Eucommia ulmoides Oliv. and its bioactive compounds: therapeutic potential in bone diseases by Cai Huang, Huan Jin, Yan Zhang, Di Wang, Ziyi He, Bo Shuai

“…Although these diseases differ in clinical manifestations and pathological features, they often share common age-associated mechanisms such as impaired bone remodeling, chronic low-grade inflammation, cellular senescence, oxidative stress, and hormonal changes. …”
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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials by Xiaohang Guo, Weikang Luo, Lingyu Wu, Lianglin Zhang, Yuxuan Chen, Teng Li, Haigang Li, Wei Zhang, Yawei Liu, Jun Zheng, Yang Wang

“…Insights into the influence of NPHM structural features on the formation of supramolecular materials are also provided. …”
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The degree of esterification influences the bioactivity of pectic polysaccharides isolated from Lithocarpus litseifolius by Yu-Jing Huang, Jing Feng, Yong Deng, Jie Li, Hong-Yan Liu, Qing Liang, Yi-Chen Hu, Jian-Yong Zhang, Liang Zou, Ding-Tao Wu

“…Pectic polysaccharides are the mainly bioactive components in Lithocarpus litseifolius (sweet tea) leaves. …”
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Effect of Salt and pH Stress of Bioactive Metabolite Production in Geitlerinema carotinosum by Tunay Karan, Ramazan Erenler

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Extraction of Bioactive Substances from Medicinal Plants with Whey: Selecting Optimal Parameters by Natalia S. Velichkovich, Ann A. Stepanova, Oksana V. Kozlova, Veronika A. Lutz, Timothy A. Larichev

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Engineering a promiscuous prenyltransferase for selective biosynthesis of an undescribed bioactive cannabinoid analog by Qin Yan, Yue-Gui Chen, Xiao-Wen Yang, An Wang, Xiao-Ping He, Xue Tang, Hong Hu, Kai Guo, Zong-Hua Xiao, Yan Liu, Sheng-Hong Li

“…These findings provide a foundation for enriching the chemical diversity of bioactive cannabinoid analogs with various prenyl moieties through combinatorial biosynthesis.…”
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Determination of Bioactive Components in Chrysanthemum Tea (Gongju) Using Hyperspectral Imaging Technique and Chemometrics by Yunpeng Wei, Huiqiang Hu, Minghua Yuan, Huaxing Xu, Xiaobo Mao, Yuping Zhao, Luqi Huang

“…The bioactive components of chrysanthemum tea are an essential indicator in evaluating its nutritive and commercial values. …”
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DetectEV: A functional enzymatic assay to assess integrity and bioactivity of extracellular vesicles by Giorgia Adamo, Sabrina Picciotto, Paola Gargano, Angela Paterna, Samuele Raccosta, Estella Rao, Daniele Paolo Romancino, Giulio Ghersi, Mauro Manno, Monica Salamone, Antonella Bongiovanni

“…Abstract The application of extracellular vesicles (EVs) as therapeutics or nanocarriers in cell‐free therapies necessitates meticulous evaluations of different features, including their identity, bioactivity, batch‐to‐batch reproducibility, and stability. …”
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Food Gels Based on Polysaccharide and Protein: Preparation, Formation Mechanisms, and Delivery of Bioactive Substances by Yong Guo, Chao Ma, Yan Xu, Lianxin Du, Xin Yang

“…Hydrogels have a unique three-dimensional network that can create a good environment for the loading of functional compounds; hence, they have considerable potential in the delivery of bioactive substances. Natural macromolecular substances (proteins, polysaccharides) have the features of low toxicity, degradability, and biosafety; thus, they can be employed in the manufacture of hydrogels in the food sector. …”
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Isolation, Structures, and Bioactivities of Polysaccharides from <i>Achyranthes bidentata</i>: A Review by Lin Li, Zhihong Wang, Wei Zhang, Longxin Chen, Yingying Yang, Wan Yang, Mengkun Li, Chunhuan Yuan, Limeng Zhang, Linqing Wang

“…<i>Achyranthes bidentata</i>, a traditional Chinese medicinal herb, has garnered significant attentions due to its diverse bioactivities and substantial market potential. Recent advancements in phytochemical and pharmacological research have identified polysaccharides as some of its primary bioactive constituents. …”
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Merging microencapsulated garlic extract as a bioactive ingredient into manufacturing functional soft cheese by Tarek Nour Soliman, Ahmed Behdal Shazly, Mahmoud Abd El-Aziz, Laila Khaled Hassan

