PD-L1 and p53 expression in squamous cell carcinoma of the oropharynx depending on human papilloma virus status by D. Sh. Polatova, A. Yu. Madaminov, A. V. Savkin, A. I. Nurzhabov, N. K. Asamedinov, D. A. Ibragimova, R. R. Davletov, S. K. Nasirov

“…High-risk human papilloma virus (Hpv), especially genotype 16, causes oropharyngeal squamous cell carcinoma (OSCC). It is detected in about 70 % of tumors developing from lymphoid tissue of the tonsils or the base of the tongue. …”
Get full text

Development of a homotrimeric PSMA radioligand based on the NOTI chelating platform by Sebastian Martin, Moritz-Valentin Schreck, Tobias Stemler, Stephan Maus, Florian Rosar, Caroline Burgard, Andrea Schaefer-Schuler, Samer Ezziddin, Mark D. Bartholomä

“…Abstract Background The NOTI chelating scaffold can readily be derivatized for bioconjugation without impacting its metal complexation/radiolabeling properties making it an attractive building block for the development of multimeric/-valent radiopharmaceuticals. …”
Get full text

MicroRNA-124 suppresses proliferation and glycolysis in non–small cell lung cancer cells by targeting AKT–GLUT1/HKII by Xiaojian Zhao, Caiping Lu, Weiwei Chu, Bing Zhang, Qiang Zhen, Renfeng Wang, Yaxiao Zhang, Zhe Li, Baolei Lv, Huixian Li, Jiabao Liu

“…Overexpression of AKT reverses the inhibitory effect of miR-124 on cell proliferation and glycolytic metabolism in non–small cell lung cancer. AKT inhibition blocks miR-124 silencing–induced AKT1/2, glucose transporter 1, hexokinase II activation, cell proliferation, and glycolytic or energy metabolism changes. …”
Get full text

A Histopathological Study of Mean Eosinophil Count in Adult Gastrointestinal Pathologies: A Cross-sectional Study by Ashwini Annappa Moger, Padma Priya Kasukurti, Sulata M Kamath, SR Mangala Gowri, Karthik Yadavalli

“…Haematoxylin and eosin-stained slides obtained from formalin-fixed paraffin-embedded blocks of all study patients were reviewed. Eosinophil counts were performed on performed on Haematoxylin and Eosin (H&E) stained slides. …”
Get full text

Land cover classification using Land Parcel Identification System (LPIS) data and open source Eo-Learn library by Fatih Fehmi Şimşek, Süleyman Savaş Durduran

“…These data play an important role as a base for determining land cover and land use classes, detecting changes, monitoring forest, agriculture and wetlands, as well as updating the LPIS data used by countries. …”
Get full text

The reliability and validity of a non-wearable indoor positioning system to assess mobility in older adults: A cross-sectional study. by Isabel B Rodrigues, Patricia Hewston, Jonathan Adachi, Sayem Borhan, George Ioannidis, Alexa Kouroukis, Carolyn Leckie, Andrea Lee, Alexander Rabinovich, Parthipan Siva, Rachel Swance, Suleman Tariq, Lehana Thabane, Alexandra Papaioannou

“…<h4>Background</h4>Detecting early changes in walking speed can allow older adults to seek preventative rehabilitation. …”
Get full text

Evaluation of secondary prevention of noncommunicable diseases at the outpatient healthcare level in the Commonwealth of Independent States countries by M. N. Mamedov, V. A. Kutsenko, T. Z. Seisembekov, S. Kh. Mekhdiev, L. V. Yakubova, L. V. Kezhun, I. T. Murkamilov, Zh. A. Kauzbay, B. Zholdin, O. M. Drapkina

“…In Kyrgyzstan, 100% staffing is detected in 84% of cases. At the same time, in Kazakhstan, 50% and 75% staffing has a comparable frequency. …”
Get full text

PARP3 promotes macrophage inflammation via mono ADP ribosylation of Ppia Glu140 by Runjie Fan, Rongxing Zhu, Xiangxiu Cao, Shuhui Ye, Fengyi Gao, Yue Wu, Wanxin Yao, Guang Liang, Yanmei Zhang

“…PARP3 promoted inflammation via NF-κB activation. ME0328 blocked NF-κB pathway activation in RAW264.7 cells and lung tissues. …”
Get full text

