNA Aptamers Enhances Salt Stress Tolerance in Rice Through Modulation of Translation Initiation by Haomin Chen, Zhihao Xie, Mingming Chen, Peiyi Zhu, Daming Chen, Yongxiang Huang, Shuangfeng Dai

“…One aptamer, eApt-2, was found to bind eIF4A with high affinity, selectively blocking cap-dependent translation initiation. …”
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The Role of Hydroxyl Modification of Peptidoglycan to Reduce the TTX Toxicity via Superior Absorption by Chang’e Wang, Yi Guo, Lili Zhang, Junjian Miao, Ying Lu

“…In this study, hydroxyl modifications of three PGs (A3α, A1γ and A4α) were realized via TEMPO-mediated selective oxidation of the primary hydroxyl group. …”
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Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. by Dick Jaarsma, Ingrid van der Pluijm, Monique C de Waard, Elize D Haasdijk, Renata Brandt, Marcel Vermeij, Yvonne Rijksen, Alex Maas, Harry van Steeg, Jan H J Hoeijmakers, Gijsbertus T J van der Horst

“…To examine to what extent overlap occurs between both repair systems, we generated TCR-deficient mice with selective inactivation of NER in postnatal neurons. …”
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The Effect of Toxicity, Physical and Thermal Properties of Fire Blanket Made of Glass Fiber on Its Quality as Small Fire Suppression Tool by Mohamed A. Hassan, Mohamed M. AlSofian, Ahmed Al Zharani, Mohammed R. AlOtaibi, Sami Al Saeed, Naif Al Anazi

“…Blankets demonstrated over 45% heat blocking efficiency at low heat flux and more than 78% at high heat flux. …”
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When Translation Meets Newswriting: Simplification in Translated Quotations by Eleonora Fois

“…This implies that the translator attempts to ease the reader’s comprehension (Vandevoorde 2020: 17), sometimes “selecting an interpretation, therefore blocking potential others”, raising “the level of explicitness by resolving ambiguity” (Baker 1996: 182). …”
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Pharmacokinetics and UPLC-MS/MS of Delsoline in Mouse Whole Blood by Lingjiu Shao, Yue Jin, Huiyan Fu, Jianshe Ma, Xianqin Wang, Yongxi Jin, Congcong Wen

“…Delsoline, a major alkaloid of Delphinium anthriscifolium Hance, has both a curare-like effect and a ganglion-blocking effect and is used to relieve muscle tension or hyperkinesia. …”
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Histological Fixation Process and Fixatives by Tuğba Dağdeviren, Hatice Kübra Yolcu, Bülent Ünver

“…Tissue monitoring generally includes the stages of fixation, dehydration, clearing, hardening (infiltration), paraffin blocking/paraffin(emmeding), sectioning, water removal, routine staining, and mounting. …”
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The problem of technical teacher training in modern conditions by A. P. Usoltsev, B. E. Starichenko, E. S. Koscheeva

“…The article deals with the problem of selecting the content of the training of future teachers of general technical disciplines. …”
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Feasibility of rational constructive and technological parameters of organization options of multigroup shunting on the basis of simulation modeling by S. V. Karasev, D. A. Sivitskiy

“…The service refers to a selection of cars in groups, and the requirements refers to handled trains. …”
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GENETIC PARAMETERS ESTIMATION OF PROMISING MAIZE HYBRIDS IN SUNDARBAZAR, LAMJUNG by Samskriti Subedi, Deepa Sharma, Bishnu Pd. Kandel

“…Phenotypic expression these traits can be used as a selection index for yield improvement of hybrid maize. …”
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Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells. by Tony Navas, Thomas D Pfister, Simona Colantonio, Amina Aziz, Lynda Dieckman, Richard G Saul, Jan Kaczmarczyk, Suzanne Borgel, Sergio Y Alcoser, Melinda G Hollingshead, Young H Lee, Donald P Bottaro, Tara Hiltke, Gordon Whiteley, Naoko Takebe, Robert J Kinders, Ralph E Parchment, Joseph E Tomaszewski, James H Doroshow

“…For all target proteins, we selected antibodies that yielded the expected target protein molecular weights by Western analysis and the correct subcellular localization patterns by immunofluorescence microscopy assay (IFA); binding selectivity was verified by immunoprecipitation-mass spectrometry and by immunohistochemistry and IFA peptide blocking experiments. …”
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Rationale and feasibility of a rapid integral biomarker program that informs immune-oncology clinical trials: the ADVISE trial by Akshita Gupta, Riyue Bao, F Stephen Hodi, Jaclyn Neely, Jason J Luke, Ashish Massey, Santanu Dutta, Janis Taube, George Lee, Katherine Bever, Peter Szabo, David Yao, Rachel Tam, Tim Reilly

“…These data emphasize the difficulty of integral biomarker development for I-O in translating from immunotherapy treatment-naïve biospecimens to the selection of patients in the PD-1-refractory state.Trial registration number NCT03335540.…”
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Identification of effective morphological traits on rice cultivars yield under moisture stress condition using multivariate statistical methods by Saeid Bakhshipour, Jafar Kambouzia, Korous Khoshbakht, Abdol Majid Mahdavi Damghani, Maryam Hosseini Chaleshtori

“…Hence, the characterization of genetic diversity and germplasm classification for parental selection in breeding purposes is of great importance.Materials and methods: In order to evaluate the adaptation of rice genotypes to drought stress and to identify tolerant and sensitive genotypes, 20 genotypes were studied using a factorial randomized complete block design with three replications at the Rice Research Institute (Rasht). …”
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Development and implementation of nested single‐nucleotide polymorphism (SNP) assays for breeding and genetic research applications by Qijian Song, Charles Quigley, Ruifeng He, Dechun Wang, Henry Nguyen, Carrie Miranda, Zenglu Li

“…To meet the needs for genomic selection, selection of parents for crosses, and characterization of breeding populations, especially early selection of ideal offspring from thousands of lines, we developed two assays, SoySNP3K and SoySNP1K, containing 3072 and 1252 SNPs, respectively, based on SoySNP50K and SoySNP6K mark sets. …”
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Prediction of 5-year survival in patients with heart failure and implanted cardiac resynchronization therapy devices by A. M. Soldatova, V. A. Kuznetsov, E. A. Gorbatenko, T. N. Enina, L. M. Malishevsky

“…Based on clinical parameters and diagnostic investigations, to create a complex model of personalized selection of patients with heart failure (HF) for cardiac resynchronization therapy (CRT). …”
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ET-Mamba: A Mamba Model for Encrypted Traffic Classification by Jian Xu, Liangbing Chen, Wenqian Xu, Longxuan Dai, Chenxi Wang, Lei Hu

“…A resampling method combining Wasserstein GAN and random selection is proposed for solving the dataset imbalance problem, and it uses Wasserstein GAN for oversampling and random selection for undersampling to achieve class equalization. …”
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