Structure-based mechanism of RyR channel operation by calcium and magnesium ions. by Alexandra Zahradníková, Jana Pavelková, Miroslav Sabo, Sefer Baday, Ivan Zahradník

“…Bioinformatics analysis of RyR structures ascertained the EF-hand loops as the M2+ binding inhibition site and revealed its allosteric coupling to the channel gate. …”
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The implementation of social policies in a pandemic context: an analysis of anger by Andrea Dettano, Rebeca Cena

“…The analysis of emotions in state interventions allows us to reformulate the study of the implementation processes. …”
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The implementation of social policies in a pandemic context: an analysis of anger by Andrea Dettano, Rebeca Cena

“…The analysis of emotions in state interventions allows us to reformulate the study of the implementation processes. …”
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Emergency unit capacity in Northern Tanzania: a cross-sectional survey by Daniel Wilhelms, Blandina Mmbaga, Catherine A Staton, Frida Shayo, Malin Ardsby, Francis M Sakita, Baraka Moshi, Parker Frankiewicz, Lincoln Luis Silva, Anjni Joiner

“…Only one facility had an ECG readily available in the EU and none was able to administer thrombolytic therapy. For trauma interventions, all facilities could immobilise fractures, yet lacked interventions such as cervical spinal immobilisation and pelvic binding. …”
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Inhibition of Pancreatic Lipase by Flavonoid Derivatives: In Vitro and In Silico Investigations by The-Huan Tran, Thanh-Tan Mai, Thi-Thu-Trang Ho, Thi-Ngoc-Dung Le, Thi-Cam-Nhung Cao, Khac-Minh Thai, Thai-Son Tran

“…This value suggested a moderate binding affinity for the pancreatic lipase enzyme. …”
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Differential contribution of PBP occupancy and efflux on the effectiveness of β-lactams at their target site in clinical isolates of Neisseria gonorrhoeae. by Silvia López-Argüello, Eva Alcoceba, Paula Ordóñez, Biel Taltavull, Gabriel Cabot, Maria Antonia Gomis-Font, Antonio Oliver, Bartolome Moya

“…Further research is warranted to optimize therapeutic interventions for cephalosporin-resistant N. gonorrhoeae infections.…”
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A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner by Sourav Dasadhikari, Shamasree Ghosh, Sudip Pal, Tuomas P. J. Knowles, Kanchan Garai

“…However, the isoform-specific interactions of apoE with Aβ aggregates and the molecular mechanisms by which these isoforms influence Aβ aggregation and clearance remain poorly understood, which is critical for developing potential therapeutic interventions. Here, we employed TIRFM, superresolution microscopy, and single-molecule photobleaching techniques to investigate the isoform-specific effects of apoE on the rate constants of Aβ42 aggregation at the single-fibril level, as well as to quantify the binding affinity and specificity of apoE isoforms to individual Aβ fibril ends. …”
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JUND plays a genome-wide role in the quiescent to contractile switch in the pregnant human myometrium. by Nawrah Khader, Anna Dorogin, Oksana Shynlova, Jennifer A Mitchell

“…Total RNA-sequencing reveals a global increase in primary transcript levels at TL, with AP-1/JUND binding motifs overrepresented in the promoters of upregulated transcripts. …”
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EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA. by Ruyang Tan, Yuling Zhang, Mengqian Huang, Honghua Chen, Zixiang Liu, Zining Wang, Xiaoyan Li, Tao Wang, Zhiyun Wang

“…Viral infection inhibits mTOR and CDK1 phosphorylation, which enhances LARP1's binding to viral RNA and inhibits viral translation. …”
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Phthalates unleashed: decoding ovarian carcinogenesis through multi-omics networks, single-cell insights, and molecular docking by Junchan Yang, Min Luo, Hongjun Wang, Jinfa Huang

“…Molecular docking revealed specific binding interactions between phthalates and six core proteins. …”
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Network toxicology combined with molecular docking technology to explore the molecular mechanism of amatoxin causing liver injury by Chenglin Wang, Xin Wang, Yaxing Deng, Yingchun Hu, Li Hu

