CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

“…CHD6 displays direct PAR-binding, interacts with PARP-1 and other PAR-associated proteins, and combined DNA- and PAR-binding loss eliminates CHD6 relocalization to DNA damage. …”
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Genetic determinants of myocardial electric instability in patients with coronary heart disease undergoing endovascular intervention by Yu. I. Afanasiev, A. V. Kuzubova, S. Yu. Grigorova

“…After endovascular intervention, immune inflammation is associated with atherosclerosis progression and myocardial electrical instability…”
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Intervention effect and mechanism of Dracocephalum moldavica L. extract on bleomycin-induced pulmonary fibrosis in rats by Xiaoyu SUN, Li CHEN, Ruifang GAO, Hui YU, Min JIN

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A review of C/EBP α: a potential novel target for solid tumor intervention by Xin Li, Tengkun Dai, Jiamin Zhao, Yidan Liang, Longqing Chen, Chao Chen, Mengmeng Guo, Yong Han, Lin Xu, Juanjuan Zhao

“…Abstract C/EBPα (CCAAT enhancer binding protein) is a pivotal transcription factor with widespread expression in multiple tissues, including hematopoietic tissues, liver, lungs, mammary glands, skin, and adipose tissue. …”
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Comparison of nutritional intervention effects at different initiation time in patients with respiratory diseases at nutritional risk by Lihong WANG, Yuan CUI, Shaoye HUO, Yunhua ZHAO, Yuhuan WEI, Rong JIANG, Chunhai SHAO

“…ResultsIn the early group, prealbumin (P-ALB) and retinol-binding protein (RBP) levels were significantly higher (P＜0.01), C-reactive protein (CRP), procalcitonin (PCT) levels were significantly lower after intervention (P＜0.05). …”
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Early Antenatal Prediction of Gestational Diabetes in Obese Women: Development of Prediction Tools for Targeted Intervention. by Sara L White, Debbie A Lawlor, Annette L Briley, Keith M Godfrey, Scott M Nelson, Eugene Oteng-Ntim, Stephen C Robson, Naveed Sattar, Paul T Seed, Matias C Vieira, Paul Welsh, Melissa Whitworth, Lucilla Poston, Dharmintra Pasupathy, UPBEAT Consortium

“…Lifestyle and pharmacological interventions in unselected obese pregnant women have been unsuccessful in preventing GDM. …”
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Linking the low‐density lipoprotein receptor‐binding segment enables the therapeutic 5‐YHEDA peptide to cross the blood‐brain barrier and scavenge excess iron and radicals in the b... by Zhenyou Zou, Shengxi Shao, Ruyi Zou, Jini Qi, Liguan Chen, Hui Zhang, Qiqiong Shen, Yue Yang, Liman Ma, Ruzeng Guo, Hongwen Li, Haibo Tian, Pengxin Li, Mingfang Yu, Lu Wang, Wenjuan Kong, Caiyu Li, Zhenhai Yu, Yuping Huang, Li Chen, Qi Shao, Xinyan Gao, Xiaolin Chen, Zhengbo Zhang, Jianguo Yan, Xiaoyun Shao, Ru Pan, Lu Xu, Jing Fang, Lei Zhao, Yaohui Huang, Anqi Li, Yuchong Zhang, Wenkao Huang, Kechun Tian, Minxin Hu, Linchao Xie, Lingbin Wu, Yu Wu, Zhen Luo, Wenxin Xiao, Shanshan Ma, Jianan Wang, Kaixin Huang, Siyuan He, Fan Yang, Shuni Zhou, Mo Jia, Hui Zhang, Hongsheng Lu, Xinjuan Wang, Jie Tan

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Lipid infiltration promotes trans-differentiation of vascular smooth muscle cells into macrophage-like cells in early lesions of human coronary atherosclerosis by Junhai Hao, Jiang Liu, Jiahui Zhou, Yuanfeng Liang, Wanwen Chen, Yueheng Wu, Zhanyi Lin

“…These findings provide novel insight into early atherogenesis and may help identify potential targets for timely prevention and intervention in cardiovascular disease.…”
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Mitigating host microRNA interference to enhance mRNA vaccine efficacy in public health interventions by Tielong Xu, Ziqi Lin, Yicheng Yu, Muhammad Irfan, Munir Ahmed, Maya Septriana, Twinky Zebrina Cysta Sumantri, Anindini Winda Amalia, Bin Zheng

“…Main text APCs express cell-type-specific miR repertoires capable of binding vaccine mRNAs through conserved seed sequences, as evidenced by synthesis of experimental data from 67 studies demonstrating miR-mediated repression of exogenous transcripts. …”
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Nintedanib regulates miR-23b-3p/TGFBR2 axis and competitively binds to TGFBR2 protein, inhibiting EMT process in human pterygium cells by Ke-Ke Zhang, Meng Li, Yan-Hong Liao, Xiao-Tian Liu, Yong-Bo Bao, Yan Gong

