Development of an aerosol intervention for COVID-19 disease: Tolerability of soluble ACE2 (APN01) administered via nebulizer. by Robert H Shoemaker, Reynold A Panettieri, Steven K Libutti, Howard S Hochster, Norman R Watts, Paul T Wingfield, Philipp Starkl, Lisabeth Pimenov, Riem Gawish, Anastasiya Hladik, Sylvia Knapp, Daniel Boring, Jonathan M White, Quentin Lawrence, Jeremy Boone, Jason D Marshall, Rebecca L Matthews, Brian D Cholewa, Jeffrey W Richig, Ben T Chen, David L McCormick, Romana Gugensberger, Sonja Höller, Josef M Penninger, Gerald Wirnsberger

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SSL5-AnxA5 Fusion Protein Constructed Based on Human Atherosclerotic Plaque scRNA-Seq Data Preventing the Binding of Apoptotic Endothelial Cells, Platelets, and Inflammatory Cells by Yifei Zhao, Xingyu He, Teng Hu, Tianli Xia, Fangyang Huang, Changming Li, Yiming Li, Fei Chen, Mao Chen, Jun Ma, Yong Peng

“…Additionally, this fusion protein exhibited remarkable capability in binding to apoptotic cells. <b>Conclusions:</b> The bifunctional protein SSL5-AnxA5 exhibits promising potential as a protective agent against local inflammation in arterial tissues, making it an excellent candidate for PSGL1-related therapeutic interventions.…”
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RNA splicing: Novel star in pulmonary diseases with a treatment perspective by Zhihui Niu, Bingqian Xu, Wei Li, Jian Sun, Haihai Liang

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Integrative computational approaches identify haptoglobin inhibitors to modulate erythrocyte sedimentation rate in trauma-linked inflammatory and haematological malignancies by Abdulaziz H. Al Khzem, Shaban Ahmad

“…MM/GBSA calculations on the simulation trajectories supported these findings by providing binding free energy and complex energy estimations for all protein-ligand complexes. …”
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Tangeretin Improves the Memory of Swiss Mice, Suggesting Potential Molecular Interventions Through Animal Behavior Assessments and In Silico Studies by Md. Sakib Al Hasan, Mohd Shahnawaz Khan, Arusha Ayub, Raihan Chowdhury, Emon Mia, Md. Shadin, Md. Showkot Akbor, Muhammad Torequl Islam, Md. Shimul Bhuia

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Study of fatty acid-binding protein and Bacteroidetes and Firmicutes levels in patients with metabolic-associated fatty liver disease in combination with type 2 diabetes mellitus a... by V. V. Cherniavskyi, O. K. Didyk

“…The prospective, interventional, randomized study included 51 patients with MAFLD in combination with Т2DM, who were examined and divided into 2 groups. …”
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circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion by Yiwen Zhang, Meiyao Wu, Xiaoling Lin, Bingfeng Lu, Xi Chen, Qianhui Li, Yinan Jiang, Baixue Li, Dongmei Zhou, Xiujie Sheng

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Protective effects of combined eptifibatide and ticagrelor in patients with unstable angina undergoing percutaneous coronary intervention: a single-center experience by Shangsong Shi, Zicheng Ling, Shaohua Gu, Tingbo Jiang, Lin Ling

“…Abstract Background We evaluated the safety and effectiveness of combined eptifibatide and ticagrelor in patients with unstable angina pectoris undergoing percutaneous coronary intervention (PCI). Methods Patients with unstable angina pectoris who underwent PCI from January 2019 to December 2020 were included. …”
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The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury by Yao Zhang, Jiaju Yan, Yuan Ren, Lifang Li, Xiaojie You, Yujia Xie, Weihong Chen, Hui Zhao, Dongming Wang

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Determination of the Infection Dynamics of <i>Escherichia coli</i> O157:H7 by Bacteriophage ΦV10 by Michael F. Oats, Claudia P. Coronel-Aguilera, Bruce M. Applegate, Laszlo N. Csonka, Arun K. Bhunia, Andrew G. Gehring, George C. Paoli

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Comparative efficacy of pharmacological interventions on metabolic and hormonal outcomes in polycystic ovary syndrome: a Network Meta-Analysis of Randomized controlled trials by Yali Bo, Jie Zhao, Chengjiang Liu, Ting Yu

