Craniofacial Fibrous Dysplasia: Surgical Management and Long-Term Outcomes at a Referral Center in Mexico City by Luis Alejandro Lopez-Garibay, Osvaldo Guevara-Valmaña, Jose Eduardo Telich-Tarriba, David Felipe Navarro-Barquín, Natalia Haro-Alvarez, Laura Andrade-Delgado, Rogelio Martínez-Wagner

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Podocyte senescence: from molecular mechanisms to therapeutics by Qian Zhao, Yongzhang Huang, Ningying Fu, Caixia Cui, Xuan Peng, Haiyan Kang, Jie Xiao, Guibao Ke

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ML-Based Screening of miRNA Inhibitors and Intervention of lncRNA/miRNA/mRNA Axis in Oncogenic KRAS-Associated Colorectal Cancer by Prasanna Srinivasan Ramalingam, Deepak B. Thimiri Govinda Raj, Murugan Subramanian, Sivakumar Arumugam

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Xiao Yao San mitigates corticosterone stimulation-induced hippocampal neuronal damage by inhibiting GR phosphorylation and nuclear translocation via FKBP4 involvement by Xuedi Kang, Ting Wang, Haiping Wan, Wenjun Fu, Songjun Lin

“…The influence of FKBP4 on the competitive binding of GR was explored via similar techniques. …”
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Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin‐... by Chuanxin Tian, Sheng Yang, Chuan Zhang, Renzhong Zhu, Chen Chen, Xiaowei Wang, Dongsheng Zhang, Qingyang Sun, Hengjie Xu, Hongxu Nie, Yue Zhang, Dongjian Ji, Junwei Tang, Kangpeng Jin, Yueming Sun

“…Among these, cellular retinoic acid‐binding protein 2 (CRABP2) has been implicated as both a tumor activator and suppressor. …”
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Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway by Xue X, Wang S, Li J, Yuan H, Pan S, Liu X, Yue Z, Liu Y

“…Therefore, this study explored the therapeutic effect of EA on PDM and determined the potential involvement of the cyclooxygenase-2 (COX-2)/nuclear factor κB (NF-κB)/NLRP3 signaling pathway.Patients and Methods: The following pain management interventions were administered to a PDM rat model: saline (control), EA, parecoxib, EA + parecoxib, or ibuprofen. …”
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Thalidomide alleviated IgA nephropathy through “gut-kidney axis” by Rui-hua Wang, Zhi-jian Zha, Zi-yang Ye, Ya-feng Li

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The Impact of Green Tea Kombucha on the Intestinal Health, Gut Microbiota, and Serum Metabolome of Individuals with Excess Body Weight in a Weight Loss Intervention: A Randomized C... by Gabriela Macedo Fraiz, Dandara Baia Bonifácio, Udielle Vermelho Lacerda, Rodrigo Rezende Cardoso, Viviana Corich, Alessio Giacomini, Hércia Stampini Duarte Martino, Sergio Esteban-Echeverría, Ana Romo-Hualde, David Muñoz-Prieto, Frederico Augusto Ribeiro de Barros, Fermín I. Milagro, Josefina Bressan

“…Intestinal permeability considered the urine excretion of lactulose and mannitol, plasma zonulin, and LPS-binding protein. After the intervention, no differences related to intestinal permeability and microbiota were found between groups, but only the CG had increased fecal pH, lactulose/mannitol ratio, and zonulin. …”
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Increase in insulin-like growth factor 1 (IGF-1) and insulin-like growth factor binding protein 1 after supplementation with selenium and coenzyme Q10. A prospective randomized dou... by Urban Alehagen, Peter Johansson, Jan Aaseth, Jan Alexander, Kerstin Brismar

“…However, as the effects of IGF-1 are complex, more research on the result of intervention with selenium and coenzyme Q10 is needed.…”
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RBM14 enhances transcriptional activity of p23 regulating CXCL1 expression to induce lung cancer metastasis by Wen Zhang, Yulin Peng, Meirong Zhou, Lei Qian, Yilin Che, Junlin Chen, Wenhao Zhang, Chengjian He, Minghang Qi, Xiaohong Shu, Manman Tian, Xiangge Tian, Yan Tian, Sa Deng, Yan Wang, Xiaokui Huo, Zhenlong Yu, Xiaochi Ma

