Structural basis for saxitoxin congener binding and neutralization by anuran saxiphilins by Sandra Zakrzewska, Samantha A. Nixon, Zhou Chen, Holly S. Hajare, Elizabeth R. Park, John V. Mulcahy, Kandis M. Arlinghaus, Eduard Neu, Kirill Konovalov, Davide Provasi, Tod A. Leighfield, Marta Filizola, J. Du Bois, Daniel L. Minor

“…Importantly, functional studies demonstrate that Sxph ‘toxin sponges’ reverse NaV block by multiple STX congeners and detect these toxins in a radioligand binding assay (RBA) used for environmental testing. …”
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Modern Views on the Neuropeptide Oxytocin. Part II. Oxytocin in the Process of Evolution. The Role of Oxytocin in the Behavioural, Somatic and Autonomic Functions of Humans and Ani... by Elena A. Leonova, Albina A. Bakhova, Irina L. Cherednik, Yulia V. Kashina, Aleksandr N. Ardelyan

“…The anti-stress and anxiolytic effects of this neuropeptide blocking the effects of the main stress hormone, cortisol, have been detected. …”
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Straightness monitoring of scraper conveyor based on CUDA-accelerated dynamic programming and optimized panoramic stitching by LI Bo, SHI Shouyi, ZHANG Jianjun, XIA Rui, WANG Xuewen, CUI Weixiu, NI Qiang

“…Then, the oriented FAST and rotated BRIEF (ORB) algorithm was used to detect and calculate feature points and descriptors from the two video frames. …”
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Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. by Gaia Nebbia, Dimitra Peppa, Anna Schurich, Pooja Khanna, Harsimran D Singh, Yang Cheng, William Rosenberg, Geoffrey Dusheiko, Richard Gilson, Joanne ChinAleong, Patrick Kennedy, Mala K Maini

“…T cells expressing Tim-3 had an impaired ability to produce IFN-γ and TNF-α upon recognition of HBV-peptides and were susceptible to galectin-9-triggered cell death in vitro. Galectin-9 was detectable at increased concentrations in the sera of patients with active CHB-related liver inflammation (p = 0.02) and was strongly expressed by Kupffer cells within the liver sinusoidal network. …”
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Overexpression of forkhead box protein M1 (FOXM1) in ovarian cancer correlates with poor patient survival and contributes to paclitaxel resistance. by Fung Zhao, Michelle K Y Siu, LiLi Jiang, Kar Fai Tam, Hextan Y S Ngan, Xiao Feng Le, Oscar G W Wong, Esther S Y Wong, Ana R Gomes, Laura Bella, Pasarat Khongkow, Eric W-F Lam, Annie N Y Cheung

“…One of the potential targets, KIF2C, exhibited similar expression pattern to FOXM1 in chemosensitive and chemoresistant cells in response to paclitaxel treatment. FOXM1 could be detected at the promoter of KIF2C and FOXM1 silencing significantly down-regulated KIF2C.…”
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Development of White Cabbage, Coffee, and Red Onion Extracts as Natural Phosphodiesterase-4B (PDE4B) Inhibitors for Cognitive Dysfunction: In Vitro and In Silico Studies by Nazir Ahmad, Kaisun Nesa Lesa, Navista Sri Octa Ujiantari, Ari Sudarmanto, Nanang Fakhrudin, Zullies Ikawati

“…Thus, the combination extracts are a promising cognitive enhancer by blocking PDE4B activity.…”
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Electrophysiological evaluation of the neuromuscular junction: a brief review by João Aris Kouyoumdjian, Eduardo de Paula Estephan

“…The jitter is the most sensitive test for detecting a neuromuscular junction dysfunction. Most neuromuscular junction disorders are responsive to treatment.…”
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P26 | HUMAN CYTOMEGALOVIRUS-DRIVEN ADAPTIVE NK CELLS AND MATRIX METALLOPROTEINASES EXPRESSION AS KEY ELEMENTS IN ATHEROSCLEROTIC PLAQUE DESTABILIZATION

“…NK cells from HR HCMV+ pts showed elevated IFN-γ production via ADCC, which correlated with FcεR1γ⁻ NK cell frequency. Blocking NKG2D reduced IFN-γ release, implying a role in activation. …”
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Influence of dams on sauger population structure and hybridization with introduced walleye by William C. Rosenthal, Elizabeth G. Mandeville, Ashleigh M. Pilkerton, Paul C. Gerrity, Joseph A. Skorupski, Annika W. Walters, Catherine E. Wagner

“…Overall, there was limited hybridization detected, however, hybridization was most prevalent in Boysen Reservoir (a large impounded section of the Wind River). …”
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A GPT-Based Code Review System With Accurate Feedback for Programming Education by Dong-Kyu Lee, Inwhee Joe

“…In usability test, the system detected up to 42.86% more errors than a conventional online judge. …”
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A survey of mosquito-borne and insect-specific viruses in hospitals and livestock markets in western Kenya. by Tatenda Chiuya, Daniel K Masiga, Laura C Falzon, Armanda D S Bastos, Eric M Fèvre, Jandouwe Villinger