Crosstalk between the serine/threonine kinase StkP and the response regulator ComE controls the stress response and intracellular survival of Streptococcus pneumoniae. by Germán E Piñas, Nicolás M Reinoso-Vizcaino, Nubia Y Yandar Barahona, Paulo R Cortes, Rosario Duran, Chandan Badapanda, Ankita Rathore, Dario R Bichara, Melina B Cian, Nadia B Olivero, Daniel R Perez, José Echenique

“…In the comET128A mutant, ASIL was blocked and acid tolerance response was higher compared to the wt strain. …”
Get full text

Predictive and prognostic features of early and locally advanced <i>PIK3CA</i>-mutated luminal HER2-negative breast cancer by A. I. Stukan, T. Yu. Semiglazova, S. I. Kutukova, V. A. Porkhanov, V. N. Bodnya, E. N. Imyanitov, V. V. Antipova, Z. K. Khachmamuk, O. Yu. Chukhray, S. D. Maksimenko

“…Primary metastatic disease was detected in 17 % of cases. An immunohistochemical evaluation was performed on sections from paraffin blocks using monoclonal antibodies to estrogen receptors, progesterone receptors, HER2, Ki-67, CD8, CD4, CD68, CD163, Bcl-2, p53, cyclin D1. …”
Get full text

Partially replacing baleage with grazed forage canola in a component feeding system: Effects on production performance, enteric methane emissions, and nutrient utilization in dairy... by L.H.P. Silva, Y. Zang, S.L. Dillard, K.J. Soder, A.F. Brito

“…A treatment by week interaction was also detected for the ruminal molar proportion of acetate, which decreased more pronouncedly in CAN than CON diet from week 3 to week 5. …”
Get full text

The results of a survey of Russian doctors in order to identify the compliance of the management of children with chronic urticaria with clinical recommendations by Yu. S. Smolkin, S. S. Masalskiy, R. F. Khakimova, O. V. Trusova, I. A. Larkova, E. V. Timofeeva, R. Ya. Meshkova, N.  B. Migacheva, E. V. Stezhkina, T. S.  Lepeshkova, A. Yu. Pischalnikov

“…Diet: 18.6 % of respondents do not recommend a special diet for children; 27.7 % exclude from the diet foods to which sensitization is detected, the rest recommend an nonspecific elimination diet.Antihistamines of 2nd generation (AG II) are the most used in clinical practice (86.5 %). …”
Get full text

Enhancement effects of seaweed iodine fertilizer application on the iodine contents of rice, vegetables and fruits in the field by HU Chunqin, LI Rui, HONG Chunlai, CAO Wenting, LIU Jiawei, ZHOU Jun, WENG Huanxin

“…This study aims to testify the feasibility of cultivating iodine- rich crops in a large scale under natural conditions, thus exploring a potential way for the prevention and elimination of the IDD.Randomized block experiments were conducted in the farmland in Sha’an Village of Bihu Basin, which located in Lishui City of Zhejiang south mountain area, to explore the biofortification effect of seaweed iodine fertilizer on iodine contents of rice, vegetables and fruits in the field. …”
Get full text

Deciphering cell cycle organization of Toxoplasma endodyogeny by Mrinalini Batra, Clem Marsilia, Danya Awshah, Lauren M. Hawkins, Chengqi Wang, Dale Chaput, Daria A. Naumova, Elena S. Suvorova

“…The ToxoFUCCIS probe efficiently detected G2/M and Spindle Assembly Checkpoints, as well as the SB505124-induced TgMAPK1-dependent block. …”
Get full text

Effects of Medical Ozone Injection via Intervertebral Foramen Epidural Space on Postherpetic Neuralgia: Protocol for a Randomized Controlled and Double-Blind Clinical Trial by Dongmei Xiang, Lei Deng, Rui Zhou, Xianjie Zhang, Yukai Zhou, Dan Zhou, Yanhua Peng

“…ObjectiveThis is a protocol for a prospective, randomized, controlled, and double-blind trial to detect whether the injection of medical ozone via the intervertebral foramen epidural space can reduce the incidence of PHN. …”
Get full text

CATHODOLUMINESCENCE AND RAMAN SPECTROSCOPY AS A BASIS FOR THE SELECTION OF REFERENCE SAMPLES FOR LA-ICP-MS ANALYSIS OF ZIRCON by S. L. Votyakov, M. V. Chervyakovskaya, Yu. V. Shchapova, E. A. Pankrushina, G. B. Mikhalevsky, V. S. Chervyakovsky

