The Detoxifying Effects of Spirulina in Promoting Liver Health and Heavy Metal Elimination – A Review by Sunil Namdeo Thitame, Ashwini Ashok Aher, Viddyasagar Mopagar

“…Furthermore, spirulina’s chelating agents support the binding and excretion of heavy metals, such as lead, mercury, and cadmium, from the body. …”
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Radiation Synovectomy: An Enticing Treatment Option for Inflammatory Joint Pain by Ashutosh Dash, Tapas Das

“…The selection of an optimal radionuclide hinges on critical nuclear and chemical properties, ensuring effective binding to microparticles and delivering favorable clinical outcomes. …”
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Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview by Zeynep Asli Oskovi Kaplan, A. Seval Ozgu-Erdinc

“…Bedside tests have also been developed for detecting markers like fetal fibronectin, insulin-like growth factor binding protein-1 (IGFBP-1), interleukin-6, and placental alpha-macroglobulin-1. …”
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Economical epidemiology, pathological populations, and the long history of the Demographic and Health Survey by John Nott

“…Focussing initially on questions of human capital, cross-sectional surveys have tended to promote and promise efficiency in terms of medical research and interventions, thereby reducing the need for extensive and expensive infrastructure. …”
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Clinical significance of lncRNA PAX8-AS1 and miR-96-5p in non-small cell lung cancer by Qiaoling Ying, Hui Xu, Xiaojiao Wu, Hang Fang, Jingjing Shi, Hangcheng Pan

“…The goal is to provide a reference for improving adverse outcomes in NSCLC and developing effective early interventions in the clinic. Methods A total of 112 NSCLC patients and 70 healthy volunteers were recruited as the study subjects. …”
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Altered network connectivity and global efficiency in tourette syndrome: insights into sensorimotor integration by Julia Schmidgen, Theresa Valentine Heinen, Felix Schmitt, Kerstin Konrad, Stephan Bender

“…This study investigates the role of theta connectivity in network mechanisms related to perception–action-binding, sensorimotor integration, and motor preparation in children with Tourette’s Syndrome (TS). …”
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Natural AI-based drug designing by modification of ascorbic acid and curcumin to combat buprofezin toxicity by using molecular dynamics study by Haleema Sadia, Irfan Zia Qureshi, Muhammad Naveed, Tariq Aziz, Metab Alharbi, Abdullah F. Alasmari, Thamer H. Albekairi

“…Docking experiments disclosed that the interaction of CAT with the ascorbic acid AI-derived drug demonstrated a binding energy of -7.1 kcal/mol, signifying a robust interaction, while the complex of IL-1B with the curcumin AI-derived drug exhibited a binding energy of -7.3 kcal/mol. …”
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The Effect of Metformin on Polycystic Ovary Syndrome in Overweight Women: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Yuanyuan Guan, Dongjun Wang, Huaien Bu, Tieniu Zhao, Hongwu Wang

“…Compared with control interventions, metformin appears to be an effective intervention for overweight women with PCOS.…”
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Progress in research on nutrition, neuroinflammation and dopaminergic alterations in Tic disorders by Lu Bai, Mei Jin, Qi Zhang, Suzhen Sun

“…Neuroimaging studies have shown increased dopamine transporter binding and decreased serotonin levels in patients with TD. …”
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The regulatory variant rs1950834 confers the risk of depressive disorder by reducing LRFN5 expression by Di Luan, Yifan Li, Aini Zhang, Qingqing Bai, Te Zhao, Xi Chen, Xinglun Dang, Junyang Wang, Shaolei Jiang, Yun Sun, Yingjie Zhu, Yan Kong, Xiong-Jian Luo, Zhijun Zhang

“…Conclusions These findings reveal that the functional risk single nucleotide polymorphism rs1950834 at 14q21.1 regulates LRNN5 expression and function in NAc, providing a novel perspective for molecular diagnosis and targeted interventions of MDD. Graphical Abstract The risk allele (A) of rs1950834 reduced the binding affinity to transcription factors POLR2A and the RAD21, leading to decreased expression of LRFN5. …”
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A highly neutralizing human monoclonal antibody targeting a novel linear epitope on staphylococcal enterotoxin B by Hongyin Fan, Liqun Zhao, Weiwei Wang, Feng Yu, Haiming Jing, Yun Yang, Xiaoli Zhang, Zhuo Zhao, Qiang Gou, Weijun Zhang, Quanming Zou, Jinyong Zhang, Hao Zeng

