Targeting the SHP2 phosphatase promotes vascular damage and inhibition of tumor growth by Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D Tran, Taekyu Ha, Jing‐Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato

“…Reduction of tumor growth ensues, independent of SHP2 targeting in the tumor cells, blocking immune checkpoints, or recruiting macrophages. …”
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Impacts of coal fracture roughness and aperture on the seepage of injected water: An experimental study by Gang WANG, Xuechang CHEN, Hao CHEN, Qingming LONG, Yixin LIU

“…In the case where fracture apertures ranged from 60 to 90 μm, the fracture roughness exhibited the most significant blocking effect on seepage. With a further increase in the fracture aperture, the blocking effect of roughness elements began to weaken, with the fracture aperture dominating the seepage process. …”
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Interaction of the Wolbachia surface protein with a novel pro-viral protein from Aedes aegypti by Mazhar Hussain, Zhi Qi, Sassan Asgari

“…To date, several reports have appeared that highlight multiple molecular and cellular pathways involved in the blocking mechanism, which underlines the complicated nature of the mechanism. …”
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Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding by Lucie Pejšková, Addolorata Pisconti, Marianne Lunde, Ka Yi Ho, Nina Therese Solberg, Shiori Koga, Erik Tengstrand, Cathrine Rein Carlson, Mona Elisabeth Pedersen, Sissel Beate Rønning

“…Additionally, by treating MuSCs with blocking peptides derived from the SDC4 ectodomain, we identified altered proliferation. …”
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Research on Formation Mechanism and Suppression Measures of Internal Overvoltage for High-speed Train by Shanqiang GU, Jingdi SUN, Rui ZHANG, Heng XU, Kun CHEN

“…In order to reduce the internal overvoltage of high-speed train, three measures of parallel blocking high-pass filter in neutral section, adopting advanced co-phase traction power supply system and selecting suitable roof voltage transformer were proposed. …”
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An Entropy-Based Gravity Model for Influential Spreaders Identification in Complex Networks by Yong Liu, Zijun Cheng, Xiaoqin Li, Zongshui Wang

“…The study is necessary for blocking the spread of epidemics, controlling public opinion, and managing transportation. …”
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Heterogeneous Wireless Network Resource Management Algorithm Based on Reinforcement Learning by Chenwei Feng, Jiangnan Yuan

“…In order to make full use of the resources of all kinds of wireless network，the integration of heterogeneous network is necessary.However，when it comes to the heterogeneous network integration，the problems of call request access control and resource management emerge.A reinforcement-learning-based algorithm was presented for heterogeneous wireless network resource management.D2D （device-to-device）communication was introduced into the proposed algorithm and the appropriate network for access could be selected according to different traffic types，terminal mobility，network load status and so on.Meanwhile，to reduce the storage requirement，the neural network technology was used to solve the problem of continuous state space.Simulation results show that the proposed algorithm has an efficient learning ability to achieve autonomous radio resource management，which effectively improves the spectrum utility and reduces the blocking probability.…”
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RESEARCH OF PARAMETERS OF ENCODING OF THE ALGORITHM WITH VARIABLE FRAGMENTATION OF THE UNIT by K. O. Zakharova

“…This article presents recommendations on the selection of parameters of the encryption algorithm with variable fragmentation of the block, developed on the basis of a study of the obtained results of the algorithm with different encryption parameters (p and q). …”
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Monoclonal Antibodies as Immune Modulators for Cancer Therapy by Robert O Dillman

“…Monoclonal antibodies directed against certain tumour cell receptors may alter the biological behaviour of tumour cells such as blocking or downregulation of growth factors essential to tumour cell proliferation. …”
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Mitochondrial damage triggers the concerted degradation of negative regulators of neuronal autophagy by Bishal Basak, Erika L. F. Holzbaur

“…Rubicon inhibits lysosomal function, blocking later steps of neuronal autophagy; Rubicon depletion relieves this inhibition. …”
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Immuno-PET Imaging of Siglec-15 Using the Zirconium-89-Labeled Therapeutic Antibody, NC318 by Elaine M. Jagoda, Falguni Basuli, Colleen Olkowski, Ido Weiss, Tim E. Phelps, Karen Wong, Anita Thien Ton, Kelly C. Lane, Steve Adler, Donna Butcher, Elijah F. Edmondson, Sol Langermann, Peter L. Choyke

“…Specific [89Zr]Zr-DFO-NC318 binding to Siglec-15 was proven with NC318 blocking studies in which dose-dependent decreases in Siglec-15+tumor T : Ms were observed. …”
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Synergy of oncolytic adenovirus and immune checkpoint inhibitors: transforming cancer immunotherapy paradigms by Chong Cheng, Qingzhe Wang, Shuang Zhang