“…The study demonstrates that the use of EGE in cheese fortification provides a healthy and promising approach to reducing the strong flavor of garlic and enhancing bioactivity in the production of functional soft cheese, offering up novel opportunities for the development of distinctive dairy products with functional features.…”
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Cheminformatics approaches to predict the bioactivity and to discover the pharmacophoric traits crucial to block NF-κB by Rahul D. Jawarkar, Suraj N. Mali, Rahul G. Ingle, Sami A. Al-Hussain, Aamal A. Al-Mutairi, Prashant Deshmukh, Magdi E.A. Zaki

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Developing Collagen Hydrogel Including Bioactive Glass Nanoparticles for being used in Bone Tissue Engineering by M. Takapoui, M. Saadatmand, F. Ghobadi

“…In this study, first we extracted the collagen type I from rat tail and characterized it with FTIR spectrum and self-assembly, second we synthesised the bioactive glass nanoparticles and characterized them with XRD and EDAX. …”
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Extraction efficiency and bioactive evaluation of Tamarix nilotica and Arthrocnemum macrostachyum extracts for anti-cancer potential. by Maryam Al Kaabi, Nancy A ElNaker, Nila Jan, Michael A Ochsenkühn, Shady A Amin, Lina F Yousef, Ahmed F Yousef

“…The 30% and 70% methanol fractions exhibited the highest cytotoxicity towards breast and colon cancer cell lines, respectively. 5) Untargeted metabolomics using UHPLC-Q-ToF-MS of T. nilotica crude extracts revealed 909 molecular features, of which only 327 were annotated using MS/MS fragmentation. …”
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Chemical Composition and Bioactivity Dataset Integration to Identify Antiproliferative Compounds in <i>Phyllanthus</i> Plants by Luis Diaz, Taylor H. Díaz-Herrera, Ericsson Coy-Barrera

“…Additionally, this study underscores the value of combining advanced analytical techniques with bioactivity testing to uncover bioactive compounds from natural sources. …”
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Establishment of <i>Dittrichia viscosa</i> L. Hairy Roots and Improvement of Bioactive Compound Production by Annalisa Paradiso, Miriana Durante, Sofia Caretto, Angelo De Paolis

“…<i>D. viscosa</i> plant tissues, especially leaves, are known to be a rich source of bioactive metabolites which have antioxidant, cytotoxic, antiproliferative and anticancer properties. …”
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A Correlation-Based Approach for Predicting Humic Substance Bioactivity from Direct Compost Characterization by Ana Catarina Silva, Pedro Rocha, Patrícia Valderrama, Juan Antelo, Dulce Geraldo, Maria Fernanda Proença, Sarah Fiol, Fátima Bento

“…The goal was to identify key compost parameters that can serve as reliable predictors of humic substance composition and bioactivity, thereby reducing reliance on labor-intensive humic substance extractions. …”
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Molecular mechanisms involved in the anticancer activity of crocin and crocetin, two bioactive compounds found in saffron by Mohammad Mehdi Haghighat_Lari, Maryam Milajerdi, Alireza Milajerdi

“…Numerous studies have shown that bioactive compounds in saffron, especially crocin and crocetin, exhibit selective toxicity against cancer cells. …”
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Cross modality learning of cell painting and transcriptomics data improves mechanism of action clustering and bioactivity modelling by Son V. Ha, Steffen Jaensch, Maciej M. Kańduła, Dorota Herman, Paul Czodrowski, Hugo Ceulemans

“…We show that in the absence of TX features for new compounds, using learned embeddings like those obtained from Constrastive Learning enhances performance of CP features on tasks where TX features excels but CP features does not. …”
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Natural Bioactive Compound-Integrated Nanomaterials for Diabetic Wound Healing: Synergistic Effects, Multifunctional Designs, and Challenges by Tao Lu, Xuan Zhou, Shuai-Yu Jiang, Qing-Ao Zhao, Zi-Yi Liu, Dao-Fang Ding

“…Conventional treatments are often limited by low drug bioavailability, transient therapeutic effects, and insufficient synergy across multiple pathways. Natural bioactive compounds are potential alternatives due to their multifunctional properties, including antioxidant, antimicrobial, and proangiogenic activities; however, their application is constrained by poor water solubility and rapid metabolism. …”
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