Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection. by Peyman Ghorbani, Sang Yong Kim, Tyler K T Smith, Lucía Minarrieta, Victoria Robert-Gostlin, Marisa K Kilgour, Maja Ilijevska, Irina Alecu, Shayne A Snider, Kaitlyn D Margison, Julia R C Nunes, Daniel Woo, Ciara Pember, Conor O'Dwyer, Julie Ouellette, Pavel Kotchetkov, Julie St-Pierre, Steffany A L Bennett, Baptiste Lacoste, Alexandre Blais, Meera G Nair, Morgan D Fullerton

“…Using murine IL-4-polarized macrophages, targeted lipidomics revealed significantly elevated levels of phosphatidylcholine, with select changes to other choline-containing lipid species. …”
Get full text

BETA-BLOCKERS AND RENOPROTECTION: THE POTENTIAL OF CARVEDILOL by I. T. Murkamilov, I. S. Sabirov, V. V. Fomin, F. A. Yusupov

“…Moreover, with the slowing down of the glomerular filtration rate in CKD, the role of non-immunefactors in the development of cardiovascular complications becomes very important. In contrast to non-selective and some β1-selective beta-blockers, the use of beta-adenoblocker with vasodilating activity, in particular carvedilol, makes it possible to prevent the onset of the terminal stage ofCKD. …”
Get full text

Fault early warning model of 4G base station out of service based on centralized monitoring data resources by Yang WANG, Yi MAN, Zhipeng CHEN

“…4G wireless base station equipment is an important link which has direct impact on information communication network customer service quality,and 4G wireless base stations out of service fault will directly block users' normal communication.Aiming at these problems,based on the centralized monitoring warning message data resources through association rule mining and time trace deduction analysis,4G base stations out of service fault short-term warning was achieved.Based on centralized monitoring equipment performance data resources,by the classification of network elements (data cleaning,feature selection,network elements clustering),index dimension reduction (grouped by cluster,principal component analysis),principal component expression and out of service fault correlation analysis,performance indicators selection and threshold analysis,4G base stations out of service fault long-term warning was achieved.The test can accurately predict the 27.8% of 4G base station equipment out of service fault next month.…”
Get full text

Covid Looming between Poetic Lines, behind Ambulance Windows and in the Margins of Screens by Elise Brault-Dreux

“…This article analyses a selection of poems written during the 2020 pandemic and which all look at the Covid from a distance: the virus is represented (and circulated) by passing ambulances whose swiftness and opaque windows block all visual access to the suffering patient that lies inside. …”
Get full text

From Infection to Tumor: Exploring the Therapeutic Potential of Ciprofloxacin Derivatives as Anticancer Agents by Hesham M. Hassan, Roket Hassan, Ranya Mohammed Elmagzoub, Ahmed Al-Emam, Konstantinos Kossenas, Ahmed S. Abdel-Samea, Hazim O. Khalifa, Suleyman Akocak, Stefan Bräse, Hamada Hashem

“…Additionally, it outlines their future directions, such as enhancing their efficacy, selectivity, and investigating potential synergy with other chemotherapeutic agents, offering a promising avenue for developing new therapies for cancer.…”
Get full text

Behavioral state and stimulus strength regulate the role of somatostatin interneurons in stabilizing network activity by Celine M. Cammarata, Yingming Pei, Tingwei Hu, Brenda C. Shields, Shaun S.X. Lim, Tammy Hawley, Jennifer Y. Li, David St. Amand, Nicolas Brunel, Michael R. Tadross, Lindsey L. Glickfeld

“…We tested the necessity of SST cells for inhibition stabilization in mouse primary visual cortex by selectively blocking excitatory glutamatergic receptors on SST cells. …”
Get full text

Protein and polysaccharide edible coatings: A promising approach for fruits preservation - recent advances by Dong My Lieu, Thuy Thi Kim Dang, Huong Thuy Nguyen

“…Fundamental EC properties include barrier properties, tensile strength, elongation at break, and UV blocking. Extra materials such as antimicrobial agents, antioxidants, anti-browning agents, and antagonistic microorganisms enhance EC benefits. …”
Get full text

Ferroptosis inducers – erastin and analogues (review) by E. V. Sanarova, A. V. Lantsova, L. L. Nikolaeva, N. A. Oborotova, L. M. Borisova

“…The search for small molecules that selectively kill tumor cells led to the accidental discovery of erastin.Text. …”
Get full text

Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins by Sandra Zakrzewska, Samantha A. Nixon, Zhou Chen, Holly S. Hajare, Elizabeth R. Park, John V. Mulcahy, Kandis M. Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi, Tod A. Leighfield, Marta Filizola, J. Du Bois, Daniel L. Minor

“…Together, our study establishes how Sxphs sequester select neurotoxins and uncover STX congener-specific interactions distinct from NaVs. …”
Get full text

Detailed Design of Lattice Tower for Low Speed Wind Turbines by James Rojas Waterhouse, Carlos Henrique Gasparetti, Kauan Pires Quevedo, Guilherme Beppu de Souza

“…The analysis covers essential structural and geometric parameters, including weight, wind blocking area, ground loading, and their influence on foundation costs. …”
Get full text