“…Staphylococcal Enterotoxin B (SEB), produced by Staphylococcus aureus (S. aureus), is a powerful superantigen that induces severe immune disruption and toxic shock syndrome (TSS) upon binding to MHC-II and TCR. Despite its significant impact on the pathogenesis of S. aureus, there are currently no specific therapeutic interventions available to counteract the mechanism of action exerted by this toxin. …”
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Drug resistance in parasites: A review of mechanisms, drivers, and mitigation strategies by Jan Clyden Tenorio

“…Resistance is often attributed to mutations in target proteins, altering their binding and efficacy. Other factors contributing to resistance include increased drug exposure due to self-medication, genetic diversity of parasites, and environmental factors like climate change. …”
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Monoclonal Antibodies for Treatment of COVID-19: An Updated Review of Current Evidence by Saurabh Nimesh, Pratibha Kumari, Rohit Kumar, Gosiya Gosiya, Md. Quamuddin, Md. Iftekhar Ahmad

“… The emergence of COVID-19 in December 2019 spurred a global effort to develop effective medical interventions. Therapeutic monoclonal antibodies (mAbs) have emerged as a promising strategy to combat the SARS-CoV-2 virus. …”
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Cytoskeletal Proteins and Alzheimer’s Disease Pathogenesis: Focusing on the Interplay with Tau Pathology by Gege Jiang, Guanfeng Xie, Xiaoyi Li, Jing Xiong

“…However, aberrant post-translational modifications (PTMs) in the MT binding domain—such as phosphorylation, acetylation and ubiquitination—trigger tau dissociation, causing microtubule collapse, transport deficits, and synaptic dysfunction. …”
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Role of the YWHAG gene mutations in Developmental and Epileptic Encephalopathy by Violet Vilmont, Richard S. Nowakowski, Yi Zhou

“…Specific missense mutations in the 14-3-3γ, such as Arg132Cys, significantly impair the protein’s binding affinity and are associated with a severe DEE. …”
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Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons by Beatrice Caballero, Scott J. Sherman, Torsten Falk

“…Vascular endothelial growth factor-B (VEGF-B), when initially discovered, was thought to be an angiogenic factor, due to its intimate sequence homology and receptor binding similarity to the prototype angiogenic factor, vascular endothelial growth factor-A (VEGF-A). …”
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Structural Basis and Mechanism of a Unique Haemophore in the Haem‐Iron Acquisition by Riemerella anatipestifer by Mengying Wang, Dandan Zhang, Xiu Tian, Jiangyang Tong, Yizhou Yao, Mingshu Wang, Dekang Zhu, Renyong Jia, Shun Chen, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Bin Tian, Di Sun, Yu He, Zhen Wu, Songying Ouyang, Mafeng Liu, Anchun Cheng

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Regulation of the promoter for capsular polysaccharide synthesis in Neisseria meningitidis serogroup B by HTH_XRE family transcription factor by Iyinoluwa Sofowora, Pumtiwitt McCarthy, James Wachira

“…Deletion of the putative lexA binding site led to an increase in GFP fluorescence. …”
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Identification of novel compounds against Trypanosoma cruzi using AlphaFold structures by Albert Ros-Lucas, Alejandra Saeteros, Juan Carlos Gabaldón-Figueira, Nieves Martínez-Peinado, Elisa Escabia, Joaquim Gascón, Julio Alonso-Padilla

“…These compounds were predicted to target previously uncharacterized T. cruzi proteins, ledipasvir interacting with a calpain-like protein and pimecrolimus likely binding a mitotic cyclin. Molecular dynamics simulations showed that pimecrolimus remains stable in the predicted binding site, while ledipasvir exhibits a higher RMSD. …”
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Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage by Sandra Rayego-Mateos, Raul Rodrigues-Diez, Jose Luis Morgado-Pascual, Floris Valentijn, Jose M. Valdivielso, Roel Goldschmeding, Marta Ruiz-Ortega

“…This growth factor, by binding to EGFR and downstream signaling pathway activation, regulates renal inflammation, cell growth, and fibrosis. …”
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