Endurance exercise attenuates Gαq-RNAi induced hereditary obesity and skeletal muscle dysfunction via improving skeletal muscle Srl/MRCC-I pathway in Drosophila by Xin-yuan Yin, Deng-tai Wen, Han-yu Li, Zhao-qing Gao, YuZe Gao, WeiJia Hao

“…Abstract G protein alpha q subunit (Gαq) can binds to the G protein-coupled receptor (GPCR) for signaling and is closely related to lipid metabolism. …”
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Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70 by Ke Lin, Wenjie Wei, Songzan Chen, Yingchao Gong, Xingchen Wang, Meihui Wang, Ran Li, Yanbo Zhao, Shengjie Xu, Chongying Jin, Chenyang Jiang, Guosheng Fu, Qinfeng Li

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Exosomal lncRNA Mir100hg from lung cancer stem cells activates H3K14 lactylation to enhance metastatic activity in non-stem lung cancer cells by Lei Shi, Bowen Li, Jiyu Tan, Ling Zhu, Sicheng Zhang, Yuhan Zhang, Meng Xiang, Jie Li, Yan Chen, Xue Han, Jiacheng Xie, Yao Tang, H. Rosie Xing, Jingyu Li, Jianyu Wang

“…Mechanistically, HNRNPF and HNRNPA2B1 directly binds to Mir100hg, facilitating its trafficking via exosomes to non-CSCs. …”
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Fibroblast growth factor 21 improves diabetic cardiomyopathy by inhibiting ferroptosis via ferritin pathway by Ruxin Wang, Xiaofang Zhang, Haowen Ye, Xian Yang, Yongting Zhao, Liangyan Wu, Han Liu, Yun Wen, Jiaxin Wang, Ying Wang, Meixin Yu, Caixia Ma, Lihong Wang

“…Furthermore, we discovered that FGF21 inhibited ferroptosis in DCM by directly acting on ferritin and prolonging its half-life. Specifically, FGF21 binded to the heavy and light chains of ferritin, thereby reducing its excessive degradation in the proteasome and lysosomal-autophagy pathways in DCM. …”
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The dual GLP-1 and GIP receptor agonist tirzapetide provides an unintended interaction with the β-adrenoceptors and plays a role in glucose metabolism in hyperglycemic or senescent... by Dunya Aydos, Zeynep Busra Aksoy, Mehmet Altay Unal, Kamil Can Akcali, Ceylan Verda Bitirim, Belma Turan

“…In addition, molecular dynamics simulations indicated that TZPD binds with the highest affinity to GLP-1R and β3-ARs rather than GIP-R and then relatively lower but almost similar affinities to β1- and β2-ARs. …”
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A novel lncRNA FLJ promotes castration resistance in prostate cancer through AR mediated autophagy by Yingying Wu, Shaojie Cheng, Ting Zhang, Leilei Wang, Ting Li, Yongbo Zheng, Guo Yang, Xiaohou Wu, Chunli Luo, Tingmei Chen, Liping Ou

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Qingre Huoxue Decoction Alleviates Atherosclerosis by Regulating Macrophage Polarization Through Exosomal miR-26a-5p by He W, Zhao H, Xue W, Luo Y, Yan M, Li J, Qing L, Wu W, Jin Z

“…These effects of BMDM-exo were further enhanced after QRHX intervention. Dual luciferase reporter assay results showed that miR-26a-5p directly binds to the 3’-UTR of PTGS2 mRNA and regulates the expression of PTGS2. …”
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European, multicentre, prospective observational phase IV clinical study to assess the impact of lebrikizumab on health-related well-being and control of skin manifestations in pat... by Matthias Augustin, Hilde Lapeere, Anthony Bewley, Christian Vestergaard, Thomas Werfel, Eric Massana, Ismail Kasujee, Marie-Charlotte Brüggen, Marjolein S de Bruin-Weller, Khaled Ezzedine, Silvia M Ferrucci, Spyridon Gkalpakiotis, Pedro Herranz, Emma K Johansson, Tomáš Kampe, Franz J Legat, Eva Maria Rehbinder, Jacek C Szepietowski, Tiago Torres, Arnau Domenech, Volker Koscielny, Siva Narayanan, Jan Gutermuth

“…Lebrikizumab is a novel, high-affinity monoclonal antibody that selectively binds to and neutralises interleukin-13 with high potency. …”
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