“…It has been found that the integral luminescence brightness varies for samples by more than an order of magnitude; the spectra are of a complex superposition nature; their decomposition into elementary components is ambiguous; a large number of components is detected, which are combined into three main Аi–Вi–Сi groups of broad bands in the near-ultraviolet (UV), blue-green and yellow regions with Emax=4.3–5.0, 2.6–3.5, and 2.1–2.3 eV, respectively. …”
Get full text

<i>IL-11</i> Expression in Systemic Sclerosis Is Dependent on Caspase-1 Activity but Does Not Increase Collagen Deposition by Caya M. McFalls, Lianne M. Connolly, Alfred G. Fustakgi, Carol M. Artlett

“…Many studies have reported decreased fibrosis when IL-11 is blocked, but few have examined factors that induce IL-11 expression. …”
Get full text

Atributos físicos, químicos e biológicos de solo sob produção orgânica impactados por sistemas de cultivo Physical, chemical and biological attributes of soil under organic product... by Eurâimi de Q. Cunha, Luís F. Stone, Enderson P. de B. Ferreira, Agostinho D. Didonet, José A. A. Moreira

“…PA were more sensitive to detect changes in the quality of the soil under cultivation. …”
Get full text

Consumer knowledge in marketing: a critical review and research agenda by Elisa Garrido-Castro, Francisco José Torres-Peña, Eva María Murgado-Armenteros, Francisco Jose Torres-Ruiz

“…Design/methodology/approach – A search was undertaken for documents in the main databases in which the term “consumer knowledge” appears in a marketing or consumer context, and a critical and reflexive approach was taken to analyse the main contributions and to structure them by content blocks. Findings – Five main content blocks were identified. …”
Get full text

JWST and Ground-based Observations of the Type Iax Supernovae SN 2024pxl and SN 2024vjm: Evidence for Weak Deflagration Explosions by Lindsey A. Kwok, Mridweeka Singh, Saurabh W. Jha, Stéphane Blondin, Raya Dastidar, Conor Larison, Adam A. Miller, Jennifer E. Andrews, Moira Andrews, G. C. Anupama, Katie Auchettl, Dominik Bánhidi, Barnabas Barna, K. Azalee Bostroem, Thomas G. Brink, Régis Cartier, Ping Chen, Collin T. Christy, David A. Coulter, Sofia Covarrubias, Kyle W. Davis, Connor B. Dickinson, Yize Dong, Joseph R. Farah, Alexei V. Filippenko, Andreas Flörs, Ryan J. Foley, Noah Franz, Christoffer Fremling, Lluís Galbany, Anjasha Gangopadhyay, Aarna Garg, Peter Garnavich, Elinor L. Gates, Or Graur, Alexa C. Gordon, Daichi Hiramatsu, Emily Hoang, D. Andrew Howell, Brian Hsu, Joel Johansson, Arti Joshi, Lordrick A. Kahinga, Ravjit Kaur, Sahana Kumar, Piramon Kumnurdmanee, Hanindyo Kuncarayakti, Natalie LeBaron, Chang Liu, Keiichi Maeda, Kate Maguire, Curtis McCully, Darshana Mehta, Luca M. Menotti, Anne J. Metevier, Kuntal Misra, C. Tanner Murphey, Megan Newsome, Estefania Padilla Gonzalez, Kishore C. Patra, Jeniveve Pearson, Anthony L. Piro, Abigail Polin, Aravind P. Ravi, Armin Rest, Nabeel Rehemtulla, Nicolas Meza Retamal, Olivia M. Robinson, César Rojas-Bravo, Devendra K. Sahu, David J. Sand, Brian P. Schmidt, Steve Schulze, Michaela Schwab, Manisha Shrestha, Matthew R. Siebert, Sunil Simha, Nathan Smith, Jesper Sollerman, Bhagya M. Subrayan, Tamás Szalai, Kirsty Taggart, Rishabh Singh Teja, Tea Temim, Jacco H. Terwel, Samaporn Tinyanont, Stefano Valenti, Jorge Anais Vilchez, József Vinkó, Aya L. Westerling, Yi Yang, WeiKang Zheng

Get full text