“…The presence of Sindbis virus in a single mosquito from a population of mosquitoes with ISFs calls for further investigation into the role ISFs may play in blocking transmission of other arboviruses in this region.…”
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LYSOSOME-DEPENDENT CELL DEATH DEFINES SPECIFIC ENDOTHELIAL TOXICITY OF CALCIUM PHOSPHATE BIONS by D. K. Shishkova, E. A. Velikanova, R. A. Mukhamadiyarov, A. E. Yuzhalin, Yu. A. Kudryavtseva, A. N. Popova, D. M. Russakov, A. G. Kutikhin

“…CPB were internalized by endothelial cells as early as 1 h upon their addition and were localized in lysosomes; after 4 h, we detected release of calcium ions (Ca2+) from lysosomes to cytosol accompanied by multifold increase in cleaved caspase 3 and its substrate PARP-1. …”
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An AI-Enabled Framework for <i>Cacopsylla chinensis</i> Monitoring and Population Dynamics Prediction by Ruijun Jing, Deyan Peng, Jingtong Xu, Zhengjie Zhao, Xinyi Yang, Yihai Yu, Liu Yang, Ruiyan Ma, Zhiguo Zhao

“…First, to enhance the model’s capability for detecting small targets, we developed a backbone network based on the RepVit block and its variants. …”
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Design of Enhanced License Plate Information Recognition Algorithm Based on Environment Perception by Zilu Wang, Limin Zheng, Gang Li

“…Furthermore, in real-world detection experiments, the H-YOLO detector was improved by 12 percentage points. …”
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Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis by Ke Wang, Jian Huang, Zhen Wang, Haijun Wang, Jun Pan, Jun Yan, Zhigang Zhang, Fang Jia, Lili Li, Chenghui Yang, Fuming Qiu, Xiaoyan Jin, Pin Wu, Shanshan Sun, Ke Su, Leyi Zhang, Xiuyan Yu, Xuan Shao

“…Finally, 120 patients’ sample were applied to confirm the acceleration of Naged formation through secreted NAMPT, and the importance of blocking this pathway in mice was evaluated.Results We find that Naged accumulate in the lung premetastatic niche at early stage of breast tumorigenesis in multiple mice models and also exist in peripheral blood and metastatic lung of patients with breast cancer. …”
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Presence of neutralizing SARS‐CoV‐2 antibodies in asymptomatic population of N'Djamena, Chad by Andrillene Laure Deutou Wondeu, Mahamat Fayiz Abakar, Federica Frasca, Aleyo Zita Nodjikouambaye, Fatima Abdelrazakh, Nathan Naibei, Guy Rodrigue Takoudjou Dzomo, Djallaye Djimtoibaye, Joseph Mad‐Toingue, Carolina Scagnolari, Guido Antonelli, Giulia Linardos, Cristina Russo, Carlo Federico Perno, Fissou Henry Yandai, Sabrina Atturo, John Hiscott, Vittorio Colizzi, Giulia Cappelli, Nambatibe Ngueadoum, Alsadick Haroun, Ouchemi Choua, Ali Mahamat Moussa

“…This could be one of the reasons for the low severity of Covid‐19 observed in this area, given the key role of NAbs in blocking SARS‐CoV‐2 infection.…”
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Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses by Qing Lei, Hui Fu, Zongjie Yao, Zijie Zhou, Yueqing Wang, Xiaosong Lin, Yin Yuan, Qi Ouyang, Xinyue Xu, Jinge Cao, Mengze Gan, Xionglin Fan

“…Additionally, varying intervals between vaccinations and detection times were examined to study IL-10 expression across different organs. …”
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The role of glycerophospholipid metabolism in feline parvovirus infected CRFK cells by Zhen Sun, Zhen Sun, Zhen Sun, Zhen Sun, Hongwei Zhu, Hongwei Zhu, Hongwei Zhu, Hongwei Zhu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Jianlong Zhang, Jianlong Zhang, Jianlong Zhang, Jianlong Zhang, Linlin Jiang, Linlin Jiang, Linlin Jiang, Linlin Jiang, Xin Yu, Xin Yu, Xin Yu, Xin Yu, Jiayu Yu, Jiayu Yu, Jiayu Yu, Jiayu Yu, Xingxiao Zhang, Xingxiao Zhang, Xingxiao Zhang, Xingxiao Zhang

“…Viral identification was performed via cytopathic effect (CPE) observation, transmission electron microscopy (TEM), PCR, and VP2 protein detection using Western blot and immunofluorescence. …”
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Portable Bioactive Paper-Based Sensor for Quantification of Pesticides by Murat Kavruk, Veli Cengiz Özalp, Hüseyin Avni Öktem

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The Advantages of Multimodal Imaging in the Diagnosis of Rhegmatogenous Retinal Detachment by N. V. Neroeva, O. V. Zaytseva, A. I. Ushakov, S. V. Milash

“…In the postoperative period, ultra-wide field imaging in combination with peripheral OCT made it possible to objectively document the attachment of the retina, the blocking of breaks and areas of rhegmatogenous degeneration by through external scleral indentation.Conclusions. …”
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