Wooden breast myopathy is characterized by satellite cell dysfunction and syndecan-4 shedding by Lucie Pejšková, Addolorata Pisconti, Marianne Lunde, Ka Yi Ho, Nina Therese Solberg, Shiori Koga, Erik Tengstrand, Cathrine Rein Carlson, Mona Elisabeth Pedersen, Sissel Beate Rønning

“…Additionally, by treating MuSCs with blocking peptides derived from the SDC4 ectodomain, we identified altered proliferation. …”
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Using the PET/CT radiotracer [68Ga]Ga-DOTA-mDesmo to target V1b receptors and localize corticotropinoma in Cushing’s disease by Somit Pandey, Rama Walia, Gurvinder Kaur, Kumud Pandav, Imran Rather, Nivedita Rana, Sushant Sahoo, Bhagwant Rai Mittal, Jaya Shukla

“…Excess cold DOTA-mDesmo results in a 50% blocking in binding. Biodistribution in rats indicates renal clearance, with high %ID/g in the kidneys (7.37 ± 0.58) and urinary bladder (4.32 ± 0.48), and negligible uptake in the pituitary gland, our organ of interest. …”
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RETRACTED ARTICLE: Tamoxifen suppresses brain metastasis of estrogen receptor-deficient breast cancer by skewing microglia polarization and enhancing their immune functions by Shih-Ying Wu, Sambad Sharma, Kerui Wu, Abhishek Tyagi, Dan Zhao, Ravindra Pramod Deshpande, Kounosuke Watabe

“…Conclusions Our results indicate that estrogen promotes brain metastasis by skewing polarity of M2 microglia and inhibiting their phagocytic ability, while tamoxifen suppresses brain metastasis by blocking the M2 polarization of microglia and increasing their anti-tumor phagocytic ability. …”
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Fostamatinib, a Spleen Tyrosine Kinase Inhibitor, Exerts Anti-Inflammatory Activity via Inhibiting STAT1/3 Signaling Pathways by Guo R, Liao H, Meng Y, Shi X, He Y, Zhu Z, Guo W

“…The activation and ROS release of neutrophils were detected by flow cytometry. Subsequently, the therapeutic effect of fostamatinib on LPS-induced SIRS in mice was examined. …”
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An Intrathermocline Eddy Observed in the Northeastern Bay of Bengal by Xiwu Zhou, Yun Qiu, Xinyu Lin, Hui Teng, Cherry Aung

“…Abstract An intrathermocline eddy (ITE) was detected to the northwest of Preparis Channel by in situ measurements in January 2018. …”
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Peptide-based PET tracer targeting LAG-3 for evaluating the efficacy of immunotherapy in melanoma by Yan Wang, Ziyang Zhu, Peizhe Yuan, Yu Long, Nannan Wei, Jinquan Han, Dawei Jiang, Xiaoli Lan, Yongkang Gai

“…Cell uptake and blocking essays were performed to verify the specificity of the tracer in vitro. …”
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Experimental Infections of Pigs with Japanese Encephalitis Virus Genotype 4 by Paul M. Hick, Deborah S. Finlaison, Kate Parrish, Xingnian Gu, Philip Hayton, Tiffany O’Connor, Andrew Read, Jing Zhang, Zoe B. Spiers, Pedro Pinczowski, Angel L. Ngo, Peter D. Kirkland

“…The detection of JEV in oral and nasal swabs and in saliva from chew ropes was less consistent. …”
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Intratumoral STING agonist reverses immune evasion in PD-(L)1-refractory Merkel cell carcinoma: mechanistic insights from detailed biomarker analyses by Shailender Bhatia, Paul Nghiem, Rima Kulikauskas, Candice Church, David M Koelle, Lisa Tachiki, Kimberly Smythe, Thomas Pulliam, Shira Tabachnick-Cherny, Saumya Jani, Peter H Goff, Rashmi Bhakuni, Brandon W Seaton

“…Background Antibodies blocking programmed death (PD)-1 or its ligand (PD-L1) have revolutionized cancer care, but many patients do not experience durable benefits. …”
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Post-treatment transmissibility of Plasmodium falciparum infections: an observational cohort study by Kassahun Habtamu, Hallelujah Getachew, Ashenafi Abossie, Assalif Demissew, Arega Tsegaye, Teshome Degefa, Daibin Zhong, Xiaoming Wang, Ming-Chieh Lee, Guofa Zhou, Solomon Kibret, Christopher L. King, James W. Kazura, Beyene Petros, Delenasaw Yewhalaw, Guiyun Yan

“…Methods A prospective cohort study was conducted using passive case detection to enrol individuals with uncomplicated P. falciparum malaria at six health facilities. …”
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Exploring the active ingredients of Banzhilian and its mechanism of action on diabetic Gastric cancer based on network pharmacology by Haikun Cao, Hui Song, Weiguo Zhou, Xiaohu Lv, Xinlei Liu, Zheng Xiang, Rui Fu, Yixian Cheng, Junjie Chen, Shengwei Wang, Yvbo Hu, Huayue Yan, Wenlong You, Changqian Guo, Bo Chen, Guodong Cao, Wei Wang, Jianguang Jia

