Analysis of the influencing factors on serum reversal in HIV-exposed children by LI Xiaoling, WU Xiaodong, YUAN Dongmei, HUANG Ting, LIU Xiaoning, XIA Junxia, LI Shaqian, HUANG Haiying, HE Yun

“…It was not related to children’s sex, gestational age, birth weight, and the type of blocking drug used (P>0.05).Conclusion No clear influencing factors were found for serum reversal in HIV-exposed 12-month-old children. …”
Get full text

Seeing Is Feeding for the Frugivorous Bird Brown-Eared Bulbul (Microscelis amaurotis) by Takeshi Honda, Jun-ichi Tsuboi, Hiroshi Kuwata

“…We examined feeding behavior by visually blocking fruit to establish a new theory of bird damage management for agricultural practices. …”
Get full text

Modeling and Simulation of a Resonant-Cavity-Enhanced InGaAs/GaAs Quantum Dot Photodetector by W. W. Wang, F. M. Guo, Y. Q. Li

“…Comparing with the conventional photodetectors, the resonant-cavity-enhanced photodiode (RCE-PD) showed higher detection efficiency, faster response speed, and better wavelength selectivity and spatial orientation selectivity. …”
Get full text

Nanobodies in animal infectious disease control: diagnosis and therapy by Jing Wang, Tiejin Tong, Qiang Wu

“…In diagnostics, Nbs enable sensitive, low-cost detection of pathogens like PRRSV, ASFV, and avian influenza. …”
Get full text

The Influence of Molecular Structure Modifications on Vibrational Properties of Some Beta Blockers: A Combined Raman and DFT Study by A. Farcaș, C. Iacoviță, E. Vințeler, V. Chiș, R. Știufiuc, C. M. Lucaciu

“…We report results of a systematic Raman, SERS, and DFT study on four beta blocking molecules: Atenolol, Metoprolol, Propranolol, and, for the first time reported in the literature, Bisoprolol. …”
Get full text

Tea Polyphenols Relieve the Fluoride-Induced Oxidative Stress in the Intestinal Porcine Epithelial Cell Model by Chunyan Xie, Shuyi Niu, Wen Tian

“…As the main antioxidant ingredient in tea, TPs alleviated F-induced cell oxidation and apoptosis via blocking F-induced ROS generation and LDH’s release, as well as promoting the transcription of tight junction (TJ) proteins and the activities of antioxidant enzymes in IPEC-J2 cells. …”
Get full text

Effects of Losartan on high glucose-induced bone marrow sources of macrophages and the relationship of angiotensin Ⅱ type 1 receptor with renal pathological damage by JIANG Xiao, WU Yong-gui

“…The macrophage infiltration in renal tissues was also compared between AT1R blocking drug-treated patients and control patients. …”
Get full text

Evaluation of Natural Peptides to Prevent and Reduce the Novel SARS-CoV-2 Infection by María Paredes-Ramos, Enma Conde Piñeiro, Horacio Pérez-Sánchez, José M. López-Vilariño

“…Employing docking, virtual screening, and molecular dynamics assays, SDRFSY, LSDRFS, and VIKP were detected as potential bioactive peptides by blocking ACE2 and CD26 or reducing the inflammation associated with COVID-19. …”
Get full text

Interferon gamma inhibits CXCL8–CXCR2 axis mediated tumor-associated macrophages tumor trafficking and enhances anti-PD1 efficacy in pancreatic cancer by Mingjie Zhang, Lifeng Huang, Guoping Ding, Huilian Huang, Guoliang Cao, Xu Sun, Neng Lou, Qiang Wei, Tao Shen, Xiaodong Xu, Liping Cao, Qiang Yan

Get full text

Highly efficient terahertz dark-field imaging system with 3D-printed components by Bryce Chung, Harrison Lees, Matthew Ibrahim, Daniel Headland, Withawat Withayachumnankul

“…Traditional dark-field methods achieve off-axis illumination by blocking the central portion of the incident beam, but this unfortunately incurs significant power losses of up to 99%. …”
Get full text

Fault diagnosis of MMC-MTDC based on traveling wave characteristics and KOA-CNN-BiGRU-AM by Bo YU, Xuejun GAO, Can WANG, Ruiling LI, Yanbin XU, Mengjie RONG

“…Firstly, the blocking effect of boundary elements on high-frequency signals is identified by analyzing the fault characteristics of the system. …”
Get full text

A RP-HPLC Method for the Analysis of Neostigmine Methylsulfate and Process-Related Impurities, Forced Degradation Studies, in the Injection Formulation by Manali Parab, Vaishali A. Shirsat, Yogita M. Kodgule, Mandar Kodgule

“…It is also used for reversing nondepolarising neuromuscular blocking agents. Neostigmine methylsulfate may be administered by intravenous, intramuscular, or subcutaneous injection. …”
Get full text

