Structure Optimization and Their Biodistribution in Tumor-bearing Mice on FAP and αⅤβ3 Dual Targeting Molecular Probes by WU Xiaoming1, 2, TIAN Guoxin3, WEN Xuejun2, 4, HE Tian1, 2, MA Fuqiu1, 3, XUE Yun1, 3

“…In addition, compared to FAPI-02, RGD, and FAPI-02+RGD blocking groups, the tumor uptake and retention of 68Ga-FAPI-RGD-02 is very much higher than these blocking groups through microPET imaging studies. …”
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Cancer-oocyte SAS1B protein is expressed at the cell surface of multiple solid tumors and targeted with antibody-drug conjugates by Craig L Slingluff, Walter C Olson, Christine A Tran, Arabinda Mandal, Jagathpala Shetty, Mriganka Mandal, Bhupal Ban, Eusebio S Pires, Sara J Adair, Todd W Bauer, John C Herr

“…SAS1B deletion constructs were developed to map SAS1B’s epitope, enabling the creation of a blocking peptide. Indirect immunofluorescence (IIF) of human transfected normal and cancer cells was performed to assess SAS1B expression. …”
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VipD of Legionella pneumophila targets activated Rab5 and Rab22 to interfere with endosomal trafficking in macrophages. by Bonsu Ku, Kwang-Hoon Lee, Wei Sun Park, Chul-Su Yang, Jianning Ge, Seong-Gyu Lee, Sun-Shin Cha, Feng Shao, Won Do Heo, Jae U Jung, Byung-Ha Oh

“…These interactions prevent Rab5 and Rab22 from binding to downstream effectors Rabaptin-5, Rabenosyn-5 and EEA1, consequently blocking endosomal trafficking and subsequent lysosomal degradation of endocytic materials in macrophage cells. …”
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Environmental Implication of Herbicide Use by Małgorzata Baćmaga, Jadwiga Wyszkowska, Jan Kucharski

“…One of the guiding principles of the sustainable use of herbicides is their targeted action exclusively against weeds, consisting of blocking photosynthesis and synthesis of amino acids and growth regulators. …”
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PROTACs for BRDs proteins in cancer therapy: a review by Chao Wang, Yujing Zhang, Shanbo Yang, Wujun Chen, Dongming Xing

“…BRDs proteins are now emerging as targets for new therapeutic development. Blocking the function of any of BRDs proteins can be a control agent for diseases, such as cancer. …”
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Principal Component Analysis-Multilinear Perceptron-based model for Distributed Denial of Service Attack Mitigation by Opeyemi Oreoluwa Asaolu, Oluwasanmi Segun Adanigbo, Afeez Adekunle Soladoye, Nnamdi Stephen Okomba

“…The firewall, utilizing IPtables, selectively permits traffic from trusted sources, successfully blocking nearly 70% of DDoS threats. …”
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Selinexor in acute myeloid leukemia: therapeutic applications and current challenges by Ziyu Qie, Li Ma, Jie Tan, Xiaochun Peng, Xiaochun Peng

“…Selinexor, as the first oral selective inhibitor of nuclear export protein Exportin-1 (XPO1), inhibits the abnormal nuclear export of tumor suppressor proteins by blocking XPO1, thereby restoring their activity and exerting antitumor effects. …”
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Bile acids reduce endocytosis of high-density lipoprotein (HDL) in HepG2 cells. by Clemens Röhrl, Karin Eigner, Stefanie Fruhwürth, Herbert Stangl

“…Taurocholate exerted these effects extracellularly and independently of HDL modification, cell membrane perturbation or blocking of endocytic trafficking. Instead, this reduction of endocytosis and increase in selective uptake was dependent on SR-BI. …”
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QoS Supported IPTV Service Architecture over Hybrid-Tree-Based Explicit Routed Multicast Network by Chih-Chao Wen, Cheng-Shong Wu

“…The goals for IPTV service are to provide two-way interactive services for viewers to select popular program channel with high quality for watching during fast channel surfing period. …”
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METHOD OF CALCULATING THE DESIGN PARAMETERS OF A MODULATOR ANTI-LOCK BRAKING SYSTEM WITH A HIGH FLOW OF WORKING FLUID by Mikhail ZHILEVICH, Sergey ERMILOV, Denis KAPSKI, Yuriy VOVK, Oleg LYASHUK, Iryna VOVK

