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861
Is current NEET PG Counselling process full of LUCK and GAMBLING?
Published 2023-10-01“…All these lead to the PG counselling process having some very confusing rules, and it causes a great deal of confusion and uncertainties among the students, while selecting for their deserved PG seats and attending subsequent rounds. …”
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862
Multi-Link Fragmentation-Aware Deep Reinforcement Learning RSA Algorithm in Elastic Optical Network
Published 2025-06-01“…Based on the numbering results, high-frequency links are selected to construct the network state matrix that reflects the resource distribution. …”
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863
The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies
Published 2015-11-01“…The drug has been experimentally tested by Kazan scientists who revealed the selectivity of its antiblastoma activity, relatively low toxicity, and high safety when it was used long. …”
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864
Phylogenetic profiles of all membrane transport proteins of the malaria parasite highlight new drug targets
Published 2016-08-01“…Furthermore, we discuss the phylogeny of selected potential drug targets identified in our functional screen. …”
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865
Noroviral p-particles as an in vitro model to assess the interactions of noroviruses with probiotics.
Published 2014-01-01“…The binding of P-particles (GI.1) to HT-29 cells in the presence of selected strains showed that bacteria can inhibit P-particle attachment in competitive exclusion experiments. …”
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866
Designing and implementing a Web-based real time routing service for crisis management (a case study for district 11 of Tehran)
Published 2019-06-01“…Open source languages, format, libraries and software such as HTML, CSS, AJAX, GeoJSON, PHP, OpenLayer, PostGIS were also used to design the service and applying online weightings, blocking each piece of routes and re-routing procedure without blocked traffics, implementation of server-side processing and reducing the volume of the client-side’s operations, being under the browser’s surveillance, no need to install any software and the ability to use it on any operating system can be named. …”
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867
Synthesis and Characterization of Transferrin Receptor-Targeted Peptide Combination SN-38 and Rucaparib Conjugate for the Treatment of Glioblastoma
Published 2025-06-01“…In vitro experiments demonstrated potent cytotoxic effects of the T7 peptide drug conjugate on glioblastoma cells (IC<sub>50</sub> = 22.27 nM), with reduced toxicity to non-cancerous HEK 293 cells (IC<sub>50</sub> = 115.78 nM), indicating selective toxicity toward cancer cells. Further investigations revealed that blocking transferrin receptors with drug-free T7 peptide significantly reduced the conjugate’s cytotoxicity, an effect that could be reversed by introducing exogenous cathepsin B to the cells. …”
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868
Modeling and Simulation of a Resonant-Cavity-Enhanced InGaAs/GaAs Quantum Dot Photodetector
Published 2015-01-01“…Comparing with the conventional photodetectors, the resonant-cavity-enhanced photodiode (RCE-PD) showed higher detection efficiency, faster response speed, and better wavelength selectivity and spatial orientation selectivity. Our simulation results also showed that when an AlAs layer is inserted into the device structure as a blocking layer, ultralow dark current can be achieved, with dark current densities 0.0034 A/cm at 0 V and 0.026 A/cm at a reverse bias of 2 V. …”
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869
Genetic variability studies of diverse cashew (Anacardium occidentale L.) cultivars for growth and yield parameters in coastal zone of Karnataka
Published 2024-12-01“…Fifteen year old standing cashew orchard planted with 42 diverse cashew cultivars were evaluated for 15 fruit, nut, growth and yield parameters following randomized complete block design with two replications. Highly significant variations of GCV and PCV coupled with high heritability and GAM was observed for most of the traits indicating the predominance of additive gene action and possibilities of achieving high genetic gain from selection. …”
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870
Incorporating Population Dynamics in the Context of Earthquake Shelter Location-Allocation Analysis
Published 2025-03-01“… Location-allocation is a widely used approach to optimally select earthquake shelters and efficiently allocate the population in case of an emergency. …”
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871
Targeting MMR-deficient colorectal cancer with a potent small molecule UNI110
Published 2025-12-01“…Mechanistically, UNI110 selectively induces DNA damage in MMR-deficient cancer cells, ultimately resulting in cell death. …”
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872
“Turn-On” Fluorescent Assay of Biothiols Based on Nitrogen-Rich Polymer Carbon Nanostrips and Its Application in Cell Imaging
Published 2019-01-01“…In this work, a sensitive and selective turn-on fluorimetric method has been developed for the determination of biothiols based on blocking Ag+-induced fluorescence quenching of nitrogen-rich polymer carbon nanostrips (NRPCNSs). …”
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873
The path less traveled: the non-canonical NF-κB pathway in systemic lupus erythematosus
Published 2025-07-01“…Traditional treatment for this disease is centered around limiting inflammation using a variety of immunosuppresants including glucocorticosteroids as well as other therapeutics including anti-malarial drugs. More recently, selective immunosuppresives and biologics including Belimumab, a BAFF monoclonal antibody, and Anifrolumab, a monoclonal antibody that selectively binds to type 1 interferon receptor (INFAR1) blocking the biological activity of type 1 IFN, have been used with various success. …”
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874
Targeted protein degradation with small molecules for cancer immunotherapy
Published 2025-08-01“…Traditional drug discovery strategies, which focus on blocking protein activity through inhibitors, face persistent hurdles, such as reliance on accessible binding pockets, poor selectivity, and the emergence of drug resistance. …”
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875
“In the interests of all of us…”: Theodore Roosevelt and the Launch of Immigration Restriction as an Executive Concern
Published 2015-08-01“…Roosevelt can be held responsible for setting in motion a selection process that included racial stereotypes, but he also deserves his reputation as beacon of hope for the immigrant.…”
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876
COMBINING ABILITY ANALYSIS IN F2 GENERATION FOR YIELD AND SOME OF ITS COMPONENTS IN UPLAND COTTON Gossypiom hirsutum L.
Published 2012-05-01“…Broad sense heritability ranged from 24.051% for seed cotton yield per plant and 71.101% for plant height, and it was high for plant height, number of fruiting branches and lint index, moderate for number of vegetative branches and boll weight, and low for number of bolls, seed index and seed cotton yield per plant. It was shown that selection for plant height gave higher percent of response to selection (5.275%) from original mean of yield, followed by number of bolls which gave percent of response to selection (2.783%) from original mean of yield.…”
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877
Convergent evolution of escape from hepaciviral antagonism in primates.
Published 2012-01-01“…From sequencing and phylogenetic analyses of MAVS from 21 simian primates, we found that MAVS has evolved under strong positive selection. We focused on how this positive selection has shaped MAVS' susceptibility to Hepatitis C virus (HCV). …”
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878
Flexible DC distribution line protection based on measuring voltage Fréchet distance
Published 2024-11-01“…Finally, the internal and external faults in the unipolar and bipolar regions are identified by using the single and bipolar measurement voltage Fréchet distance to construct the integral, and the unipolar fault is selected according to the positive electrode voltage change rate. …”
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879
Sodium Channel Blockers for Vestibular Paroxysmia in Children
Published 2025-06-01“…<b>Methods</b>: PubMed, Medline, Cochrane, and Crossref databases were searched, and all studies on VP in children and sodium channel blockers were selected. <b>Results</b>: Only five articles reporting small case series or single case reports were identified. …”
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880
Stabilization of a G-Quadruplex from Unfolding by Replication Protein A Using Potassium and the Porphyrin TMPyP4
Published 2011-01-01“…Of the six RPA ssDNA binding domains (labeled A-F), RPA-CDE selectively binds a G-quadruplex forming sequence (5′-TAGGGGAAGGGTTGGAGTGGGTT-3′ called Gq23). …”
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