“…Oncolytic viruses (OVs) offer a promising antitumor strategy by selectively lysing tumor cells and simultaneously activating innate and adaptive immune responses. …”
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Pancreatic cancer and adaptive metabolism in a nutrient-deficient environment by Robert Słotwiński, Sylwia Małgorzata Słotwińska

“…Early diagnosis and new therapeutic approaches based on the adaptive metabolism of the tumor in a nutrient-deficient environment are expected to improve the future treatment of PDAC patients. It was found that blocking selected metabolic pathways related to the local adaptive metabolic activity of pancreatic cancer cells, improving nutrient acquisition and metabolic crosstalk within the microenvironment to sustain proliferation, may inhibit cancer development, increase cancer cell death, and increase sensitivity to other forms of treatment (e.g., chemotherapy). …”
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Tracheal Intubation through the I-gel for Emergency Cesarean Section in a Patient with Multidrug Hypersensitivity: A New Technique by Kartika Balaji Samala, Yuri Uchiyama, Yasuyuki Tokinaga, Yukitoshi Niiyama, Soshi Iwasaki, Michiaki Yamakage

“…We believe this method would be helpful in selected situations.…”
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Fostamatinib, a Spleen Tyrosine Kinase Inhibitor, Exerts Anti-Inflammatory Activity via Inhibiting STAT1/3 Signaling Pathways by Guo R, Liao H, Meng Y, Shi X, He Y, Zhu Z, Guo W

“…Meanwhile, fostamatinib selectively blocked the phosphorylation of STAT1 and STAT3 in PMs induced by LPS and cytokines (IFN-γ and IL-6).Conclusion: Fostamatinib can significantly inhibit LPS-induced inflammatory response through blocking STAT1/3 signaling pathways and has the potential to be used in the therapy of acute inflammatory diseases, especially SIRS and sepsis, which are resulting from the infection of Gram-negative bacteria.Keywords: fostamatinib, inflammation, macrophages, neutrophils, STAT1/3 signaling pathways, systemic inflammatory response syndrome…”
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Properties and Application of Chemical Grouting Materials for Construction Joint Leakage by Baozhi Li, Weiwei Han, Shuyin Wu, Yanyan Shi, Pan Wang, Xiaoguo Wang

“…Then, the tunnel construction joints were simulated, and the injectability and water blocking effect were analyzed to evaluate the suitability of the different grouting slurry. …”
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In silico analysis of conformational changes induced by mutation of aromatic binding residues: consequences for drug binding in the hERG K+ channel. by Kirsten Knape, Tobias Linder, Peter Wolschann, Anton Beyer, Anna Stary-Weinzinger

“…Many drugs reduce hERG current by directly binding to the channel, thereby blocking ion conduction. Mutation of two aromatic residues (F656 and Y652) substantially decreases the potency of numerous structurally diverse compounds. …”
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Adaptive anti-jamming technologies based on direct sequence spread spectrum and single carrier frequency domain equalization by Fanglin GU, Yuzhen HUANG, Ying ZHAO, Haitao ZHAO, Jibo WEI

“…To solve the performance limitation of direct sequence spread spectrum system in complex multipath environment, an adaptive anti-jamming spread spectrum framework that organically combines single carrier frequency domain equalization (SCFDE) and direct sequence spread spectrum (DSSS) technologies was proposed.The frequency multipath fading was overcame by frequency domain equalization, and the transmission rates and high reliability was reconfigured by deploying variable spread factors.Moreover, the inherent fast Fourier transform process was made full use at the receiver to realize the adjoint detection and analysis of interference intensity, interference type and other information, etc.Then, the frequency domain bearing point online was optimized and selected to improve the adaptability to the interference, especially blocking interference.The simulation results show that the proposed direct spread spectrum waveform based on SCFDE has good communication performance in both Gaussian and multipath environments, and the notch of some frequency bands has little impact on the communication performance, which verifies the effectiveness of anti-jamming by adaptive optimizing information frequency domain bearers.…”
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Comparison of CRISPR-Cas9, CRISPR-Cas12f1, and CRISPR-Cas3 in eradicating resistance genes KPC-2 and IMP-4 by Jun Huang, Kanghui Ding, Jiahui Chen, Jiao Fan, Luyao Huang, Shaofu Qiu, Ligui Wang, Xinying Du, Chao Wang, Haifeng Pan, Zhengquan Yuan, Hongbo Liu, Hongbin Song

“…In addition, the three CRISPR plasmids could block the horizontal transfer of drug-resistant plasmids, with a blocking rate as high as 99%. …”
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Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus by Marie-France Martin-Eauclaire, Pierre E. Bougis

“…We have participated in the isolation and in the characterization of several structurally distinct families of scorpion toxin peptides exhibiting different K+ channel blocking functions. In particular, the venom from the Moroccan scorpion Androctonus mauretanicus mauretanicus provided several high-affinity blockers selective for diverse K+ channels  (SKCa,  Kv4.x, and  Kv1.x K+ channel families). …”
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