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Unraveling a novel FBN1 variant in Marfan syndrome with dilated aortic root manifestation by Amirreza Sabahizadeh, Amir Askarinejad, Saranaz Seyed AliAkbar, Mahdieh Soveizi, Golnaz Houshmand, Hojjat Mortezaeian, Amin Elahifar, Majid Maleki, Samira Kalayinia

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Deep learning algorithm reveals probabilities of stage‐specific time to conversion in individuals with neurodegenerative disease LATE by Xinxing Wu, Chong Peng, Peter T. Nelson, Qiang Cheng

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Oral delivery of GLP-1 peptide using recombinant Lactobacillus gasseri for the treatment of type 2 diabetes mellitus by Zhiqiang Ke, Qianqian Ma, Xiaonan Ye, Yan Jin, Yanlin Wang, Xinyuan Zhao, Zhengding Su

“…Collectively, our results highlight the potential of this probiotic-based approach as a promising therapeutic and preventive intervention for T2DM.IMPORTANCEIt is important to develop the oral delivery strategy for therapeutic peptides. …”
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Efficacy of brodalumab in psoriasis patients with a body weight >100 kg: Real‐world evidence (RWE) from the LIBERO study by Ralph vonKiedrowski, Khusru Asadullah, Bernhard Korge, Konstantina Tsarovina, Matthias Augustin

“…Methods LIBERO is a large prospective, multicenter, non‐interventional, real‐world‐evidence study including adult patients with plaque psoriasis treated with brodalumab 210 mg. …”
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Exploring the therapeutic mechanisms of millet in obesity through molecular docking, pharmacokinetics, and dynamic simulation by Komal G. Lakhani, Rasmeih Hamid, Sheetal Gupta, Poojaben Prajapati, Ratna Prabha, Saumya Patel, Kirankumar P. Suthar

“…Our research demonstrates that four bioactive compounds from Little Millet exhibit superior binding energies ranging from 7.22 to 8.83 kcal/mol, compared to the standard anti-obesity drug, orlistat, which has a binding energy of 5.96 kcal/mol. …”
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Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT by Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye

“…Hence, blockade of AEP via therapeutic intervention may provide an unprecedented strategy for fighting aging and various age‐associated diseases.…”
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A qualitative exploration of active ingredients and mechanisms of action of an online singing programme with mothers experiencing postnatal depression during the COVID-19 pandemic:... by Alexandra Burton, Rebecca H. Bind, Rachel Davis, Lorna Greenwood, Ching Yin Lee, Carolina Estevao, Katie Hazelgrove, Celeste Miller, Kristi Priestley, Lavinia Rebecchini, Tim Osborn, Hannah Dye, Paola Dazzan, Anthony Woods, Nikki Crane, Carmine M. Pariante, Daisy Fancourt

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Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7 by Shiyu Sun, Cen Cao, Yaru Guo, Yi Hou, Yanze Meng, Yuman Li, Feng Mei, Zhewen Hu, Yao Li, Yuting Niu, Yiming Chen, Lili Chen, Ying Huang, Xuliang Deng

“…Furthermore, it is found that early IGFBP7 intervention, which accelerates sprouting angiogenesis deceleration during the early stage of healing, impedes bone defect healing. …”
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International Law in Cyberspace: An Evaluation of the Tallinn Manuals by Ebru Oğurlu

“….], 2017), the most comprehensive, albeit non-binding, works published to date on the applicability of existing international law in cyberspace. …”
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Supplemental Nucleus Pulposus Allograft in Patients with Lumbar Discogenic Pain: Evaluation of Clinical Outcomes and Quality of Life in Medicare Beneficiaries by Azeem N, Myers TJ, Tate JL, Gilmore CA, Harper AS, Block JE

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