Unveiling the role of hexon-associated host proteins in fowl adenovirus serotype 4 replication by Xiaojun Zhang, Xueping Wang, Yina Zhao, Shifan Li, Xingang Xu

“…Western blot and coimmunoprecipitation validation tests revealed that randomly selected significant proteins (CCT5, CCT7, and HSP70) interact with hexon, and these results are consistent with those of TAP/MS. …”
Get full text

JS-K induces ferroptosis in renal carcinoma cells by regulating the c-Myc-GSTP1 Axis by Yuwan Zhao, LuGang Zhu, Xinghua Lin, Bin Li, Bailiang Miu, Jingping Qiu, Sheng Gao, Jianjun Liu

“…At the molecular level, JS-K downregulated GSTP1 by blocking the transcription factor c-Myc. Finally, JS-K inhibited tumor growth in a mouse model by inducing ferroptosis. …”
Get full text

An anion exchange membrane sensor detects EGFR and its activity state in plasma CD63 extracellular vesicles from patients with glioblastoma by Nalin H. Maniya, Sonu Kumar, Jeffrey L. Franklin, James N. Higginbotham, Andrew M. Scott, Hui K. Gan, Robert J. Coffey, Satyajyoti Senapati, Hsueh-Chia Chang

“…Abstract We present a quantitative sandwich immunoassay for CD63 Extracellular Vesicles (EVs) and a constituent surface cargo, EGFR and its activity state, that provides a sensitive, selective, fluorophore-free and rapid alternative to current EV-based diagnostic methods. …”
Get full text

A Printed Gate Controlled Electrochemical Capacitor‐Diode (G‐CAPode) for AC Filtering Applications by Christin Gellrich, Przemyslaw Galek, Leonid Shupletsov, Nick Niese, Ahmed Bahrawy, Julia Grothe, Stefan Kaskel

“…The heart of the device consists of a recently developed asymmetric electrical double‐layer capacitor system based on selective, size‐dependent ion adsorption. Due to the introduction of a sieving carbon with ultramicroporous pores (d = 0.69 nm) as one electrode material, an effective blocking of ions with sizes below the pore size of the carbon can be achieved, leading to a unidirectional charging comparable to a diode (CAPode). …”
Get full text

The potential of polyphenol compounds in grapes to reduce oxidative stress and inflammation after exercise: systematic review by Novadri Ayubi, Atika Syafawi, Anton Komaini, Dhea Regita Sastika Putri, Ilham Ilham, Deby Tri Mario, Dyah Fitria Padmasari, Junian Cahyanto Wibawa, Procopio B. Dafun Jr.

“…In this case, grapes work by blocking several inflammatory pathways and decreasing inflammatory markers. …”
Get full text

The no-reflow phenomenon: current treatment and prevention strategies by S. V. Dil, E. V. Vyshlov, M. A. Kercheva, L. N. Maslov, V. V. Ryabov

“…Future research directions involve the exploration of monoclonal antibodies capable of selectively blocking key inflammatory pathways and the use of hyperoxemic reperfusion. …”
Get full text

K(Ca)3.1 channel-blockade attenuates airway pathophysiology in a sheep model of chronic asthma. by Joanne Van Der Velden, Grace Sum, Donna Barker, Emmanuel Koumoundouros, Garry Barcham, Heike Wulff, Neil Castle, Peter Bradding, Kenneth Snibson

“…<h4>Methodology and principal findings</h4>Atopic sheep were administered either 30 mg/kg Senicapoc (ICA-17073), a selective inhibitor of the K(Ca)3.1-channel, or vehicle alone (0.5% methylcellulose) twice daily (orally). …”
Get full text

Intelligent Priority-Aware Spectrum Access in 5G Vehicular IoT: A Reinforcement Learning Approach by Adeel Iqbal, Tahir Khurshaid, Yazdan Ahmad Qadri

“…QL demonstrates the lowest average delay and the highest energy efficiency, making it a suitable candidate for edge-constrained vehicular deployments. Selecting the appropriate RL method, RL-PASM offers a robust and adaptable solution for scalable, intelligent, and priority-aware spectrum access in vehicular communication infrastructures.…”
Get full text

Different Stability and Proteasome-Mediated Degradation Rate of SMN Protein Isoforms. by Denise Locatelli, Mineko Terao, Mami Kurosaki, Maria Clara Zanellati, Daniela Rita Pletto, Adele Finardi, Francesca Colciaghi, Enrico Garattini, Giorgio Stefano Battaglia

“…The key pathogenic steps leading to spinal muscular atrophy (SMA), a genetic disease characterized by selective motor neuron degeneration, are not fully clarified. …”
Get full text

Exercise-induced Nogo-A influences rodent motor learning in a time-dependent manner. by Jörg H Stehle, Zhiyuan Sheng, Laura Hausmann, Philipp Bechstein, Oliver Weinmann, Juha Hernesniemi, Joseph S Neimat, Martin E Schwab, Ajmal Zemmar

“…Following one week of exercise, rats exhibited a decrease in Nogo-A levels, selectively in motor cortex layer 2/3, but not in layer 5. …”
Get full text