“…Molecular docking simulations were subsequently conducted to characterize three-dimensional binding conformations between amatoxin and core target proteins. …”
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Counter-hegemonic uses of law in struggles for freedom of movement in the Central Mediterranean by Kiri Olivia Santer, Lucia Gennari

“…It regulates the irreducible impulse to move, binding people to territories through the institution of citizenship and limiting the possibilities of crossing international borders. …”
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ANIMAL MODELS OF METASTATIC CANCER - ADVANCED IMAGE ANALYSIS FOR DISSECTION OF DRIVING SIGNALING PATHWAYS

“…A signaling axis triggered by Trop-2 defines key control hubs for cancer growth and metastatic diffusion, and identifies specific molecular targets for tailored therapeutic interventions …”
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Biochemical characterization of a novel purified lectin extracted from Pleurotus ostreatus mushroom for its antiviral activity by Yousra A. El-Maradny, Marwa M. Abu-Serie, Mona H. Hashish, Heba S. Selim, Abdulrahman M. Saleh, Esmail M. El-Fakharany

“…In this context, lectins, which are carbohydrate-binding proteins, have garnered attention due to their antiviral properties against RNA and DNA viruses. …”
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Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protea... by Mohamed Elagawany, Ayman Abo Elmaaty, Ahmed Mostafa, Noura M. Abo Shama, Eman Y. Santali, Bahaa Elgendy, Ahmed A. Al-Karmalawy

“…Compound 3b docking score was very promising (−6.94 kcal/mol) and its binding mode was nearly similar to that of WR1. Besides, the molecular dynamics (MD) simulations of compound 3b showed its great stability inside the binding pocket until around 40 ns. …”
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Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review by Tingting Zhang, Mingyue Li, Jingyang Lu, Jia Wang, Min Zhang, Pharkphoom Panichayupakaranant, Haixia Chen

“…Emerging research highlights the hypoglycemic activities of quinones, mainly driven by their redox properties, which lead to covalent binding, and their structural substituent specificity, which leads to their non-covalent binding to biocomplexes. …”
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Under conditions of high wall shear stress, several PfEBA and PfRH ligands are important for malaria Plasmodium falciparum blood-stage growth by Emma Kals, Morten Kals, Pietro Cicuta, Julian C. Rayner

“…Red blood cell invasion depends on two families of parasite attachment proteins, the Plasmodium falciparum erythrocyte-binding antigen and the Plasmodium falciparum reticulocyte-binding protein. …”
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Dynamic changes of iron metabolism and the effectiveness of health education among apheresis donors in Guangzhou under the GLMM framework by CHEN Xiaowen, LI Fanhai, ZHONG Bi, LIU Guanghuan, CHEN Jinyan, WANG Hao, LI Shijie

“…Hemoglobin (Hb), serum ferritin (SF), unsaturated iron-binding capacity (UIBC), total iron-binding capacity (TIBC), and transferrin saturation (TS) were selected as outcome variables. …”
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Comparative in silico and in vivo study of the antioxidant activity of lactoferrin, Geobacillus stearothermophilus, and Lactobacillus delbrueckii subsp. lactis against Rotavirus in... by Tarek A. M. Ismail, Naglaa Elshafey, Shehab E. Talat, Mona E. Saif, Amany Mohammed Hegab, Komla Mawunyo Dossouvi, Hanan M. Alharbi, Amr Elkelish, Khalid Abd El Ghany

“…The findings also suggest that bacteriocins, particularly those with high binding affinities to Rotavirus proteins, could serve as promising candidates for therapeutic interventions against Rotavirus infections.…”
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a-synuclein PET Imaging: From Clinical Utility in Multiple System Atrophy to the Possible Diagnosis of Parkinson’s Disease by Francesca Capotosti

“…The development of PET tracers for the detection of pathological alpha-synuclein (a-synuclein) has the potential to revolutionize the diagnosis, monitoring, and therapeutic interventions of synucleinopathies, including Parkinson’s disease. …”
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