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PUBLIC CHOICE ECONOMICS: A CRITICAL REVIEW OF THE LITERATURE ON MARKET FAILURE, GOVERNMENT INTERVENTION AND ARROW THEOREM by Stephen Onıfade, Mehmet Okan Taşar

“…This paper provides a critical review of the literature on public choice economics by highlighting some of its intriguing complexities to include issues like market failure and government intervention, rent-seeking activities with individual and collective interest, and Arrow’s impossibility theorem. …”
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A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway by Min Hee Yang, Basappa Basappa, Suresha N. Deveshegowda, Akshay Ravish, Arunkumar Mohan, Omantheswara Nagaraja, Mahendra Madegowda, Kanchugarakoppal S. Rangappa, Amudha Deivasigamani, Vijay Pandey, Peter E. Lobie, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn

“…In-depth analysis using structure-based bioinformatics showed that CHL-C strongly binds to β-catenin, with a binding affinity comparable to that of ICG-001, a well-known β-catenin inhibitor. …”
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DeepMiRBP: a hybrid model for predicting microRNA-protein interactions based on transfer learning and cosine similarity by Sasan Azizian, Juan Cui

“…Abstract Background Interactions between microRNAs and RNA-binding proteins are crucial for microRNA-mediated gene regulation and sorting. …”
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Predictive value of inflammatory markers in inguinal hernia surgery: General vs. spinal anesthesia by Marko Kordić, Davorin Kozomara, Ivanka Mikulić, Vinka Mikulić, Martin Kajić, Miran Boras, Mateo Bevanda, Neven Soldo, Mijo Jović, Vedran Dragišić, Ines Rozić

“… Inguinal hernia is a prevalent condition requiring surgical intervention, and accumulating evidence suggests that the type of anesthesia administered may influence systemic inflammatory responses. …”
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Implementation of singing groups for postnatal depression: experiences of participants and professional stakeholders in the SHAPER-PND randomised controlled trial by Emeline Han, Rachel Davis, Rachel Davis, Tayana Soukup, Tayana Soukup, Alexandra Bradbury, Julie Williams, Maria Baldellou Lopez, Lorna Greenwood, Rebecca Bind, Carolina Estevao, Tim Osborn, Hannah Dye, Kristi Priestley, Lavinia Rebecchini, Katie Hazelgrove, Manomani Manoharan, Anthony Woods, Nikki Crane, Andy Healey, Paola Dazzan, Nick Sevdalis, Carmine M. Pariante, Daisy Fancourt, Ioannis Bakolis, Ioannis Bakolis, Alexandra Burton

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Bioinformatics pipeline to guide late‐onset Alzheimer's disease (LOAD) post‐GWAS studies: Prioritizing transcription regulatory variants within LOAD‐associated regions by Michael W. Lutz, Ornit Chiba‐Falek

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Effects of Trimetazidine Pretreatment on Endothelial Dysfunction and Myocardial Injury in Unstable Angina Patients Undergoing Percutaneous Coronary Intervention by Shuai Shao, Zhaozhao Shi, Gary Tse, Xinghua Wang, Yanping Ni, Hongmei Liu, Tong Liu, Guangping Li

“…Serum levels of creatine kinase-muscle/brain (CK-MB), cardiac troponin I (cTnI), heart-type fatty acid-binding protein (h-FABP), von Willebrand factor (vWF), and nitric oxide (NO) were measured before and the morning following PCI. …”
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An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV by Hailong Guo, Bomsoo Cho, Paul R. Hinton, Sijia He, Yongjun Yu, Ashwin Kumar Ramesh, Jwala Priyadarsini Sivaccumar, Zhiqiang Ku, Kristen Campo, Sarah Holland, Sameer Sachdeva, Christopher Mensch, Mohamed Dawod, Annalis Whitaker, Philip Eisenhauer, Allison Falcone, Rebekah Honce, Jason W. Botten, Stephen F. Carroll, Bruce A. Keyt, Andrew W. Womack, William R. Strohl, Kai Xu, Ningyan Zhang, Zhiqiang An, Sha Ha, John W. Shiver, Tong-Ming Fu

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Verteporfin Inhibits Severe Fever with Thrombocytopenia Syndrome Virus Infection via Inducing the Degradation of the Viral Gn Protein by Bingan Wu, Chenyang Yu, Yuxiang Lin, Ping Zhao, Zhongtian Qi, Xijing Qian

“…We performed time-of-addition experiments with VP, along with binding, endocytosis, and membrane fusion assays, to determine which part of the SFTSV life cycle VP has its effect on. …”
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Tackling Disinformation Through Public Administration Recommendations –The Czech Experience by Tomáš Svoboda

“…Practical Implications: It is inadvisable to view non-binding public administration activity as incapable of infringing upon or otherwise influencing the rights of the addressees of public administration. …”
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