“…This study aimed to evaluate the comparative efficacy of pharmacological interventions on these outcomes. Methods We conducted a systematic review and network meta-analysis of randomized controlled trials (RCTs) assessing pharmacological treatments for PCOS. …”
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Insulin‐Like Growth Factor 2 mRNA‐Binding Protein 2 (IGF2BP2) Promotes Castration‐Resistant Prostate Cancer Progression by Regulating AR‐V7 mRNA Stability by Taruna Saini, Devesh Srivastava, Rajnikant Raut, Parul Mishra, Ashish Misra

“…ABSTRACT Background The emergence of constitutively active androgen receptor (AR) splice variant AR‐V7 poses a formidable challenge in treating prostate cancer, as it lacks the ligand binding region targeted by androgen‐deprivation therapies such as enzalutamide and abiraterone. …”
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In-silico analysis of nsSNPs in BCL-2 family proteins: Implications for colorectal cancer pathogenesis and therapeutics by Amanda Shen-Yee Kong, Yong Chiang Tan, Hin-Yee Thew, Kok-Song Lai, Swee-Hua Erin Lim, Sathiya Maran, Hwei-San Loh

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Circular RNAs in Cervical Cancer: What are the Prospects? by S. A. Begliarzade, R. I. Tamrazov

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Structural and functional roles of conserved residues of human papillomavirus (HPV) E2 protein and biological consequences by Sean Fletcher, Esther E. Biswas-Fiss, Subhasis B. Biswas

“…Results Structural modeling using AlphaFold3 and visualization in PyMOL revealed that conserved E2 residues cluster near the DNA-binding surface in the C-terminal domain and at critical interaction sites in the N-terminal transactivation domain, important for E1 DNA helicase binding and potentially other host factor interactions. …”
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Markers of myocardial injury and inflammation after radiofrequency ablation in children and adolescents by O. L. Peregudina, K. A. Chueva, R. B. Tatarsky, D. S. Lebedev, E. Yu. Vasilyeva, E. E. Kayumova, E. S. Vasichkina

“…Their relationship with changes in the concentration of biochemical markers before and after intervention was studied.Results. Two hours after the operation, the concentrations of myoglobin, creatine phosphokinase-MB, MMP-9, heart-type fatty acid binding protein were increased several times (p&lt;0,05). …”
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Demethylase FTO mediates m6A modification of ENST00000619282 to promote apoptosis escape in rheumatoid arthritis and the intervention effect of Xinfeng Capsule by Fanfan Wang, Fanfan Wang, Jianting Wen, Jianting Wen, Jian Liu, Jian Liu, Ling Xin, Yanyan Fang, Yanyan Fang, Yue Sun, Mingyu He, Mingyu He

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Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection by Wenxu Jia, Rudragouda Channappanavar, Chao Zhang, Mingxi Li, Haixia Zhou, Shuyuan Zhang, Panpan Zhou, Jiuyang Xu, Sisi Shan, Xuanling Shi, Xinquan Wang, Jincun Zhao, Dongming Zhou, Stanley Perlman, Linqi Zhang

“…However, no approved prophylactic and therapeutic interventions are currently available. The MERS-CoV envelope spike protein serves as a crucial target for neutralizing antibodies and vaccine development, as it plays a critical role in mediating viral entry through interactions with the cellular receptor, dipeptidyl peptidase 4 (DPP4). …”
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Os Relatórios do Desenvolvimento Humano (RDHs) e o padrão de intervenção pública na área social: os desafios postos à forma de organização do Estado no Brasil by Maria José de Rezende

“…This study aims to demonstrate both the social policy suggestions contained in the HDRs, and the difficulties faced by such proposals in Brazil, where the main binding in the redefinition of forms of intervention in the social area, consists of a political logic that does not dismantle a model of income transfer which strengthens the concentration of resources and power. …”
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MYOCARDIAL DAMAGE BIOMARKERS DYNAMICS AFTER EXTRACARDIAC SURGERY IN CORONARY HEART DISEASE PATIENTS TAKING TRIMETAZIDINE MR by O. A. Bolshedvorskaya, K. V. Protasov, E. V. Batunova, V. V. Dvornichenko, E. R. Batorova, E. G. Kazankova

“…Patients were randomized to the intervention group (n=35), receiving trimetazidine MR (Preductal MR®) 35 mg b. i.d., prescribed before operation for 2 weeks, and controls (n=37). …”
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