“…Therefore, dimensions of the anti-blocking system modulator spool pair require unique electromagnets or hydraulic amplifiers to control. …”
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A dominant negative zebrafish Ahr2 partially protects developing zebrafish from dioxin toxicity. by Kevin A Lanham, Amy L Prasch, Kasia M Weina, Richard E Peterson, Warren Heideman

“…One of these dnAhr2s was selected for expression from the ubiquitously active e2fα promoter in transgenic zebrafish. …”
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Opening new frontiers with catalytic nucleic acids in miRNA inhibition by Olga Patutina, Svetlana Miroshnichenko, Daria Chiglintseva, Marina Zenkova

“…Current approaches to pathological microRNA (miRNA) regulation primarily rely on physical blocking or sequestration mechanisms. However, these non-enzymatic strategies are limited by their stoichiometric nature, necessitating high drug doses to achieve therapeutic efficacy. …”
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Reduction of the Ca2+ permeability of ligand-gated ion channels as a strategy against excitotoxicity by Tiziano D’Andrea, Sergio Fucile, Sergio Fucile

“…We posit that excitotoxicity due to the overactivation of Ca2+-permeable LGICs may be counteracted by using molecules able to reduce selectively the Ca2+ entry, without blocking Na+ influx, thus reducing the adverse effects induced by channel blockers. …”
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P16-positive senescent cells promote DKD by the dysregulation of glycolysis and mitochondrial metabolism by Xiao Lu, Jiao Wu, Ewud Agborbesong, Xiaogang Li

“…In addition, p16 mediated the blocking of the cell cycle is through the CDK4-Rb pathway in DKD kidneys. …”
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PROSPECTS FOR SEARCHING MULTITARGET TOPOISOMERASE INHIBITORS WITH ANTITUMOR PROPERTIES by M. I. Treshchalin, E. V. Neborak, H. M. Treshalina

“…The antitumor and side effect characteristics of the agents, associated with the selective suppression of the activity of type I and/or II topoisomerase (Top1, Top2) in tumor cells were emphasized. …”
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Effects of Coverage Area Treatment, Spatial Analysis Unit, and Regression Model on the Results of Station-Level Demand Modeling of Urban Rail Transit by Hongtai Yang, Chaojing Li, Xuan Li, Jinghai Huo, Yi Wen, Emma G. P. Sexton, Yugang Liu

“…However, the selection of these methods and models seems arbitrary. …”
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Satellite-derived land surface temperature spatial sharpening: A comprehensive review on current status and perspectives by Mohammad Karimi Firozjaei, Majid Kiavarz, Seyed Kazem Alavipanah

“…Secondly, to eliminate non-relevant papers, several criteria were applied and 207 out of 391 papers were selected for this review. Finally, the assembled database was used to extract important information. …”
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Molecular recognition of CCR5 by an HIV-1 gp120 V3 loop. by Phanourios Tamamis, Christodoulos A Floudas

“…The computationally derived structure sheds light into the functional role of HIV-1 gp120 V3 loop and CCR5 residues associated with the HIV-1 coreceptor activity, and provides insights into the HIV-1 coreceptor selectivity and the blocking mechanism of HIV-1 gp120 by maraviroc. …”
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Effects of the Shock Wave Structure on the Tip Clearance Leakage Flow in Transonic Compressor Rotors by Xinlong Ye, Zhenggui Zhou

“…The movement speed of the annular wall is less than that of the leakage flow, which has a minor blocking effect on the tip clearance leakage flow. …”
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Distribution and molecular evolution of the anti-CRISPR family AcrIF7. by Wendy Figueroa, Adrian Cazares, Daniel Cazares, Yi Wu, Ana de la Cruz, Martin Welch, Luis Kameyama, Franklin L Nobrega, Gabriel Guarneros

“…Anti-clustered regularly interspaced short palindromic repeats (CRISPRs) are proteins capable of blocking CRISPR-Cas systems and typically their genes are located on mobile genetic elements. …”
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