Water-soluble vidarabine derivatives alleviate catecholamine-induced heart failure and arrhythmia without impairing cardiac function in mice. by Kenji Suita, Yoshio Hayakawa, Yujiro Hoshino, Wenqian Cai, Reiko Kurotani, Yoshiki Ohnuki, Yasumasa Mototani, Yoshihiro Ishikawa, Satoshi Okumura

“…Indeed, we have demonstrated that vidarabine's selective AC-inhibitory effect in the heart can inhibit the development of HF and arrhythmia without suppressing cardiac function in mice. …”
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Molecular basis of TRPV3 channel blockade by intracellular polyamines by Jingying Zhang, Peng Yuan, Colin G. Nichols, Grigory Maksaev

“…We identify a high-affinity polyamine interaction site at the intracellular side of the pore, formed by residues E679 and E682, with no significant contribution of residues at the channel selectivity filter. A cryo-EM structure of TRPV3 in the presence of NASPM reveals conformational changes coupled to polyamine blockade. …”
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Skin-derived TSLP triggers progression from epidermal-barrier defects to asthma. by Shadmehr Demehri, Mitsuru Morimoto, Michael J Holtzman, Raphael Kopan

“…Based on these findings, we propose that in addition to early treatment of the primary skin-barrier defects, selective inhibition of systemic TSLP may be the key to blocking the development of asthma in AD patients.…”
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The effect of domestication on inhibitory control: wolves and dogs compared. by Sarah Marshall-Pescini, Zsófia Virányi, Friederike Range

“…Inhibitory control i.e. blocking an impulsive or prepotent response in favour of a more appropriate alternative, has been suggested to play an important role in cooperative behaviour. …”
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On the mechanism of anti-CD39 immune checkpoint therapy by John Stagg, Bertrand Allard, David Allard

“…This resulted in the development of selective inhibitors targeting various components of the adenosinergic pathway, including small molecules antagonists targeting the high affinity A2A adenosine receptor and low affinity A2B receptor, therapeutic monoclonal antibodies (mAbs) and small molecules targeting CD73 and therapeutic mAbs targeting CD39. …”
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The influence of atmospheric circulation on the formation of snow cover on the north eastern Siberia by N. K. Kononova

“…The differences in the fluctuations of selected indicators in circulation epochs are considered. …”
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Efficient Data Collection Method in Sensor Networks by Keyan Cao, Haoli Liu, Yefan Liu, Gongjie Meng, Si Ji, Gui Li

“…The algorithm is improved on the basis of the random node selection algorithm. This method can effectively avoid the failure of random path node selection and improve the node selection of random path in wireless sensor networks. …”
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Genetic diversity, population structure in a historical panel of Brazilian soybean cultivars. by Adriel Carlos da Silva, Danielle C Gregorio da Silva, Everton Geraldo Capote Ferreira, Ricardo V Abdelnoor, Aluízio Borém, Carlos Arrabal Arias, Marcelo F Oliveira, Marcio Elias F de Oliveira, Francismar Corrêa Marcelino-Guimarães

“…In turns, the genetic diversity can affect the linkage disequilibrium blocks (LD) patterns and, consequently, molecular breeding strategies for selection of target loci for agronomic traits. …”
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Increasing COVID-19 Testing and Vaccination Uptake in the Take Care Texas Community-Based Randomized Trial: Adaptive Geospatial Analysis by Kehe Zhang, Jocelyn V Hunyadi, Marcia C de Oliveira Otto, Miryoung Lee, Zitong Zhang, Ryan Ramphul, Jose-Miguel Yamal, Ashraf Yaseen, Alanna C Morrison, Shreela Sharma, Mohammad Hossein Rahbar, Xu Zhang, Stephen Linder, Dritana Marko, Rachel White Roy, Deborah Banerjee, Esmeralda Guajardo, Michelle Crum, Belinda Reininger, Maria E Fernandez, Cici Bauer

“…The project titled Take Care Texas ObjectiveWe aimed to develop a novel procedure for adaptive selections of census block groups (CBGs) to include in the community-based randomized trial for the Take Care Texas project. …”
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CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma by Lei Shi, Christian M Capitini, Amy K Erbe, Fernanda Szewc, Longzhen Song, Matthew H Forsberg, David P Turicek, Paul D Bates, Devin M Burpee, Aicha E Quamine, Johnathan D Ebben, Jillian M Kline, Emily O Lafeber, Madison F Phillips, Monica M Cho, Amanda S Ceas, John A Kink