Targeted mutagenesis on PDGFRα-Fc identifies amino acid modifications that allow efficient inhibition of HCMV infection while abolishing PDGF sequestration. by Svenja Feldmann, Immanuel Grimm, Dagmar Stöhr, Chiara Antonini, Peter Lischka, Christian Sinzger, Cora Stegmann

“…PDGFRα-Fc with this mutation was fully effective at blocking HCMV entry and had a drastically reduced affinity for PDGF-BB. …”
Get full text

Development and Optimization of a Cost-Effective Electrochemical Immunosensor for Rapid COVID-19 Diagnosis by Thaís Machado Lima, Daiane Martins Leal, Zirlane Coelho Ferreira, Fernando de Jesus Souza, Danilo Bretas de Oliveira, Etel Rocha-Vieira, Helen Rodrigues Martins, Arnaldo César Pereira, Lucas Franco Ferreira

“…The optimal conditions for virus detection in clinical samples were a 1:10 dilution with a response time of 20 min. …”
Get full text

The effects of canonical Wnt signaling pathways on the CXCR4 expression of bone marrow derived mesenchymal stem cells by SUN Ji-ping, MA Ying, ZHANG Wen-jing, LV Jia, YIN Ai-ping

“…Objective To evaluate the effects of Wnt signaling pathways on the CXCR4 expression of bone marrow mesenchymal stem cells(BMSCs),and to investigate the possible regulation mechanisms of the Wnt signaling pathways on the migration ability of BMSCs.Methods BMSCs were obtained from the femurs,tibias,humeri and radius of adult male SD rats.The expression of Wnt signaling pathway downstream target geneβ-catenin was detected via RT-PCR and western-blotting after activating and blocking Wnt signaling pathway of BMSs.Meanwhile,expression of CXCR4 was also detected via RT-PCR and western-blotting after activating and blocking Wnt signaling pathway of BMSCs.Results(1)Dentification of BMSCs:BMSCs could expression CD29 and CD90,which were both marker of mesenchymal stem cells.Besides,BMSCs could express nerve culluar marker such as NSE,GFAP,and could be induced to differentiate into adipocytic cells,suggesting multi-directional differentiation.(2)Wnt3 a(200 ng/ml)could fully activate Wnt signaling pathway in 24 h,with high expression level ofβ-catenin(compared with control group,P<0.05).While DKK-1(100 ng/ml)could fully blockade Wnt signaling pathway in24 h(compared with control group,P<0.05).(3)When the Wnt signaling pathway was blockaded,expression levels of CXCR4 in BMSCs was obviously increased(compared with control group,P<0.05);while the activated of such signaling pathway could decrease the expression of CXCR4 of BMSCs(compared with control group,P<0.05).Conclusions Wnt signaling pathway could regulate the expression of CXCR4 of BMSCs,and such regulation maypromote the migration of BMSCs to kidney.…”
Get full text

A self-driven perovskite photodetector array for imaging application by suppressing optoelectrical crosstalk by Pengfei Kong, Huishan Han, Guanxia Dai, Yanhong Huang, Wei Zhang, Weixi Kong, Haodi Yang, Zixuan Li, Beiyun Liu, Feihong Chu

“…The device shows excellent responsivity, detectivity, and pixel-wise rectifying properties due to the integration of a blocking diode (BD) into the positive-intrinsic-negative (PIN) structure. …”
Get full text

Modeling of double ground fault modes in power supply systems of non-traction consumers of railway transport by A. V. Kryukov, I. S. Ovechkin, K. V. Suslov

“…The results obtained can be used in practice to configure relay protection devices for overhead signaling lines in order to reliably detect double ground fault modes and take measures to eliminate them. …”
Get full text

A preliminary imaging observation of the newly formed maxillary sinus floor after lateral maxillary sinus floor elevation by GUAN Xiangyu, GAO Yiming

“…[Objective:] To explore the imaging features and clinical significance of the white blocking line appearing on the newly formed maxillary sinus floor surface after lateral maxillary sinus floor elevation. …”
Get full text

Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists. by Melissa D Chengalroyen, Nurudeen Oketade, Aneta Worley, Megan Lucas, Luisa Maria Nieto Ramirez, Mabule L Raphela, Gwendolyn M Swarbrick, Paul S Soma, Mandisa Zuma, Digby F Warner, Deborah A Lewinsohn, Carolina Mehaffy, Erin J Adams, William Hildebrand, Karen M Dobos, Valerie Mizrahi, David M Lewinsohn

“…The semi-invariant antigen recognition receptor of MAIT cells specifically detects the non-polymorphic antigen-presenting molecule, major histocompatibility complex class I-related protein 1 (MR1), which primarily binds riboflavin-derived metabolites of microbial origin. …”
Get full text

TRIM29 Reverses Oxaliplatin Resistance of P53 Mutant Colon Cancer Cell by Guoqiong Lei, Sushun Liu, Xin Yang, Chao He

“…The coimmunoprecipitation method and immunofluorescence detection were used to examine the interaction between TRIM29 and mutant P53 protein in HT29 cells. …”
Get full text