“…The experimental findings confirmed that quercetin, as an active monomer in Banzhilian, suppresses the proliferation of HGC-27-HG cells by inhibiting the PI3K/AKT/MYC pathway, promoting apoptosis, blocking cell cycle progression, and inhibiting cell migration and invasion.…”
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Soil moisture monitoring using sheet-type GHz metamaterial perfect absorber by Fumiya NOTO, Soma SATO, Hiroaki ONOE, Tetsuo KAN

“…Reflection measurements demonstrated that changes in soil moisture levels could be detected in both air and on soil surfaces without being affected by reflection waves. …”
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Lightweight grape leaf disease recognition method based on transformer framework by Ning Zhang, Enxu Zhang, Guowei Qi, Fei Li, Cheng Lv

“…This module can effectively acquire and fuse multi-scale information and global information in the feature map. (3) Use the dense connection method to combine the LVT Block and the MARI Block to propose a new architecture, the DLVT Block. …”
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Inhibition of hedgehog pathway reveals the regulatory role of SMO in gastric cancer cells by Zixin Yang, Yingqian Lv, Long Wang, Yong Chen, Jinzhu Han, Shan Zhao, Wei Liu

“…Cell proliferation and cycle were assayed in gastric cancer cells after blocking the hedgehog pathway by lentiviral-short hairpin RNA knockdown. …”
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Slowing down single-molecule trafficking through a protein nanopore reveals intermediates for peptide translocation by Loredana Mereuta, Mahua Roy, Alina Asandei, Jong Kook Lee, Yoonkyung Park, Ioan Andricioaei, Tudor Luchian

“…Calculations of the expected current ratios of the different pore-blocking microstates and their time sequencing are in accord with the recorded current traces.…”
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3-D Image Analysis of Fluorescent Drug Binding by M. Raquel Miquel, Venessa Segura, Z. Ali, M. P. D'Ocon, J. C. McGrath, Craig J. Daly

“…In the presence of 10 μM phenoxybenzamine (blocking agent), the QAPB (50 nM) histogram overlaps the autofluorescence curve. …”
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Text analysis of DNS queries for data exfiltration protection of computer networks by Ya. V. Bubnov, N. N. Ivanov

“…The paper proposes a method of detecting such DNS requests based on text classification of domain names by convolutional neural network. …”
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Neocortical layer-5 tLTD relies on non-ionotropic presynaptic NMDA receptor signaling by Aurore Thomazeau, Sabine Rannio, Jennifer A Brock, Hovy Ho-Wai Wong, Per Jesper Sjöström

“…Hebbian coincidence detection requires that NMDARs be located postsynaptically, but enigmatic presynaptic NMDARs (preNMDARs) also exist. …”
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Design and Implementation of a Low-Power Biopotential Amplifier in 28 nm CMOS Technology with a Compact Die-Area of 2500 μm² and an Ultra-High Input Impedance by Esmaeil Ranjbar Koleibi, William Lemaire, Konin Koua, Maher Benhouria, Reza Bostani, Mahziar Serri Mazandarani, Luis-Philip Gauthier, Marwan Besrour, Jérémy Ménard, Mahdi Majdoub, Benoit Gosselin, Sébastien Roy, Réjean Fontaine

“…This work presents a bioamplifier optimized for action potential detection, designed using TSMC 28 nm HPC CMOS technology. …”
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Photothermal Therapeutic Gold Nanoparticles Loaded with PD-L1 siRNA Enhanced Killing of NSCLC Cells by Immune Cells by Gao L, Yang LH, Jiang FC, Ye WY, Chen X, Liu ZJ, He RQ, Huang WY, Feng ZB, Kong JL, Lai ZF, Chen G

“…Li Gao,1,* Li-Hua Yang,2,* Fang-Cheng Jiang,1,3 Wang-Yang Ye,4 Xin Chen,3 Zhao-Ji Liu,3 Rong-Quan He,2 Wan-Ying Huang,1 Zhen-Bo Feng,1 Jin-Liang Kong,5 Ze-Feng Lai,3,6 Gang Chen1 1Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 2Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 3Guangxi Key Laboratory of Pharmaceutical Precision Detection and Screening, Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 4College of Basic Medicine, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 5Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China; 6State Key Laboratory of Targeting Oncology, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Chen, Email chengang@gxmu.edu.cn Ze-Feng Lai, Email laizefeng@gxmu.edu.cnBackground: Although immune checkpoint blocking (ICB) therapeutic agents have significantly improved the survival for many cancer patients, the efficacy of ICB therapy for non-small cell lung cancer (NSCLC) patients remains limited. …”
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Diversification of Antitumour Immunity in a Patient with Metastatic Melanoma Treated with Ipilimumab and an IDO-Silenced Dendritic Cell Vaccine by Mouldy Sioud, Marta Nyakas, Stein Sæbøe-Larssen, Anne Mobergslien, Steinar Aamdal, Gunnar Kvalheim

“…Here, a patient with metastatic melanoma pretreated with ipilimumab, an anti-CTLA-4 blocking antibody, was vaccinated with IDO-silenced DCs cotransfected with mRNA for survivin or hTERT tumour antigens. …”
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