“…Mice bearing pulmonary OS metastases underwent alloBMT and alloNK cell infusion with anti-CD155 either before or after tumor induction, with select groups receiving anti-DNAM-1 pretreated alloNK cells. …”
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Catalytically inactive Cas9 attenuates DNA end resection: A potential application for region-restricted random mutagenesis by Suchin Towa, Satoshi Okada, Takashi Ito

“…Blocking end resection could, therefore, confine hypermutation to a limited region. …”
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New Therapies in the Biological Treatment of Psoriasis: A Review by Mateusz Kamil Ożóg, Alicja Derkacz, Dawid Klimczak, Sara Winkler, Laura Wojciuch

“…In the past few years, immune checkpoint inhibitors have revolutionized moderate to severe psoriasis management by blocking crucial pro-inflammatory cytokines, introducing new avenues for biological therapies. …”
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Stimulation of Neural Stem Cell Proliferation by Inhibition of Phosphodiesterase 5 by Ana I. Santos, Bruno P. Carreira, Rui J. Nobre, Caetana M. Carvalho, Inês M. Araújo

“…Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy to enhance the first step of neurogenesis, proliferation of neural stem cells (NSC). …”
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Sugammadex: Breaking Through Residual Paralysis after Neostigmine’s Limits by Aparna Bagle, Sania Rodrigues

“…Persistent neuromuscular blockade following the use of Neuromuscular Blocking Agents (NMBAs) remains a significant postoperative concern, often resulting in delayed recovery and prolonged stays in the Post- Anaesthesia Care Unit (PACU). …”
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SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. by Chelsi D Cassilly, Marcus M Maddox, Philip T Cherian, John J Bowling, Mark T Hamann, Richard E Lee, Todd B Reynolds

“…SB-224289, previously reported as a selective human 5-HT1B receptor antagonist, also confers resistance to the similar toxin theopapuamide (TPap-A), but not to other cytotoxic depsipeptides tested. …”
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Description of environmental stress mediators in <i>Candida</i> species by Olga V. Enoktaeva

“…The successful spread of the genus Candida micromycetes in various host niches is accounted for by their ability to avoid stress caused by host immune system and other factors aimed at blocking fungal vital processes. The article studies the Transcriptional activator of CDR and the Multidrug resistance regulator controlling overexpression of target genes supposed to ensure resistant properties in genus Candida species against fluconazole. …”
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Autophagy inhibitor chloroquine enhanced the cell death inducing effect of the flavonoid luteolin in metastatic squamous cell carcinoma cells. by Lien Verschooten, Kathleen Barrette, Sofie Van Kelst, Noemí Rubio Romero, Charlotte Proby, Rita De Vos, Patrizia Agostinis, Marjan Garmyn

“…Transmission electron microscopy, mRFP-GFP-LC3 assay and p62 protein degradation, confirmed that Luteolin stimulated the autophagic process in the metastatic MET4 cells. Blocking autophagy using chloroquine magnified Luteolin-induced apoptosis in the metastatic SCC cells.…”
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Demographic Processes in Developmentally Peripheral Areas of Hungary by János Pénzes, István Zoltán Pásztor, Patrik Tátrai

“…Using methods of multivariate statistical analysis, seven indicators were selected in order to achieve the goals of the paper. …”
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Transfection of unmodified oligodeoxynucleotide with polyethylenimine reduces the level of hepatitis B surface antigen by Junyu Lin, Jing Li

“…IntroductionThe delivery of nucleic acid into cells using polyethylenimine (PEI) as non-viral carrier is a potential candidate technique for the treatment of hepatitis B virus (HBV) infection.MethodsIn the present study, PEI was used as cationic polymers and transfected with unmodified oligodeoxynucleotides in cell cultures and the BALB/c mouse model to investigate its efficiency in blocking HBV surface antigen (HBsAg) secretion.Results and discussionPEI/oligonucleotide complexes selectively inhibited HBsAg secretion in the culture supernatant, while there were no evident alterations in HBeAg and HBV DNA levels, thereby suggesting its potential inhibitory activity against the production of HBsAg. …”
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Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest by Ruiyu Wang, Ning Zhou, Yue Luo, Xiaohong Zhang, Chuanzhu Lv

“…In vivo , in rats with ventricular fibrillation (VF)-induced CA, a selective cGAS inhibitor (RU.521) was used to specifically inhibit cGAS activity, thereby blocking its downstream signaling pathway. …”
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